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The Mechanism and Function of Group II Chaperonins.

Abstract：

:Protein folding in the cell requires the assistance of enzymes collectively called chaperones. Among these, the chaperonins are 1-MDa ring-shaped oligomeric complexes that bind unfolded polypeptides and promote their folding within an isolated chamber in an ATP-dependent manner. Group II chaperonins, found in archaea and eukaryotes, contain a built-in lid that opens and closes over the central chamber. In eukaryotes, the chaperonin TRiC/CCT is hetero-oligomeric, consisting of two stacked rings of eight paralogous subunits each. TRiC facilitates folding of approximately 10% of the eukaryotic proteome, including many cytoskeletal components and cell cycle regulators. Folding of many cellular substrates of TRiC cannot be assisted by any other chaperone. A complete structural and mechanistic understanding of this highly conserved and essential chaperonin remains elusive. However, recent work is beginning to shed light on key aspects of chaperonin function and how their unique properties underlie their contribution to maintaining cellular proteostasis.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Lopez T,Dalton K,Frydman J

doi

10.1016/j.jmb.2015.04.013

subject

Has Abstract

pub_date

2015-09-11 00:00:00

pages

2919-30

issue

18

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(15)00267-3

journal_volume

427

pub_type

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