Adjunctive Psychotherapy for Bipolar Disorder: A Systematic Review and Component Network Meta-analysis.

Abstract:

Importance:Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective:To use systematic review and network meta-analysis to compare the association of using manualized psychotherapies and therapy components with reducing recurrences and stabilizing symptoms in patients with bipolar disorder. Data Sources:Major bibliographic databases (MEDLINE, PsychInfo, and Cochrane Library of Systematic Reviews) and trial registries were searched from inception to June 1, 2019, for randomized clinical trials of psychotherapy for bipolar disorder. Study Selection:Of 3255 abstracts, 39 randomized clinical trials were identified that compared pharmacotherapy plus manualized psychotherapy (cognitive behavioral therapy, family or conjoint therapy, interpersonal therapy, or psychoeducational therapy) with pharmacotherapy plus a control intervention (eg, supportive therapy or treatment as usual) for patients with bipolar disorder. Data Extraction and Synthesis:Binary outcomes (recurrence and study retention) were compared across treatments using odds ratios (ORs). For depression or mania severity scores, data were pooled and compared across treatments using standardized mean differences (SMDs) (Hedges-adjusted g using weighted pooled SDs). In component network meta-analyses, the incremental effectiveness of 13 specific therapy components was examined. Main Outcomes and Measures:The primary outcome was illness recurrence. Secondary outcomes were depressive and manic symptoms at 12 months and acceptability of treatment (study retention). Results:A total of 39 randomized clinical trials with 3863 participants (2247 of 3693 [60.8%] with data on sex were female; mean [SD] age, 36.5 [8.2] years) were identified. Across 20 two-group trials that provided usable information, manualized treatments were associated with lower recurrence rates than control treatments (OR, 0.56; 95% CI, 0.43-0.74). Psychoeducation with guided practice of illness management skills in a family or group format was associated with reducing recurrences vs the same strategies in an individual format (OR, 0.12; 95% CI, 0.02-0.94). Cognitive behavioral therapy (SMD, -0.32; 95% CI, -0.64 to -0.01) and, with less certainty, family or conjoint therapy (SMD, -0.46; 95% CI, -1.01 to 0.08) and interpersonal therapy (SMD, -0.46; 95% CI, -1.07 to 0.15) were associated with stabilizing depressive symptoms compared with treatment as usual. Higher study retention was associated with family or conjoint therapy (OR, 0.46; 95% CI, 0.26-0.82) and brief psychoeducation (OR, 0.44; 95% CI, 0.23-0.85) compared with standard psychoeducation. Conclusions and Relevance:This study suggests that outpatients with bipolar disorder may benefit from skills-based psychosocial interventions combined with pharmacotherapy. Conclusions are tempered by heterogeneity in populations, treatment duration, and follow-up.

journal_name

JAMA Psychiatry

journal_title

JAMA psychiatry

authors

Miklowitz DJ,Efthimiou O,Furukawa TA,Scott J,McLaren R,Geddes JR,Cipriani A

doi

10.1001/jamapsychiatry.2020.2993

subject

Has Abstract

pub_date

2020-10-14 00:00:00

eissn

2168-622X

issn

2168-6238

pii

2771207

pub_type

杂志文章
  • Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III.

    abstract:IMPORTANCE:National epidemiologic information from recently collected data on the new DSM-5 classification of alcohol use disorder (AUD) using a reliable, valid, and uniform data source is needed. OBJECTIVE:To present nationally representative findings on the prevalence, correlates, psychiatric comorbidity, associated...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.0584

    authors: Grant BF,Goldstein RB,Saha TD,Chou SP,Jung J,Zhang H,Pickering RP,Ruan WJ,Smith SM,Huang B,Hasin DS

    更新日期:2015-08-01 00:00:00

  • Prediction of functional outcome in individuals at clinical high risk for psychosis.

    abstract:IMPORTANCE:A major public health concern associated with schizophrenia and psychotic disorders is the long-term disability that involves impaired cognition, lack of social support, and an inability to function independently in the community. A critical goal of early detection and intervention studies in psychosis is th...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.1909

    authors: Carrión RE,McLaughlin D,Goldberg TE,Auther AM,Olsen RH,Olvet DM,Correll CU,Cornblatt BA

    更新日期:2013-11-01 00:00:00

  • Emotional and Behavioral Symptom Network Structure in Elementary School Girls and Association With Anxiety Disorders and Depression in Adolescence and Early Adulthood: A Network Analysis.

    abstract:Importance:The onset of adult psychopathologic disorders can be traced to behavioral or emotional symptoms observed in childhood, which could be targeted in early interventions to prevent future mental disorders. The network perspective is a novel conceptualization of psychopathologic disorders that could help to ident...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2018.2119

    authors: Rouquette A,Pingault JB,Fried EI,Orri M,Falissard B,Kossakowski JJ,Vitaro F,Tremblay R,Cote SM,Borsboom D

    更新日期:2018-11-01 00:00:00

  • The Development of Kraepelin's Concept of Dementia Praecox: A Close Reading of Relevant Texts.

    abstract::In 1893 and 1896, in his fourth and fifth textbook editions, Emil Kraepelin brought together 3 syndromes to form the first and second of his 2 prequels to dementia praecox (DP), a definitive version of which he would propose in his 1899 sixth textbook edition. These syndromes, which would become hebephrenic DP, catato...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.1266

    authors: Kendler KS

    更新日期:2020-06-10 00:00:00

  • Neural Oscillations and Synchrony in Brain Dysfunction and Neuropsychiatric Disorders: It's About Time.

    abstract::Neural oscillations are rhythmic fluctuations over time in the activity or excitability of single neurons, local neuronal populations or "assemblies," and/or multiple regionally distributed neuronal assemblies. Synchronized oscillations among large numbers of neurons are evident in electrocorticographic, electroenceph...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,评审

    doi:10.1001/jamapsychiatry.2015.0483

    authors: Mathalon DH,Sohal VS

    更新日期:2015-08-01 00:00:00

  • A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence.

    abstract:IMPORTANCE:Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conducted in Mexico. OBJECTIVE:To evaluate the safety a...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamapsychiatry.2013.872

    authors: Somoza EC,Winship D,Gorodetzky CW,Lewis D,Ciraulo DA,Galloway GP,Segal SD,Sheehan M,Roache JD,Bickel WK,Jasinski D,Watson DW,Miller SR,Somoza P,Winhusen T

    更新日期:2013-06-01 00:00:00

  • Incidence and Determinants of Mental Health Service Use After Bariatric Surgery.

    abstract:Importance:Obesity is associated with an increased prevalence of psychiatric disorders. The association of bariatric surgery with mental health outcomes is poorly understood. Objective:To investigate the association of bariatric surgery with the incidence of outpatient, emergency department (ED), and inpatient mental ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.2741

    authors: Morgan DJR,Ho KM,Platell C

    更新日期:2020-01-01 00:00:00

  • Identification of pathways for bipolar disorder: a meta-analysis.

    abstract:IMPORTANCE:Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders. OBJECTIVE:To identify biological pathways that contribute to risk for bipolar disorder (BP) using genes with consistent evidence for association in multiple genome-wide association studies (GWAS). ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamapsychiatry.2014.176

    authors: Nurnberger JI Jr,Koller DL,Jung J,Edenberg HJ,Foroud T,Guella I,Vawter MP,Kelsoe JR,Psychiatric Genomics Consortium Bipolar Group.

    更新日期:2014-06-01 00:00:00

  • Prediction of Sex-Specific Suicide Risk Using Machine Learning and Single-Payer Health Care Registry Data From Denmark.

    abstract:Importance:Suicide is a public health problem, with multiple causes that are poorly understood. The increased focus on combining health care data with machine-learning approaches in psychiatry may help advance the understanding of suicide risk. Objective:To examine sex-specific risk profiles for death from suicide usi...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.2905

    authors: Gradus JL,Rosellini AJ,Horváth-Puhó E,Street AE,Galatzer-Levy I,Jiang T,Lash TL,Sørensen HT

    更新日期:2020-01-01 00:00:00

  • Neural correlates of recall of life events in conversion disorder.

    abstract:IMPORTANCE:Freud argued that in conversion disorder (CD) the affect attached to stressful memories is "repressed" and "converted" into physical symptoms, although this has never been subject to scientific study to our knowledge. OBJECTIVE:To examine the neural correlates of recall of life events judged to be of causal...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.2842

    authors: Aybek S,Nicholson TR,Zelaya F,O'Daly OG,Craig TJ,David AS,Kanaan RA

    更新日期:2014-01-01 00:00:00

  • Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.

    abstract:Importance:Bipolar disorder (BD) overlaps schizophrenia in its clinical presentation and genetic liability. Alternative approaches to patient stratification beyond current diagnostic categories are needed to understand the underlying disease processes and mechanisms. Objective:To investigate the association between co...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.3485

    authors: Allardyce J,Leonenko G,Hamshere M,Pardiñas AF,Forty L,Knott S,Gordon-Smith K,Porteous DJ,Haywood C,Di Florio A,Jones L,McIntosh AM,Owen MJ,Holmans P,Walters JTR,Craddock N,Jones I,O'Donovan MC,Escott-Price V

    更新日期:2018-01-01 00:00:00

  • Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials.

    abstract:Importance:Recent estimates suggest that more than 50% of all deaths worldwide are currently attributable to inflammation-related diseases. Psychosocial interventions may represent a potentially useful strategy for addressing this global public health problem, but which types of interventions reliably improve immune sy...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.0431

    authors: Shields GS,Spahr CM,Slavich GM

    更新日期:2020-10-01 00:00:00

  • Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial.

    abstract:Importance:More effective, tolerable interventions for bipolar depression treatment are needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with few severe adverse events that showed promising results for unipolar depression. Objective:To determine the efficacy and safety of tDCS as ...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2017.4040

    authors: Sampaio-Junior B,Tortella G,Borrione L,Moffa AH,Machado-Vieira R,Cretaz E,Fernandes da Silva A,Fraguas R,Aparício LV,Klein I,Lafer B,Goerigk S,Benseñor IM,Lotufo PA,Gattaz WF,Brunoni AR

    更新日期:2018-02-01 00:00:00

  • Incidence of Depression After Stroke, and Associated Risk Factors and Mortality Outcomes, in a Large Cohort of Danish Patients.

    abstract:Importance:More than 30 million people live with a stroke diagnosis worldwide. Depression after stroke is frequent, and greater knowledge of associated risk factors and outcomes is needed to understand the etiology and implications of this disabling complication. Objectives:To examine whether the incidence of and risk...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2016.1932

    authors: Jørgensen TS,Wium-Andersen IK,Wium-Andersen MK,Jørgensen MB,Prescott E,Maartensson S,Kragh-Andersen P,Osler M

    更新日期:2016-10-01 00:00:00

  • Metabolic Effects of Antipsychotics on Adiposity and Insulin Sensitivity in Youths: A Randomized Clinical Trial.

    abstract:Importance:Antipsychotic medications are commonly used to treat nonpsychotic disruptive behavioral disorders in youths. Objective:To characterize the metabolic effects of first exposure to antipsychotics in youths using criterion standard assessments of body composition and insulin sensitivity. Design, Setting, and P...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2018.1088

    authors: Nicol GE,Yingling MD,Flavin KS,Schweiger JA,Patterson BW,Schechtman KB,Newcomer JW

    更新日期:2018-08-01 00:00:00

  • Association of Intrinsic Brain Architecture With Changes in Attentional and Mood Symptoms During Development.

    abstract:Importance:Understanding the neurodevelopmental trajectory of psychiatric symptoms is important for improving early identification, intervention, and prevention of mental disorders. Objective:To test whether the strength of the coupling of activation between specific brain regions, as measured by resting-state functio...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.4208

    authors: Whitfield-Gabrieli S,Wendelken C,Nieto-Castañón A,Bailey SK,Anteraper SA,Lee YJ,Chai XQ,Hirshfeld-Becker DR,Biederman J,Cutting LE,Bunge SA

    更新日期:2020-04-01 00:00:00

  • Motivational deficits and cognitive test performance in schizophrenia.

    abstract:IMPORTANCE:Motivational and cognitive deficits are core features of schizophrenia, both closely linked with functional outcomes. Although poor effort and decreased motivation are known to affect performance on cognitive tests, the extent of this relationship is unclear in patients with schizophrenia. OBJECTIVE:To eval...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2014.1105

    authors: Fervaha G,Zakzanis KK,Foussias G,Graff-Guerrero A,Agid O,Remington G

    更新日期:2014-09-01 00:00:00

  • The Emerging Clinical Neuroscience of Autism Spectrum Disorder: A Review.

    abstract:Importance:Autism spectrum disorder (ASD) is a highly prevalent disorder, and community psychiatrists are likely to treat many individuals with ASD during their clinical practice. This clinical case challenge describes a routine evaluation of irritability and self-injury in a preschool-aged child who meets the criteria...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,评审

    doi:10.1001/jamapsychiatry.2017.4685

    authors: Muhle RA,Reed HE,Stratigos KA,Veenstra-VanderWeele J

    更新日期:2018-05-01 00:00:00

  • Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia.

    abstract:IMPORTANCE:Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism in schizophrenia. OBJECTIVE:To evaluate hippocampal volumetric measures and neurometabolites in unmedicated patients with schizophrenia and the correlations between these markers. Our a priori hypothes...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.2437

    authors: Kraguljac NV,White DM,Reid MA,Lahti AC

    更新日期:2013-12-01 00:00:00

  • Clinical Validity of DSM-5 Attenuated Psychosis Syndrome: Advances in Diagnosis, Prognosis, and Treatment.

    abstract:Importance:Since the release of the DSM-5 diagnosis of attenuated psychosis syndrome (DSM-5-APS) in 2013, several research studies have investigated its clinical validity. Although critical and narrative reviews have reviewed these progresses, no systematic review has comprehensively summarized the available evidence r...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2019.3561

    authors: Salazar de Pablo G,Catalan A,Fusar-Poli P

    更新日期:2020-03-01 00:00:00

  • Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study.

    abstract:Importance:Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective:To identify genetic variants associated with adolescent brain structure and explo...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamapsychiatry.2018.4126

    authors: Luo Q,Chen Q,Wang W,Desrivières S,Quinlan EB,Jia T,Macare C,Robert GH,Cui J,Guedj M,Palaniyappan L,Kherif F,Banaschewski T,Bokde ALW,Büchel C,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,

    更新日期:2019-04-01 00:00:00

  • Identification of Suicide Attempt Risk Factors in a National US Survey Using Machine Learning.

    abstract:Importance:Because more than one-third of people making nonfatal suicide attempts do not receive mental health treatment, it is essential to extend suicide attempt risk factors beyond high-risk clinical populations to the general adult population. Objective:To identify future suicide attempt risk factors in the genera...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.4165

    authors: García de la Garza Á,Blanco C,Olfson M,Wall MM

    更新日期:2021-01-06 00:00:00

  • Interventions to Reduce Compulsory Psychiatric Admissions: A Systematic Review and Meta-analysis.

    abstract:IMPORTANCE:Compulsory admissions, defined as admissions against the will of the patient (according to local judicial procedures), have a strong effect on psychiatric patients. In several Western countries, the rate of such admissions is tending to rise. Its reduction is urgently needed. OBJECTIVE:To establish which in...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1001/jamapsychiatry.2016.0501

    authors: de Jong MH,Kamperman AM,Oorschot M,Priebe S,Bramer W,van de Sande R,Van Gool AR,Mulder CL

    更新日期:2016-07-01 00:00:00

  • Comparison of 2 family therapies for adolescent anorexia nervosa: a randomized parallel trial.

    abstract:IMPORTANCE:Anorexia nervosa (AN) is a serious disorder with high rates of morbidity and mortality. Family-based treatment (FBT) is an evidence-based therapy for adolescent AN, but less than half of those who receive this approach recover. Hence, it is important to identify other approaches to prevent the development of...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1001/jamapsychiatry.2014.1025

    authors: Agras WS,Lock J,Brandt H,Bryson SW,Dodge E,Halmi KA,Jo B,Johnson C,Kaye W,Wilfley D,Woodside B

    更新日期:2014-11-01 00:00:00

  • Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction.

    abstract:IMPORTANCE:Cocaine addiction is associated with altered resting-state functional connectivity among regions of the mesocorticolimbic dopamine pathways. Methylphenidate hydrochloride, an indirect dopamine agonist, normalizes task-related regional brain activity and associated behavior in cocaine users; however, the neur...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamapsychiatry.2013.1129

    authors: Konova AB,Moeller SJ,Tomasi D,Volkow ND,Goldstein RZ

    更新日期:2013-08-01 00:00:00

  • Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.

    abstract:IMPORTANCE:The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. OBJECTIVES:To characterize ZNF804A expression in human br...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2014.1079

    authors: Tao R,Cousijn H,Jaffe AE,Burnet PW,Edwards F,Eastwood SL,Shin JH,Lane TA,Walker MA,Maher BJ,Weinberger DR,Harrison PJ,Hyde TM,Kleinman JE

    更新日期:2014-10-01 00:00:00

  • Discriminating risk and resilience endophenotypes from lifetime illness effects in familial major depressive disorder.

    abstract:IMPORTANCE:The neural systems that confer risk or vulnerability for developing familial depression, and those that protect against or confer resilience to becoming ill, can be disentangled from the effects of prior illness by comparing brain imaging measures in previously ill and never ill persons who have either a hig...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2013.4048

    authors: Peterson BS,Wang Z,Horga G,Warner V,Rutherford B,Klahr KW,Graniello B,Wickramaratne P,Garcia F,Yu S,Hao X,Adams PB,Qian M,Liu J,Gerber A,Weissman MM

    更新日期:2014-02-01 00:00:00

  • Association of Heavy Drinking With Deviant Fiber Tract Development in Frontal Brain Systems in Adolescents.

    abstract:Importance:Maturation of white matter fiber systems subserves cognitive, behavioral, emotional, and motor development during adolescence. Hazardous drinking during this active neurodevelopmental period may alter the trajectory of white matter microstructural development, potentially increasing risk for developing alcoh...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2020.4064

    authors: Zhao Q,Sullivan EV,Honnorat N,Adeli E,Podhajsky S,De Bellis MD,Voyvodic J,Nooner KB,Baker FC,Colrain IM,Tapert SF,Brown SA,Thompson WK,Nagel BJ,Clark DB,Pfefferbaum A,Pohl KM

    更新日期:2020-12-30 00:00:00

  • Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.

    abstract:Importance:Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Ob...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2017.0669

    authors: Sheffield JM,Kandala S,Tamminga CA,Pearlson GD,Keshavan MS,Sweeney JA,Clementz BA,Lerman-Sinkoff DB,Hill SK,Barch DM

    更新日期:2017-06-01 00:00:00

  • Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study.

    abstract:IMPORTANCE:Serotonin is involved in negative affect, but whether anxiety syndromes, such as social anxiety disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. Serotonin 1A autoreceptors, which inhibit serotonin synthesis and release, are downregulated in SAD, and...

    journal_title:JAMA psychiatry

    pub_type: 杂志文章

    doi:10.1001/jamapsychiatry.2015.0125

    authors: Frick A,Åhs F,Engman J,Jonasson M,Alaie I,Björkstrand J,Frans Ö,Faria V,Linnman C,Appel L,Wahlstedt K,Lubberink M,Fredrikson M,Furmark T

    更新日期:2015-08-01 00:00:00