Abstract:
:In the setting of recent exciting clinical results and numerous ongoing trials, Piotrowska and colleagues explore mechanisms of acquired resistance to the mutant-specific EGFR inhibitor rociletinib, and demonstrate that loss of T790M, EGFR amplification, and small-cell transformation are all clinically relevant mechanisms of drug resistance. The authors provide a new paradigm for using quantitative assessment of the EGFR T790M:activation mutation allele frequency ratio to prognosticate responses to rociletinib and also demonstrate that plasma-based assessments of circulating tumor DNA can be used to monitor drug response and the emergence of drug resistance.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
Ichihara E,Lovly CMdoi
10.1158/2159-8290.CD-15-0616subject
Has Abstractpub_date
2015-07-01 00:00:00pages
694-6issue
7eissn
2159-8274issn
2159-8290pii
5/7/694journal_volume
5pub_type
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