Abstract:
BACKGROUND:Bone morphogenetic protein-2 (BMP2) has been successfully utilized in dentistry to promote new bone formation because of its osteoinductive ability to recruit mesenchymal progenitor cells and induce their differentiation to bone-forming osteoblasts. Recently, novel biphasic calcium phosphate scaffolds have been developed with similar osteoinductive properties capable of forming ectopic bone formation. PURPOSE:The aim of the present study was to assess whether the combination of BMP2 with this novel Biphasic Calcium Phosphate (BCP) scaffold may additionally promote new bone regeneration. MATERIALS AND METHODS:Cylindrical bone defects measuring 2.5 mm were created bilaterally in the femurs of 18 Wistar rats. After 4 weeks, the following six groups were assessed for new bone formation by micro-computed tomography (CT) as well as histological assessment: 1) collagen scaffolds + 20 μg of BMP2; 2) collagen scaffolds + 50 μg of BMP2; 3) collagen scaffolds + 100 μg of BMP2; 4) BCP scaffolds + 20 μg of BMP2; 5) BCP scaffolds + 50 μg of BMP2; and 6) BCP scaffolds + 100 μg of BMP2. Furthermore, tartrate-resistant acid phosphatase (TRAP) staining was utilized to assess osteoclast activity and osteoclast number. The release kinetics of BMP2 from both BCP and collagen scaffolds was investigated over a 14-day period. RESULTS:The results from present study demonstrate that BMP2 is able to promote new bone formation in a concentration dependant manner when loaded with either a collagen scaffolds or BCP scaffolds. Micro-CT analysis demonstrated significantly higher levels of new bone formation in groups containing BCP + BMP2 when compared with collagen scaffolds + BMP2. BMP2 had little effect on osteoclast activity; however, less TRAP staining and osteoclast number was observed in the defects receiving collagen scaffolds when compared with BCP scaffolds. The release of BMP2 over time was rapidly released after 1 day on BCP scaffolds whereas a gradually release over time was observed for collagen scaffolds up to 14 days. CONCLUSION:The osteoinductive properties of BMP2 may further be enhanced by its combination with a novel synthetically fabricated osteoinductive BCP scaffold. Future clinical testing is required to further assess these preliminary findings.
journal_name
Clin Implant Dent Relat Resjournal_title
Clinical implant dentistry and related researchauthors
Zhang Y,Yang S,Zhou W,Fu H,Qian L,Miron RJdoi
10.1111/cid.12384subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1238-1247issue
6eissn
1523-0899issn
1708-8208journal_volume
18pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to compare survival rates and marginal bone resorption of the Lifecore (LC) Restore Implant System with the benchmark Nobel Biocare (NB) MK II Implant System. MATERIALS AND METHODS:All implants were inserted by the same surgeon and all radiological analyses were performed by the s...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00115.x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:In the Literature, there are several studies demonstrating that infraposition happens also in adult patients. PURPOSE:To conduct a retrospective evaluation of infraocclusion of implant-retained crowns in the anterior maxilla of adult patients and of the patient awareness and perception of the problem. MATE...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12790
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Studies assessing clinical and radiographic peri-implant parameters around short dental implants (SDIs) in treated generalized aggressive periodontitis (GAgP) patients are scant. OBJECTIVES:This 3-year follow-up study aimed to compare the clinical peri-implant and radiographic bone status around SDIs placed...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12761
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Although small perforation of the maxillary sinus schneiderian membrane is a well-documented complication during lateral sinus floor elevation (LSFE), complete perforations larger than 10 mm often result in discontinuation of surgery. Reports on reentry LSFE and its long-term outcomes are sparse. PURPOSE:To...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12932
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Various designs of dental implants representing different geometries and surface technologies are commercially available and clinically used in patients. However, data with regard to bone tissue responses and stability for comparison of their biologic performances are rare. PURPOSE:The aim of the present ex...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2012.00439.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:In oral implantology there has been a general trend away from machine-turned minimally rough and acid-etched and blasted implants toward intermediary roughened surfaces. Mechanical interlocking at micron resolution is claimed to be the dominant reason for the fixation of such implants in bone. However, clini...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2004.tb00032.x
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:By mixing hydroxyapatite (HA) and tricalcium phosphate (TCP), biphasic calcium phosphate ceramics can be obtained, and by varying their ratio it is possible to tailor the characteristics of the biomaterial. PURPOSE:The aim of the present human study was to evaluate the histological and radiographical aspect...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12145
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Elicitation of the relationship of periodontopathogens and pro-inflammatory cytokines to bone resorption and formation is significant to a growing body of research known as osteoimmunology. It is essential that clinically healthy peri-implant and periodontal sites are studied to contribute comparison data fo...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2007.00076.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:The use of computer software and stereolithography for dental implant therapy has significantly increased during the last few years. The aim of this study was to evaluate and compare the mean accuracy and maximum deviations values of dental implant placement using two stereolithographic (SLA) guide systems. ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00369.x
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:There is a need for more studies investigating the outcome of implant-supported rehabilitations in patients with systemic disorders. MATERIALS AND METHODS:This retrospective clinical study included 721 patients with systemic disorders or smoking habits (422 females; 299 males), with an average age of 51 yea...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12346
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:The use of removable provisional prosthesis after implant placement is undesirable for many patients. In addition, removable prostheses place unfavorable pressure over implants during the healing period. PURPOSE:The use of temporary implants enable greater stability and functionality of the prostheses. MAT...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2009.00225.x
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the rotational freedom between implant and abutment counterpart of two abutments types over external hexagon implants submitted to mechanical cycling. MATERIALS AND METHODS:Ten implants with external hexagon (3.75 mm × 13 mm), five cast abutments, and five premachined ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00430.x
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Clinical studies show promising outcomes with implants inserted at the time of extraction. However, this often results in an initial bone defect at the marginal region which preferably should heal for an optimal function. Therefore, monitoring of these implants is vital. PURPOSES:The aims of this study were...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00095.x
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To investigate the effectiveness of adding leukocyte and platelet-rich fibrin (L-PRF) to deproteinized bovine bone mineral (DBBM) for early implant placement after maxillary sinus augmentation. MATERIALS AND METHODS:Twelve patients requiring two-stage bilateral maxillary sinus augmentation were enrolled to the...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,随机对照试验
doi:10.1111/cid.12713
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Discrimination between ongoing and solved research questions may help to distinguish established dogmas from evidence-based implant dentistry. PURPOSE:The purpose of this study was to investigate topics of interest in the field of oral implant science and evolving thematic trends in clinical studies during ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章,评审
doi:10.1111/cid.12371
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:In vivo bone response was assessed by removal torque, hystological and histometrical analysis on a recently developed biomedical Ti-15Mo alloy, after surface modification by laser beam irradiation, installed in the tibia of rabbits. MATERIALS AND METHODS:A total of 32 wide cylindrical Ti-15Mo dental implants w...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00354.x
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate bone regeneration at surgically created dehiscence buccal defects at implants placed immediately into extraction sockets (IPIES) of small dimensions filled with autogenous bone or deproteinized bovine bone mineral (DBBM) associated with a collagen membrane. MATERIALS AND M...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12328
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:In the maxillary incisor area infraposition of implant restorations can be an esthetic problem. PURPOSE:The aim was to analyze the prevalence of infraposition of single-tooth implant restorations in the anterior maxilla in adolescent and adult patients. MATERIAL AND METHODS:The study comprised of 31 patien...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12818
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Maxillary sinus floor elevation surgery is widely used as a preimplantology method to permit implant insertion. Nevertheless, very few data are available about long-term stability of dental implants inserted in grafted sites. PURPOSE:The aims of the present study were to evaluate the evolution of resonance ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2008.00113.x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:There are no studies that have evaluated the correlation between self-rated pain, peri-implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TN...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12866
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to document the long-term outcome of Brånemark implants installed in augmented maxillary bone and to identify parameters that are associated with peri-implant bone level. MATERIAL AND METHODS:Patients of a periodontal practice who had been referred to a maxillofacial surgeon for i...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2011.00359.x
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Few reports are available on treatment using implant-supported frameworks with maxillary obturators after total maxillectomy on tumor patients. PURPOSE:To describe, evaluate, and report the clinical and radiographic performance of implant-supported frameworks and maxillary obturators after maxillectomy duri...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2009.00164.x
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Information on the microbiota in peri-implantitis is limited. We hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. MATERIALS AND METHODS:Baseline microbiological samples collected at one implant in each of 166 participants with pe...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12052
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:One of the objectives of postoperative radiographic examinations of implants is to evaluate the marginal bone height and its changes over time. PURPOSE:The purpose of this study was to assess the influence of digital image processing on measurements of the marginal bone level around implants. MATERIAL AND ...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2000.tb00102.x
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Posterior superior alveolar artery (PSAA) is the most important limiting anatomic structure while lateral approach sinus surgeries. PSAA should be taken into consideration to avoid bleeding during preparation of bony window. PURPOSE:The aim of this article was to inform topography of PSAA and to evaluate me...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12794
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Straumann® BoneCeramic™ is a synthetic biphasic calcium phosphate (BCP) aimed for sinus floor augmentation. Long-term follow-up of implants placed in BCP after sinus augmentation is still missing. PURPOSE:The primary aim of the study was to compare survival rates and marginal bone loss of Straumann SLActive...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12374
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The replacement of a single tooth or several teeth by means of single-implant restorations is an increasingly used method that needs long-term validation. PURPOSE:The goal of this study was to evaluate the outcome of single-implant restorations by means of fixed restorations and to define the prognosis thro...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/j.1708-8208.2000.tb00119.x
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate a possible biomarker for bisphosphonate-related osteonecrosis of the jaw (BRONJ) in an animal model. MATERIALS AND METHODS:Forty-eight Sprague-Dawley rats were randomly divided into the bisphosphonate group (n = 36), who were injected once a week with zoledronic acid, a...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12297
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:To compare five different implant treatment protocols in the anterior maxilla, including immediate, early, and delayed implant placement, as well as implant placement in conjunction with simultaneous guided bone regeneration and implant placement 3 months following horizontal autologous bone block grafting. MA...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12212
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To prospectively assess long-term (20 year) clinical, radiographic, and patient-reported outcomes of an elderly population provided with mandibular implant-supported overdentures. MATERIALS AND METHODS:A total of 53 elderly (aged ≥60 years at the time of treatment) were provided with two endosseous implants su...
journal_title:Clinical implant dentistry and related research
pub_type: 杂志文章
doi:10.1111/cid.12772
更新日期:2019-08-01 00:00:00