Alterations in DNA methylation profiles in cancellous bone of postmenopausal women with osteoporosis.

abstract：:Osteonecrosis of the femoral head (ONFH) is a common clinical disease with a high disability rate. Apoptosis of osteoblasts caused by high-dose short-term or low-dose long-term glucocorticoid (GC) administration is the biological basis of steroid-induced avascular necrosis of the femoral head (SANFH). The pathogenesis...

journal_title：FEBS open bio

authors： Peng P,Nie Z,Sun F,Peng H

更新日期：2020-11-15 00:00:00

abstract：:Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor (CS-) without the ...

journal_title：FEBS open bio

authors： Ueoka Y,Hiroi M,Abe T,Tabata T

更新日期：2017-02-22 00:00:00

abstract：:Niclosamide is a potent inhibitor of osteoclastogenesis and bone remodeling. DK-520 is an acyl derivative of Niclosamide and significantly increased both the plasma concentration and the duration of exposure of Niclosamide when dosed orally. However, at present the effect of DK-520 on osteoclastogenesis has not been r...

journal_title：FEBS open bio

authors： Jiao Y,Chen C,Hu X,Feng X,Shi Z,Cao J,Li Q,Zhu Y

更新日期：2020-08-01 00:00:00

abstract：:Tropomyosins, a family of actin-associated proteins, bestow actin filaments with distinct biochemical and physical properties which are important for determining cell shape and regulating many cellular processes in eukaryotic cells. Here, we used RNA-seq to investigate the effect of four tropomyosin isoforms on gene e...

journal_title：FEBS open bio

authors： Stefen H,Suchowerska AK,Chen BJ,Brettle M,Kuschelewski J,Gunning PW,Janitz M,Fath T

更新日期：2018-02-19 00:00:00

abstract：:Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC ...

journal_title：FEBS open bio

authors： Khusainov R,Moll GN,Kuipers OP

更新日期：2013-05-30 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease with increased risk of cardiovascular events and mortality that can be attributed to accelerated atherosclerosis. This pilot study aimed to investigate if changes in blood parameters were compatible with atherosclerotic events in RA patients. To this aim, 45 ...

journal_title：FEBS open bio

authors： Vona R,Di Franco M,Gambardella L,Di Lollo AC,Iannuccelli C,Valesini G,Malorni W,Straface E

更新日期：2018-11-06 00:00:00

abstract：:Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down-regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the hepatocellular carcinoma cell line HuH-7. TXNIP contains putative phosphorylation sites, but the effe...

journal_title：FEBS open bio

authors： Kamitori K,Yamaguchi F,Dong Y,Hossain A,Katagi A,Noguchi C,Hirata Y,Tsukamoto I,Hatano N,Tokuda M

更新日期：2018-10-01 00:00:00

abstract：:Inovirus XacF1 (7325 nucleotides) is integrated into the genome of Xanthomonas citri pv. citri (Xcc) strains at the host dif site (attB) by the host XerC/D recombination system. The XacF1 attP sequence is located within the coding region of ORF12, a possible phage regulator. After integration, this open reading frame ...

journal_title：FEBS open bio

authors： Ahmad AA,Kawabe M,Askora A,Kawasaki T,Fujie M,Yamada T

更新日期：2017-09-19 00:00:00

abstract：:Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-β-barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is still unknown. We report the first evidence of the heme-Fe(III)-bas...

journal_title：FEBS open bio

authors： De Simone G,di Masi A,Polticelli F,Ascenzi P

更新日期：2018-11-09 00:00:00

abstract：:In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...

journal_title：FEBS open bio

authors： Matsui D,Im DH,Sugawara A,Fukuta Y,Fushinobu S,Isobe K,Asano Y

更新日期：2014-02-07 00:00:00

abstract：:Mutations in the eye lens gap junction protein connexin 50 cause cataract. Earlier we identified a frameshift mutant of connexin 50 (c.670insA; p.Thr203AsnfsX47) in a family with autosomal recessive cataract. The mutant protein is smaller and contains 46 aberrant amino acids at the C-terminus after amino acid 202. Her...

journal_title：FEBS open bio

authors： Somaraju Chalasani ML,Muppirala M,G Ponnam SP,Kannabiran C,Swarup G

更新日期：2012-11-27 00:00:00

abstract：:In the brain, REST (Repressor Element-1 Silencing Transcription factor) is a key regulator of neuron cell-specific gene expression. Nuclear translocation of neuronal REST has been shown to be neuroprotective in a healthy ageing context. In contrast, inability to upregulate nuclear REST is thought to leave ageing neuro...

journal_title：FEBS open bio

authors： Mampay M,Velasco-Estevez M,Rolle SO,Chaney AM,Boutin H,Dev KK,Moeendarbary E,Sheridan GK

更新日期：2020-11-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated with HCC and the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential key genes of HCC. We identified 17 key genes closely related to HCC by yellow mo...

journal_title：FEBS open bio

authors： Chen F,Zhang K,Huang Y,Luo F,Hu K,Cai Q

更新日期：2020-07-01 00:00:00

abstract：:A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 recep...

journal_title：FEBS open bio

authors： Tsukamoto I,Inoue S,Teramura T,Takehara T,Ohtani K,Akagi M

更新日期：2013-07-04 00:00:00

abstract：:DNA damage-inducible 1 (Ddi1) is a multidomain protein with one of the domains being retropepsin-like. HIV-1 protease inhibitors were found to reduce opportunistic infections caused by pathogens like Leishmania and Plasmodium, and some of them were shown to inhibit the growth of these parasites. In Leishmania, Ddi1 wa...

journal_title：FEBS open bio

authors： Kumar S,Suguna K

更新日期：2018-08-03 00:00:00

abstract：:Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is an important enzyme in phospholipid remodeling, a process that influences the biophysical properties of cell membranes and thus cell function. Multiple lines of evidence suggest that LPCAT3 is involved in several diseases, including atherosclerosis, non-alcoholic s...

journal_title：FEBS open bio

authors： Du X,Hu J,Zhang Q,Liu Q,Xiang X,Dong J,Lou B,He S,Gu X,Cao Y,Li Y,Ding T

更新日期：2019-10-01 00:00:00

abstract：:Sorafenib, the first-line agent for treatment of advanced hepatocellular carcinoma (HCC), improves median overall survival by approximately 3 months. In the present study, we investigated whether sorafenib combined with cucurbitacin B (CuB), a natural tetracyclic triterpenoid isolated from Cucurbitaceae, exerts enhanc...

journal_title：FEBS open bio

authors： Wang X,Li H,Li D,Bai Y,Zhang Y,Yan X,Li J,Zhao R,Liu J,Liu W,Shi M,Xu C,Yang T,Zhang T

更新日期：2020-11-11 00:00:00

abstract：:RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...

journal_title：FEBS open bio

authors： Alvarado CV,Rubio MF,Fernández Larrosa PN,Panelo LC,Azurmendi PJ,Ruiz Grecco M,Martínez-Nöel GA,Costas MA

更新日期：2014-05-02 00:00:00

abstract：:Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in ...

journal_title：FEBS open bio

authors： Chi W,Gan X,Xiao W,Wang W,He S

更新日期：2013-09-19 00:00:00

abstract：:Immunoglobulin (Ig) A nephropathy (IgAN) is the most common glomerulonephritis, which is characterized by the deposition of IgA antibody in the glomerulus. Systematic dissection of immune composition may contribute to a better understanding of the alternations in the immune system in IgAN. To this end, here we applied...

journal_title：FEBS open bio

authors： Zhang X,Zeng J,Tong Y,Zhang L,Lu X,Zhu S,Li Z

更新日期：2020-12-01 00:00:00

abstract：:Understanding the role of specific amino acid residues in the molecular mechanism of a protein's function is one of the most challenging problems in modern biology. A systematic bioinformatic analysis of protein families and superfamilies can help in the study of structure-function relationships and in the design of i...

journal_title：FEBS open bio

authors： Fesko K,Suplatov D,Švedas V

更新日期：2018-05-21 00:00:00

abstract：:Despite progress in the treatment of hepatocellular carcinoma (HCC), 5-year survival rates remain low. Thus, a more comprehensive approach to explore the mechanism of HCC is needed to provide new leads for targeted therapy. We performed an integrated analysis to discover the relationship between DNA methylation and ge...

journal_title：FEBS open bio

authors： Sun XJ,Wang MC,Zhang FH,Kong X

更新日期：2018-05-30 00:00:00

abstract：:Osteoarthritis (OA) is a chronic degenerative disease that commonly affects the elderly. Current drug therapies for treating OA may cause adverse side effects, and so there remains a need to develop alternative treatments. Bergapten (BG) is a coumarin phytohormone that is widely found in fruits and has antioxidative a...

journal_title：FEBS open bio

authors： He Y,Zisan Z,Lu Z,Zheng L,Zhao J

更新日期：2019-06-01 00:00:00

abstract：:The proton-coupled folate transporter (PCFT, SLC46A1) transports folic acid across the plasma membrane, together with an excess of protons such that the net charge translocation is positive. We developed 3D structural models of PCFT threaded onto the X-ray structures of major facilitator superfamily (MFS) members that...

journal_title：FEBS open bio

authors： Date SS,Chen CY,Chen Y,Jansen M

更新日期：2016-02-22 00:00:00

abstract：:Cisplatin-based chemotherapy is the standard treatment of choice for head and neck squamous cell carcinoma (HNSCC). The efficiency of platinum-based therapies is directly influenced by the development of tumor resistance. Multiple signaling pathways have been linked to tumor resistance, including activation of nuclear...

journal_title：FEBS open bio

authors： Almeida LO,Abrahao AC,Rosselli-Murai LK,Giudice FS,Zagni C,Leopoldino AM,Squarize CH,Castilho RM

更新日期：2013-12-30 00:00:00

abstract：:PSMD9 (Proteasome Macropain non-ATPase subunit 9), a proteasomal assembly chaperone, harbors an uncharacterized PDZ-like domain. Here we report the identification of five novel interacting partners of PSMD9 and provide the first glimpse at the structure of the PDZ-domain, including the molecular details of the interac...

journal_title：FEBS open bio

authors： Sangith N,Srinivasaraghavan K,Sahu I,Desai A,Medipally S,Somavarappu AK,Verma C,Venkatraman P

更新日期：2014-06-06 00:00:00

abstract：:Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...

journal_title：FEBS open bio

authors： Qin L,Zhang Z,Zhao X,Wu X,Chen Y,Tan Z,Li S

更新日期：2014-02-07 00:00:00

abstract：:Zinc deficiency impairs the immune system leading to frequent infections. Although zinc is known to play critical roles in maintaining healthy immune function, the underlying molecular targets are largely unknown. In this study, we demonstrate that zinc is important for the CD154-CD40-mediated activation of downstream...

journal_title：FEBS open bio

authors： Tepaamorndech S,Oort P,Kirschke CP,Cai Y,Huang L

更新日期：2017-03-27 00:00:00

abstract：:Epigallocatechin gallate (EGCG), a major polyphenol in green tea, possesses antioxidant properties and regulates various cell functions. Here, we examined the function of EGCG in inflammatory bone resorption. In calvarial organ cultures, lipopolysaccharide (LPS)-induced bone resorption was clearly suppressed by EGCG. ...

journal_title：FEBS open bio

authors： Tominari T,Matsumoto C,Watanabe K,Hirata M,Grundler FM,Miyaura C,Inada M

更新日期：2015-06-12 00:00:00

abstract：:Soft cheese with white rind lacks essential fatty acids (EFAs), and as a result its long-term consumption may lead to various kinds of cardiovascular and cerebrovascular diseases, such as hyperlipidemia, hypertension, and atherosclerosis. Geotrichum candidum is a dimorphic yeast that plays an important role in the rip...

journal_title：FEBS open bio

authors： Luo X,Shi H,Wu R,Wu J,Pi Y,Zheng Y,Yue X

更新日期：2018-12-06 00:00:00