Effect of sucralfate on gastric mucosal blood flow in rats.

abstract：:We investigated the distribution of short chain fatty acids (SCFA) in enema samples taken from subjects before sigmoidoscopy as an indicator of possible microbial community differences between subjects subsequently diagnosed as normal or having colonic disorders. The major SCFA in all groups were acetic, propionic, an...

journal_title：Gut

authors： Weaver GA,Krause JA,Miller TL,Wolin MJ

更新日期：1988-11-01 00:00:00

abstract：:Four asymptomatic patients are described with raised serum alkaline phosphatase values and a positive serum mitochondrial antibody test. In all four needle liver biopsy showed destructive bile duct lesions. Lymphocyte transformation to phytohaemagglutinin was normal in three and impaired in one who also suffered from ...

journal_title：Gut

authors： Fox RA,Scheuer PJ,Sherlock S

更新日期：1973-06-01 00:00:00

abstract：:Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months' treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was o...

journal_title：Gut

authors： Bardhan KD,Morris P,Thompson M,Dhande DS,Hinchliffe RF,Jones RB,Daly MJ,Carroll NJ

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab. DESIGN:Safety data (May 2009-June 2013) from six trials of vedolizumab were integrated. Adverse events were evaluated i...

journal_title：Gut

authors： Colombel JF,Sands BE,Rutgeerts P,Sandborn W,Danese S,D'Haens G,Panaccione R,Loftus EV Jr,Sankoh S,Fox I,Parikh A,Milch C,Abhyankar B,Feagan BG

更新日期：2017-05-01 00:00:00

abstract：:We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency. ...

journal_title：Gut

authors： Lyons DJ,Gilvarry JM,Fielding JF

更新日期：1990-07-01 00:00:00

abstract：:Rats were subjects to right hemicolectomy (including removal of the caecum), left hemicolectomy or subtotal colectomy. Body weight resumed and maintained a rate of increase very similar to that in control rats. After hemicolectomy, food intake showed no change. Faecal weight increased by about one-third after right he...

journal_title：Gut

authors： Masesa PC,Forrester JM

更新日期：1977-01-01 00:00:00

abstract：:The human gut microbiome is a complex ecosystem, densely colonised by thousands of microbial species. It varies among individuals and depends on host genotype and environmental factors, such as diet and antibiotics. In this review, we focus on stability and resilience as essential ecological characteristics of the gut...

journal_title：Gut

authors： Fassarella M,Blaak EE,Penders J,Nauta A,Smidt H,Zoetendal EG

更新日期：2020-10-13 00:00:00

abstract：:The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was used as a model to study the expression of the growth promoting peptide, transforming growth factor alpha (TGF alpha), during experimental gastric carcinogenesis. TGF alpha was iden...

journal_title：Gut

authors： Livingstone JI,Filipe MI,Wastell C

更新日期：1994-05-01 00:00:00

abstract：:Sex differences exist in the site specific incidences of colorectal cancer. The increased incidence of colonic cancer in women with breast cancer and the protective effect of increasing parity suggest a role for sex hormones. To explore the molecular basis, the expression of messenger RNA for oestrogen and progesteron...

journal_title：Gut

authors： Singh S,Sheppard MC,Langman MJ

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the neutrophil activating protein (NapA) and alkyl hydroperoxide reductase (AphC). These antigens were ident...

journal_title：Gut

authors： Windle HJ,Ang YS,Athie-Morales V,McManus R,Kelleher D

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects. AIMS:The aim of the present study was to investigate the response in vivo of zinc transporters in the human enterocyte to dietary zinc supple...

journal_title：Gut

authors： Cragg RA,Phillips SR,Piper JM,Varma JS,Campbell FC,Mathers JC,Ford D

更新日期：2005-04-01 00:00:00

abstract：:Small intestinal mucosa obtained from six fasting patients with cholera by a peroral biopsy technique was studied with the electron microscope. The cultures of their rectal swabs were all positive for Vibrio cholerae. In the absorptive cells, large pseudopod-like cytoplasmic processes with deformed microvilli or witho...

journal_title：Gut

authors： Asakura H,Tsuchiya M,Watanabe Y,Enomoto Y,Morita A

更新日期：1974-07-01 00:00:00

abstract：OBJECTIVE:Enterochromaffin cell-derived serotonin (5-HT) promotes intestinal inflammation. We tested hypotheses that peripheral tryptophan hydroxylase (TPH) inhibitors, administered orally, block 5-HT biosynthesis and deplete 5-HT from enterochromaffin cells sufficiently to ameliorate intestinal inflammation; moreover,...

journal_title：Gut

authors： Margolis KG,Stevanovic K,Li Z,Yang QM,Oravecz T,Zambrowicz B,Jhaver KG,Diacou A,Gershon MD

更新日期：2014-06-01 00:00:00

abstract：:Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient. The patient described here, who had clear-cut clinical and histological features of chronic...

journal_title：Gut

authors： Falaiye JM,Okeke GC,Fregene AO

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND AND AIMS:A low dietary folate intake can cause genomic DNA hypomethylation and may increase the risk of colorectal neoplasia. The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma...

journal_title：Gut

authors： Pufulete M,Al-Ghnaniem R,Khushal A,Appleby P,Harris N,Gout S,Emery PW,Sanders TA

更新日期：2005-05-01 00:00:00

abstract：:Intragastric total bile acid concentrations were measured before and after a corn oil test meal in 16 patients with erosive oesophagitis and symptoms of gastro-oesophageal reflux. Sixteen age and sex matched control subjects were also studied. No significant difference was detected between fasting or postprandial gast...

journal_title：Gut

authors： Collins BJ,Crothers G,McFarland RJ,Love AH

更新日期：1985-05-01 00:00:00

abstract：:We investigated the distribution of the collagen band in 33 patients with collagenous colitis to estimate the likelihood of the disease being diagnosed in biopsy specimens from the left side of the colon, such as those obtained using flexible sigmoidoscopy. To be included in this study patients had a subepithelial col...

journal_title：Gut

authors： Tanaka M,Mazzoleni G,Riddell RH

更新日期：1992-01-01 00:00:00

abstract：:In a single centre double blind study of 66 patients, the value of cisapride (10 mg twice daily) was compared with placebo in the prevention of duodenal ulcer relapse. Patients who remained ulcer free attended for clinical review every two months and had a mandatory endoscopy at 0, 4, 8, and 12 months or if symptoms s...

journal_title：Gut

authors： Kerrigan DD,Taylor ME,Read NW,Johnson AG

更新日期：1993-08-01 00:00:00

abstract：:The activity of an interferon induced enzyme, (2',5') oligo adenylate synthetase, was determined in peripheral blood mononuclear cells and granulocytes of patients with inflammatory bowel disease and compared with its activity in cells isolated from normal subjects. In spite of the fact that circulating interferon is ...

journal_title：Gut

authors： Stalnikowicz R,Goder K,Karmeli F,Fiocchi C,Rachmilewitz D

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

journal_title：Gut

authors： Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The efficacy of a levofloxacin-based regimen as the first-line treatment and a clarithromycin-based regimen as the second-line treatment for Helicobacter pylori infection remains unknown. The aim of this study was to assess the eradication rates of these two regimens using different administration sequences....

journal_title：Gut

authors： Liou JM,Lin JT,Chang CY,Chen MJ,Cheng TY,Lee YC,Chen CC,Sheng WH,Wang HP,Wu MS

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Saccharomyces boulardii is a non-pathogenic yeast which exerts trophic effects on human and rat small intestinal mucosa. AIMS:To examine the effects of S boulardii on ileal adaptation after proximal enterectomy in rats. METHODS:Wistar rats, aged eight weeks, underwent 60% proximal resection or transection ...

journal_title：Gut

authors： Buts JP,De Keyser N,Marandi S,Hermans D,Sokal EM,Chae YH,Lambotte L,Chanteux H,Tulkens PM

更新日期：1999-07-01 00:00:00

abstract：:The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...

journal_title：Gut

authors： Staniforth DH,Rose D

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Intestinal allograft rejection resembles Crohn's disease clinically and pathologically. An understanding of its mechanism could impact this life-saving procedure, as well as provide insight into the pathophysiology of inflammatory bowel disease. The NOD2 protein has been implicated as a key player in intesti...

journal_title：Gut

authors： Fishbein T,Novitskiy G,Mishra L,Matsumoto C,Kaufman S,Goyal S,Shetty K,Johnson L,Lu A,Wang A,Hu F,Kallakury B,Lough D,Zasloff M

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Suboptimal adenoma detection rate (ADR) at colonoscopy is associated with increased risk of interval colorectal cancer. It is uncertain how ADR might be improved. We compared the effect of leadership training versus feedback only on colonoscopy quality in a countrywide randomised trial. DESIGN:40 colonoscopy...

journal_title：Gut

authors： Kaminski MF,Anderson J,Valori R,Kraszewska E,Rupinski M,Pachlewski J,Wronska E,Bretthauer M,Thomas-Gibson S,Kuipers EJ,Regula J

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. METHODS:Nucleos(t)ide analogue (NUC) treatment was disco...

journal_title：Gut

authors： Seto WK,Liu KS,Mak LY,Cloherty G,Wong DK,Gersch J,Lam YF,Cheung KS,Chow N,Ko KL,To WP,Fung J,Yuen MF

更新日期：2020-08-05 00:00:00

abstract：:The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal injury induced by indomethacin. Indomethacin caused acute gastroduodenal ...

journal_title：Gut

authors： Shorrock CJ,Rees WD

更新日期：1992-02-01 00:00:00

abstract：:A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient an...

journal_title：Gut

authors： Burman JF,Jenkins WJ,Walker-Smith JA,Phillips AD,Sourial NA,Williams CB,Mollin DL

更新日期：1985-03-01 00:00:00

abstract：:Marked decreases in 24-hour Heidenhain pouch secretion, lasting from nine to 18 days, were observed in five mongrel bitches during periods of naturally occurring oestrus. Neither oophorectomy nor control celiotomy caused significant change in Heidenhain pouch secretion in bitches who were not experiencing oestrus. The...

journal_title：Gut

authors： Landor JH,Wild RA

更新日期：1970-10-01 00:00:00

abstract：:A case of adenocarcinoma of the ileum, occurring in an area concomitantly the site of Crohn's disease, is described. Examination of the literature suggests that there are certain characteristics of the small bowel carcinoma which arises in Crohn's disease. These include invisibility of the tumour on macroscopic inspec...

journal_title：Gut

authors： Fleming KA,Pollock AC

更新日期：1975-07-01 00:00:00