Is oxidative damage in operation in patients with hereditary spastic paraparesis?

Abstract:

:Oxidative stress resulting from increased free radical production and/or defects in antioxidant defences may be the cause of various neurodegenerative disorders. In this study, the roles of oxygen free radicals, nitric oxide, superoxide dismutase, vitamin E and vitamin C were investigated in pure and complicated hereditary spastic paraparesis (HSP) patients. The results showed that plasma SOD, vitamin E and nitric oxide levels were significantly low in HSP patients. These findings indicate the influence of oxidative damage in the degenerative process of HSP.

journal_name

Brain Dev

journal_title

Brain & development

authors

Gücüyener K,Pinarli FG,Erbaş D,Hasanoğlu A,Serdaroğlu A,Topaloğlu H

doi

10.1016/j.braindev.2008.12.014

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

130-6

issue

2

eissn

0387-7604

issn

1872-7131

pii

S0387-7604(08)00300-8

journal_volume

32

pub_type

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