Langerhans cell histiocytosis.

Abstract:

:Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian's disease, which involves multiple organ systems and, most typically, the skull base; and Letterer-Siwe's disease, the most severe disease manifestation, which typically involves the abdominal viscera. This article reviews our current understanding of Langerhans cell histiocytosis by discussing the history, histology, etiology, and treatment of the disease. It focuses on the radiographic findings and imaging modalities that are the most useful in disease diagnosis and management.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Hoover KB,Rosenthal DI,Mankin H

doi

10.1007/s00256-006-0193-2

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

95-104

issue

2

eissn

0364-2348

issn

1432-2161

journal_volume

36

pub_type

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