Abstract:
:This is the first study to report differences between Japanese children with and without dyslexia in the way string-length and lexicality effects are manifested when reading Japanese kana. These children were asked to read kana words and non-words consisting of either two or five kana characters. The results showed that the error rates of the normal Preschoolers and Primary-School children with dyslexia were higher than those of the normal Primary-School children. Further, the reading latencies of the normal Preschoolers, First-graders and dyslexics were significantly longer than those of the normal Second, Third and Fifth/Sixth graders. Moreover, reading latencies became shorter as the age of the participants increased. Both normal and dyslexic children showed significant effects of length and lexicality on reading latencies. However, the interaction between the length and lexicality was only seen in normal children from the Second-grade onwards. These results suggest that (1) normal First-graders reach a ceiling in terms of reading accuracy and that (2) as Japanese normal children become older, they become better at lexical reading processes, which leads to fluent kana reading, but that (3) the dyslexics, even at Fifth/Sixth grades, have not developed sufficient lexical reading processes.
journal_name
Brain Devjournal_title
Brain & developmentauthors
Sambai A,Uno A,Kurokawa S,Haruhara N,Kaneko M,Awaya N,Kozuka J,Goto T,Tsutamori E,Nakagawa K,Wydell TNdoi
10.1016/j.braindev.2011.09.005subject
Has Abstractpub_date
2012-06-01 00:00:00pages
520-8issue
6eissn
0387-7604issn
1872-7131pii
S0387-7604(11)00252-Xjournal_volume
34pub_type
杂志文章abstract:OBJECTIVE:Acute encephalitis with refractory repetitive partial seizure (AERRPS) is a peculiar type of post-encephalitic/encephalopathic epilepsy. Here we report an analysis of AERRPS in a series of children and propose an effective treatment option for seizure control in these children. METHODS:We retrospectively rev...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2008.09.010
更新日期:2009-09-01 00:00:00
abstract::A 7-year-old boy began to complain that his pitch perception was decreased just after oral medication with carbamazepine was initiated for the treatment of epilepsy. When he played the piano, he felt as if he had played a musical note of almost a half pitch lower than he had. His pitch perception recovered soon after ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(02)00155-9
更新日期:2003-03-01 00:00:00
abstract::A family in which three siblings were affected with severe cerebral malformations in association with ocular anomalies and muscle disease is reported. One sibling was diagnosed as having Fukuyama type congenital muscular dystrophy (FCMD) because he showed severe hypotonia with dystrophic findings on a muscle biopsy in...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(12)80154-9
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Cohen syndrome (CS) is a rare multi-system autosomal recessive disorder with a high prevalence in the Finnish population. Clinical features of Finnish-type CS are homogeneous, however, in non-Finnish populations, CS diagnosis is challenging due to broad phenotypic variability. METHODS:We studied a consangui...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2020.04.010
更新日期:2020-09-01 00:00:00
abstract::Teratological study on microgyra is rare, and its morphogenesis is still on dispute. Microgyra associated with cranial meningocele and progressive hydrocephalus were induced in rat siblings by administration of 10 mg/kg.bw of n-methyl n-nitrosourea (MNU) to rat dams on day 9 of gestation. Microgyra were closely simila...
journal_title:Brain & development
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Six females with Rett syndrome (RS)--all seriously motor disabled with clinical symptomatology indicating not only brain but also spinal cord impairment--were investigated using auditory and somatosensory evoked responses techniques. In all patients the responses representing the pathways through the upper spinal cord...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(87)80076-1
更新日期:1987-01-01 00:00:00
abstract::The abnormalities of intracranial hemodynamics associated with strokelike episodes in MELAS are variable depend on the time phase from the onset of strokelike episodes and on the progression of the dementia state. To clarify the regional cerebral blood flows (rCBF) in the natural course of MELAS is very important to u...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2007.06.008
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Bottom shuffling is a locomotion strategy that precedes independent walking in some infants. Shuffling babies are generally considered to have favorable outcomes. The aim of the present study was to reveal clinical features and neurodevelopmental outcomes of shuffling babies who visited a child d...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2020.08.007
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:Filamin A (FLNA) is located in Xq28, and encodes the actin binding protein, filamin A. A mutation in FLNA is the most common cause of periventricular nodular heterotopia (PVNH), but a clear phenotype-genotype correlation has not been established. Indeed, some patients with a FLNA mutation have recently bee...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2018.01.010
更新日期:2018-06-01 00:00:00
abstract::To clarify the predictive value of the seven more commonly used postural reactions (PR) in the 1st year of life regarding the diagnosis of cerebral palsy (CP), we prospectively examined 204 high-risk infants of whom 58 developed CP, 22 had developmental retardation (DR) and 124 were normal at follow-up at 3 years of a...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(98)00036-9
更新日期:1998-08-01 00:00:00
abstract::The effects of drug on the cholinergic system (atropine and physostigmine) were evaluated in acute tests in 12 infant patients with the West syndrome (WS) and in 12 older ones who had suffered from WS at typical ages, displaying various types of epileptic symptoms. In both groups paroxysmal EEG activity was inhibited ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(12)80008-8
更新日期:1990-01-01 00:00:00
abstract::A 14-year-old female had repeated vomiting, headache, abdominal pain, visual field deficit and lethargy at the onset of hypertensive encephalopathy. Cerebrospinal fluid (CSF) test revealed a high level of IgG and protein. MRI demonstrated no supratentorial cerebral lesions but hyperintense lesions were observed from t...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.07.002
更新日期:2010-08-01 00:00:00
abstract::Potassium bromide was tried for two children with daily convulsive focal motor seizures with unconsciousness and focal motor seizure status. The treatment resulted in complete cessation of the attacks. It has been reported that bromide is effective for generalized tonic-clonic seizures and not for complex partial seiz...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(02)00023-2
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVES:Preterm children with severe dyskinetic cerebral palsy due to bilirubin encephalopathy often suffer from marked generalised hypertonus as they age. We performed a questionnaire survey to investigate patient-reported outcomes of treatments for improving their activities of daily life. METHODS:A mail question...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2020.01.006
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Ictal fear is an uncommon condition in which fear manifests as the main feature of epileptic seizures. The literature has suggested that ictal fear is generally associated with poor seizure outcomes. We wanted to clarify the variability in seizure outcome of children with ictal fear. SUBJECTS AND METHODS:We id...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2013.11.011
更新日期:2014-10-01 00:00:00
abstract::To elucidate the nature of an overabundance of collagen seen on microscopic examination in tuberous sclerous (TS), the hydroxyproline content in tissues and urine was determined. TS tissues of 5 patients were obtained on necropsy or plastic surgery. Urine was collected from 10 patients with TS and 19 controls. Tumors ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(81)80009-5
更新日期:1981-01-01 00:00:00
abstract::Oxidative stress resulting from increased free radical production and/or defects in antioxidant defences may be the cause of various neurodegenerative disorders. In this study, the roles of oxygen free radicals, nitric oxide, superoxide dismutase, vitamin E and vitamin C were investigated in pure and complicated hered...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2008.12.014
更新日期:2010-02-01 00:00:00
abstract::Thirty-one epileptic patients, selected from among 900 children with previous febrile convulsions and subsequent epilepsy, were typed for HLA antigens. In 16 of the 31 patients CMV was isolated from the urine shortly after the appearance of spontaneous fits; in the remaining 15 patients the virus was never detected. A...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(88)80008-1
更新日期:1988-01-01 00:00:00
abstract::21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia, an autosomal recessive disorder characterized by impaired synthesis of cortisol from cholesterol by the adrenal cortex. Subclinical involvement of brain white matter has been reported in subjects with congenital adrenal hyperplasia. ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2009.04.004
更新日期:2010-05-01 00:00:00
abstract::A 6-month-old boy with persistent primitive trigeminal artery (PPTA) presented with stridor, dysphagia, delayed motor development and postural neck and shoulder dystonia. Magnetic resonance imaging/angiography and ultrasonography revealed PPTA, with flow from the dilated basilar artery to the right internal carotid ar...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2006.08.008
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The pathogenesis of acute encephalopathy (AE) remains unclear, and a biomarker has not been identified. METHODS:Levels of 49 cytokines and chemokines, including osteopontin (OPN), were measured in serum and cerebrospinal fluid (CSF) of children with AE (n = 17) or febrile convulsion (FC; n = 8; control grou...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2019.11.002
更新日期:2020-02-01 00:00:00
abstract::The aim of this study is to investigate predictive factors of post-traumatic syndrome in children with minor head injury. Prospective neurological, electroencephalographic and psychological investigations were performed in 98 children aged 3-13 years within 24 h after the trauma and 4-6 weeks later. Inclusion criteria...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/S0387-7604(03)00110-4
更新日期:2004-03-01 00:00:00
abstract::The juvenile form of neuronal ceroid lipofuscinosis (JNCL) is caused by mutations in the CLN3 gene, and is characterized by progressive loss of vision and development of motor deficits. A few patients exhibit a more protracted clinical course and are diagnosed with protracted JNCL (PJNCL). Here, we report the autopsy ...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2005.12.004
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Rapid-onset dystonia-parkinsonism (RDP) is a disease characterized by an abrupt onset of dystonia accompanied by signs of parkinsonism and prominent bulbar symptoms. CASE REPORT:We describe a case of a female patient, born after normal delivery, but diagnosed with mild intellectual disability at age 7. She ...
journal_title:Brain & development
pub_type:
doi:10.1016/j.braindev.2020.12.009
更新日期:2021-01-12 00:00:00
abstract::A servo system including a microwave generator was applied to raise a rat's body temperature at a pre-set rate. Using this system the effects of age and the temperature elevation rate upon febrile seizures in rats were studied. The relationship between the brain GABA content and hyperthermia was also studied. From the...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(12)80307-x
更新日期:1990-01-01 00:00:00
abstract::In order to elucidate the molecular mechanisms underlying neuronal migration in the developing rat cerebral cortex, a novel primary tissue culture system in which neuronal migration can be evaluated was developed. Using this culture system, through autoradiographic studies we demonstrated the migration of [3H]thymidin...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/s0387-7604(97)00057-0
更新日期:1997-11-01 00:00:00
abstract::Organic acidemias (OAs) have been detected worldwide in symptomatic patients using gas chromatography mass spectrometry. We diagnosed 188 Asian cases of OAs by analysis of urinary organic acids and investigated their clinical onset and outcome. Methylmalonic acidemia (MMA) was most common (74 cases), followed by propi...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2004.04.004
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Hypophosphatasia (HPP) is a rare genetic disorder characterized by rachitic bone manifestations and a low serum alkaline phosphatase (ALP) level. It is caused by mutations in the tissue non-specific alkaline phosphatase (TNSALP) gene, which encodes the tissue non-specific isozyme of ALP. HPP patients exhibit...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2017.07.015
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical and neurophysiological characteristics, particularly therapeutic considerations, of epileptic negative myoclonus (ENM) in atypical benign partial epilepsy (ABPE) of childhood. METHODS:From 1998 to 2006, 14/242 patients with benign children epilepsy with centrotemporal spikes (BECT...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2008.04.004
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Patients with pathogenic cyclin-dependent kinase-like-5 gene (CDKL5) variants are designated CDKL5 deficiency disorder (CDD). This study aimed to delineate the clinical characteristics of Japanese patients with CDD and elucidate possible appropriate treatments. METHODS:We recruited patients with pathogenic o...
journal_title:Brain & development
pub_type: 杂志文章
doi:10.1016/j.braindev.2020.12.006
更新日期:2021-01-09 00:00:00