Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma.

Abstract:

:Pseudotumours are well recognised as a complication of metal-on-metal hip arthroplasties and are thought to develop on the basis of an innate and adaptive immune response to cobalt-chrome (Co-Cr) wear particles. We report a case of a large pseudotumour that developed following a knee endoprosthetic replacement (EPR) undertaken for Ewing sarcoma. The lesion contained necrotic and degenerate connective tissue in which there were numerous scattered metal wear-containing macrophages, eosinophil polymorphs, lymphocytes, plasma cells and aseptic lymphocyte-dominated vascular-associated lesion-like lymphoid aggregates. Metal ion levels were elevated. No evidence of infection or tumour was noted and it was concluded that the lesion was most likely an inflammatory pseudotumour developing on the basis of an innate and adaptive immune response to components of Co-Cr metal wear derived from the knee EPR.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Craig R,Vlychou M,McCarthy CL,Gibbons CLMH,Athanasou NA

doi

10.1007/s00256-017-2610-0

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

967-974

issue

7

eissn

0364-2348

issn

1432-2161

pii

10.1007/s00256-017-2610-0

journal_volume

46

pub_type

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