Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy.

Abstract:

PURPOSE:To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute macular serpiginous choroiditis (SC). METHODS:Patients with acute macular SC with lesions threatening and/or involving fovea were enrolled. All patients received CyP (1 g/m2) for 3 days followed by high-dose oral steroids (1.5 mg/kg) tapered over 6 months and monitored for visual acuity, response to treatment and systemic side effects. RESULTS:Eight patients (seven unilateral and one bilateral) with median age of 27 years (range: 13-40 years) were recruited. Mean visual acuity at presentation was 0.71 ± 0.35 logarithm of the minimum angle of resolution while postpulse visual acuity was 0.40 ± 0.32. Final mean visual acuity at 1-year was 0.31 ± 0.23 (P ≤ 0.05). Three eyes had recurrence and 3 patients developed transient hair loss with no other adverse effect. CONCLUSION:Intravenous CyP provides rapid resolution of lesion activity and thereby helps in maintaining good functional acuity.

journal_name

Indian J Ophthalmol

authors

Venkatesh P,Gogia V,Gupta S,Tayade A,Shilpy N,Shah BM,Guleria R

doi

10.4103/0301-4738.158070

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

318-22

issue

4

eissn

0301-4738

issn

1998-3689

pii

IndianJOphthalmol_2015_63_4_318_158070

journal_volume

63

pub_type

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