Abstract:
:Event-related potential (ERP) studies with infants are often limited by a small number of measurements. We introduce a weighted general linear mixed model analysis with a time-varying covariate, which allows for the efficient analysis of all available event-related potential data of infants. This method allows controlling the signal to noise ratio effect on averaged ERP estimates due to small and varying numbers of trials. The method enables analyzing ERP data sets of infants, which would often not be possible otherwise. We illustrate this method by analyzing an experimental study and discuss the advantages in comparison to currently used methods as well as its potential limitations. In this study, 6-month-old infants saw a face showing a neutral or an angry expression in combination with direct or averted eye gaze. We examined how the infant brain processes facial expressions and whether the direction of eye gaze has an influence on it. We focused on the infant Negative Central ERP component (Nc). The neutral expression elicited larger amplitude and peaked earlier than the angry expression. An interaction between emotion and gaze was found for Nc latency, suggesting that emotions are processed in combination with eye gaze in infancy.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Stahl D,Parise E,Hoehl S,Striano Tdoi
10.1016/j.braindev.2009.04.001subject
Has Abstractpub_date
2010-04-01 00:00:00pages
305-17issue
4eissn
0387-7604issn
1872-7131pii
S0387-7604(09)00129-6journal_volume
32pub_type
杂志文章abstract::Ring chromosome 20 [r(20)] syndrome is a rare chromosomal disorder that is characterized by the development of refractory epilepsy during childhood with gradual declines in cognitive performance and behavior. Although the prognoses of seizures and intellectual disability associated with this condition are poor, life-t...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2016.02.013
更新日期:2016-09-01 00:00:00
abstract::Many benzodiazepines used as anticonvulsants have nitrogen radicals in positions 1 and 4. Clobazam has nitrogen radicals in positions 1 and 5. We studied the antiepileptic effect of clobazam in 36 patients with intractable epilepsies in childhood. Their ages were 1 year 1 month to 16 years 5 months (mean 8 years). The...
journal_title:Brain & development
pub_type: 临床试验,杂志文章
doi:10.1016/s0387-7604(82)80102-2
更新日期:1982-01-01 00:00:00
abstract::Serial polygraphic recordings of two to three hours duration were made in five full-term newborns with trisomy 18 and one full-term newborn with trisomy 13 syndrome. The newborns with 18 trisomy syndrome were poor sleepers with long periods of wakefulness and/or drowsiness. There were no consistent abnormalities in th...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(79)80029-7
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:We performed this study to evaluate the long-term efficacy and tolerability of ethosuximide (ESX), valproic acid (VPA), and lamotrigine (LTG) as initial monotherapies for patients with newly diagnosed childhood absence epilepsy. METHODS:We retrospectively reviewed the medical records of 128 patients (45 boys a...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2011.08.007
更新日期:2012-05-01 00:00:00
abstract:AIMS:Abnormalities of gross motor function in children with autism are well known to clinicians but have not received much empirical documentation and, with the exception of stereotypies, are not among its diagnostic criteria. We recorded the characteristics of gait and prevalence of toe walking, the range of passive j...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2012.02.005
更新日期:2014-02-01 00:00:00
abstract::Penicillin (PC) neurotoxicity (convulsions and encephalopathy) is considered to be due to GABAergic inhibition. The effects of penicillin G(PCG) on [3H]flunitrazepam (FNZ) binding in rat neuron-enriched primary cultures was examined to assess the role of the benzodiazepine (BDZ) receptor in the neurotoxicity. PCG appl...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(93)90121-n
更新日期:1993-09-01 00:00:00
abstract::We report on the clinical, neuropathological, and genetic findings of a Japanese case with myocerebrohepatopathy spectrum (MCHS) disorder due to polymerase gamma (POLG) mutations. A girl manifested poor sucking and failure to thrive since 4 months of age and had frequent vomiting and developmental regression at 5 mont...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2014.10.013
更新日期:2015-08-01 00:00:00
abstract::The electroencephalographic features and their evolutional changes with age were described in three cases of lissencephaly syndrome diagnosed by CT scan. The case with more severe lissencephaly displayed very similar EEG findings. In early or middle infancy when infantile spasms began, EEG showed very high amplitude (...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(79)80042-x
更新日期:1979-01-01 00:00:00
abstract::A 10-year-old male patient, who had suffered from intractable convulsions from the neonatal period, is presented. Serial brain images suggested slow, gradual destruction of neural elements. Human cytomegalovirus (HCMV) DNA was detected in his cerebrospinal fluid (CSF) by means of the polymerase chain reaction. Intrath...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/0387-7604(93)90086-n
更新日期:1993-11-01 00:00:00
abstract::Neurofibrillary tangles (NFTs) have been shown in 20% of subacute sclerosing panencephalitis (SSPE) cases. NFTs contain paired helical filaments formed by hyperphosphorylated tau. The intraneuronal tau metabolism and the rate of formation of paired helical filaments can be regulated by interactions between tau and iso...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2011.07.001
更新日期:2012-04-01 00:00:00
abstract::Mutations of the gene encoding the alpha2 subunit of the neuronal sodium channel, SCN2A, have been found in benign familial neonatal-infantile seizures (BFNIS). In Dravet syndrome, only one nonsense mutation of SCN2A was identified, while hundreds of mutations were found in the paralogue gene, SCN1A, which encodes the...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.08.009
更新日期:2009-11-01 00:00:00
abstract::We recorded serially brainstem auditory evoked response (BAER) during the neonatal period in term infants who suffered perinatal asphyxia. The amplitudes of BAER components was analysed at 40 dB above BAER threshold of each subject who had a threshold journal_title:Brain & development pub_type: 杂志文章 doi:10.1016/j.braindev.2006.03.004 更新日期:2006-10-01 00:00:00
abstract::We previously reported that knockout mice lacking the p85alpha regulatory subunit of phosphoinositide-3 kinase (PI3K) (p85alpha(-/-) mice) significantly showed spatial learning-deficits, restlessness and motivation-deficit in water maze tests. It was also shown in the report that decline of PI3K activity in several br...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2008.04.006
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Neuroimaging studies demonstrate that not only the lesions of malformations of cortical development (MCD) but also the normal-appearing parenchyma (NAP) present metabolic impairments, as revealed with (1)H-MRS. We have previously detected biochemical disturbances in MCD lesions with phosphorus-31 magnetic ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2013.12.010
更新日期:2014-11-01 00:00:00
abstract::We report on a 9-year-old boy who presented with acute encephalopathy and hemophagocytic lymphohistiocytosis (HLH). The patient was referred to our hospital because of fever, seizures, and decreased consciousness. He showed moderately elevated levels of proinflammatory cytokines in the cerebrospinal fluid and plasma, ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2011.07.005
更新日期:2012-05-01 00:00:00
abstract:UNLABELLED:X-linked adenoleukodystrophy is a genetic disease that affects the degradation of very long-chain fatty acids. In male patients, common pictures are the cerebral form (CALD), myeloneuropathy (AMN), and Addison-only. OBJECTIVE:To describe the clinical course of affected male patients from South Brazil betwee...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.02.002
更新日期:2010-03-01 00:00:00
abstract::Alternating hemiplegia in childhood (AHC) has clinically characteristic features which are easily defined and recognizable. Laboratory investigations were basically normal although they were extensively examined during and between attacks. There is still much debate about its etiology, particularly its relation to mig...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/s0387-7604(12)80144-6
更新日期:1992-09-01 00:00:00
abstract::Microdeletions in the 1q44 region encompassing the HNRNPU gene have been associated with infantile spasms and hemiconvulsion-hemiplegia-epilepsy syndrome. Recent studies have revealed that heterozygous HNRNPU variants resulted in early onset epilepsy and severe intellectual disability. A de novo frameshift mutation in...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2018.05.010
更新日期:2018-10-01 00:00:00
abstract:AIM:To report on two children with encephalopathy caused by dietary thiamine deficiency due to newly developing nutritional problems in contemporary Japan. SUBJECTS:A 1-year-old boy who had consumed 1l of isotonic drinks per day for 4 months after an episode of diarrhea, and presented with ocular movement disorder, dy...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.08.004
更新日期:2010-08-01 00:00:00
abstract::Oxidative stress resulting from increased free radical production and/or defects in antioxidant defences may be the cause of various neurodegenerative disorders. In this study, the roles of oxygen free radicals, nitric oxide, superoxide dismutase, vitamin E and vitamin C were investigated in pure and complicated hered...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2008.12.014
更新日期:2010-02-01 00:00:00
abstract::A seven-year-old girl with Krabbe disease presenting palatal myoclonus only when awake is reported. The patient was diagnosed as having Krabbe disease enzymatically at the age of eleven months. She developed rhythmical contractions of the soft palate, pharynx, larynx, lips and tongue at two years. The surface electrom...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(12)80133-1
更新日期:1991-09-01 00:00:00
abstract::Glucose transporter type1 (GLUT-1) deficiency may be rare, but it is a preventable cause of severe learning difficulties; and therefore there is an urgency in making an early diagnosis. Suspicions must be roused when intractable seizures occur in infancy. These may be associated with acquired microcephaly and developm...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/s0387-7604(03)00058-5
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:Epilepsy with continuous spikes and waves during slow sleep (ECSWS) is associated with cognitive deficits. The underlying mechanism is thought to relate to disturbance of functions of the foci by the persistent epileptic activity. However, the relationship between epileptic foci and cognitive deficits remains...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2018.09.005
更新日期:2019-02-01 00:00:00
abstract::21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia, an autosomal recessive disorder characterized by impaired synthesis of cortisol from cholesterol by the adrenal cortex. Subclinical involvement of brain white matter has been reported in subjects with congenital adrenal hyperplasia. ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.04.004
更新日期:2010-05-01 00:00:00
abstract::Bedside monitoring of cerebral circulation or oxygen metabolism in infants to appropriately manage circulation and establish the oxygen dose, aiming at improving the neurological prognosis, is needed in general clinical practice. Near-infrared spectroscopy is used for measurements of neonatal cerebral Hb oxygen satura...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/j.braindev.2013.05.011
更新日期:2014-04-01 00:00:00
abstract::Valproic acid (VPA) is a widely used and well-tolerable antiepileptic drug in epileptic patients. However, VPA has many side effects dose-dependent or non-dose-dependent. It is reported that VPA treatment may lead to biotin deficiency and low serum and liver tissue biotinidase enzyme activity (BEA). Major clinical man...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2008.07.008
更新日期:2009-06-01 00:00:00
abstract::Sphingolipidoses are a subgroup of lysosomal storage diseases. They are defined as disorders caused by a genetic defect in catabolism of sphingosine-containing lipids. Catabolism of these lipids involves enzymes and activator proteins. After the discovery of lysosomes by de Duve and the demonstration of the first defe...
journal_title:Brain & development
pub_type: 杂志文章,评审
doi:10.1016/j.braindev.2004.01.005
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Epilepsy with myoclonic absences (EMA) is a rare childhood-onset syndrome characterized by absences of responsiveness accompanied by bilateral rhythmic clonic-like myoclonic jerks. Herein, we describe the case of a child with EMA, resistant to multiple commonly used antiepileptic drugs, in whom low-dose phen...
journal_title:Brain & development
pub_type:
doi:10.1016/j.braindev.2020.12.018
更新日期:2021-01-15 00:00:00
abstract::This paper reports 504 cases admitted with acute polyradiculoneuritis (AP) to Beijing Children's Hospital from 1975 through 1984. 343 of the 504 cases (68.1%) with AP had respiratory paralysis and in 198/504 (39.3%), tracheotomy was performed. In this study, none of the patients received steroids. We attempted to asse...
journal_title:Brain & development
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Takuto Rehabilitation Center for Children is located in Sendai, the capital of the Miyagi prefecture, and faces the Pacific Ocean. The tsunami caused by the Great East Japan Earthquake resulted in tremendous damage to this region. Many physically handicapped patients with epilepsy who are treated at our hosp...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2016.01.005
更新日期:2016-08-01 00:00:00