Abstract:
:Epigallocatechin gallate (EGCG), a major polyphenol in green tea, possesses antioxidant properties and regulates various cell functions. Here, we examined the function of EGCG in inflammatory bone resorption. In calvarial organ cultures, lipopolysaccharide (LPS)-induced bone resorption was clearly suppressed by EGCG. In osteoblasts, EGCG suppressed the LPS-induced expression of COX-2 and mPGES-1 mRNAs, as well as prostaglandin E2 production, and also suppressed RANKL expression, which is essential for osteoclast differentiation. LPS-induced bone resorption of mandibular alveolar bones was attenuated by EGCG in vitro, and the loss of mouse alveolar bone mass was inhibited by the catechin in vivo.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Tominari T,Matsumoto C,Watanabe K,Hirata M,Grundler FM,Miyaura C,Inada Mdoi
10.1016/j.fob.2015.06.003subject
Has Abstractpub_date
2015-06-12 00:00:00pages
522-7issn
2211-5463pii
S2211-5463(15)00057-1journal_volume
5pub_type
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