当前位置： SCI文献检索 > BRAIN & DEVELOPMENT期刊下所有文献 > Developmental expression of monocyte chemoattractant protein-1 in the human cerebellum and brainstem.

Developmental expression of monocyte chemoattractant protein-1 in the human cerebellum and brainstem.

Abstract：

:The developmental expression of monocyte chemoattractant protein-1 (MCP-1) in the cerebellum, medulla oblongata and pons was investigated in 26 normal human brains, ranging from 20 weeks of gestation (GW) to adulthood by means of an immunohistochemical method. Immunoreactivity to MCP-1 was observed in neurons of the cerebellum and brainstem, and was mainly distributed in the cytoplasm and dendrites. MCP-1-positive Purkinje cells appeared at 27 GW, reached a peak at 36 GW, and then decreased after 1 month of age, almost completely disappearing by 1-2 years of age. MCP-1-reactive neurons in the dentate nucleus and inferior olivary nucleus showed temporal increases similar to that of Purkinje cells. In the pons, however, MCP-1 reactivity was low in neurons of the pontine nuclei persisting from the fetal to the adult period, and was very low and short in the reticular formation and cranial nerve nuclei during the fetal and/or neonatal period. MCP-1 Western blotting of the cerebellar cortex confirmed the specificity of the immunohistochemistry. Our results suggest that MCP-1 may be related to the maturation of Purkinje cells, the dentate nucleus, the inferior olivary nucleus, and their network, promoting the growth of dendrites and synapses. Furthermore, MCP-1 may also be useful for the study of abnormal neuron development and ischemic damage.

journal_name

Brain Dev

journal_title

Brain & development

authors

Meng SZ,Oka A,Takashima S

doi

10.1016/s0387-7604(98)00065-5

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

30-5

issue

1

eissn

0387-7604

issn

1872-7131

pii

S0387760498000655

journal_volume

21

pub_type

杂志文章

相关文献

BRAIN & DEVELOPMENT文献大全
  • Tourette syndrome and chronic tics in a sample of children and adolescents.

    abstract：:Forty-eight subjects with Tourette syndrome (M 36, F 12; mean age 11.2 years) and 48 with chronic tic disorder (M 33, F 15; mean age 12.1 years) were recruited in order to study the vertical transmission within families of a vulnerability to tic disorders or to other psychiatric disorders, the role of adverse pre- and...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2004.09.007

    authors： Saccomani L,Fabiana V,Manuela B,Giambattista R

    更新日期：2005-08-01 00:00:00

  • Early development destructive brain lesions and their relationship to epilepsy and hippocampal damage.

    abstract：:Fifty-one consecutive adult patients with epilepsy and early development destructive brain lesions were divided into three main groups according to the topographic distribution of the lesion on magnetic resonance imaging: hemispheric (H) (n=9); main arterial territory (AT) (n=25) and arterial borderzone (Bdz) (n=17). ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(03)00065-2

    authors： Teixeira RA,Li LM,Santos SL,Zanardi VA,Honorato DC,Guerreiro CA,Cendes F

    更新日期：2003-12-01 00:00:00

  • Thiamine-deficient encephalopathy due to excessive intake of isotonic drink or overstrict diet therapy in Japanese children.

    abstract：AIM:To report on two children with encephalopathy caused by dietary thiamine deficiency due to newly developing nutritional problems in contemporary Japan. SUBJECTS:A 1-year-old boy who had consumed 1l of isotonic drinks per day for 4 months after an episode of diarrhea, and presented with ocular movement disorder, dy...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.08.004

    authors： Saeki K,Saito Y,Komaki H,Sakakibra T,Nakagawa E,Sugai K,Sakuma H,Sasaki M,Honda T,Hayashi H,Katori N,Miyahara Y

    更新日期：2010-08-01 00:00:00

  • Predictive value of the early clinical signs in Rett disorder.

    abstract：:The British Isles Survey for Rett has registered 1,159 cases over up to 20 years. Indicators of health and severity, recorded at intervals throughout life, are drawn from clinical examinations, reports and postal questionnaires. This study aimed to establish the stability and predictive value of an early severity scor...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2004.10.007

    authors： Kerr AM,Prescott RJ

    更新日期：2005-11-01 00:00:00

  • Multicolor fluorescent in situ hybridization on post-mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseases.

    abstract：:Fluorescence in situ hybridization (FISH) of DNA-DNA or DNA-RNA using post-mortem brain samples is one approach to study low-level chromosomal aneuploidy and selective expression of specific genes in the brain of patients with neuropsychiatric diseases. We have performed a pilot molecular-cytogenetic analysis of post-...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(01)00363-1

    authors： Yurov YB,Vostrikov VM,Vorsanova SG,Monakhov VV,Iourov IY

    更新日期：2001-12-01 00:00:00

  • Sequential MRI findings in a patient with a germ cell tumor in the basal ganglia.

    abstract：:Serial changes of MRI scanning of an 11-year-old boy with hemiparesis due to a germ cell tumor in the basal ganglia are presented. Initial brain MRI T1-weighted images revealed a subtle mixed signal intensity lesion at left anterior and posterior limbs of the internal capsule. This lesion was not enhanced with Gd-DTPA...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(93)90024-3

    authors： Takano T,Matsui E,Yamano T,Shimada M,Nakasu Y,Handa J

    更新日期：1993-07-01 00:00:00

  • Comparison of the strengths and difficulties questionnaire (SDQ) scores between children with high-functioning autism spectrum disorder (HFASD) and attention-deficit/hyperactivity disorder (AD/HD).

    abstract：:The aim of this research was to compare the Strengths and Difficulties Questionnaire (SDQ) scores and subscale scores in children with high-functioning autism spectrum disorder (HFASD) and attention-deficit/hyperactivity disorder (AD/HD), and also to clarify the differences between parent- and teacher-assessed SDQ sco...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.09.009

    authors： Iizuka C,Yamashita Y,Nagamitsu S,Yamashita T,Araki Y,Ohya T,Hara M,Shibuya I,Kakuma T,Matsuishi T

    更新日期：2010-09-01 00:00:00

  • Two siblings with partial trisomy 1(q42.3-ter).

    abstract：:Two brothers, aged 6 and 4 years, with an unbalanced chromosome translocation (partial trisomy 1), and their mother, a balanced carrier of the translocation, t(1;3)(q42.3;p26.3), were described. Both patients show minor anomalies; a large head with a prominent forehead, low-set and soaring ears, a high-arched palate, ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(93)90048-d

    authors： Sunaga Y,Ohtsuka T,Nagashima K,Kuroume T

    更新日期：1993-03-01 00:00:00

  • Increased fetal heart rate variability in periventricular leukomalacia.

    abstract：OBJECTIVE:This study used quantitative analysis to determine whether increased variability in fetal heart rate (FHR) is related to the risk of developing periventricular leukomalacia (PVL). METHODS:We analyzed 124 FHR traces of neonates delivered preterm at 27-33 weeks' gestation to 105 mothers. FHR traces 1-3h before...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2015.08.008

    authors： Kurahashi H,Okumura A,Kubota T,Kidokoro H,Maruyama K,Hayakawa M,Itakura A,Matsuzawa K,Yamamoto H,Kato T,Hayakawa F,Watanabe K

    更新日期：2016-02-01 00:00:00

  • Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness.

    abstract：PURPOSE:To assess the efficacy of diazepam suppositories at preventing febrile seizure recurrence during a single febrile illness to determine how to treat children with a febrile seizure on presentation at the hospital. METHODS:We studied 203 children with febrile seizures from December 2004 through March 2006. On ad...

    journal_title：Brain & development

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.braindev.2008.07.010

    authors： Hirabayashi Y,Okumura A,Kondo T,Magota M,Kawabe S,Kando N,Yamaguchi H,Natsume J,Negoro T,Watanabe K

    更新日期：2009-06-01 00:00:00

  • Unique astrocytic inclusion in a 2 month-old baby showing Leigh-like brain lesions with lactic acidosis.

    abstract：:An unique cytoplasmic inclusion was found in astrocytes of a 2-month-old female baby who showed Leigh-like brain lesions with lactic acidosis, hypoglycemia and hepatomegaly. Although a defective enzyme was not determined, a metabolic disorder was suggested from clinicopathological observations. Symmetrically distribut...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00117-0

    authors： Yamamoto T,Armstrong D,Shibata N,Kato Y,Kobayashi M

    更新日期：2000-06-01 00:00:00

  • Pathological and biochemical studies of fetal Krabbe disease.

    abstract：:Morphological and biochemical analysis of tissue from a 21-week-old fetus with Krabbe disease was performed. Galactosylceramidase activity was virtually absent in cultured amniotic cells obtained during the pregnancy of this fetus. The prenatal diagnosis was confirmed by enzymatic analysis of fetal cultured skin fibro...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(94)90013-2

    authors： Ida H,Rennert OM,Watabe K,Eto Y,Maekawa K

    更新日期：1994-11-01 00:00:00

  • MicroRNA-31 regulating apoptosis by mediating the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in treatment of spinal cord injury.

    abstract：:Apoptosis is a highly conservative energy demand program for non-inflammatory cell death, which is extremely significant in normal physiology and disease. There are many techniques used for studying apoptosis. MicroRNA (miRNA) is closely related to cell apoptosis, and especially microRNA-31 (miR-31) is involved in apo...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/j.braindev.2019.04.010

    authors： Wang Y,Yuan Y,Gao Y,Li X,Tian F,Liu F,Du R,Li P,Wang F,Xu S,Wu X,Wang C

    更新日期：2019-09-01 00:00:00

  • Effects of neurosurgical treatment on diffuse slow spike and wave complex: a case of left frontal mass lesion with diffuse slow spike and wave complex (DSSW).

    abstract：:A 10-year-old girl with a mass lesion in the left deep frontal lobe was reported. Clinically, seizures occurred at 3 years and 8 months and became intractable around the age of 5.5 years. EEG initially showed focal spikes on the left fronto-central area and later developed into diffuse slow spike and wave complexes (D...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(85)80116-9

    authors： Honda K,Shinomiya N,Nomura Y,Sato K,Segawa M

    更新日期：1985-01-01 00:00:00

  • X-linked adrenoleukodystrophy: clinical course and minimal incidence in South Brazil.

    abstract：UNLABELLED:X-linked adenoleukodystrophy is a genetic disease that affects the degradation of very long-chain fatty acids. In male patients, common pictures are the cerebral form (CALD), myeloneuropathy (AMN), and Addison-only. OBJECTIVE:To describe the clinical course of affected male patients from South Brazil betwee...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.02.002

    authors： Jardim LB,da Silva AC,Blank D,Villanueva MM,Renck L,Costa ML,Vargas CR,Deon M,Coelho Dl,Vedolin L,de Castro CG Jr,Gregianin L,Bonfim C,Giugliani R

    更新日期：2010-03-01 00:00:00

  • Reduction in cerebral blood flow volume in infants complicated with hypoxic ischemic encephalopathy resulting in cerebral palsy.

    abstract：:Hypoxic ischemic brain can result in cerebral palsy, mental retardation, and learning disabilities in surviving children. The purpose of this study was to elucidate the cerebral blood flow volume in infants complicated with brain damage after the birth. Nine term infants with hypoxic ischemic encephalopathy and 41 nor...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2007.08.008

    authors： Fukuda S,Mizuno K,Kawai S,Kakita H,Goto T,Hussein MH,Daoud GA,Ito T,Kato I,Suzuki S,Togari H

    更新日期：2008-04-01 00:00:00

  • Inappropriate intracranial hemodynamics in the natural course of MELAS.

    abstract：:The abnormalities of intracranial hemodynamics associated with strokelike episodes in MELAS are variable depend on the time phase from the onset of strokelike episodes and on the progression of the dementia state. To clarify the regional cerebral blood flows (rCBF) in the natural course of MELAS is very important to u...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2007.06.008

    authors： Nishioka J,Akita Y,Yatsuga S,Katayama K,Matsuishi T,Ishibashi M,Koga Y

    更新日期：2008-02-01 00:00:00

  • Stroke in neonates with cardiac right-to-left shunt.

    abstract：:Neonatal focal cerebral arterial infarction has been rarely reported in the literature, in contrast to the watershed infarctions, which are common entities among asphyxiated infants. In neonatal postmortem series, thromboembolism was the commonest cause of cerebral arterial occlusion; the source of emboli was associat...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(12)80344-5

    authors： Pellicer A,Cabañas F,García-Alix A,Pérez-Higueras A,Quero J

    更新日期：1992-11-01 00:00:00

  • Which factors determine febrile seizure recurrence? A prospective study.

    abstract：PURPOSE:Many factors have been studied as potential predictors of recurrent febrile seizures (FS), however the available data in literature are inconsistent. The aim of the present paper is to determine which factors are responsible for the first and for multiple recurrences of FS, in a large sample of children with a ...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2007.05.001

    authors： Pavlidou E,Tzitiridou M,Kontopoulos E,Panteliadis CP

    更新日期：2008-01-01 00:00:00

  • The test of variables of attention (TOVA) is useful in the diagnosis of Japanese male children with attention deficit hyperactivity disorder.

    abstract：:The purpose of this study was to evaluate the ability of the test of variables of attention (TOVA) to distinguish between 6- to 12-year-old Japanese male children with attention deficit hyperactivity disorder (ADHD group; n=17) meeting DSM-IV and ICD-10 criteria, and age-matched, normal Japanese male controls (control...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00168-6

    authors： Wada N,Yamashita Y,Matsuishi T,Ohtani Y,Kato H

    更新日期：2000-09-01 00:00:00

  • Familial lissencephaly with extreme neopallial hypoplasia.

    abstract：:Two siblings, male and female, with identical lethal brain malformation are described. Their anomaly is characterized by very low brain weight, lissencephaly, wide ventricles and thin neopallium (colpocephaly) varying in thickness between 0.2 and 3 mm. The neocortex is four layered as in classic lissencephaly. Brainst...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(82)80008-9

    authors： Barth PG,Mullaart R,Stam FC,Slooff JL

    更新日期：1982-01-01 00:00:00

  • Missense mutants inactivate guanosine triphosphate cyclohydrolase I in hereditary progressive dystonia.

    abstract：:Hereditary progressive dystonia (HPD) with marked diurnal fluctuation is caused by mutant guanosine triphosphate (GTP) cyclohydrolase I (GCH). The clinical presentation of dominant HPD varies considerably. We proposed the hypothesis that a relative increase of mutant GCH capable of inhibiting normal GCH is responsible...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00135-2

    authors： Ueno S,Hirano M

    更新日期：2000-09-01 00:00:00

  • Effectiveness of lidocaine infusion for status epilepticus in childhood: a retrospective multi-institutional study in Japan.

    abstract：:We evaluated the usefulness of intravenous lidocaine therapy for managing of status epilepticus (SE) during childhood in a retrospective multi-institutional study. Questionnaires were sent to 28 hospitals concerning patients admitted for SE who were managed with lidocaine, assessing patient characteristics, treatment ...

    journal_title：Brain & development

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.braindev.2007.12.016

    authors： Hattori H,Yamano T,Hayashi K,Osawa M,Kondo K,Aihara M,Haginoya K,Hamano S,Izumi T,Kaneko K,Kato I,Matsukura M,Minagawa K,Miura T,Ohtsuka Y,Sugai K,Takahashi T,Yamanouchi H,Yamamoto H,Yoshikawa H

    更新日期：2008-09-01 00:00:00

  • Lower brainstem dysfunction in an infant with persistent primitive trigeminal artery.

    abstract：:A 6-month-old boy with persistent primitive trigeminal artery (PPTA) presented with stridor, dysphagia, delayed motor development and postural neck and shoulder dystonia. Magnetic resonance imaging/angiography and ultrasonography revealed PPTA, with flow from the dilated basilar artery to the right internal carotid ar...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.08.008

    authors： Okanishi T,Saito Y,Miki S,Nagaishi J,Hanaki K,Tomita Y,Fukuda C,Fujii S,Fujiwara K,Kawamoto K,Hata F,Maegaki Y,Ohno K

    更新日期：2007-04-01 00:00:00

  • Childhood-onset anti-MuSK antibody positive myasthenia gravis demonstrates a distinct clinical course.

    abstract：:Anti-muscle-specific tyrosine kinase antibody (MuSK-Ab) is the second most frequent autoantibody identified in adult patients with myasthenia gravis (MG). Adult patients with MuSK-Ab demonstrate characteristic clinical features but very little information is available for childhood-onset patients with MuSK-positive MG...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2011.12.014

    authors： Takahashi Y,Sugiyama M,Ueda Y,Itoh T,Yagyu K,Shiraishi H,Ukeba-Terashita Y,Nakanishi M,Nagashima T,Imai T,Motomura M,Saitoh S

    更新日期：2012-10-01 00:00:00

  • Ictal EEG in patients with convulsions with mild gastroenteritis.

    abstract：:The aim of this study is to reveal detailed clinical manifestations and an evolution of ictal EEG discharges of convulsions with mild gastroenteritis (CwG). We recorded ictal EEGs of six patients with CwG. Clinical manifestations included loss of responsiveness, motion arrest, cyanosis, lateral eye deviation, and hemi...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.06.002

    authors： Maruyama K,Okumura A,Sofue A,Ishihara N,Watanabe K

    更新日期：2007-01-01 00:00:00

  • Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging.

    abstract：:In the present study, we investigated age-related changes in pteridine levels and enzymatic activity responsible for tetrahydrobiopterin biosynthesis in mouse tissues. Until about 15 weeks after the birth, the remarkable change of tetrahydrobiopterin (BH4) was observed in all tissues tested. Between 20 and 50 weeks af...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00144-3

    authors： Yoshida YI,Eda S,Masada M

    更新日期：2000-09-01 00:00:00

  • Tuberous sclerosis: the incidence of sporadic cases versus familial cases.

    abstract：:In 48 families in which tuberous sclerosis occurred, extensive examination presented almost the same incidence of sporadic cases as reported in previous studies. Although inspection of the skin and cranial computed tomography seem to be the most sensitive diagnostic tests available, negative results with these methods...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(80)80031-3

    authors： Fleury P,de Groot WP,Delleman JW,Verbeeten B Jr,Frankenmolen-Witkiezwicz IM

    更新日期：1980-01-01 00:00:00

  • Influence of ACTH therapy on overnight sleep polygrams in infantile spasms.

    abstract：:Overnight sleep polygrams were recorded before and during therapy in nine patients with infantile spasms. Results showed that ACTH therapy increased the waking time and decreased rapid eye movement sleep. Thus it caused sleep disturbance in patients with infantile spasms. During ACTH therapy the number of rapid eye mo...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(81)80006-x

    authors： Hashimoto T,Hiura K,Suzue J,Nokawa T,Fukuda K,Endo S,Tayama M,Tamura Y,Miyao M

    更新日期：1981-01-01 00:00:00

  • Complex regional pain syndrome in childhood: report of three cases.

    abstract：:We describe three patients with the limb pain of complex regional pain syndrome (CRPS) in childhood with autonomic nervous system function involvement. Their autonomic nerve abnormality was non-invasively examined by means of laser doppler flowmetry (LDF) and a sympathetic skin response (SSR) test. In one it was resol...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00174-1

    authors： Matsui M,Ito M,Tomoda A,Miike T

    更新日期：2000-10-01 00:00:00