Abstract:
:The pathological role of autoantibodies in development of CNS disorders is a new idea with growing interest among neuroscientists. The involvement of autoimmune response in the pathogenesis of autism spectrum disorders (ASD) has been suggested by the presence of multiple brain-specific autoantibodies in children with ASD and in their mothers. The possibility of the effect of autoimmunity on neurogenesis and postnatal brain plasticity has not been determined. The presence of autoantibodies against human neuronal progenitor cells (NPCs) stimulated for neuronal differentiation in culture was tested in sera from children with autism (n=20) and age-matched controls (n=18) by immunoblotting and immunocytochemistry. Immunoreactivity against multiple NPCs proteins of molecular sizes of approximately 55 kDa, 105 kDa, 150 kDa, and 210 kDa in sera from individuals with autism had a higher incidence and was stronger than in control sera which immunoreacted mainly with a 150 kDa protein. The sera from children with autism immunoreacted the strongest with NPCs expressing neuronal markers Tuj1 and doublecortin, but not astrocyte marker GFAP. The epitopes recognized by antibodies from sera were not human-specific because they detected also NPCs in situ in murine hippocampus. The autoimmune reactions against NPCs suggest an impaired tolerance to neural antigens in autism. These autoantibodies may be symptomatic for autism and furthermore, their presence suggests that autoimmunity may affect postnatal neuronal plasticity particularly after impairment of blood-brain barrier. Future studies will determine the diagnostic value of the presence of autoantibodies in autism and the therapeutic value of prevention of autoimmunity in autism.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Mazur-Kolecka B,Cohen IL,Gonzalez M,Jenkins EC,Kaczmarski W,Brown WT,Flory M,Frackowiak Jdoi
10.1016/j.braindev.2013.04.015subject
Has Abstractpub_date
2014-04-01 00:00:00pages
322-9issue
4eissn
0387-7604issn
1872-7131pii
S0387-7604(13)00168-Xjournal_volume
36pub_type
杂志文章abstract:PURPOSE:The aim of this study is to elucidate the clinical and neurophysiological characteristics of the myoclonic, myoclonic-astatic, or astatic seizures in patients with myoclonic-astatic epilepsy (MAE) of early childhood, and to discuss on the nosology of this unique epileptic syndrome. SUBJECTS:The subjects includ...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/s0387-7604(01)00281-9
更新日期:2001-11-01 00:00:00
abstract::We are presenting two cases with subacute sclerosing panencephalitis of acute and rapid form, which were initially diagnosed as acute viral encephalitis. We obtained both diffusion-weighted imaging and magnetic resonance spectroscopy, whose findings suggested the presence of acute inflammatory and metabolic changes wi...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2006.09.013
更新日期:2007-06-01 00:00:00
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doi:10.1016/0387-7604(94)90064-7
更新日期:1994-05-01 00:00:00
abstract::Both xeroderma pigmentosum group A (XPA) and Cockayne syndrome (CS) are rare autosomal disorders, have a genetic defect in the step of nucleotide repair, and involve various neurological abnormalities caused by progressive neurodegeneration. We performed comprehensive neuropathological analysis of five cases of XPA an...
journal_title:Brain & development
pub_type: 临床试验,杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2015.08.008
更新日期:2016-02-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2018.03.007
更新日期:2018-09-01 00:00:00
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journal_title:Brain & development
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doi:10.1016/j.braindev.2012.01.009
更新日期:2013-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.04.002
更新日期:2013-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/j.braindev.2017.01.001
更新日期:2017-05-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/s0387-7604(01)00312-6
更新日期:2001-11-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2010.07.013
更新日期:2011-06-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(98)00002-3
更新日期:1998-04-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(12)80195-1
更新日期:1990-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.11.013
更新日期:2014-01-01 00:00:00
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doi:10.1016/j.braindev.2017.07.001
更新日期:2017-11-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2010.06.004
更新日期:2010-10-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2005.12.006
更新日期:2006-08-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Brain & development
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更新日期:2016-11-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.07.014
更新日期:2013-04-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2013.08.003
更新日期:2014-08-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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journal_title:Brain & development
pub_type: 临床试验,杂志文章
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更新日期:1996-03-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Brain & development
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00