Motivational deficits and cognitive test performance in schizophrenia.

abstract：IMPORTANCE:In 1939, English mathematician, geneticist, and psychiatrist Lionel Sharples Penrose hypothesized that the numbers of psychiatric hospital beds and the sizes of prison populations were inversely related; 75 years later, the question arises as to whether the hypothesis applies to recent developments in South ...

journal_title：JAMA psychiatry

authors： Mundt AP,Chow WS,Arduino M,Barrionuevo H,Fritsch R,Girala N,Minoletti A,Mitkiewicz F,Rivera G,Tavares M,Priebe S

更新日期：2015-02-01 00:00:00

abstract：Importance:Because more than one-third of people making nonfatal suicide attempts do not receive mental health treatment, it is essential to extend suicide attempt risk factors beyond high-risk clinical populations to the general adult population. Objective:To identify future suicide attempt risk factors in the genera...

journal_title：JAMA psychiatry

authors： García de la Garza Á,Blanco C,Olfson M,Wall MM

更新日期：2021-01-06 00:00:00

abstract：IMPORTANCE:Although high rates of current mental disorder are known to exist in the US Army, little is known about the proportions of these disorders that had onsets prior to enlistment. OBJECTIVE:To estimate the proportions of 30-day DSM-IV mental disorders among nondeployed US Army personnel with first onsets prior ...

journal_title：JAMA psychiatry

authors： Kessler RC,Heeringa SG,Stein MB,Colpe LJ,Fullerton CS,Hwang I,Naifeh JA,Nock MK,Petukhova M,Sampson NA,Schoenbaum M,Zaslavsky AM,Ursano RJ,Army STARRS Collaborators.

更新日期：2014-05-01 00:00:00

abstract：Importance:Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective:To compare national trends and patterns of self-injur...

journal_title：JAMA psychiatry

authors： Rockett IR,Lilly CL,Jia H,Larkin GL,Miller TR,Nelson LS,Nolte KB,Putnam SL,Smith GS,Caine ED

更新日期：2016-10-01 00:00:00

abstract：IMPORTANCE:Despite its high prevalence and morbidity, the underlying neural basis of major depressive disorder (MDD) in youth is not well understood. OBJECTIVES:To identify in youth diagnosed as having MDD the most reliable neural abnormalities reported in existing functional neuroimaging studies and characterize thei...

journal_title：JAMA psychiatry

authors： Miller CH,Hamilton JP,Sacchet MD,Gotlib IH

更新日期：2015-10-01 00:00:00

abstract：Importance:Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding, making causal inference and determining the direction of these associations difficult. Objective:To investigate the potential bidirectional associations...

journal_title：JAMA psychiatry

authors： Rosoff DB,Smith GD,Lohoff FW

更新日期：2020-11-11 00:00:00

abstract：Importance:Great interest exists in identifying methods to predict neuropsychiatric disease states and treatment outcomes from high-dimensional data, including neuroimaging and genomics data. The goal of this review is to highlight several potential problems that can arise in studies that aim to establish prediction. ...

journal_title：JAMA psychiatry

authors： Poldrack RA,Huckins G,Varoquaux G

更新日期：2020-05-01 00:00:00

abstract：Importance:Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective:To use systematic review and network meta-analysis to compare the association of using manualized psychotherapies and th...

journal_title：JAMA psychiatry

authors： Miklowitz DJ,Efthimiou O,Furukawa TA,Scott J,McLaren R,Geddes JR,Cipriani A

更新日期：2020-10-14 00:00:00

abstract：IMPORTANCE:Cigarette smoking leads to upregulation of nicotinic acetylcholine receptors (nAChRs) in the human brain, including the common α4β2* nAChR subtype. While subjective aspects of tobacco dependence have been extensively examined as predictors of quitting smoking with treatment, no studies to our knowledge have ...

journal_title：JAMA psychiatry

authors： Brody AL,Mukhin AG,Mamoun MS,Luu T,Neary M,Liang L,Shieh J,Sugar CA,Rose JE,Mandelkern MA

更新日期：2014-07-01 00:00:00

abstract：IMPORTANCE:Depression and obesity are 2 prevalent disorders that have been repeatedly shown to be associated. However, the mechanisms and temporal sequence underlying this association are poorly understood. OBJECTIVE:To determine whether the subtypes of major depressive disorder (MDD; melancholic, atypical, combined, ...

journal_title：JAMA psychiatry

authors： Lasserre AM,Glaus J,Vandeleur CL,Marques-Vidal P,Vaucher J,Bastardot F,Waeber G,Vollenweider P,Preisig M

更新日期：2014-08-01 00:00:00

abstract：Importance:Obesity is associated with an increased prevalence of psychiatric disorders. The association of bariatric surgery with mental health outcomes is poorly understood. Objective:To investigate the association of bariatric surgery with the incidence of outpatient, emergency department (ED), and inpatient mental ...

journal_title：JAMA psychiatry

authors： Morgan DJR,Ho KM,Platell C

更新日期：2020-01-01 00:00:00

abstract：Importance:In light of increasing cannabis use among pregnant women, the US Surgeon General recently issued an advisory against the use of marijuana during pregnancy. Objective:To evaluate whether cannabis use during pregnancy is associated with adverse outcomes among offspring. Design, Setting, and Participants:In t...

journal_title：JAMA psychiatry

authors： Paul SE,Hatoum AS,Fine JD,Johnson EC,Hansen I,Karcher NR,Moreau AL,Bondy E,Qu Y,Carter EB,Rogers CE,Agrawal A,Barch DM,Bogdan R

更新日期：2021-01-01 00:00:00

abstract：IMPORTANCE:Mental health (MH) conditions are undertreated in late life. It is important to identify treatment strategies that address variability in treatment content and delivery and take individual-specific symptoms into account, particularly among low-income, community-dwelling older adults. OBJECTIVE:To evaluate p...

journal_title：JAMA psychiatry

authors： Mavandadi S,Benson A,DiFilippo S,Streim JE,Oslin D

更新日期：2015-12-01 00:00:00

abstract：IMPORTANCE:The requirement of a childhood onset has always been a key criterion for the diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults, but recently this requirement has become surrounded by controversy. OBJECTIVE:To investigate whether impaired young adults with ADHD symptoms always have a chi...

journal_title：JAMA psychiatry

authors： Caye A,Rocha TB,Anselmi L,Murray J,Menezes AM,Barros FC,Gonçalves H,Wehrmeister F,Jensen CM,Steinhausen HC,Swanson JM,Kieling C,Rohde LA

更新日期：2016-07-01 00:00:00

abstract：:IMPORTANCE—Suicide can be viewed as an escape from unendurable punishment at the cost of any future rewards. Could faulty estimation of these outcomes predispose to suicidal behavior? In behavioral studies, many of those who have attempted suicide misestimate expected rewards on gambling and probabilistic learning tas...

journal_title：JAMA psychiatry

authors： Dombrovski AY,Szanto K,Clark L,Reynolds CF,Siegle GJ

更新日期：2013-10-01 00:00:00

abstract：Importance:The US Army suicide attempt rate increased sharply during the wars in Afghanistan and Iraq. Although soldiers with a prior mental health diagnosis (MH-Dx) are known to be at risk, little is known about risk among those with no history of diagnosis. Objective:To examine risk factors for suicide attempt among...

journal_title：JAMA psychiatry

authors： Ursano RJ,Kessler RC,Naifeh JA,Herberman Mash HB,Nock MK,Aliaga PA,Fullerton CS,Wynn GH,Ng THH,Dinh HM,Sampson NA,Kao TC,Heeringa SG,Stein MB

更新日期：2018-10-01 00:00:00

abstract：Importance:Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Ob...

journal_title：JAMA psychiatry

authors： Sheffield JM,Kandala S,Tamminga CA,Pearlson GD,Keshavan MS,Sweeney JA,Clementz BA,Lerman-Sinkoff DB,Hill SK,Barch DM

更新日期：2017-06-01 00:00:00

abstract：Importance:Suicide is a leading cause of deaths in the United States. Although the emergency department (ED) is an opportune setting for initiating suicide prevention efforts, ED-initiated suicide prevention interventions remain underdeveloped. Objective:To determine whether an ED-initiated intervention reduces subseq...

journal_title：JAMA psychiatry

authors： Miller IW,Camargo CA Jr,Arias SA,Sullivan AF,Allen MH,Goldstein AB,Manton AP,Espinola JA,Jones R,Hasegawa K,Boudreaux ED,ED-SAFE Investigators.

更新日期：2017-06-01 00:00:00

abstract：Importance:Since the release of the DSM-5 diagnosis of attenuated psychosis syndrome (DSM-5-APS) in 2013, several research studies have investigated its clinical validity. Although critical and narrative reviews have reviewed these progresses, no systematic review has comprehensively summarized the available evidence r...

journal_title：JAMA psychiatry

authors： Salazar de Pablo G,Catalan A,Fusar-Poli P

更新日期：2020-03-01 00:00:00

abstract：Importance:Suicide deaths are a leading cause of maternal mortality in the US, yet the prevalence and trends in suicidality (suicidal ideation and/or intentional self-harm) among childbearing individuals remain poorly described. Objective:To characterize trends in suicidality among childbearing individuals. Design, S...

journal_title：JAMA psychiatry

authors： Admon LK,Dalton VK,Kolenic GE,Ettner SL,Tilea A,Haffajee RL,Brownlee RM,Zochowski MK,Tabb KM,Muzik M,Zivin K

更新日期：2020-11-18 00:00:00

abstract：IMPORTANCE:Psychosis-risk studies have examined help-seeking adolescents and young adults. Population-based studies evaluating psychotic symptoms and neurocognitive performance across childhood are needed for "growth charting" cognitive development. We hypothesized that psychosis spectrum youths have delayed neurocogni...

journal_title：JAMA psychiatry

authors： Gur RC,Calkins ME,Satterthwaite TD,Ruparel K,Bilker WB,Moore TM,Savitt AP,Hakonarson H,Gur RE

更新日期：2014-04-01 00:00:00

abstract：IMPORTANCE:Adverse childhood experiences (ACEs) are associated with several adulthood health problems, such as self-directed violence. For some individuals, enlistment in the military may be an instrumental act to escape adverse household environments; however, to our knowledge prevalence of ACEs among persons with a h...

journal_title：JAMA psychiatry

authors： Blosnich JR,Dichter ME,Cerulli C,Batten SV,Bossarte RM

更新日期：2014-09-01 00:00:00

abstract：IMPORTANCE:Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conducted in Mexico. OBJECTIVE:To evaluate the safety a...

journal_title：JAMA psychiatry

authors： Somoza EC,Winship D,Gorodetzky CW,Lewis D,Ciraulo DA,Galloway GP,Segal SD,Sheehan M,Roache JD,Bickel WK,Jasinski D,Watson DW,Miller SR,Somoza P,Winhusen T

更新日期：2013-06-01 00:00:00

abstract：IMPORTANCE:At least 11 rare copy number variants (CNVs) have been shown to be major risk factors for schizophrenia (SZ). These CNVs also increase the risk for other neurodevelopmental disorders, such as intellectual disability. It is possible that additional intellectual disability-associated CNVs increase the risk for...

journal_title：JAMA psychiatry

authors： Rees E,Kendall K,Pardiñas AF,Legge SE,Pocklington A,Escott-Price V,MacCabe JH,Collier DA,Holmans P,O'Donovan MC,Owen MJ,Walters JTR,Kirov G

更新日期：2016-09-01 00:00:00

abstract：IMPORTANCE:Although depression and type 2 diabetes mellitus (DM) may independently increase the risk for dementia, no studies have examined whether the risk for dementia among people with comorbid depression and DM is higher than the sum of each exposure individually. OBJECTIVE:To examine the risk for all-cause dement...

journal_title：JAMA psychiatry

authors： Katon W,Pedersen HS,Ribe AR,Fenger-Grøn M,Davydow D,Waldorff FB,Vestergaard M

更新日期：2015-06-01 00:00:00

abstract：Importance:Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective:To identify genetic variants associated with adolescent brain structure and explo...

journal_title：JAMA psychiatry

authors： Luo Q,Chen Q,Wang W,Desrivières S,Quinlan EB,Jia T,Macare C,Robert GH,Cui J,Guedj M,Palaniyappan L,Kherif F,Banaschewski T,Bokde ALW,Büchel C,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,

更新日期：2019-04-01 00:00:00

abstract：:In 1893 and 1896, in his fourth and fifth textbook editions, Emil Kraepelin brought together 3 syndromes to form the first and second of his 2 prequels to dementia praecox (DP), a definitive version of which he would propose in his 1899 sixth textbook edition. These syndromes, which would become hebephrenic DP, catato...

journal_title：JAMA psychiatry

authors： Kendler KS

更新日期：2020-06-10 00:00:00

abstract：Importance:There has been limited systematic examination of whether risk of suicide attempt (SA) among US Army soldiers is associated with time-related deployment variables, such as time in service before first deployment, duration of first deployment, and dwell time (DT) (ie, length of time between deployments). Obje...

journal_title：JAMA psychiatry

authors： Ursano RJ,Kessler RC,Naifeh JA,Herberman Mash H,Fullerton CS,Aliaga PA,Wynn GH,Ng THH,Dinh HM,Sampson NA,Kao TC,Bliese PD,Stein MB

更新日期：2018-06-01 00:00:00

abstract：IMPORTANCE:The neural systems that confer risk or vulnerability for developing familial depression, and those that protect against or confer resilience to becoming ill, can be disentangled from the effects of prior illness by comparing brain imaging measures in previously ill and never ill persons who have either a hig...

journal_title：JAMA psychiatry

authors： Peterson BS,Wang Z,Horga G,Warner V,Rutherford B,Klahr KW,Graniello B,Wickramaratne P,Garcia F,Yu S,Hao X,Adams PB,Qian M,Liu J,Gerber A,Weissman MM

更新日期：2014-02-01 00:00:00

abstract：IMPORTANCE:In schizophrenia, working memory deficits appear to reflect abnormalities in the generation of gamma oscillations in the dorsolateral prefrontal cortex. The generation of gamma oscillations requires the phasic excitation of inhibitory parvalbumin-containing interneurons. Thus, gamma oscillations depend, in p...

journal_title：JAMA psychiatry

authors： Kimoto S,Zaki MM,Bazmi HH,Lewis DA

更新日期：2015-08-01 00:00:00