Focal adhesion kinase and its role in skeletal muscle.

abstract：:Skeletal muscle tissue is mechanosensitive, as it is able to sense mechanical impacts and to translate these into biochemical signals making the tissue adapt. Among its mechanosensitive nature, skeletal muscle tissue is the largest metabolic organ of the human body. Disturbances in skeletal muscle mechanosensing and m...

journal_title：Journal of muscle research and cell motility

authors： Pingel J,Suhr F

更新日期：2017-08-01 00:00:00

abstract：:The efficacy of the 'EGTA-treatment' for producing a model of selectively 'skinned' cardiac muscle has been questioned. This paper deals with ultrastructural evidence designed to test whether small ions can gain access to the myofibrillar space of the heart after 'EGTA-treatment'. Lanthanum has been employed because o...

journal_title：Journal of muscle research and cell motility

authors： Miller DJ,Elder HY,Smith GL

更新日期：1985-10-01 00:00:00

abstract：:Critical illness myopathy (CIM) is associated with severe muscle atrophy and fatigue in affected patients. Apoptotic signaling is involved in atrophy and is elevated in muscles from patients with CIM. In this study we investigated underlying mechanisms of apoptosis-related pathways in muscles with different fiber type...

journal_title：Journal of muscle research and cell motility

authors： Barnes BT,Confides AL,Rich MM,Dupont-Versteegden EE

更新日期：2015-06-01 00:00:00

abstract：:MagFluo-4 fluorescence (Ca2+) transients associated with action potentials were measured in intact muscle fibres, manually dissected from toads ( Leptodactylus insularis ) or enzymatically dissociated from mice. In toads, the decay phase of the Ca2+ transients is described by a single exponential with a time constant ...

journal_title：Journal of muscle research and cell motility

authors： Caputo C,Bolaños P,Gonzalez A

更新日期：2004-01-01 00:00:00

abstract：:The ability for muscle to repeatedly generate force is limited by fatigue. The cellular mechanisms behind muscle fatigue are complex and potentially include breakdown at many points along the excitation-contraction pathway. In this paper we construct a mathematical model of the skeletal muscle excitation-contraction p...

journal_title：Journal of muscle research and cell motility

authors： Shorten PR,O'Callaghan P,Davidson JB,Soboleva TK

更新日期：2007-01-01 00:00:00

abstract：:RNA-binding motif protein 3 (RBM3), a stress-inducible RNA-binding protein that increases protein synthesis and confers cell protection in multiple cell types, has been identified as a possible regulator of skeletal muscle mass. Therefore, the primary aim of this study was to examine the impact of elevated RBM3 on ske...

journal_title：Journal of muscle research and cell motility

authors： Van Pelt DW,Confides AL,Judge AR,Vanderklish PW,Dupont-Versteegden EE

更新日期：2018-04-01 00:00:00

abstract：:We examined the tension responses induced by rapid temperature-jumps (T-jumps) applied at different times during twitch and tetanic contractions in small intact fibre bundles (5-10 fibres) isolated from a fast foot muscle (flexor hallucis brevis) of the rat. A rapid T-jump of 2-4 degrees C was induced by a 0.2 ms infr...

journal_title：Journal of muscle research and cell motility

authors： Coupland ME,Pinniger GJ,Ranatunga KW

更新日期：2005-01-01 00:00:00

abstract：:Two of the most characteristic features of striated muscle are (i) its ability to contract and generate tension when activated and (ii) its ability to return to its original length and form after contraction or stretching ceases. These two properties are to a large extent the primary manifestations of separate sets of...

journal_title：Journal of muscle research and cell motility

authors： Vigoreaux JO

更新日期：1994-06-01 00:00:00

abstract：:We determined the effects of epigallocatechin-3-gallate (EGCG) and epicatechin (EC), on pump turnover and Ca2+ transport by the cardiac form of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA). Fluorescence spectroscopy was used to directly measure SERCA ATPase activity and to measure Ca2+ uptake into cardia...

journal_title：Journal of muscle research and cell motility

authors： Kargacin ME,Emmett TL,Kargacin GJ

更新日期：2011-09-01 00:00:00

abstract：:Two single mutations, R694N and E45Q, were introduced in the beta isoform of human cardiac myosin to remove permanent salt bridges E45:R694 and E98:R694 in the SH1-SH2 helix of the myosin head. Beta isoform-specific bridges E45:R694 and E98:R694 were discovered in the molecular dynamics simulations of the alpha and be...

journal_title：Journal of muscle research and cell motility

authors： Gargey A,Iragavarapu SB,Grdzelishvili AV,Nesmelov YE

更新日期：2020-09-14 00:00:00

abstract：:The cellular function of the giant protein titin in striated muscle is a major focus of scientific attention. Particularly, its role in passive mechanics has been extensively investigated. In strong contrast, the structural details of this filament are very poorly understood. To date, only a handful of atomic models f...

journal_title：Journal of muscle research and cell motility

authors： Marino M,Svergun DI,Kreplak L,Konarev PV,Maco B,Labeit D,Mayans O

更新日期：2005-01-01 00:00:00

abstract：:Cytokinesis is the mechanical process that allows the simplest unit of life, the cell, to divide, propagating itself. To divide, the cell converts chemical energy into mechanical energy to produce force. This process is thought to be active, due in large part to the mechanochemistry of the myosin-II ATPase. The cell's...

journal_title：Journal of muscle research and cell motility

authors： Robinson DN,Girard KD,Octtaviani E,Reichl EM

更新日期：2002-01-01 00:00:00

abstract：:In mammalian ventricles, two myosin heavy chain (MHC) isoforms have been identified. Small animals express α-MHC, whereas large animals express β-MHC, which contribute to a large difference in the heart rate. Sprague-Dawley rats possessing ~99% α-MHC were treated with propylthiouracil to result in 100% β-MHC. Papillar...

journal_title：Journal of muscle research and cell motility

authors： Kawai M,Karam TS,Michael JJ,Wang L,Chandra M

更新日期：2016-12-01 00:00:00

abstract：:In isolated myosin the reaction sequence of essential thiol groups with N-ethylmaleimide was studied using the following five approaches: kinetics of the modification reaction, effects of modification on enzyme properties, affinity chromatography of isolated subfragment-1 stemming from modified myosin, isolation of cy...

journal_title：Journal of muscle research and cell motility

authors： Kunz PA,Loth K,Watterson JG,Schaub MC

更新日期：1980-03-01 00:00:00

abstract：:Creatine kinase (CK) isoenzyme compositions of different types of single muscle fibres dissected from soleus (SOL) and extensor digitorum longus (EDL) muscles from rats were examined. CK isoenzymes were separated into cytoplasmic (CK-MM, CK-MB, CK-BB) (muscle, brain and hybrid types, respectively) and mitochondrial (m...

journal_title：Journal of muscle research and cell motility

authors： Yamashita K,Yoshioka T

更新日期：1991-02-01 00:00:00

abstract：:Clenbuterol is a beta2-adrenoceptor agonist primarily used for treating bronchospasm and alleviating the symptoms of chronic obstructive pulmonary disease (COPD) in the horse. In other species (rats, mice, sheep, and cattle), chronic high doses of clenbuterol (typically in the milligram per kilogram body weight range)...

journal_title：Journal of muscle research and cell motility

authors： Plant DR,Kearns CF,McKeever KH,Lynch GS

更新日期：2003-01-01 00:00:00

abstract：:The sonic muscle of the oyster toadfish, Opsanus tau, can produce unfused contractions at 300 Hz. Electron microscopy shows a great abundance of the Sarcoplasmic reticulum (SR) in this muscle, but no functional characterization of the capabilities of the SR has been reported. We measured the oxalate-supported Ca2+ upt...

journal_title：Journal of muscle research and cell motility

authors： Feher JJ,Waybright TD,Fine ML

更新日期：1998-08-01 00:00:00

abstract：:The fine structure of leech body wall muscles, has been analysed under great length variations. All the measurable parameters of the fibre (distance between thick filaments, sarcomere and A band width, percentage of actin crowns around myosin filaments, fibre radius) at different elongations were tested with equations...

journal_title：Journal of muscle research and cell motility

authors： Lanzavecchia G,de Eguileor M,Valvassori R

更新日期：1985-10-01 00:00:00

abstract：:Scallop S1 has a region sensitive to tryptic hydrolysis not found thus far in S1s of other species, located 65K from the N-terminus as determined by SDS/polyacrylamide-gel electrophoresis. In the presence of actin the S1 heavy chain is preferentially cleaved at this site. The high-salt EDTA and calcium ATPase activiti...

journal_title：Journal of muscle research and cell motility

authors： Szentkiralyi EM

更新日期：1987-08-01 00:00:00

abstract：:Single twitch muscle fibres have been isolated from various parts of the iliofibularis muscle of Xenopus laevis. After measurements of their isotonic contractile properties, myosin extraction was performed on individual fibres and the extract analysed by various forms of gel electrophoresis. In agreement with previous...

journal_title：Journal of muscle research and cell motility

authors： Lännergren J

更新日期：1987-06-01 00:00:00

abstract：:A high resolution, time efficient method is described for determining the complex modulus of activated striated muscle. In this method the applied oscillation of muscle length takes the form of pseudo-random binary noise, PRBN. As a time-domain signal, PRBN is an extension of the double step approach to include n step...

journal_title：Journal of muscle research and cell motility

authors： Rossmanith GH

更新日期：1986-08-01 00:00:00

abstract：:White muscle fibres from dogfish were used to compare the energetic costs of shortening by fully active muscle and by relaxing muscle. The muscle preparation was tetanized for 0.6 s and shortened either during stimulation or during relaxation. The distance shortened was 1 mm (about 15% L0, the muscle length optimum fo...

journal_title：Journal of muscle research and cell motility

authors： Lou F,Curtin NA,Woledge RC

更新日期：1998-10-01 00:00:00

abstract：:Cardiac muscle M-band structures in several mammals (guinea pig, rabbit, rat and cow) and also from three teleosts (plaice, carp and roach), have been studied using electron microscopy and image processing. Axial structure seen in negatively stained isolated myofibrils or negatively stained cryo-sections shows the pre...

journal_title：Journal of muscle research and cell motility

authors： Pask HT,Jones KL,Luther PK,Squire JM

更新日期：1994-12-01 00:00:00

abstract：:Effects of Mn2+ and Ca2+ on the mechanical properties of glycerinated myofibrillar bundles originating from slow S1 type muscle fibres of superficial flexor muscles of the lobster Nephrops norvegicus were investigated. Mn2+ (5-20 microM) activated the preparations in a dose-dependent manner. The sensitivity of myofibr...

journal_title：Journal of muscle research and cell motility

authors： Holmes JM,Hilber K,Galler S,Neil DM

更新日期：1998-06-01 00:00:00

abstract：:The kinetics of smooth muscle are thought to be partially determined by the level of the expression of the 7 amino acid insert, SMB, in the myosin heavy chain, as SMB is generally expressed at higher levels in faster smooth muscle. In this study, we determined the role of this insert on shortening velocity and force r...

journal_title：Journal of muscle research and cell motility

authors： Karagiannis P,Babu GJ,Periasamy M,Brozovich FV

更新日期：2004-01-01 00:00:00

abstract：:Mechanical properties of myofibrillar bundles from single chemically skinned fibres from the superficial abdominal flexor muscle of the Norway lobster Nephrops norvegicus were measured, and the protein content of these fibres was analysed by SDS-PAGE. Two slow fibre phenotypes (S1, S2) were distinguished on the basis ...

journal_title：Journal of muscle research and cell motility

authors： Holmes JM,Hilber K,Galler S,Neil DM

更新日期：1999-04-01 00:00:00

abstract：:Tropomyosins (Tm) in humans are expressed from four distinct genes and by alternate splicing >40 different Tm polypeptide chains can be made. The functional Tm unit is a dimer of two parallel polypeptide chains and these can be assembled from identical (homodimer) or different (heterodimer) polypeptide chains provided...

journal_title：Journal of muscle research and cell motility

authors： Janco M,Suphamungmee W,Li X,Lehman W,Lehrer SS,Geeves MA

更新日期：2013-08-01 00:00:00

abstract：:When skinned skeletal muscle fibres with rest sarcomere length (L = 2.5 microns) are compressed by the addition of various concentrations ([PVP]) of polyvinylpyrrolidine, the relation between the 1,0 spacing (d) of thick filament lattice and [PVP] has been known to break at d of around 35 nm, resulting in a steeper sl...

journal_title：Journal of muscle research and cell motility

authors： Umazume Y,Higuchi H,Takemori S

更新日期：1991-10-01 00:00:00

abstract：:Secophalloidin (SPH) is known to cause in cardiac myofibrils force without Ca(2+) (half-maximal effect approximately 2 mM) followed by irreversible loss of Ca(2+)-activated force. At maximal Ca(2+) activation, SPH increases force (half-maximal effect < 0.1 mM). We found that SPH at low concentration (0.5 mM) did not c...

journal_title：Journal of muscle research and cell motility

authors： Bukatina AE,Sieck GC,Campbell KB,Belohlavek M

更新日期：2009-01-01 00:00:00

abstract：:The remodelling of connective tissue components is a fundamental requirement for a number of pivotal processes in cell biology. These may include myoblast migration and fusion during development and regeneration. In other systems, similar biological processes are facilitated by secretion of the matrix metalloproteinas...

journal_title：Journal of muscle research and cell motility

authors： Lewis MP,Tippett HL,Sinanan AC,Morgan MJ,Hunt NP

更新日期：2000-04-01 00:00:00