Microscopic correlation of radiographically disparate appearing well differentiated osteosarcoma.

Abstract:

:Well differentiated (low grade) osteosarcomas are often unrecognized and inadequately treated. We report on a patient with a well differentiated osteosarcoma of the tibia that radiographically presented with two strikingly dissimilar appearing juxtaposed lesions. Proximally, the lesion was sclerotic, and distally, osteolytic. The distal lytic half of the lesion showed focal cortical disruption on MR imaging. Microscopic correlation of the resected specimen suggested that the sclerotic component of the lesion had more fibrous dysplasia-like tissue with fewer features of well differentiated osteosarcoma, and the lytic component, features suggestive of well differentiated osteosarcoma. We believe this microscopic interpretation explains the disparate radiographic appearance as all belonging to well differentiated osteosarcoma with varying amounts of fibrous dysplasia-like tissue rather than the development of well differentiated osteosarcoma in fibrous dysplasia.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Wenger DE,Sundaram M,Unni KK,Janney CG,Merkel K

doi

10.1007/s00256-002-0534-8

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

488-92

issue

8

eissn

0364-2348

issn

1432-2161

journal_volume

31

pub_type

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