Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study.

abstract：Importance:The increase in deaths related to drugs, alcohol, and suicide (referred to as deaths from despair) has been identified as a public health crisis. The antecedents associated with these deaths have, however, seldom been investigated empirically. Objective:To prospectively examine the association between relig...

journal_title：JAMA psychiatry

authors： Chen Y,Koh HK,Kawachi I,Botticelli M,VanderWeele TJ

更新日期：2020-07-01 00:00:00

abstract：:Suicide rates have continued to rise in the United States. Speculations for this rise proliferate but the causes for the increase remain unknown. While research focuses on identifying causes, the health care system is an important site for identification of patients at risk. Forty percent of individuals who die by sui...

journal_title：JAMA psychiatry

authors： Stanley B,Mann JJ

更新日期：2020-01-01 00:00:00

abstract：IMPORTANCE:National epidemiologic information from recently collected data on the new DSM-5 classification of alcohol use disorder (AUD) using a reliable, valid, and uniform data source is needed. OBJECTIVE:To present nationally representative findings on the prevalence, correlates, psychiatric comorbidity, associated...

journal_title：JAMA psychiatry

authors： Grant BF,Goldstein RB,Saha TD,Chou SP,Jung J,Zhang H,Pickering RP,Ruan WJ,Smith SM,Huang B,Hasin DS

更新日期：2015-08-01 00:00:00

abstract：Importance:Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective:To identify genetic variants associated with adolescent brain structure and explo...

journal_title：JAMA psychiatry

authors： Luo Q,Chen Q,Wang W,Desrivières S,Quinlan EB,Jia T,Macare C,Robert GH,Cui J,Guedj M,Palaniyappan L,Kherif F,Banaschewski T,Bokde ALW,Büchel C,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,

更新日期：2019-04-01 00:00:00

abstract：IMPORTANCE:Fragile X syndrome (FXS) is an X-linked neurogenetic disorder characterized by a cognitive and behavioral phenotype resembling features of autism spectrum disorder. Until now, research has focused largely on identifying regional differences in brain structure and function between individuals with FXS and var...

journal_title：JAMA psychiatry

authors： Hall SS,Jiang H,Reiss AL,Greicius MD

更新日期：2013-11-01 00:00:00

abstract：Importance:Great interest exists in identifying methods to predict neuropsychiatric disease states and treatment outcomes from high-dimensional data, including neuroimaging and genomics data. The goal of this review is to highlight several potential problems that can arise in studies that aim to establish prediction. ...

journal_title：JAMA psychiatry

authors： Poldrack RA,Huckins G,Varoquaux G

更新日期：2020-05-01 00:00:00

abstract：Importance:Antipsychotic medications are commonly used to treat nonpsychotic disruptive behavioral disorders in youths. Objective:To characterize the metabolic effects of first exposure to antipsychotics in youths using criterion standard assessments of body composition and insulin sensitivity. Design, Setting, and P...

journal_title：JAMA psychiatry

authors： Nicol GE,Yingling MD,Flavin KS,Schweiger JA,Patterson BW,Schechtman KB,Newcomer JW

更新日期：2018-08-01 00:00:00

abstract：Importance:Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There cur...

journal_title：JAMA psychiatry

authors： Berk M,Woods RL,Nelson MR,Shah RC,Reid CM,Storey E,Fitzgerald S,Lockery JE,Wolfe R,Mohebbi M,Dodd S,Murray AM,Stocks N,Fitzgerald PB,Mazza C,Agustini B,McNeil JJ

更新日期：2020-10-01 00:00:00

abstract：IMPORTANCE:The continuum view of the psychosis spectrum (PS) implies that, in population-based samples, PS symptoms should be associated with neural abnormalities similar to those found in help-seeking clinical risk individuals and in schizophrenia. To our knowledge, functional neuroimaging has not previously been appl...

journal_title：JAMA psychiatry

authors： Wolf DH,Satterthwaite TD,Calkins ME,Ruparel K,Elliott MA,Hopson RD,Jackson CT,Prabhakaran K,Bilker WB,Hakonarson H,Gur RC,Gur RE

更新日期：2015-05-01 00:00:00

abstract：Importance:Fatal self-injury in the United States associated with deliberate behaviors is seriously underestimated owing to misclassification of poisoning suicides and mischaracterization of most drug poisoning deaths as "accidents" on death certificates. Objective:To compare national trends and patterns of self-injur...

journal_title：JAMA psychiatry

authors： Rockett IR,Lilly CL,Jia H,Larkin GL,Miller TR,Nelson LS,Nolte KB,Putnam SL,Smith GS,Caine ED

更新日期：2016-10-01 00:00:00

abstract：IMPORTANCE:Developmental brain disorders are a group of clinically and genetically heterogeneous disorders characterized by high heritability. Specific highly penetrant genetic causes can often be shared by a subset of individuals with different phenotypic features, and recent advances in genome sequencing have allowed...

journal_title：JAMA psychiatry

authors： Gonzalez-Mantilla AJ,Moreno-De-Luca A,Ledbetter DH,Martin CL

更新日期：2016-03-01 00:00:00

abstract：IMPORTANCE:Recent estimates indicate that 6.5 million adolescents and young adults in the United States are neither in school nor working. These youth have significant mental health concerns that require intervention. OBJECTIVE:To determine whether a mental health intervention, integrated into an employment training p...

journal_title：JAMA psychiatry

authors： Tandon SD,Latimore AD,Clay E,Mitchell L,Tucker M,Sonenstein FL

更新日期：2015-01-01 00:00:00

abstract：Importance:In light of increasing cannabis use among pregnant women, the US Surgeon General recently issued an advisory against the use of marijuana during pregnancy. Objective:To evaluate whether cannabis use during pregnancy is associated with adverse outcomes among offspring. Design, Setting, and Participants:In t...

journal_title：JAMA psychiatry

authors： Paul SE,Hatoum AS,Fine JD,Johnson EC,Hansen I,Karcher NR,Moreau AL,Bondy E,Qu Y,Carter EB,Rogers CE,Agrawal A,Barch DM,Bogdan R

更新日期：2021-01-01 00:00:00

abstract：IMPORTANCE:The 16p11.2 BP4-BP5 duplication is the copy number variant most frequently associated with autism spectrum disorder (ASD), schizophrenia, and comorbidities such as decreased body mass index (BMI). OBJECTIVES:To characterize the effects of the 16p11.2 duplication on cognitive, behavioral, medical, and anthro...

journal_title：JAMA psychiatry

authors： D'Angelo D,Lebon S,Chen Q,Martin-Brevet S,Snyder LG,Hippolyte L,Hanson E,Maillard AM,Faucett WA,Macé A,Pain A,Bernier R,Chawner SJ,David A,Andrieux J,Aylward E,Baujat G,Caldeira I,Conus P,Ferrari C,Forzano F,Gér

更新日期：2016-01-01 00:00:00

abstract：Importance:Suicide is a public health problem, with multiple causes that are poorly understood. The increased focus on combining health care data with machine-learning approaches in psychiatry may help advance the understanding of suicide risk. Objective:To examine sex-specific risk profiles for death from suicide usi...

journal_title：JAMA psychiatry

authors： Gradus JL,Rosellini AJ,Horváth-Puhó E,Street AE,Galatzer-Levy I,Jiang T,Lash TL,Sørensen HT

更新日期：2020-01-01 00:00:00

abstract：IMPORTANCE:Cocaine dependence is a significant public health problem, yet no validated pharmacological treatment exists. The potent γ-aminobutyric acid (GABA)ergic medication vigabatrin has previously been shown to be effective in a double-blind single-site study conducted in Mexico. OBJECTIVE:To evaluate the safety a...

journal_title：JAMA psychiatry

authors： Somoza EC,Winship D,Gorodetzky CW,Lewis D,Ciraulo DA,Galloway GP,Segal SD,Sheehan M,Roache JD,Bickel WK,Jasinski D,Watson DW,Miller SR,Somoza P,Winhusen T

更新日期：2013-06-01 00:00:00

abstract：Importance:Depressive severity is typically measured according to total scores on questionnaires that include a diverse range of symptoms despite convincing evidence that depression is not a unitary construct. When evaluated according to aggregate measurements, treatment efficacy is generally modest and differences in ...

journal_title：JAMA psychiatry

authors： Chekroud AM,Gueorguieva R,Krumholz HM,Trivedi MH,Krystal JH,McCarthy G

更新日期：2017-04-01 00:00:00

abstract：IMPORTANCE:Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and the basal ganglia, but it is unclear whether these areas are also characterized by altered brain network properties. OBJECTIVES:To determine regions of abnormal degree...

journal_title：JAMA psychiatry

authors： Beucke JC,Sepulcre J,Talukdar T,Linnman C,Zschenderlein K,Endrass T,Kaufmann C,Kathmann N

更新日期：2013-06-01 00:00:00

abstract：Importance:Altered neurodevelopmental trajectories are thought to reflect heterogeneity in the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these trajectories are associated with future psychosis is unclear. Objective:To investigate distinct neuroanatomical markers that can diffe...

journal_title：JAMA psychiatry

authors： Chung Y,Addington J,Bearden CE,Cadenhead K,Cornblatt B,Mathalon DH,McGlashan T,Perkins D,Seidman LJ,Tsuang M,Walker E,Woods SW,McEwen S,van Erp TGM,Cannon TD,North American Prodrome Longitudinal Study (NAPLS) Consortium and

更新日期：2018-09-01 00:00:00

abstract：IMPORTANCE:Twin-family studies have shown that parent-child resemblance on substance use disorders and antisocial behavior can be accounted for by the transmission of a general liability to a spectrum of externalizing disorders. Most studies, however, include only biological parents and offspring, which confound geneti...

journal_title：JAMA psychiatry

authors： Hicks BM,Foster KT,Iacono WG,McGue M

更新日期：2013-10-01 00:00:00

abstract：Importance:Since the release of the DSM-5 diagnosis of attenuated psychosis syndrome (DSM-5-APS) in 2013, several research studies have investigated its clinical validity. Although critical and narrative reviews have reviewed these progresses, no systematic review has comprehensively summarized the available evidence r...

journal_title：JAMA psychiatry

authors： Salazar de Pablo G,Catalan A,Fusar-Poli P

更新日期：2020-03-01 00:00:00

abstract：IMPORTANCE:The single-nucleotide polymorphism rs1344706 in the zinc finger protein 804A gene (ZNF804A) shows genome-wide association with schizophrenia and bipolar disorder. Little is known regarding the expression of ZNF804A and the functionality of rs1344706. OBJECTIVES:To characterize ZNF804A expression in human br...

journal_title：JAMA psychiatry

authors： Tao R,Cousijn H,Jaffe AE,Burnet PW,Edwards F,Eastwood SL,Shin JH,Lane TA,Walker MA,Maher BJ,Weinberger DR,Harrison PJ,Hyde TM,Kleinman JE

更新日期：2014-10-01 00:00:00

abstract：Importance:A recent increase in patients presenting with nonfatal opioid overdoses has focused clinical attention on characterizing their risks of premature mortality. Objective:To describe all-cause mortality rates, selected cause-specific mortality rates, and standardized mortality rate ratios (SMRs) of adults durin...

journal_title：JAMA psychiatry

authors： Olfson M,Crystal S,Wall M,Wang S,Liu SM,Blanco C

更新日期：2018-08-01 00:00:00

abstract：Importance:Posttraumatic stress disorder (PTSD) is associated with an increased risk of type 2 diabetes mellitus (T2DM). Existing literature has adjusted for obesity in combination with other confounders, which does not allow estimating the contribution of obesity alone on the association of PTSD with incident T2DM. O...

journal_title：JAMA psychiatry

authors： Scherrer JF,Salas J,Lustman PJ,van den Berk-Clark C,Schnurr PP,Tuerk P,Cohen BE,Friedman MJ,Norman SB,Schneider FD,Chard KM

更新日期：2018-11-01 00:00:00

abstract：IMPORTANCE:The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. OBJECTIVES:First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to diff...

journal_title：JAMA psychiatry

authors： Redlich R,Almeida JJ,Grotegerd D,Opel N,Kugel H,Heindel W,Arolt V,Phillips ML,Dannlowski U

更新日期：2014-11-01 00:00:00

abstract：Importance:Because more than one-third of people making nonfatal suicide attempts do not receive mental health treatment, it is essential to extend suicide attempt risk factors beyond high-risk clinical populations to the general adult population. Objective:To identify future suicide attempt risk factors in the genera...

journal_title：JAMA psychiatry

authors： García de la Garza Á,Blanco C,Olfson M,Wall MM

更新日期：2021-01-06 00:00:00

abstract：Importance:Growing evidence suggests that prescription opioid use affects depression and anxiety disorders; however, observational studies are subject to confounding, making causal inference and determining the direction of these associations difficult. Objective:To investigate the potential bidirectional associations...

journal_title：JAMA psychiatry

authors： Rosoff DB,Smith GD,Lohoff FW

更新日期：2020-11-11 00:00:00

abstract：Importance:Recent estimates suggest that more than 50% of all deaths worldwide are currently attributable to inflammation-related diseases. Psychosocial interventions may represent a potentially useful strategy for addressing this global public health problem, but which types of interventions reliably improve immune sy...

journal_title：JAMA psychiatry

authors： Shields GS,Spahr CM,Slavich GM

更新日期：2020-10-01 00:00:00

abstract：IMPORTANCE:Brain imaging studies have identified robust changes in brain structure and function during the development of psychosis, but the contribution of abnormal brain connectivity to the onset of psychosis is unclear. Furthermore, antipsychotic treatment can modulate brain activity and functional connectivity duri...

journal_title：JAMA psychiatry

authors： Schmidt A,Smieskova R,Aston J,Simon A,Allen P,Fusar-Poli P,McGuire PK,Riecher-Rössler A,Stephan KE,Borgwardt S

更新日期：2013-09-01 00:00:00

abstract：IMPORTANCE:Major depressive disorder (MDD) is a heterogeneous condition in terms of symptoms, course, and underlying disease mechanisms. Current classifications do not adequately address this complexity. In novel network approaches to psychopathology, psychiatric disorders are conceptualized as complex dynamic systems ...

journal_title：JAMA psychiatry

authors： van Borkulo C,Boschloo L,Borsboom D,Penninx BW,Waldorp LJ,Schoevers RA

更新日期：2015-12-01 00:00:00