Abstract:
OBJECTIVE:Imaging criteria for measuring the response of desmoid fibromatosis to systemic therapy are not well established. We evaluated a series of patients with desmoids who underwent systemic therapy to document magnetic resonance imaging (MRI) features associated with a positive clinical response. MATERIALS AND METHODS:This Institutional Review Board-approved retrospective study included 23 patients (mean age 40.5) with 29 extra-abdominal tumors. Therapeutic regimens included cytotoxic chemotherapy (n = 19), targeted therapy (n = 3), and nonsteroid anti-inflammatory drugs (NSAIDS; n = 1). Clinical effects were categorized as progressive disease, stable, or partial response. Maximum tumor dimension (Dmax), approximate tumor volume (VTumor), and quantitative tumor T2 hyperintensity and contrast enhancement (relative to muscle) for pre- and post-treatment MRIs were compared. RESULTS:Three lesions progressed, 5 lesions were stable, whereas 21 showed a clinical response. Dmax decreased more in responders (mean -11.0 %) than in stable/progressive lesions (mean -3.6 and 0 % respectively, p = 0.28, ANOVA); by Response Evaluation Criteria in Solid Tumors (RECIST 1.1) 27 out of 29 lesions were "stable," including the 3 progressive lesions. In responders, VTumor change averaged -29.4 %, but -19.2 % and +32.5 % in stable and progressive lesions respectively (p = 0.002, ANOVA); by 3D criteria 14 out of 29 lesions showed a partial response. T2 hyperintensity decreased by 50-54 % in partial response/stable disease, but only by 10 % in progressive lesions (p = 0.049, t test). Changes in contrast enhancement ranged from -23 % to 0 %, but were not statistically significant among response groups (p = 0.37). Change in T2 hyperintensity showed a positive correlation with volumetric change (r = 0.40). CONCLUSION:Decreases in volume and T2 hyperintensity reflect the positive response of desmoid fibromatosis to systemic therapy; RECIST 1.1 criteria are not sensitive to clinically determined tumor response.
journal_name
Skeletal Radioljournal_title
Skeletal radiologyauthors
Sheth PJ,Del Moral S,Wilky BA,Trent JC,Cohen J,Rosenberg AE,Temple HT,Subhawong TKdoi
10.1007/s00256-016-2439-ysubject
Has Abstractpub_date
2016-10-01 00:00:00pages
1365-73issue
10eissn
0364-2348issn
1432-2161pii
10.1007/s00256-016-2439-yjournal_volume
45pub_type
杂志文章abstract::An exceptionally rare case of periosteal Ewing's sarcoma involving the mid shaft of the right tibia was reported. In this case, MRI was the technique that confirmed the integrity of the bone marrow. The clinical, radiographic, and histopathologic features of Ewing's sarcoma have been discussed, as has the differential...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00203705
更新日期:1994-01-01 00:00:00
abstract::The posterolateral corner (PLC) is a complex functional unit, consisting of several structures, which is responsible for posterolateral stabilization. The PLC is not consistently defined in the literature. However, most descriptions include the popliteal tendon (PT), the lateral collateral ligament (LCL), the popliteo...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-006-0271-5
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate retrospectively the safety and effectiveness of the computed tomography (CT) fluoroscopy-guided placement of iliosacral screws in patients with unstable posterior pelvic fractures. MATERIALS AND METHODS:Six patients (four women and two men; mean age 55.8 years; range...
journal_title:Skeletal radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00256-009-0826-3
更新日期:2010-07-01 00:00:00
abstract::Anterior cruciate ligament (ACL) reconstructions have increased over the past 25 years. The increased incidence of ACL reconstructions has translated into a larger number of graft failures and revision ACL procedures. It is important to understand the causes of graft failure when evaluating for a revision ACL reconstr...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-016-2535-z
更新日期:2017-02-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) is a complex disease entity comprised of three distinct clinical syndromes that demonstrate indistinguishable histology. These syndromes are: eosinophilic granuloma, which is predominantly osseous or pulmonary; Hand-Schûller-Christian's disease, which involves multiple organ systems...
journal_title:Skeletal radiology
pub_type: 杂志文章,评审
doi:10.1007/s00256-006-0193-2
更新日期:2007-02-01 00:00:00
abstract::A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was stri...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00350961
更新日期:1987-01-01 00:00:00
abstract::An os acromiale is a developmental abnormality of ossification involving the anterior acromion which may contribute to impingement and rotator cuff disease. When axial MR sections do not include the acromioclavicular joint, the diagnosis of this often subtle abnormality will rest on its recognition on oblique and coro...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560050187
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To establish a high-resolution US technique that enables a systematic morphometric examination of the three components that form the distal biceps brachii tendinous complex; the internal bicipital aponeurosis, the distal biceps brachii tendon and the external bicipital aponeurosis (also known as lacertus fibr...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-018-3043-0
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To clarify the phenotype in a bone dysplasia termed "spondyloepiphyseal dysplasia with accumulation of glycoprotein in the chondrocytes" by Stanescu et al. DESIGN AND PATIENTS:Subjects comprised two definitive cases of one family and one probable case of another family. Histologic examination in one patient ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560050363
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility of non-invasive diffusion-weighted imaging (DWI) of the knee of children with juvenile idiopathic arthritis (JIA) and, further, to analyze the apparent diffusion coefficient (ADC) levels to distinguish synovium from effusion. MATERIALS AND METHODS:Standard magnetic resonance imagi...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-015-2208-3
更新日期:2015-12-01 00:00:00
abstract::Osteoma of long bone is an extremely rare, benign bone-forming surface lesion with the largest published case series consisting of only 14 patients. The most important and often most difficult lesion to differentiate from osteoma of long bone radiographically is parosteal osteosarcoma, which is a rare, low-grade surfa...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-014-2046-8
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To determine the ultrasonographic changes after steroid injection in carpal tunnel syndrome (CTS) and to evaluate the diagnostic value of ultrasound in post-treatment examination with clinical correlation. MATERIALS AND METHODS:Twenty-seven wrists with idiopathic CTS after a single injection of 40 mg of pred...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-017-2738-y
更新日期:2017-11-01 00:00:00
abstract::Injection of steroid and anesthetic into the greater trochanteric bursa is commonly performed for trochanteric bursitis, gluteus medius/minimus tendinopathy, or as a part of a barbotage procedure for gluteus medius or minimus calcific tendonosis. Trochanteric bursal injection is widely performed both with and without ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-020-03411-1
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To compare knee MRI performed with the integrated parallel acquisition technique (PAT) and simultaneous multislice (SMS) turbo spin echo (TSE) T2-weighted (T2w) sequences with conventional TSE sequences in pediatric patients. MATERIALS AND METHODS:This was a retrospective IRB-approved study. Seventy-four subje...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-017-2868-2
更新日期:2018-06-01 00:00:00
abstract::During recent years the combination of surgery, radiotherapy, and multiple chemotherapy in the treatment of patients with cancer has resulted in increased survival periods and, in some cases, complete cures. In children, however, the subsequent development of other and apparently unrelated malignancies has been observ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00348796
更新日期:1984-01-01 00:00:00
abstract::A rare case of chondroblastoma arising from the temporal bone that occurred in a 60-year-old woman is reported. The tumor appeared well demarcated and osteolytic on the radiographs. CT scan clearly depicted marginal and central calcification in the tumor. MR imaging demonstrated two components in the tumor: a solid co...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560100435
更新日期:2001-12-01 00:00:00
abstract::Thirteen patients with similar painful tender swelling in the region of the sternocostal joint (SCJ) are reported. X-ray tomography revealed changes which might explain the swelling in 11 patients. Three patients had anatomical variants of the sternum. One of these and a further two patients had marginal osteophytes a...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00351265
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To look for any association between oedema in the superolateral portion of the infrapatellar fat pad and patellar maltracking. MATERIALS AND METHODS:We compared two groups of knee MRI with regard to five patellar maltracking parameters. The first group included 100 knees with evidence of oedema in the supero...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-011-1299-8
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:The description of femoral head sphericity and related risk for femoroacetabularimpingement is currently limited to an angular estimate-the alpha angle-whose relevance and accuracy have been challenged. We developed a three-dimensional approach for both automated digital measurement of the alpha angle and the...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-010-1021-2
更新日期:2011-07-01 00:00:00
abstract::The appearance on magnetic resonance imaging (MRI) of 16 cases of pathologically proven eosinophilic granuloma were reviewed retrospectively and correlated with the radiographic appearance of the lesion. The most common MR appearance (ten cases) was a focal lesion, surrounded by an extensive, ill-defined bone marrow a...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00206144
更新日期:1993-01-01 00:00:00
abstract::Cortical desmoids are self-limiting fibro-osseous lesions commonly occurring at the medial supracondylar femur in active adolescents, at either the origin of the medial head of the gastrocnemius or at the insertion of the adductor magnus aponeurosis. Less commonly, in a similar demographic, cortical desmoids may occur...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-017-2638-1
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To highlight focal bone abnormality in the cuboid due to tendinopathy of the adjacent peroneus longus. DESIGN:A retrospective review was carried out of the relevant clinical and imaging features. PATIENTS:Two male and two female patients were studied, mean age 51.5 years (range 32-67 years), referred with f...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-005-0907-x
更新日期:2005-07-01 00:00:00
abstract::The case of a 58-year-old man with a normal immune status with primary localized skeletal cryptococcosis of the right tibia was presented. Radiologically it appeared as an osteolytic lesion with marginally indistinct borders in the epimetaphyseal region of the proximal tibia. Histologically, necrotizing granulomatous ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00241838
更新日期:1992-01-01 00:00:00
abstract::While well-recognized in the orthopedic literature as a cause of chronic hip pain, acetabular retroversion has not been specifically described in the radiologic literature. Acetabular retroversion represents a particular form of hip dysplasia characterized by abnormal posterolateral orientation of the acetabulum. This...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-006-0150-0
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To compare CR with CT (static and dynamic) to evaluate upper spine instability and to determine if CT in flexion adds value compared to MR imaging in neutral position to assess compression of the subarachnoid space and of the spinal cord. MATERIALS AND METHODS:Twenty-one consecutive patients with atlantoaxia...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-014-2000-9
更新日期:2015-02-01 00:00:00
abstract::Thirty-three ultrasound examinations of the corticotomy interval of patients undergoing Ilizarov procedures were retrospectively evaluated for the presence or absence of an acoustic edge artifact. This artifact, consisting of a fine anechoic band, has been previously described in phantom models and is presumed to be d...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00241766
更新日期:1992-01-01 00:00:00
abstract::Well differentiated (low grade) osteosarcomas are often unrecognized and inadequately treated. We report on a patient with a well differentiated osteosarcoma of the tibia that radiographically presented with two strikingly dissimilar appearing juxtaposed lesions. Proximally, the lesion was sclerotic, and distally, ost...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-002-0534-8
更新日期:2002-08-01 00:00:00
abstract::We report the development of isolated lower extremity metastases, in a child, 9 years after her initial diagnosis and treatment of bilateral infantile retinoblastomas. The radiographic, scintigraphic, computed tomographic, and magnetic resonance imaging findings are discussed. The dominant metastatic focus was blastic...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s00256-005-0916-9
更新日期:2006-10-01 00:00:00
abstract::We present a unique case of metastatic leiomyomatosis to the skeleton. The very extensive involvement of the axial and peripheral skeleton with "ring" lesions and associated cyclical premenstrual pain eventually led to the correct diagnosis and total relief with hormonal therapy. ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/s002560100425
更新日期:2002-01-01 00:00:00
abstract::Skeletal lesions were radiographically apparent in 6 of 36 (16%) patients with chronic myelogenous leukemia. The spectrum of radiographic changes including diffuse osteoporosis, focal osteolytic and osteoblastic lesions, chloroma, and arthritis, and their clinical behavior is discussed. ...
journal_title:Skeletal radiology
pub_type: 杂志文章
doi:10.1007/BF00347255
更新日期:1980-01-01 00:00:00