Abstract:
BACKGROUND:Studies on the biological processes in different bone types and the reaction of different bone types to biomaterials are often hindered because of the difficulties in sampling procedures and lack of sensitive techniques. PURPOSE:The purpose was to assess the suitability of quantitative polymerase chain reaction (qPCR) for investigation of the biological differences between cortical and trabecular bone types and their responses to biomaterials. MATERIALS AND METHODS:Gene expression of selected markers in rat bone samples from different locations was evaluated. Samples were harvested by trephines from the trabecular femoral epiphysis, cortico-trabecular proximal tibial metaphysic, and the cortical distal tibial metaphysis. Gene expression was also evaluated at the surfaces of anodically oxidized implants retrieved from cortical and trabecular sites after 3 days of implantation. mRNA in the bone samples and in the tissue associated with the implant surfaces was extracted and quantified using qPCR. Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), alkaline phosphatase (ALP), osteocalcin (OC), tartrate-resistant acid phosphatase (TRAP), cathepsin K (CATK), and 18S ribosomal subunits (18S) were analyzed. RESULTS:In the bone samples, higher expression of ALP, OC, TRAP, and CATK was found in femoral epiphysis compared to proximal or distal tibial metaphysis, indicating a higher turnover in the trabecular bone. On the other hand, TNF-α and IL-1β showed higher expression in both tibia sites compared with the femur site, which suggests higher inflammatory potential in the cortical bone. In response to the oxidized implants trabecular bone expressed a higher level of IL-1β, whereas the implants in cortical bone were associated with higher expression of ALP and OC. CONCLUSION:There are biological differences between cortical and trabecular bone types, both in the normal steady-state condition and in response to biomaterials. Such differences can be characterized and discriminated quantitatively using a sensitive technique such as qPCR.
journal_name
Clin Implant Dent Relat Resjournal_title
Clinical implant dentistry and related researchauthors
Omar O,Suska F,Lennerås M,Zoric N,Svensson S,Hall J,Emanuelsson L,Nannmark U,Thomsen Pdoi
10.1111/j.1708-8208.2009.00195.xsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
146-56issue
2eissn
1523-0899issn
1708-8208pii
CID195journal_volume
13pub_type
杂志文章abstract:PURPOSE:The aim of this study was to evaluate bone regeneration at surgically created dehiscence buccal defects at implants placed immediately into extraction sockets (IPIES) of small dimensions filled with autogenous bone or deproteinized bovine bone mineral (DBBM) associated with a collagen membrane. MATERIALS AND M...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12328
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:This study investigated how the primary stability of a dental implant as measured by the insertion torque value (ITV), Periotest value (PTV), and implant stability quotient (ISQ) is affected by varying thicknesses of cortical bone and strengths of trabecular bone using synthetic bone models. MATERIALS AND METH...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00349.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:A moderately rough surface implant (TiUnite, Nobel Biocare AB, Göteborg, Sweden) was introduced in 2000. Laboratory studies and some clinical studies have demonstrated excellent bone response in the early healing phase. PURPOSE:The aim of this prospective multicenter study was to follow a large number of co...
journal_title:Clinical implant dentistry and related research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1708-8208.2005.tb00077.x
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess, for implant placement in the posterior maxilla, the accuracy of linear measurements provided by cone beam computed tomography (CBCT) using an image intensifier tube and television (TV) chain as an X-ray detector despite a loss of contrast resolution. The NewTom 9000 (Quantit...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00083.x
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Platelet concentrate/platelet-rich plasma (PRP) has been studied extensively in various experimental models and there is some agreement among workers to its early effect in bone regeneration and healing. We have earlier showed in vitro that titanium in whole blood activates the thrombogenic response to a hig...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00405.x
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:There is lack of studies regarding preservation and possible changes in BBT at dental implants. PURPOSE:To assess, on cone beam computer tomograms, the presence of bone at the time of tooth extraction in the maxillary esthetic region and the mean buccal bone thickness 1 month and 1 year after final restorat...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12701
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Long-term data (>10 years) concerning the survival and success rates of implants and implant-supported prostheses are scarce. PURPOSE:The present investigation represents one of the first studies on dental implants covering an observational period of 25 years. MATERIALS AND METHODS:This study presents the ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12944
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Peri-implantitis is an infection of the implant surface caused by adhesion of bacteria that generate bone resorption and sometimes even consequent implant loss. Both screw-retained and cemented fixed implants are affected. PURPOSE:The purpose of this study is to investigate the morphological defects at the ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12133
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The purpose of this study is to evaluate the retention of two-piece computer-aided design (CAD)/computer aided manufacturing (CAM) zirconia abutments after artificial aging under simulated oral conditions using three different types of resin-based luting agents. MATERIAL AND METHODS:Twenty-one CAD/CAM-generate...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12060
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:The study aims to determine if midline mandibular dental implants pose a risk for the midline lingual canal (MLC). MATERIALS AND METHODS:Cone beam computed tomography was used to scan 122 mandibles (31 black males; 28 black females; 32 white males and 31 white females). Midsagittal sections in the reconstructe...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12080
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the probability of survival of cemented and screwed three-unit implant-supported fixed dental prostheses (ISFDP) using different implant-abutment horizontal matching configurations (regular vs switching platforms). METHODS:One hundred and sixty-eight implants with internal...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12363
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:The existing approaches to the treatment of the atrophic maxilla are difficult and involve an element of risk. PURPOSE:The aim of the present study was to establish a new surgical/prosthetic protocol for the treatment of extremely atrophic maxillae using four zygomatic implants (ZIs) in an immediate loading...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2007.00046.x
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Few long-term follow-up studies on treatment concepts using computer numeric control-milled titanium frameworks have been conducted. OBJECTIVE:To evaluate the clinical and radiographic performance of implant-supported prostheses provided with computer numeric control-milled titanium frameworks in the edentu...
journal_title:Clinical implant dentistry and related research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1708-8208.2004.tb00036.x
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:The surface chemical and physical properties of materials used for implants have a major influence on blood clot organization. This study aims to evaluate the blood clot extension (bce) on zirconia and titanium. bce was measured in association to surface roughness (Ra) and static contact angle (θ). MATERIALS A...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12038
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Extraction of impacted mandibular third molar (M3) has been cited as causing osseous defect at the distal aspect of the adjacent second molar (M2). PURPOSE:This randomized controlled trial was aimed to evaluate the effect of autogenous bone grafting in situ for regeneration of periodontal osseous defect dis...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,随机对照试验
doi:10.1111/cid.12466
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:In the Literature, there are several studies demonstrating that infraposition happens also in adult patients. PURPOSE:To conduct a retrospective evaluation of infraocclusion of implant-retained crowns in the anterior maxilla of adult patients and of the patient awareness and perception of the problem. MATE...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12790
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:The objective of this study was to evaluate the immediate bone damage and bone repair after osteotomy for implants using conventional drills and drills powered by piezoelectric motor. MATERIALS AND METHODS:Twelve rabbits received a tibial osteotomy with a conventional drill (control), with a diamond like carbo...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12907
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:The aim of this retrospective clinical study was to evaluate the clinical outcome of fixed implant-supported complete prostheses on Astra or Brånemark implants when using either conventional cast frameworks or frameworks produced according to the Cresco Ti Precision method (Cresco Ti Systems Sàrl., Lausanne, Sw...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2005.tb00064.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Zirconia (ZrO(2)) might be an alternative material to titanium (Ti) for dental implant fabrication. However, no data are available on the fracture strength of one-piece ZrO(2) oral implants. PURPOSE:The objective of this study was to evaluate the fracture strength of ZrO(2) implants after exposure to the ar...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00105.x
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Improvements of soft tissue to the abutment surface results in more stable peri-implant conditions, however, few human histological studies have compared soft tissue responses around different abutment materials. PURPOSE:To describe the peri-implant tissue around 3 abutment materials; titanium, zirconia, an...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,随机对照试验
doi:10.1111/cid.12562
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The increase in implant patients is expected to give rise to a new problem: the changing general health status of those who have had implants placed. PURPOSE:The aim of this present study was to find out the needs of and proper measures for elderly implant patients in long-term care facilities. MATERIALS A...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12148
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Conventional freehand immediate placement of dental implants is technically challenging in the jaw reconstructive surgery. Computer-aided surgery might be the best solution, however, there has not been any standard approach to ensure the accuracy and efficiency of simultaneous dental implants in fibula flap ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12954
更新日期:2020-11-12 00:00:00
abstract:BACKGROUND:There is limited knowledge on the relationship between implant failures and patient age at implant surgery. PURPOSE:To further analyze and report long-term data on previously presented significant associations between implant failures and age at surgery in patients receiving treatment in the edentulous jaw....
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12753
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Bone morphogenetic protein-2 (BMP2) has been successfully utilized in dentistry to promote new bone formation because of its osteoinductive ability to recruit mesenchymal progenitor cells and induce their differentiation to bone-forming osteoblasts. Recently, novel biphasic calcium phosphate scaffolds have b...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12384
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to prospectively evaluate the clinical and radiographic outcomes of immediate full-arch fixed maxillary prosthesis supported by two axial and four tilted implants after 3 years of loading. MATERIALS AND METHODS:Thirty-two patients with atrophic maxilla were consecutively enrolled and ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2012.00482.x
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Immediate/early loading protocols are becoming frequently used in implant dentistry, but the prerequisites for achieving good results and the limitations of such protocols are not fully known. Moreover, the terminology used in immediate/early loading is still confusing. PURPOSE:The purpose of this article i...
journal_title:Clinical implant dentistry and related research
pub_type: 共识发展会议,杂志文章,评审
doi:10.1111/j.1708-8208.2003.tb00183.x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Bovine-derived grafting materials are frequently used in a variety of bone augmentation techniques. The aim of this paper is to assess the unique safety issue of bovine-derived grafting materials that is rarely addressed in dental literature: risk of bovine spongiform encephalopathy (BSE). METHODS:The valid...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12391
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The use of computer numeric controlled (CNC)-milled titanium frameworks is a new technique for framework fabrication, and few clinical reports have been made on this treatment modality. PURPOSE:The goal of this study was to report the clinical performance of implant-supported prostheses with CNC-milled tita...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2002.tb00159.x
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Patients have in many studies been identified with progressive bone loss and peri-implantitis problems, but few studies are available where these groups of patients have been followed up. PURPOSE:The purpose of this paper is to study further progression of bone loss in a cohort of 182 patients that have bee...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12166
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:There is a need for prospective, long-term follow-up studies of implants placed after maxillary sinus floor augmentation (MSFA). PURPOSE:The aim of the present study was to determine whether deprotenized bovine bone (DPBB) used for MSFA may result in long-term stability of placed dental implants. MATERIAL ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12008
更新日期:2014-06-01 00:00:00