Abstract:
OBJECTIVE:Zoledronic acid (ZOL) has a suppressive effect on marrow adiposity in ovariectomized rats. Currently, however, data on the effect of ZOL on marrow fat in humans are unavailable. The purpose of this work was to determine the in vivo effect of ZOL on bone remodeling and marrow adipogenesis in postmenopausal osteoporosis. MATERIALS AND METHODS:In a 12-month, randomized, double-blind, placebo-controlled trial, we studied 100 postmenopausal women with osteoporosis who were randomly given either a single dose of intravenous infusion of ZOL (5 mg) or placebo. All subjects received adequate dietary calcium and vitamin D3. Main outcome measures included bone mineral density by dual-energy X-ray absorptiometry, vertebral marrow fat content by proton MR spectroscopy, serum markers of bone turnover by biochemical analysis. RESULTS:Ninety percent of the participants completed the 12-month follow-up. With respect to baselines, marrow fat content reduced by 8.1% in the ZOL-treated women and increased by 3.0% in the controls (all p < 0.05). In addition, there were significant increases of bone mineral density by 2.8, 2.0, and 1.7% in the lumbar spine, femoral neck, and total hip, respectively, in the ZOL group compared with the placebo group. Serum levels of bone resorption marker CTX and bone formation marker BALP decreased by 33 and 18% in postmenopausal women receiving ZOL. CONCLUSIONS:In postmenopausal women with osteoporosis, a single dose of ZOL therapy significantly reduced marrow adiposity. MR spectroscopy of vertebral marrow fat may therefore serve as a novel tool for BMD-independent efficacy assessment.
journal_name
Skeletal Radioljournal_title
Skeletal radiologyauthors
Yang Y,Luo X,Yan F,Jiang Z,Li Y,Fang C,Shen Jdoi
10.1007/s00256-015-2200-ysubject
Has Abstractpub_date
2015-10-01 00:00:00pages
1499-505issue
10eissn
0364-2348issn
1432-2161journal_volume
44pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To examine the efficacy of ultrasound (US)-guided injections for midfoot joint degenerative changes. MATERIALS AND METHODS:The US images and radiographs of 63 patients with midfoot joint degenerative changes were retrospectively reviewed. In those patients who had US-guided intra-articular steroid injection,...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-010-1094-y
更新日期:2011-08-01 00:00:00
abstract::The 23rd Annual Scientific Meeting of the European Society of Musculoskeletal Radiology (ESSR) 2016 in Switzerland, Zurich will be summarized. ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-017-2568-y
更新日期:2017-04-01 00:00:00
abstract::The ischiorectal fossa may give rise to a wide variety of pathological entities, although it is composed of relatively few structures. Developmental cysts are included among the list. Large epidermoid cysts in the ischiorectal fossa have been previously described (Fujimoto et al., Clin Imaging 17:146-148, 1993; Ng et ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-009-0705-y
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to use morphological as well as biochemical (T2 and T2* relaxation times and diffusion-weighted imaging (DWI)) magnetic resonance imaging (MRI) for the evaluation of healthy cartilage and cartilage repair tissue after matrix-associated autologous chondrocyte transplantation (MACT) of...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-009-0682-1
更新日期:2009-08-01 00:00:00
abstract::Spinal giant cell tumor of bone (GCTB) is a rare benign, but locally aggressive, entity. We report the case of a 40-year-old man diagnosed with GCTB of the thoracic spine. The only symptom upon presentation was progressive back pain with pain radiating to the chest. Magnetic resonance imaging showed that the soft tiss...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-018-2911-y
更新日期:2018-10-01 00:00:00
abstract::The os styloideum, an accessory carpal bone, may suffer injury during traumatic wrist flexion. The case described corresponds to an acute os styloideum injury in an elite athlete; a diagnosis made using high-resolution computed tomography and magnetic resonance imaging permitted not only the identification of the anom...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-005-0027-7
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:The reliability of radiographic measurements has been studied in pediatric hips, but less has been published on the adult hip, and none have examined the reliability of measurements for the location of the center of rotation (COR) of the hip joint. We have investigated the reliability of various radiographic ...
journal_title:Skeletal radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00256-015-2101-0
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To describe the CT and MR imaging appearance of both osseous and extraosseous manifestations of melorheostosis. DESIGN AND PATIENTS:We retrospectively reviewed the CT (n=7) and/or MR imaging findings (n=12) of 17 patients with characteristic radiographic findings of melorheostosis (undulating cortical hypero...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560100366
更新日期:2001-08-01 00:00:00
abstract:: ...
journal_title:Skeletal radiology
pub_type: 社论
doi:10.1007/s00256-018-3101-7
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:Imaging criteria for measuring the response of desmoid fibromatosis to systemic therapy are not well established. We evaluated a series of patients with desmoids who underwent systemic therapy to document magnetic resonance imaging (MRI) features associated with a positive clinical response. MATERIALS AND ME...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-016-2439-y
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:We used magnetic resonance imaging (MRI) to evaluate where articular degeneration begins and which ligaments are most often involved in the early clinical stage first carpometacarpal joint (CMCJ-1) osteoarthritis. MATERIALS AND METHODS:We retrospectively analyzed the MRI findings of 26 patients with early cl...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-020-03383-2
更新日期:2020-07-01 00:00:00
abstract::Primary synovial chondromatosis is a relatively uncommon condition. Synovial chondrosarcoma is considered to be very rare and it is not always clear whether the sarcoma develops by malignant transformation of synovial chondromatosis or whether it arises de novo. Differentiation of the two conditions on clinical and ra...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s002560050312
更新日期:1997-11-01 00:00:00
abstract::A 13-year-old female presented after repeated trauma with pain of the distal end of the thigh. The findings on plain films, bone scan, and CT were indeterminate. MRI accurately demonstrated a fracture line with bone marrow edema, suggesting the diagnosis of stress fracture. MRI patterns of stress fracture were conside...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00191091
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:Real-time sonoelastography (SE) is a new ultrasound-based imaging technique that provides information on tissue elasticity and stiffness. We determined the efficacy of SE for assessing Achilles tendon abnormalities in patients with ankylosing spondylitis (AS). MATERIALS AND METHODS:Forty-one consecutive AS p...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-013-1637-0
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate skeletal muscle denervation using diffusion-weighted magnetic resonance imaging (DWMRI). MATERIALS AND METHODS:Sciatic nerve axotomy was performed in a group of nine New Zealand White rabbits, and electromyographic (EMG), pathological, and DWMRI studies were conducted...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-008-0552-2
更新日期:2008-12-01 00:00:00
abstract::An os acromiale is a developmental abnormality of ossification involving the anterior acromion which may contribute to impingement and rotator cuff disease. When axial MR sections do not include the acromioclavicular joint, the diagnosis of this often subtle abnormality will rest on its recognition on oblique and coro...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560050187
更新日期:1997-01-01 00:00:00
abstract::Chromomycosis is primarily a skin disease that superficially presents as slowly growing, verrucous lesions, often warty or cauliflower-like in appearance. It may occasionally create a flat, plaque-like lesion in the skin but deep-seated tumorous presentation has not previously been reported. As the lesion is limited t...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-008-0580-y
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:Accurate insertion of a guidewire under image intensifier guidance is a fundamental skill required by orthopaedic surgeons. This study investigated how image intensifier distortion, which is composed of pin-cushion and sigmoidal components, changed the apparent trajectory of a guidewire, and the resulting dev...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-019-03171-7
更新日期:2019-09-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian's disease, which involves multiple organ systems...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-006-0193-2
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this article was to evaluate the radiologic findings of adult pelvis and appendicular skeletal Langerhans cell histiocytosis (LCH), emphasizing the CT and MR findings. MATERIALS AND METHODS:The images of nine patients with pathologically proven LCH (five men and four women; mean age, 37.11 yea...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-010-1078-y
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine normative values for volume and fat content of the gluteus medius (GMed) and minimus (GMin) muscle in healthy volunteers and to evaluate their dependence on age, gender and leg dominance. MATERIALS AND METHODS:The IRB approval was obtained for this study. 80 healthy volunteers (females, 40; male...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-015-2325-z
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Preoperative diffusion-weighted MRI (DW-MRI) has been described as an efficient method to differentiate good and poor responders to chemotherapy in osteosarcoma patients. A DW-MRI performed earlier during treatment could be helpful in monitoring chemotherapy. OBJECTIVE:To assess the accuracy of DW-MRI in ev...
journal_title:Skeletal radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00256-012-1360-2
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To establish a novel method of quantifying meniscal deformation using loaded MRI. More specifically, the goals were to evaluate the (1) accuracy, (2) inter-rater reliability, (3) intra-rater reliability, and (4) scan-rescan reliability. The secondary purpose of this experiment was to evaluate group difference...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-014-2022-3
更新日期:2015-01-01 00:00:00
abstract::Self-regressing subperiosteal defects appearing during consolidation of fractures were observed in two children aged 6 and 10 years, in the tibia and the radius respectively. These transient defects appeared several weeks after fracture, at a distance from the fracture site. They involved the newly formed subperiostea...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00348864
更新日期:1986-01-01 00:00:00
abstract::Axial magnetic resonance (MR) imaging of the patellofemoral compartment was performed in 75 patients with arthroscopic correlation. Proton density and T2(2500/20/80) weighted images were obtained in all patients. Chondromalacia in stages I and II could not be reliably identified with MR imaging. For the evaluation of ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00198391
更新日期:1993-01-01 00:00:00
abstract::Congenital bone anomalies are occasionally located adjacent to deep lipomas. These bone dysplasias may take the form of localized overgrowth or osseous malformation. Two patients with iliac anomalies and spinal dysraphism and one with a hypertrophied rib and vertebra associated with lipomas are described. As both the ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00355349
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:Myxofibrosarcoma (MFS) is characterized by a high frequency of local recurrence after surgery because of infiltrative growth of the tumor cells. This infiltrative growth creates a characteristic 'tail-like' pattern on magnetic resonance imaging (MRI), and it has been reported that this pattern is especially o...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-014-1992-5
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To develop and validate a deep convolutional neural network (CNN) method capable of (1) selecting a specific shoulder sagittal MR image (Y-view) and (2) automatically segmenting rotator cuff (RC) muscles on a Y-view. We hypothesized a CNN approach can accurately perform both tasks compared with manual referen...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-020-03599-2
更新日期:2020-09-16 00:00:00
abstract::A case of aneurysmal bone cyst of the patella in a 15-year-old woman was presented. An ABC occurring in a female patient is rare, and to our knowledge this is the first report in the literature. All other reports of patellar ABCs reported have occurred in young black men [2, 3]. The radiographic findings and clinical ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF02580394
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to describe the suprascapular nerve block using CT guidance and to evaluate the short- and medium-term efficacy in a range of shoulder pathologies. DESIGN AND PATIENTS:CT-guided infiltration around the suprascapular nerve was performed with bupivacaine and Celestone Chronodose...
journal_title:Skeletal radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00256-003-0733-y
更新日期:2004-05-01 00:00:00