Abstract:
BACKGROUND:Few studies have targeted psychomotor development and associated perinatal risk factors in Japanese very low birth weight (VLBW) infants who are severely small for gestational age (SGA). DESIGN/SUBJECTS:A single-center study was conducted in 104 Japanese VLBW infants who were born preterm, due to maternal, umbilical cord, or placental abnormalities, between 2000 and 2007. Psychomotor development as a developmental quotient (DQ) was assessed using the Kyoto Scale of Psychological Development at 3 years corrected age. Severely SGA was defined as birth weight or length below -2 standard deviation values of the mean values at the same gestation. VLBW infants were divided into 2 subgroups based on gestational age at birth: ⩾28 weeks (n=64) and <28 weeks (n=40). DQs of infants with severe SGA were compared with those of infants who were appropriate for gestational age (AGA). Factors associated with developmental disabilities in VLBW infants with severe SGA (n=23) were determined. RESULTS:In the group born at ⩾28 weeks gestation, infants with severe SGA had normal DQ values and did not significantly differ from those with AGA. However, in the group born at <28 weeks gestation, severe SGA infants had significantly lower postural-motor DQ values than AGA infants. Gestational age <28 weeks was an independent factor for low postural-motor DQ, regardless of the cause of severe SGA or pregnancy termination. CONCLUSIONS:Extremely preterm newborns with severe SGA are at risk of motor developmental disability at age 3 years.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Kato T,Mandai T,Iwatani S,Koda T,Nagasaka M,Fujita K,Kurokawa D,Yamana K,Nishida K,Taniguchi-Ikeda M,Tanimura K,Deguchi M,Yamada H,Iijima K,Morioka Idoi
10.1016/j.braindev.2015.07.008subject
Has Abstractpub_date
2016-02-01 00:00:00pages
188-95issue
2eissn
0387-7604issn
1872-7131pii
S0387-7604(15)00139-4journal_volume
38pub_type
杂志文章abstract:BACKGROUND:Benign epilepsy with centrotemporal spikes is the most common partial epilepsy syndrome in children. The long-term prognosis for children with BECTS is believed to be generally excellent with seizures usually responding well to AEDs. The goal of the present study was to determine the risk factors associated ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2014.02.008
更新日期:2015-01-01 00:00:00
abstract::A 2-year-old boy with herpes simplex encephalitis developed diffuse brain lesions involving the white matter of both cerebral hemispheres. These lesions in the white matter were clearly observed on magnetic resonance imaging (MRI) with the T2-weighted sequence, and were found to have spontaneously disappeared on subse...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(95)00141-7
更新日期:1996-03-01 00:00:00
abstract::This report describes a 60-year-old female patient with Krabbe disease who presented with slowly progressive gait disturbance due to mild spastic paraplegia. Brain magnetic resonance imaging showed high-intensity lesions along the upper parts of the bilateral pyramidal tracts in fluid-attenuated inversion recovery ima...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.08.004
更新日期:2013-06-01 00:00:00
abstract::A 2-yr-3-mo-old girl with metachromatic leukodystrophy (MLD) was examined using serial multiple electrophysiological procedures. Sensory nerve conduction velocity was delayed earlier and more severely than motor nerve conduction velocity. Visual evoked potentials (VEPs) showed prolonged latency of wave IV. Auditory br...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(85)80141-8
更新日期:1985-01-01 00:00:00
abstract::Moyamoya syndrome is a chronic, progressive occlusion of cerebrovascular arteries that leads to the development of characteristic collateral vessels. It is usually accompanied with sickle cell disease and other hemoglobinopathies. We report a 7-year-old boy, who admitted to our clinic with headache, diagnosed as moyam...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2013.07.010
更新日期:2014-06-01 00:00:00
abstract::The aim of this research was to compare the Strengths and Difficulties Questionnaire (SDQ) scores and subscale scores in children with high-functioning autism spectrum disorder (HFASD) and attention-deficit/hyperactivity disorder (AD/HD), and also to clarify the differences between parent- and teacher-assessed SDQ sco...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.09.009
更新日期:2010-09-01 00:00:00
abstract::Here we describe two patients with 5p- syndrome who suffered from epilepsy characterised by stimulus-induced epileptic spasms manifesting as head nodding. In patient 1, a series of spasms were exclusively triggered by eating, and were associated with diffuse high-voltage slow waves on ictal EEG, particularly presentin...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2015.08.002
更新日期:2016-02-01 00:00:00
abstract::Angelman syndrome (AS) is a genetic disorder with characteristic clinical and EEG findings. We report here the results of long-term follow-up studies on the epileptic seizures and EEG findings of 23 cases of deletion type AS confirmed by FISH analysis, including seven cases previously reported by Matsumoto et al. in 1...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2004.01.009
更新日期:2005-08-01 00:00:00
abstract::Morphological and biochemical analysis of tissue from a 21-week-old fetus with Krabbe disease was performed. Galactosylceramidase activity was virtually absent in cultured amniotic cells obtained during the pregnancy of this fetus. The prenatal diagnosis was confirmed by enzymatic analysis of fetal cultured skin fibro...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(94)90013-2
更新日期:1994-11-01 00:00:00
abstract::Two siblings with adenosine deaminase deficiency were successfully treated with allogeneic bone marrow transplantation without conditioning. Although the patients were free from infections after immunologic reconstitution, both showed sensorineural deafness at 1 year of age. Because there were no structural abnormalit...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(96)00014-9
更新日期:1996-07-01 00:00:00
abstract::Relative to their numbers, more than twice the number of disabled children fell victim to the Great East Japan Earthquake than did normal people. It was important to find out needs and provide support, as the needs of disabled children vulnerable to the disaster, such as a shortage of diapers of the right size for dis...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/j.braindev.2012.09.008
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:This study was conducted to describe the natural course of tic disorders over a long period of time in Japanese adults patients with Tourette's syndrome (TS) in terms of symptomatology. METHODS:An extensive literature on TS cases was reviewed selectively and 31 TS patients (mean age: 31.4 years; sex: 28 male...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(03)90006-4
更新日期:2003-12-01 00:00:00
abstract::Tourette syndrome (TS) is a neurodevelopmental disorder defined by tics, but most patients also experience bothersome sensory phenomena, in the form of premonitory urges and/or sensory hypersensitivity. Whereas premonitory urges are temporally paired with tics, sensory hypersensitivity is a constant, heightened awaren...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/j.braindev.2020.06.003
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The characteristics of epilepsy in patients with Kabuki syndrome with KMT2D mutations (KABUK1) have not yet been well documented. This is the first review to explore this. MATERIALS & METHODS:We enrolled 14 patients with KABUK1, whose median age was 13.6years (range=4.1-21.3years). Their medical records fro...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2017.03.025
更新日期:2017-09-01 00:00:00
abstract::Alexander disease is a major entity of leukodystrophy; magnetic resonance imaging (MRI) studies of the brain typically show extensive changes in the cerebral white matter with frontal predominance. Heterozygous missense mutations of GFAP are thought to be sufficient for the molecular diagnosis, which has widened the A...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2010.10.007
更新日期:2011-08-01 00:00:00
abstract::A female was diagnosed as a late variant form of infantile Krabbe disease at 1 year and 3 months because of the late onset of regressive clinical course, decreased motor nerve conduction velocities, high cerebrospinal protein concentration and partial deficiency of galactocerebrosidase (15.6%) in the cultured skin fib...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(88)80045-7
更新日期:1988-01-01 00:00:00
abstract::The pathological role of autoantibodies in development of CNS disorders is a new idea with growing interest among neuroscientists. The involvement of autoimmune response in the pathogenesis of autism spectrum disorders (ASD) has been suggested by the presence of multiple brain-specific autoantibodies in children with ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2013.04.015
更新日期:2014-04-01 00:00:00
abstract::The developmental expression of monocyte chemoattractant protein-1 (MCP-1) in the cerebellum, medulla oblongata and pons was investigated in 26 normal human brains, ranging from 20 weeks of gestation (GW) to adulthood by means of an immunohistochemical method. Immunoreactivity to MCP-1 was observed in neurons of the c...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(98)00065-5
更新日期:1999-01-01 00:00:00
abstract::Infantile myositis, observed in the neonatal period, is rare and may be confused with congenital muscular dystrophy. The patient presented here showed evidence of a myopathy with in utero onset with intrauterine growth retardation and decreased fetal movements. A muscle biopsy demonstrated characteristic perifascicula...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(96)00049-6
更新日期:1996-09-01 00:00:00
abstract:PURPOSE:The aim of the present study was to investigate the correlation between epileptiform discharges on EEGs after febrile seizures and the prognosis of patients in terms of the development of epilepsy and recurrence of febrile seizures. This study also evaluated the characteristics of epileptiform discharges and EE...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.07.014
更新日期:2013-04-01 00:00:00
abstract::We report an autopsy case of bathtub drowning in epilepsy. A 26-year-old female with mental retardation had been treated for refractory epilepsy. Her younger sister found her floating supine in the bathtub 45 min after starting bathing. Neuropathological examination revealed cerebral cortical dysplasia in the precentr...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(97)00064-8
更新日期:1997-11-01 00:00:00
abstract::Alternating hemiplegia in childhood (AHC) has clinically characteristic features which are easily defined and recognizable. Laboratory investigations were basically normal although they were extensively examined during and between attacks. There is still much debate about its etiology, particularly its relation to mig...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/s0387-7604(12)80144-6
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Bottom shuffling is a locomotion strategy that precedes independent walking in some infants. Shuffling babies are generally considered to have favorable outcomes. The aim of the present study was to reveal clinical features and neurodevelopmental outcomes of shuffling babies who visited a child d...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2020.08.007
更新日期:2021-02-01 00:00:00
abstract::A 2-month-old Japanese girl exhibited tonic seizure, agenesis of the corpus callosum, lacunar chorioretinopathy, vertebral anomalies, electroencephalographic abnormalities and a malignant tumor. Autopsy revealed a hepatoblastoma and severe brain malformations consisting of callosal agenesis, arhinencephaly, marked pol...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(85)80119-4
更新日期:1985-01-01 00:00:00
abstract::Heterotopic gray matter was detected by means of magnetic resonance imaging in a 3-year-old girl with left hemiparesis and atonic seizures. In the inversion recovery sequence, a large area of decreased signal intensity was noted in the right centrum semiovale and differentiation of the right basal ganglia was not clea...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(87)80012-8
更新日期:1987-01-01 00:00:00
abstract::The relationship between febrile seizures and hippocampal sclerosis has been the subject of longstanding discussion. Animal models for prolonged seizures have shown a clear causal relationship with focal limbic features at low dose and hippocampal damage at high dose. Careful history taking of febrile seizure semiolog...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/j.braindev.2009.09.013
更新日期:2010-01-01 00:00:00
abstract::The future of human societies depends on children being able to achieve their optimal physical and psychological development. Developmental delay is failure to acquire age-appropriate functionality. It may involve one or more streams of development. Responsive parenting has potential to promote better development. Pri...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/j.braindev.2009.06.004
更新日期:2010-02-01 00:00:00
abstract::3-Ketothiolase deficiency (3KTD) manifests with intermittent acidosis and is due to deficiency of mitochondrial 2-methylacetoacetate thiolase. Only 22 patients have been previously reported. Although its variable clinical presentation is recognized, the associated neurological findings have not been detailed. We repor...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(94)90095-7
更新日期:1994-11-01 00:00:00
abstract::Penicillin (PC) neurotoxicity (convulsions and encephalopathy) is considered to be due to GABAergic inhibition. The effects of penicillin G(PCG) on [3H]flunitrazepam (FNZ) binding in rat neuron-enriched primary cultures was examined to assess the role of the benzodiazepine (BDZ) receptor in the neurotoxicity. PCG appl...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(93)90121-n
更新日期:1993-09-01 00:00:00
abstract::Event-related potential (ERP) studies with infants are often limited by a small number of measurements. We introduce a weighted general linear mixed model analysis with a time-varying covariate, which allows for the efficient analysis of all available event-related potential data of infants. This method allows control...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.04.001
更新日期:2010-04-01 00:00:00