Abstract:
UNLABELLED:Osteonecrosis of the jaw (ONJ) is a severe complication of bisphosphonate treatment. PURPOSE:A detailed characterization of sampled peri-necrotic jawbone from bisphosphonate-treated patients was performed at tissue and cellular level (histological analyses and gene expression). MATERIALS AND METHODS:Alveolar bone samples were collected from patients with (n = 5) and without ONJ (n = 5). Healthy patients served as controls (n = 10). RESULTS:The histological analysis demonstrated low to moderate inflammation, displaying areas of inflammatory infiltrate in the bone marrow. Multinuclear giant cells and osteoclasts were found in both groups. Markers of bone formation (alkaline phosphatase, Col1a1, and osteocalcin), bone resorption (receptor activator of NF-kappaB ligand [RANKL], osteoprotegerin [OPG], tartrate-resistant acid phosphatase, and cathepsin K), inflammation (tumor necrosis factor-alpha, interleukin [IL]-1β, and IL-6), angiogenesis (vascular endothelial growth factor A), and apoptosis (Casp3, Casp8, p53, and Smac) were evaluated. Nonparametric statistical tests were used to identify differences between the groups. In patients with ONJ, the expression level of the proinflammatory marker IL-1β was strongly up-regulated compared with controls (p = .040). CONCLUSIONS:A down-regulated expression of Casp8 compared with controls was observed (p = .014) in patients treated with bisphosphonates. The RANKL/OPG ratios were similar in the three groups. The results indicate a need to further investigate the molecular mechanisms involved in the course of ONJ related to antiresorptive treatment.
journal_name
Clin Implant Dent Relat Resjournal_title
Clinical implant dentistry and related researchauthors
Cardemil C,Thomsen P,Larsson Wexell Cdoi
10.1111/cid.12307subject
Has Abstractpub_date
2015-10-01 00:00:00pages
e679-91eissn
1523-0899issn
1708-8208journal_volume
17 Suppl 2pub_type
杂志文章abstract:BACKGROUND:Implant survival and success have shown to be related to a number of factors. AIM:To evaluate the impact of implant design on implant survival and success, focusing on thread pitch and implant shape. MATERIALS AND METHODS:Non-smoking patients treated by two experienced periodontists with standard diameter ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2010.00308.x
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:Within the fossa of the submaxillary gland (FSG), there is a portion superior to the mandibular canal (SMCP) that can affect implant placement. Our study evaluated this specific portion's prevalence and its average dimensional difference between the first and the second molar regions in a dental implant populat...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00429.x
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:The aim of this retrospective clinical study was to evaluate the clinical outcome of fixed implant-supported complete prostheses on Astra or Brånemark implants when using either conventional cast frameworks or frameworks produced according to the Cresco Ti Precision method (Cresco Ti Systems Sàrl., Lausanne, Sw...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2005.tb00064.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Positive effects on the clinical outcome of moderately rough implant surfaces are described. Intercomparison of clinical data, however, is rarely found. PURPOSE:The aim of this study was to compare the clinical results of two macroscopically identical implants, the one with a turned, machined and the other ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2007.00030.x
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The use of removable provisional prosthesis after implant placement is undesirable for many patients. In addition, removable prostheses place unfavorable pressure over implants during the healing period. PURPOSE:The use of temporary implants enable greater stability and functionality of the prostheses. MAT...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2009.00225.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Bone allografts have shown satisfactory clinical results in alveolar ridge reconstructions. However, the process of incorporation and the resorption rates of these grafts are not yet fully understood. PURPOSE:The aim of this study was to use computed tomography (CT), histology, and histomorphometry to asses...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,随机对照试验
doi:10.1111/cid.12108
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Reactive oxygen species contribute to periodontal tissue homeostasis under control of anti-oxidative responses. Disruption in this balance induces severe inflammation and extended tissue degradation. PURPOSE:Aim of this study was to identify the expression levels of nuclear factor, erythroid 2 like 2 (NFE2L...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12619
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Differences in implant microtexture are important in conditioning the bone response around dental implants. PURPOSE:The aim of the present study was an evaluation of the bone response in machined (M), blasted with apatitic calcium phosphate (tricalcium phosphate/hydrossyapatite [HA] blend) particles (resorb...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12033
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Studies on the biological processes in different bone types and the reaction of different bone types to biomaterials are often hindered because of the difficulties in sampling procedures and lack of sensitive techniques. PURPOSE:The purpose was to assess the suitability of quantitative polymerase chain reac...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2009.00195.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Immediate occlusal implant loading has been documented as a viable treatment option for various indications. However, documentations related to full-arch rehabilitation are usually limited to treatment of one jaw at a time, thereby leaving the opposing dentition unchanged. Furthermore, clinical documentation...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.2310/j.6480.2005.00027.x
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Bone morphogenetic protein-2 (BMP2) has been successfully utilized in dentistry to promote new bone formation because of its osteoinductive ability to recruit mesenchymal progenitor cells and induce their differentiation to bone-forming osteoblasts. Recently, novel biphasic calcium phosphate scaffolds have b...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12384
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Human studies on implants with the same design but with different surfaces are lacking at the present time. PURPOSE:The aim of this study was to compare the survival rate of and marginal bone loss (MBL) around 2 types of implants with the same design, but with different surfaces: fully "sandblasted and doub...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12504
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Platelet concentrate/platelet-rich plasma (PRP) has been studied extensively in various experimental models and there is some agreement among workers to its early effect in bone regeneration and healing. We have earlier showed in vitro that titanium in whole blood activates the thrombogenic response to a hig...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00405.x
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:In vivo bone response was assessed by removal torque, hystological and histometrical analysis on a recently developed biomedical Ti-15Mo alloy, after surface modification by laser beam irradiation, installed in the tibia of rabbits. MATERIALS AND METHODS:A total of 32 wide cylindrical Ti-15Mo dental implants w...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00354.x
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:A real-time surgical navigation system potentially increases the accuracy when used for quad-zygomatic implant placement. PURPOSE:To evaluate the accuracy of a real-time surgical navigation system when used for quad zygomatic implant placement. MATERIALS AND METHODS:Patients with severely atrophic maxillae...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12475
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Information on the microbiota in peri-implantitis is limited. We hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. MATERIALS AND METHODS:Baseline microbiological samples collected at one implant in each of 166 participants with pe...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12052
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:High failure rates have been presented for implants placed in grafted bone. The bone graft-implant interface constitutes a most complex healing situation, where the time scale for osseointegration and development of implant stability currently is not known. PURPOSE:The aim of the study was to measure the st...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.1999.tb00094.x
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Although many studies have been published on single implants, long-term data remain scarce. PURPOSE:To evaluate immediately restored single implants after at least 8 years of follow-up in terms of buccal bone, soft tissue alterations, aesthetic ratings, and patient-reported outcomes. MATERIALS AND METHODS:...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12613
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Clinical studies show promising outcomes with implants inserted at the time of extraction. However, this often results in an initial bone defect at the marginal region which preferably should heal for an optimal function. Therefore, monitoring of these implants is vital. PURPOSES:The aims of this study were...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00095.x
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:A recent in vivo study has shown considerable contamination of internal implant and suprastructure components with great biodiversity, indicating bacterial leakage along the implant-abutment interface, abutment-prosthesis interface, and restorative margins. The goal of the present study was to compare microbiol...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2009.00220.x
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Comparisons between different techniques measuring fit of implant-supported frameworks are few. PURPOSE:The purpose of this study was to compare data on precision of fit from two highly accurate measuring techniques and, also, to compare results using software programs for fit assessments considering both a...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00416.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:One of the objectives of postoperative radiographic examinations of implants is to evaluate the marginal bone height and its changes over time. PURPOSE:The purpose of this study was to assess the influence of digital image processing on measurements of the marginal bone level around implants. MATERIAL AND ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2000.tb00102.x
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Implant restorations first started with total edentulism. Later, the scientific community gave its approval for restorations in partial edentulism, and only recently some studies confirmed the validity of the treatment for single-tooth replacement. PURPOSE:The purpose of the study was to evaluate implant su...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1708-8208.2000.tb00006.x
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:There is lack of studies regarding preservation and possible changes in BBT at dental implants. PURPOSE:To assess, on cone beam computer tomograms, the presence of bone at the time of tooth extraction in the maxillary esthetic region and the mean buccal bone thickness 1 month and 1 year after final restorat...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12701
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To prospectively assess long-term (20 year) clinical, radiographic, and patient-reported outcomes of an elderly population provided with mandibular implant-supported overdentures. MATERIALS AND METHODS:A total of 53 elderly (aged ≥60 years at the time of treatment) were provided with two endosseous implants su...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12772
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Changes in the macrogeometry of dental implants are known to influence primary stability and the osseointegration process. PURPOSE:The purpose of the present in vitro study was to evaluate the mechanical behavior of geometric changes in the apex region of dental implants. METHODS:Thirty-five cylindrical de...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12574
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Oral implant treatment ad modum Brånemark has been used for decades in the rehabilitation of edentate and partially dentate patients. Posterior jaw regions frequently exhibit bone of poor texture, and it is often difficult to obtain primary stability. Thus, it may prove beneficial to deviate from the origina...
journal_title:Clinical implant dentistry and related research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1708-8208.2003.tb00186.x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:In previous studies, immediate implant placement in molar sites has been widely applied. PURPOSE:To study the clinical effect and feasibility of immediate implant placement combined with maxillary sinus floor elevation utilizing the transalveolar approach and nonsubmerged healing for failing teeth in the ma...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,随机对照试验
doi:10.1111/cid.12783
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:The purpose of this prospective follow-up study was to evaluate survival and success of early-loaded implants placed in the edentulous mandible and the survival of the fixed dental prostheses (FDPs) after in mean 7.2 years. MATERIALS AND METHODS:Thirty-seven patients (mean age 64.5 years, 18.9% male) received ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12062
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Posterior maxillary tilted implants are gaining prevalence as an alternative to sinus grafts supporting fixed maxillary restorations. This paper reports long-term results after loading using this technique. MATERIALS AND METHODS:Consecutive patients presenting for either routine hygiene maintenance or unplanne...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12433
更新日期:2017-02-01 00:00:00