Abstract:
:Gene therapy is a novel form of drug delivery that enlists the synthetic machinery of the patient's cells to produce a therapeutic agent. Genes may be delivered into cells in vitro or in vivo utilising viral or non-viral vectors. Recent technical advances have led to the demonstration of the molecular basis of various ocular diseases. Ocular disorders with the greatest potential for benefit of gene therapy include hereditary diseases such as retinitis pigmentosa, tumours such as retinoblastoma or melanoma, and acquired proliferative and neovascular retinal disorders. Gene transfer into ocular tissues has been demonstrated with growing functional success and may develop into a new therapeutic tool for clinical ophthalmology in future.
journal_name
Indian J Ophthalmoljournal_title
Indian journal of ophthalmologyauthors
Singh VK,Tripathi Pkeywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
173-81issue
3eissn
0301-4738issn
1998-3689journal_volume
50pub_type
杂志文章,评审abstract:PURPOSE:The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_157_17
更新日期:2017-11-01 00:00:00
abstract::A 42-year-old man presenting with complaints of squint for last 20 years. His visual acuity was 20/400 in right eye (RE) and 20/30 in left eye (LE) with glasses. His refraction was RE -16.75/-2.5 D cycl 180 and LE was -14.5/-1.5 D cycl 180. His axial length was 31.23 mm In RE and 29.72 mm in LE. On examination we foun...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.151480
更新日期:2015-01-01 00:00:00
abstract::We report a case series of patients who developed post-laser-assisted in situ keratomileusis (LASIK) ectasia or had a progression of keractesia during pregnancy. We reviewed the medical records of 12 patients (20 eyes) who had reported deterioration of vision during their pregnancy and were diagnosed with keractesia. ...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_1508_20
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the surgical outcomes of combined femtosecond laser-assisted cataract surgery (FLACS) with 25-gauge vitrectomy surgery. MATERIALS AND METHODS:A retrospective analysis of 45 patients who underwent combined FLACS with 25-gauge vitrectomy surgery. RESULTS:A total number of ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.191501
更新日期:2016-08-01 00:00:00
abstract::Susac syndrome (SS) is a rare retinal-cochlear-cerebral disease with an unclear etiology. A 35-year-old man presented with sudden painless vision loss in the right eye and 2 months later in the left eye with hemiparesis, behavioral changes, and hearing loss. Ophthalmic examinations revealed multiple branch retinal art...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.194334
更新日期:2016-09-01 00:00:00
abstract::This report deals with a chronological measurement of Na-K ATPase enzyme activity in human and bovine corneas stored in a moist chamber at 4 degrees C. Paired human and bovine eyes were sterilized by the standard eye bank procedure and stored up to 6 days. At the desired time, the corneal endothelium was assayed for N...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:CONTEXT:Pupil cycle time (PCT) has been widely used for examination of ocular diabetic autonomic neuropathy (DAN). AIMS:The primary aim of this study was to evaluate the difference of contrast sensitivity according to PCT results, and the secondary aim was to determine the factors associated with PCT difference for ty...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.81027
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To assess the efficacy and advantages of femtosecond laser enabled keratoplasty (FLEK) over conventional penetrating keratoplasty (PKP) in advanced keratoconus. MATERIALS AND METHODS:Detailed review of literature of published randomized controlled trials of operative techniques in PKP and FLEK. RESULTS:Fiftee...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.4103/0301-4738.116060
更新日期:2013-08-01 00:00:00
abstract:: ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_1273_18
更新日期:2019-03-01 00:00:00
abstract::The human face is composed of small functional and cosmetic units, of which the eyes and periocular region constitute the main point of focus in routine face-to-face interactions. This dynamic region plays a pivotal role in the expression of mood, emotion, and character, thus making it the most relevant component of t...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.4103/ijo.IJO_540_17
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:To ascertain whether the changes in intraocular pressure (IOP) that occur during hypobaric hypoxic exposure are related to plasma N-terminal pro-brain natriuretic peptide (BNP) levels. MATERIALS AND METHODS:The study group comprised 26 healthy participants (all male, mean age 23.1 years). IOP was measured at l...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.62642
更新日期:2010-05-01 00:00:00
abstract::An intraocular biopsy is performed for diagnostic, prognostic and investigational purposes. Biopsies help to confirm or exclude malignancies and differentiate inflammatory from infectious processes. Histopathological analysis is the final verdict in unresponsive uveitis, atypical inflammation, metastases and masquerad...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.4103/ijo.IJO_1325_20
更新日期:2020-09-01 00:00:00
abstract::The prevalence of youth-onset diabetes, both type 1 diabetes (T1D) and young-onset type 2 diabetes (YT2D) are gradually increasing in India. Early and repetitive screening for diabetic retinopathy (DR) is essential to provide timely management, and thereby prevent visual impairment due to the silent sight-threatening ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_1851_19
更新日期:2020-02-01 00:00:00
abstract::The present study analyses the precorneal teat film using schirmer's test and tear film breakup time (BKUT) in 400 eyes of patients with various types of leprosy. An abnormal tear film BKUT (47.2%) was observed to be much more informative in the present series than the study of schirmer's test alone (25.4%). In patien...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Dye-assisted internal limiting membrane (ILM) peeling and gas tamponade is the surgery of choice for idiopathic macular holes. Indocyanine green and trypan blue have been extensively used to stain the ILM. However, the retinal toxicity of indocyanine green and non-uniform staining with trypan blue has necessitated dev...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.77047
更新日期:2011-03-01 00:00:00
abstract::Optical coherence tomography (OCT) has revolutionized imaging of ocular structures and various disease conditions. Though it has been used in the clinic for some decades, the OCT has only recently found its way into the operating theater. Early attempts at intraoperative OCT, hand-held and microscope mounted, have alr...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.4103/0301-4738.159865
更新日期:2015-05-01 00:00:00
abstract::Neurofibromatosis (NF) with sphenoid wing dysplasia is a rare clinical entity. Herewith, we present a case of NF with sphenoid wing dysplasia which presented with pulsatile progressive proptosis. Other ocular symptoms or visual disturbances were absent. Diagnosis of the condition was not easy and the management was a ...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_429_17
更新日期:2018-01-01 00:00:00
abstract:: ...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_570_18
更新日期:2018-12-01 00:00:00
abstract::Xeroderma pigmentosum (XP) is an autosomal recessive disease with ophthalmic, dermatologic, and neurologic manifestations. Ophthalmological changes are described in up to 100% of XP patients. We report a young XP patient that presented with bilateral conjunctival masses. She was treated by surgical excision with suppl...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_1106_18
更新日期:2019-07-01 00:00:00
abstract::Parry-Romberg syndrome (PRS) may overlap localized scleroderma (morphea) lesions with linear depression (en coup de sabre [ECDS]). Overlap case with PRS and ECDS was presented. Enophthalmos, uveitis, ocular torticollis, keratic linear precipitates, and anti-double-stranded DNA positivity were identified. Subendothelia...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_196_17
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To compare the outcome of Collagen cross-linking (CXL) with that following topography-guided customized ablation treatment (T-CAT) with simultaneous CXL in eyes with progressive keratoconus. MATERIALS AND METHODS:This was a prospective, non-randomized single centre study of 66 eyes with progressive keratoconus...
journal_title:Indian journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.4103/0301-4738.111209
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To observe the effect of prophylactic intraocular pressure (IOP)-lowering medication (brinzolamide) on IOP after ranibizumab intravitreal injections (IVIs). MATERIALS AND METHODS:This prospective case-control study included 352 eyes from 352 patients (1 eye per patient) who were treated with ranibizumab intrav...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.4103/0301-4738.195006
更新日期:2016-10-01 00:00:00
abstract::Pupillary block glaucoma is a common complication of cataract surgery, especially following anterior chamber intraocular lens implantation. We report a case of pupillary block glaucoma with a posterior chamber IOL that was implanted in the anterior chamber following a complicated extracapsular cataract extraction. The...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:Purpose:To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute. Methods:Records of all the patients who presented from March 25th to May 3rd, 2020 were scanned to evaluate the details regarding the presenting complaints, diagnosis, advised treatment...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_1673_20
更新日期:2020-08-01 00:00:00
abstract::A rare case of unilateral cryptophthalmos have unique findings is reported. The lateral part of the left eye was replaced by downward extension of the frontal hairline. The left upper eyelid, except in the lateral 4mm fully developed portion, was replaced by a fold adherent to the underlying disorganized globe (6.9 mm...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::To study the risk factors in the development of glaucoma following penetrating keratoplasty, we retrospectively analysed 190 eyes of 185 consecutive patients who had undergone surgery during 1990. The donor button was larger by 0.2 mm and 0.5 mm in phakia and aphakia/pseudophakia patients, respectively. Over a mean fo...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract:PURPOSE:The purpose of this study is to evaluate the safety and benefits of immediate sequential bilateral cataract surgery. PATIENTS AND METHODS:Retrospective data analysis of patients who underwent immediate sequential bilateral phacoemulsification with foldable intraocular lens (IOL) implantation under topical anes...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_947_16
更新日期:2017-05-01 00:00:00
abstract:Purpose:To evaluate the long-term safety and efficacy of the intravitreal dexamethasone implant in the treatment of diabetic macular edema (DME) as initial therapy. Methods:A hospital-based prospective, non-comparative case study of recently detected DME patients was conducted between July 2016 and December 2017, in w...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/ijo.IJO_620_19
更新日期:2020-03-01 00:00:00
abstract::Choroidal nodules in neurofibromatosis type-1 are common and are best imaged with near-infrared reflectance (NIR) imaging. The authors describe swept-source optical coherence tomography angiography (SSOCTA) of choroidal nodules. These nodules are seen as hyperflow areas on SSOCTA and correlate well to bright patches o...
journal_title:Indian journal of ophthalmology
pub_type:
doi:10.4103/ijo.IJO_1095_17
更新日期:2018-04-01 00:00:00
abstract::We report a case of dislocation of WIOL-CF® polyfocal full-optics intraocular lens (IOL) after neodymium-doped yttrium aluminum garnet (Nd: YAG) laser capsulotomy in the vitrectomized eye. At 22 months before the dislocation of the IOL, a 55-year-old male patient underwent phacoemulsification with WIOL-CF® IOL implant...
journal_title:Indian journal of ophthalmology
pub_type: 杂志文章
doi:10.4103/0301-4738.119335
更新日期:2013-11-01 00:00:00