Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder.

abstract：IMPORTANCE:Cigarette smoking leads to upregulation of nicotinic acetylcholine receptors (nAChRs) in the human brain, including the common α4β2* nAChR subtype. While subjective aspects of tobacco dependence have been extensively examined as predictors of quitting smoking with treatment, no studies to our knowledge have ...

journal_title：JAMA psychiatry

authors： Brody AL,Mukhin AG,Mamoun MS,Luu T,Neary M,Liang L,Shieh J,Sugar CA,Rose JE,Mandelkern MA

更新日期：2014-07-01 00:00:00

abstract：IMPORTANCE:Despite the prevalence of antenatal depression and the fact that only one-third of pregnant women with depression consider it acceptable to take antidepressants, the effect of untreated depression on neonatal outcomes remains to be addressed thoroughly. OBJECTIVE:To undertake a systematic review and meta-an...

journal_title：JAMA psychiatry

authors： Jarde A,Morais M,Kingston D,Giallo R,MacQueen GM,Giglia L,Beyene J,Wang Y,McDonald SD

更新日期：2016-08-01 00:00:00

abstract：IMPORTANCE:Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems ...

journal_title：JAMA psychiatry

authors： van Borkulo C,Boschloo L,Borsboom D,Penninx BW,Waldorp LJ,Schoevers RA

更新日期：2015-12-01 00:00:00

abstract：IMPORTANCE:A major public health concern associated with schizophrenia and psychotic disorders is the long-term disability that involves impaired cognition, lack of social support, and an inability to function independently in the community. A critical goal of early detection and intervention studies in psychosis is th...

journal_title：JAMA psychiatry

authors： Carrión RE,McLaughlin D,Goldberg TE,Auther AM,Olsen RH,Olvet DM,Correll CU,Cornblatt BA

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:Motivational and cognitive deficits are core features of schizophrenia, both closely linked with functional outcomes. Although poor effort and decreased motivation are known to affect performance on cognitive tests, the extent of this relationship is unclear in patients with schizophrenia. OBJECTIVE:To eval...

journal_title：JAMA psychiatry

authors： Fervaha G,Zakzanis KK,Foussias G,Graff-Guerrero A,Agid O,Remington G

更新日期：2014-09-01 00:00:00

abstract：IMPORTANCE:Adverse childhood experiences (ACEs) are associated with several adulthood health problems, such as self-directed violence. For some individuals, enlistment in the military may be an instrumental act to escape adverse household environments; however, to our knowledge prevalence of ACEs among persons with a h...

journal_title：JAMA psychiatry

authors： Blosnich JR,Dichter ME,Cerulli C,Batten SV,Bossarte RM

更新日期：2014-09-01 00:00:00

abstract：IMPORTANCE:The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. OBJECTIVES:To characterize ZNF804A expression in human br...

journal_title：JAMA psychiatry

authors： Tao R,Cousijn H,Jaffe AE,Burnet PW,Edwards F,Eastwood SL,Shin JH,Lane TA,Walker MA,Maher BJ,Weinberger DR,Harrison PJ,Hyde TM,Kleinman JE

更新日期：2014-10-01 00:00:00

abstract：IMPORTANCE:In schizophrenia, working memory deficits appear to reflect abnormalities in the generation of gamma oscillations in the dorsolateral prefrontal cortex. The generation of gamma oscillations requires the phasic excitation of inhibitory parvalbumin-containing interneurons. Thus, gamma oscillations depend, in p...

journal_title：JAMA psychiatry

authors： Kimoto S,Zaki MM,Bazmi HH,Lewis DA

更新日期：2015-08-01 00:00:00

abstract：Importance:Dysfunctional reward processing is a leading candidate mechanism for the development of certain depressive symptoms, such as anhedonia. However, to our knowledge, there has not yet been a systematic assessment of whether and to what extent depression is associated with impairments on behavioral reward-proces...

journal_title：JAMA psychiatry

authors： Halahakoon DC,Kieslich K,O'Driscoll C,Nair A,Lewis G,Roiser JP

更新日期：2020-07-29 00:00:00

abstract：IMPORTANCE:Compulsory admissions, defined as admissions against the will of the patient (according to local judicial procedures), have a strong effect on psychiatric patients. In several Western countries, the rate of such admissions is tending to rise. Its reduction is urgently needed. OBJECTIVE:To establish which in...

journal_title：JAMA psychiatry

authors： de Jong MH,Kamperman AM,Oorschot M,Priebe S,Bramer W,van de Sande R,Van Gool AR,Mulder CL

更新日期：2016-07-01 00:00:00

abstract：Importance:The onset of adult psychopathologic disorders can be traced to behavioral or emotional symptoms observed in childhood, which could be targeted in early interventions to prevent future mental disorders. The network perspective is a novel conceptualization of psychopathologic disorders that could help to ident...

journal_title：JAMA psychiatry

authors： Rouquette A,Pingault JB,Fried EI,Orri M,Falissard B,Kossakowski JJ,Vitaro F,Tremblay R,Cote SM,Borsboom D

更新日期：2018-11-01 00:00:00

abstract：IMPORTANCE:The inverse social gradient in mental disorders is a well-established research finding with important implications for causal models and policy. This research has used traditional objective social status (OSS) measures, such as educational level, income, and occupation. Recently, subjective social status (SS...

journal_title：JAMA psychiatry

authors： Scott KM,Al-Hamzawi AO,Andrade LH,Borges G,Caldas-de-Almeida JM,Fiestas F,Gureje O,Hu C,Karam EG,Kawakami N,Lee S,Levinson D,Lim CC,Navarro-Mateu F,Okoliyski M,Posada-Villa J,Torres Y,Williams DR,Zakhozha V,Kessler

更新日期：2014-12-01 00:00:00

abstract：:CONTEXT Clinical experience and factor analytic studies suggest that some psychiatric disorders may be more closely related to one another, as indicated by the frequency of their co-occurrence, which may have etiologic and treatment implications. OBJECTIVE To construct a virtual space of common psychiatric disorders, ...

journal_title：JAMA psychiatry

authors： Blanco C,Krueger RF,Hasin DS,Liu SM,Wang S,Kerridge BT,Saha T,Olfson M

更新日期：2013-02-01 00:00:00

abstract：IMPORTANCE:Given minority patients' unequal access to quality care, patient activation and self-management strategies have been suggested as a promising approach to improving mental health care. OBJECTIVE:To determine whether the DECIDE (Decide the problem; Explore the questions; Closed or open-ended questions; Identi...

journal_title：JAMA psychiatry

authors： Alegría M,Carson N,Flores M,Li X,Shi P,Lessios AS,Polo A,Allen M,Fierro M,Interian A,Jimenez A,La Roche M,Lee C,Lewis-Fernández R,Livas-Stein G,Safar L,Schuman C,Storey J,Shrout PE

更新日期：2014-05-01 00:00:00

abstract：Importance:Suicide is a leading cause of deaths in the United States. Although the emergency department (ED) is an opportune setting for initiating suicide prevention efforts, ED-initiated suicide prevention interventions remain underdeveloped. Objective:To determine whether an ED-initiated intervention reduces subseq...

journal_title：JAMA psychiatry

authors： Miller IW,Camargo CA Jr,Arias SA,Sullivan AF,Allen MH,Goldstein AB,Manton AP,Espinola JA,Jones R,Hasegawa K,Boudreaux ED,ED-SAFE Investigators.

更新日期：2017-06-01 00:00:00

abstract：:Neural oscillations are rhythmic fluctuations over time in the activity or excitability of single neurons, local neuronal populations or "assemblies," and/or multiple regionally distributed neuronal assemblies. Synchronized oscillations among large numbers of neurons are evident in electrocorticographic, electroenceph...

journal_title：JAMA psychiatry

authors： Mathalon DH,Sohal VS

更新日期：2015-08-01 00:00:00

abstract：Importance:Because more than one-third of people making nonfatal suicide attempts do not receive mental health treatment, it is essential to extend suicide attempt risk factors beyond high-risk clinical populations to the general adult population. Objective:To identify future suicide attempt risk factors in the genera...

journal_title：JAMA psychiatry

authors： García de la Garza Á,Blanco C,Olfson M,Wall MM

更新日期：2021-01-06 00:00:00

abstract：IMPORTANCE:Mental health (MH) conditions are undertreated in late life. It is important to identify treatment strategies that address variability in treatment content and delivery and take individual-specific symptoms into account, particularly among low-income, community-dwelling older adults. OBJECTIVE:To evaluate p...

journal_title：JAMA psychiatry

authors： Mavandadi S,Benson A,DiFilippo S,Streim JE,Oslin D

更新日期：2015-12-01 00:00:00

abstract：IMPORTANCE:Some, but not all, previous magnetic resonance imaging studies have indicated smaller cortical and local gray matter volumes (GMVs) in men with schizotypal personality disorder (SPD) compared with healthy control (HC) subjects. Thus, there is need for a whole-brain comparison to resolve inconsistencies and p...

journal_title：JAMA psychiatry

authors： Asami T,Whitford TJ,Bouix S,Dickey CC,Niznikiewicz M,Shenton ME,Voglmaier MM,McCarley RW

更新日期：2013-04-01 00:00:00

abstract：IMPORTANCE:Patients with attention-deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) share impaired inhibitory control. However, it is unknown whether impairments are mediated by shared or disorder-specific neurostructural and neurofunctional abnormalities. OBJECTIVE:To establish shared and...

journal_title：JAMA psychiatry

authors： Norman LJ,Carlisi C,Lukito S,Hart H,Mataix-Cols D,Radua J,Rubia K

更新日期：2016-08-01 00:00:00

abstract：:CONTEXT Suicide bereavement remains understudied and poorly understood. OBJECTIVES To examine outcomes of parents bereaved by the suicide death of their offspring and to compare these with both nonbereaved parent controls and parents who had offspring die in a motor vehicle crash (MVC). DESIGN Population-based case-co...

journal_title：JAMA psychiatry

authors： Bolton JM,Au W,Leslie WD,Martens PJ,Enns MW,Roos LL,Katz LY,Wilcox HC,Erlangsen A,Chateau D,Walld R,Spiwak R,Seguin M,Shear K,Sareen J

更新日期：2013-02-01 00:00:00

abstract：Importance:A relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (CS). Preclinical studies suggest that drug reward memories can undergo memory reconsolida...

journal_title：JAMA psychiatry

authors： Xue YX,Deng JH,Chen YY,Zhang LB,Wu P,Huang GD,Luo YX,Bao YP,Wang YM,Shaham Y,Shi J,Lu L

更新日期：2017-03-01 00:00:00

abstract：IMPORTANCE:In 1939, English mathematician, geneticist, and psychiatrist Lionel Sharples Penrose hypothesized that the numbers of psychiatric hospital beds and the sizes of prison populations were inversely related; 75 years later, the question arises as to whether the hypothesis applies to recent developments in South ...

journal_title：JAMA psychiatry

authors： Mundt AP,Chow WS,Arduino M,Barrionuevo H,Fritsch R,Girala N,Minoletti A,Mitkiewicz F,Rivera G,Tavares M,Priebe S

更新日期：2015-02-01 00:00:00

abstract：IMPORTANCE:Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conducted in Mexico. OBJECTIVE:To evaluate the safety a...

journal_title：JAMA psychiatry

authors： Somoza EC,Winship D,Gorodetzky CW,Lewis D,Ciraulo DA,Galloway GP,Segal SD,Sheehan M,Roache JD,Bickel WK,Jasinski D,Watson DW,Miller SR,Somoza P,Winhusen T

更新日期：2013-06-01 00:00:00

abstract：Importance:Since the release of the DSM-5 diagnosis of attenuated psychosis syndrome (DSM-5-APS) in 2013, several research studies have investigated its clinical validity. Although critical and narrative reviews have reviewed these progresses, no systematic review has comprehensively summarized the available evidence r...

journal_title：JAMA psychiatry

authors： Salazar de Pablo G,Catalan A,Fusar-Poli P

更新日期：2020-03-01 00:00:00

abstract：Importance:Antipsychotic medications are commonly used to treat nonpsychotic disruptive behavioral disorders in youths. Objective:To characterize the metabolic effects of first exposure to antipsychotics in youths using criterion standard assessments of body composition and insulin sensitivity. Design, Setting, and P...

journal_title：JAMA psychiatry

authors： Nicol GE,Yingling MD,Flavin KS,Schweiger JA,Patterson BW,Schechtman KB,Newcomer JW

更新日期：2018-08-01 00:00:00

abstract：Importance:The increase in deaths related to drugs, alcohol, and suicide (referred to as deaths from despair) has been identified as a public health crisis. The antecedents associated with these deaths have, however, seldom been investigated empirically. Objective:To prospectively examine the association between relig...

journal_title：JAMA psychiatry

authors： Chen Y,Koh HK,Kawachi I,Botticelli M,VanderWeele TJ

更新日期：2020-07-01 00:00:00

abstract：IMPORTANCE:Serotonin is involved in negative affect, but whether anxiety syndromes, such as social anxiety disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. Serotonin 1A autoreceptors, which inhibit serotonin synthesis and release, are downregulated in SAD, and...

journal_title：JAMA psychiatry

authors： Frick A,Åhs F,Engman J,Jonasson M,Alaie I,Björkstrand J,Frans Ö,Faria V,Linnman C,Appel L,Wahlstedt K,Lubberink M,Fredrikson M,Furmark T

更新日期：2015-08-01 00:00:00

abstract：IMPORTANCE:The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. OBJECTIVES:First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to diff...

journal_title：JAMA psychiatry

authors： Redlich R,Almeida JJ,Grotegerd D,Opel N,Kugel H,Heindel W,Arolt V,Phillips ML,Dannlowski U

更新日期：2014-11-01 00:00:00

abstract：Importance:Several recent population-based studies have linked exposure to maternal smoking during pregnancy to increased risk of severe mental illness in offspring (eg, bipolar disorder, schizophrenia). It is not yet clear, however, whether this association results from causal teratogenic effects or from confounding i...

journal_title：JAMA psychiatry

authors： Quinn PD,Rickert ME,Weibull CE,Johansson ALV,Lichtenstein P,Almqvist C,Larsson H,Iliadou AN,D'Onofrio BM

更新日期：2017-06-01 00:00:00