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MRI findings associated with development of incident knee pain over 48 months: data from the osteoarthritis initiative.

Abstract：

PURPOSE:The purpose of this nested case-control study was to identify baseline, incident, and progressive MRI findings visible on standard MRI clinical sequences that were associated with development of incident knee pain in subjects at risk for OA over a period of 48 months. METHODS:We analyzed 60 case knees developing incident pain (WOMAC(pain) = 0 at baseline and WOMAC(pain) ≥ 5 at 48 months) and 60 control knees (WOMAC(pain) = 0 at baseline and WOMAC(pain) = 0 at 48 months) from the Osteoarthritis Initiative. 3 T knee MRIs were analyzed using a modified WORMS score (cartilage, meniscus, bone marrow) at baseline and after 48 months. Baseline and longitudinal findings were grouped into logistic regression models and compared using likelihood-ratio tests. For each model that was significant, a stepwise elimination was used to isolate significant MRI findings. RESULTS:One baseline MRI finding and three findings that changed from baseline to 48 months were associated with the development of pain: at baseline, the severity of a cartilage lesion in the medial tibia was associated with incident pain--(odds ratio (OR) for incident pain = 3.05; P = 0.030). Longitudinally, an incident effusion (OR = 9.78; P = 0.005), a progressive cartilage lesion of the patella (OR = 4.59; P = 0.009), and an incident medial meniscus tear (OR = 4.91; P = 0.028) were associated with the development of pain. CONCLUSIONS:Our results demonstrate that baseline abnormalities of the medial tibia cartilage as well as an incident joint effusion, progressive patella cartilage defects, and an incident medial meniscus tear over 48 months may be associated with incident knee pain. Clinically, this study helps identify MRI findings that are associated with the development of knee pain.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Joseph GB,Hou SW,Nardo L,Heilmeier U,Nevitt MC,McCulloch CE,Link TM

doi

10.1007/s00256-016-2343-5

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

653-60

issue

eissn

0364-2348

issn

1432-2161

pii

10.1007/s00256-016-2343-5

journal_volume

pub_type

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MRI findings associated with development of incident knee pain over 48 months: data from the osteoarthritis initiative.