Addition of a Synthetically Fabricated Osteoinductive Biphasic Calcium Phosphate Bone Graft to BMP2 Improves New Bone Formation.

Abstract:

BACKGROUND:Bone morphogenetic protein-2 (BMP2) has been successfully utilized in dentistry to promote new bone formation because of its osteoinductive ability to recruit mesenchymal progenitor cells and induce their differentiation to bone-forming osteoblasts. Recently, novel biphasic calcium phosphate scaffolds have been developed with similar osteoinductive properties capable of forming ectopic bone formation. PURPOSE:The aim of the present study was to assess whether the combination of BMP2 with this novel Biphasic Calcium Phosphate (BCP) scaffold may additionally promote new bone regeneration. MATERIALS AND METHODS:Cylindrical bone defects measuring 2.5 mm were created bilaterally in the femurs of 18 Wistar rats. After 4 weeks, the following six groups were assessed for new bone formation by micro-computed tomography (CT) as well as histological assessment: 1) collagen scaffolds + 20 μg of BMP2; 2) collagen scaffolds + 50 μg of BMP2; 3) collagen scaffolds + 100 μg of BMP2; 4) BCP scaffolds + 20 μg of BMP2; 5) BCP scaffolds + 50 μg of BMP2; and 6) BCP scaffolds + 100 μg of BMP2. Furthermore, tartrate-resistant acid phosphatase (TRAP) staining was utilized to assess osteoclast activity and osteoclast number. The release kinetics of BMP2 from both BCP and collagen scaffolds was investigated over a 14-day period. RESULTS:The results from present study demonstrate that BMP2 is able to promote new bone formation in a concentration dependant manner when loaded with either a collagen scaffolds or BCP scaffolds. Micro-CT analysis demonstrated significantly higher levels of new bone formation in groups containing BCP + BMP2 when compared with collagen scaffolds + BMP2. BMP2 had little effect on osteoclast activity; however, less TRAP staining and osteoclast number was observed in the defects receiving collagen scaffolds when compared with BCP scaffolds. The release of BMP2 over time was rapidly released after 1 day on BCP scaffolds whereas a gradually release over time was observed for collagen scaffolds up to 14 days. CONCLUSION:The osteoinductive properties of BMP2 may further be enhanced by its combination with a novel synthetically fabricated osteoinductive BCP scaffold. Future clinical testing is required to further assess these preliminary findings.

authors

Zhang Y,Yang S,Zhou W,Fu H,Qian L,Miron RJ

doi

10.1111/cid.12384

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1238-1247

issue

6

eissn

1523-0899

issn

1708-8208

journal_volume

18

pub_type

杂志文章
  • Five-year evaluation of Lifecore Restore implants: a retrospective comparison with Nobel Biocare MK II implants.

    abstract:PURPOSE:The purpose of this study was to compare survival rates and marginal bone resorption of the Lifecore (LC) Restore Implant System with the benchmark Nobel Biocare (NB) MK II Implant System. MATERIALS AND METHODS:All implants were inserted by the same surgeon and all radiological analyses were performed by the s...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2008.00115.x

    authors: Kallus T,Bessing C,Homsi G,Eklund I

    更新日期:2009-09-01 00:00:00

  • Continuous craniofacial growth in adult patients treated with dental implants in the anterior maxilla.

    abstract:BACKGROUND:In the Literature, there are several studies demonstrating that infraposition happens also in adult patients. PURPOSE:To conduct a retrospective evaluation of infraocclusion of implant-retained crowns in the anterior maxilla of adult patients and of the patient awareness and perception of the problem. MATE...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12790

    authors: Cocchetto R,Pradies G,Celletti R,Canullo L

    更新日期:2019-08-01 00:00:00

  • Clinical and radiographic peri-implant outcomes of short dental implants placed in posterior jaws of patients with treated generalized aggressive periodontitis: A 3-year follow-up study.

    abstract:BACKGROUND:Studies assessing clinical and radiographic peri-implant parameters around short dental implants (SDIs) in treated generalized aggressive periodontitis (GAgP) patients are scant. OBJECTIVES:This 3-year follow-up study aimed to compare the clinical peri-implant and radiographic bone status around SDIs placed...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12761

    authors: Akram Z,Vohra F,Sheikh SA,Albaijan R,Bukhari IA,Hussain M

    更新日期:2019-08-01 00:00:00

  • Clinical and radiographic outcomes of reentry lateral sinus floor elevation after a complete membrane perforation.

    abstract:BACKGROUND:Although small perforation of the maxillary sinus schneiderian membrane is a well-documented complication during lateral sinus floor elevation (LSFE), complete perforations larger than 10 mm often result in discontinuation of surgery. Reports on reentry LSFE and its long-term outcomes are sparse. PURPOSE:To...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12932

    authors: Wang D,Tian J,Wang Y,Wei D,Lin Y

    更新日期:2020-10-01 00:00:00

  • An experimental comparison of two different clinically used implant designs and surfaces.

    abstract:BACKGROUND:Various designs of dental implants representing different geometries and surface technologies are commercially available and clinically used in patients. However, data with regard to bone tissue responses and stability for comparison of their biologic performances are rare. PURPOSE:The aim of the present ex...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2012.00439.x

    authors: Gottlow J,Barkarmo S,Sennerby L

    更新日期:2012-05-01 00:00:00

  • Biomechanical measurements of calcium-incorporated oxidized implants in rabbit bone: effect of calcium surface chemistry of a novel implant.

    abstract:BACKGROUND:In oral implantology there has been a general trend away from machine-turned minimally rough and acid-etched and blasted implants toward intermediary roughened surfaces. Mechanical interlocking at micron resolution is claimed to be the dominant reason for the fixation of such implants in bone. However, clini...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2004.tb00032.x

    authors: Sul YT,Byon ES,Jeong Y

    更新日期:2004-01-01 00:00:00

  • A Human Clinical, Histological, Histomorphometrical, and Radiographical Study on Biphasic HA-Beta-TCP 30/70 in Maxillary Sinus Augmentation.

    abstract:BACKGROUND:By mixing hydroxyapatite (HA) and tricalcium phosphate (TCP), biphasic calcium phosphate ceramics can be obtained, and by varying their ratio it is possible to tailor the characteristics of the biomaterial. PURPOSE:The aim of the present human study was to evaluate the histological and radiographical aspect...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12145

    authors: Mangano C,Sinjari B,Shibli JA,Mangano F,Hamisch S,Piattelli A,Perrotti V,Iezzi G

    更新日期:2015-06-01 00:00:00

  • Microbiology and cytokine levels around healthy dental implants and teeth.

    abstract:BACKGROUND:Elicitation of the relationship of periodontopathogens and pro-inflammatory cytokines to bone resorption and formation is significant to a growing body of research known as osteoimmunology. It is essential that clinically healthy peri-implant and periodontal sites are studied to contribute comparison data fo...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2007.00076.x

    authors: Nowzari H,Botero JE,DeGiacomo M,Villacres MC,Rich SK

    更新日期:2008-09-01 00:00:00

  • Accuracy of two stereolithographic surgical templates: a retrospective study.

    abstract:BACKGROUND:The use of computer software and stereolithography for dental implant therapy has significantly increased during the last few years. The aim of this study was to evaluate and compare the mean accuracy and maximum deviations values of dental implant placement using two stereolithographic (SLA) guide systems. ...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2011.00369.x

    authors: Cassetta M,Giansanti M,Di Mambro A,Calasso S,Barbato E

    更新日期:2013-06-01 00:00:00

  • Long-Term Outcome of Implant Rehabilitations in Patients with Systemic Disorders and Smoking Habits: A Retrospective Clinical Study.

    abstract:BACKGROUND:There is a need for more studies investigating the outcome of implant-supported rehabilitations in patients with systemic disorders. MATERIALS AND METHODS:This retrospective clinical study included 721 patients with systemic disorders or smoking habits (422 females; 299 males), with an average age of 51 yea...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12346

    authors: Maló P,de Araújo Nobre M,Gonçalves Y,Lopes A

    更新日期:2016-08-01 00:00:00

  • Temporary implants for patients with low bone density of the upper maxilla: an alternative rehabilitation strategy.

    abstract:BACKGROUND:The use of removable provisional prosthesis after implant placement is undesirable for many patients. In addition, removable prostheses place unfavorable pressure over implants during the healing period. PURPOSE:The use of temporary implants enable greater stability and functionality of the prostheses. MAT...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2009.00225.x

    authors: de Aguiar RC,Zabolotsky B,de Souza DC,Ferreira CF,Cardoso AC

    更新日期:2012-03-01 00:00:00

  • Abutment rotational freedom evaluation of external hexagon single-implant restorations after mechanical cycling.

    abstract:PURPOSE:The purpose of this study was to evaluate the rotational freedom between implant and abutment counterpart of two abutments types over external hexagon implants submitted to mechanical cycling. MATERIALS AND METHODS:Ten implants with external hexagon (3.75 mm × 13 mm), five cast abutments, and five premachined ...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2011.00430.x

    authors: Junqueira MC,Silva TE,Ribeiro RF,Faria AC,Macedo AP,de Almeida RP

    更新日期:2013-12-01 00:00:00

  • Influence of defect depth on resonance frequency analysis and insertion torque values for implants placed in fresh extraction sockets: a human cadaver study.

    abstract:BACKGROUND:Clinical studies show promising outcomes with implants inserted at the time of extraction. However, this often results in an initial bone defect at the marginal region which preferably should heal for an optimal function. Therefore, monitoring of these implants is vital. PURPOSES:The aims of this study were...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2008.00095.x

    authors: Turkyilmaz I,Sennerby L,Yilmaz B,Bilecenoglu B,Ozbek EN

    更新日期:2009-03-01 00:00:00

  • Evaluation of L-PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized clinical trial.

    abstract:PURPOSE:To investigate the effectiveness of adding leukocyte and platelet-rich fibrin (L-PRF) to deproteinized bovine bone mineral (DBBM) for early implant placement after maxillary sinus augmentation. MATERIALS AND METHODS:Twelve patients requiring two-stage bilateral maxillary sinus augmentation were enrolled to the...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/cid.12713

    authors: Pichotano EC,de Molon RS,de Souza RV,Austin RS,Marcantonio E,Zandim-Barcelos DL

    更新日期:2019-04-01 00:00:00

  • Scientific Interests of 21st Century Clinical Oral Implant Research: Topical Trend Analysis.

    abstract:BACKGROUND:Discrimination between ongoing and solved research questions may help to distinguish established dogmas from evidence-based implant dentistry. PURPOSE:The purpose of this study was to investigate topics of interest in the field of oral implant science and evolving thematic trends in clinical studies during ...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章,评审

    doi:10.1111/cid.12371

    authors: Pommer B,Valkova V,Ubaidha Maheen C,Fürhauser L,Rausch-Fan X,Seeman R

    更新日期:2016-08-01 00:00:00

  • Biomedical Ti-Mo alloys with surface machined and modified by laser beam: biomechanical, histological, and histometric analysis in rabbits.

    abstract:PURPOSE:In vivo bone response was assessed by removal torque, hystological and histometrical analysis on a recently developed biomedical Ti-15Mo alloy, after surface modification by laser beam irradiation, installed in the tibia of rabbits. MATERIALS AND METHODS:A total of 32 wide cylindrical Ti-15Mo dental implants w...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2011.00354.x

    authors: Oliveira NT,Guastaldi FP,Perrotti V,Hochuli-Vieira E,Guastaldi AC,Piattelli A,Iezzi G

    更新日期:2013-06-01 00:00:00

  • Deproteinized Bovine Bone Mineral or Autologous Bone at Dehiscence Type Defects at Implants Installed Immediately into Extraction Sockets: An Experimental Study in Dogs.

    abstract:PURPOSE:The aim of this study was to evaluate bone regeneration at surgically created dehiscence buccal defects at implants placed immediately into extraction sockets (IPIES) of small dimensions filled with autogenous bone or deproteinized bovine bone mineral (DBBM) associated with a collagen membrane. MATERIALS AND M...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12328

    authors: Pereira FP,De Santis E,Hochuli-Vieira E,de Souza Faco EF,Pantani F,Salata LA,Botticelli D

    更新日期:2016-06-01 00:00:00

  • Infraposition of anterior maxillary implant-supported single-tooth restorations in adolescent and adult patients-A prospective follow-up study up to 6 years.

    abstract:BACKGROUND:In the maxillary incisor area infraposition of implant restorations can be an esthetic problem. PURPOSE:The aim was to analyze the prevalence of infraposition of single-tooth implant restorations in the anterior maxilla in adolescent and adult patients. MATERIAL AND METHODS:The study comprised of 31 patien...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12818

    authors: Nilsson A,Johansson LÅ,Stenport VF,Wennerberg A,Ekfeldt A

    更新日期:2019-10-01 00:00:00

  • RFA values of implants placed in sinus grafted and nongrafted sites after 6 and 12 months.

    abstract:BACKGROUND:Maxillary sinus floor elevation surgery is widely used as a preimplantology method to permit implant insertion. Nevertheless, very few data are available about long-term stability of dental implants inserted in grafted sites. PURPOSE:The aims of the present study were to evaluate the evolution of resonance ...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2008.00113.x

    authors: Degidi M,Daprile G,Piattelli A

    更新日期:2009-09-01 00:00:00

  • Relationship between self-rated pain and peri-implant clinical, radiographic and whole salivary inflammatory markers among patients with and without peri-implantitis.

    abstract:BACKGROUND:There are no studies that have evaluated the correlation between self-rated pain, peri-implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TN...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12866

    authors: Abduljabbar T,Vohra F,Ullah A,Alhamoudi N,Khan J,Javed F

    更新日期:2019-12-01 00:00:00

  • Long-term clinical, microbiological, and radiographic outcomes of Brånemark™ implants installed in augmented maxillary bone for fixed full-arch rehabilitation.

    abstract:PURPOSE:The purpose of this study was to document the long-term outcome of Brånemark implants installed in augmented maxillary bone and to identify parameters that are associated with peri-implant bone level. MATERIAL AND METHODS:Patients of a periodontal practice who had been referred to a maxillofacial surgeon for i...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2011.00359.x

    authors: De Bruyn H,Bouvry P,Collaert B,De Clercq C,Persson GR,Cosyn J

    更新日期:2013-02-01 00:00:00

  • Three tumor patients with total maxillectomy rehabilitated with implant-supported frameworks and maxillary obturators: a follow-up report.

    abstract:BACKGROUND:Few reports are available on treatment using implant-supported frameworks with maxillary obturators after total maxillectomy on tumor patients. PURPOSE:To describe, evaluate, and report the clinical and radiographic performance of implant-supported frameworks and maxillary obturators after maxillectomy duri...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2009.00164.x

    authors: Örtorp A

    更新日期:2010-12-01 00:00:00

  • Cluster of bacteria associated with peri-implantitis.

    abstract:BACKGROUND:Information on the microbiota in peri-implantitis is limited. We hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. MATERIALS AND METHODS:Baseline microbiological samples collected at one implant in each of 166 participants with pe...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12052

    authors: Persson GR,Renvert S

    更新日期:2014-12-01 00:00:00

  • Marginal bone level around implants assessed in digital and film radiographs: in vivo study in the dog.

    abstract:BACKGROUND:One of the objectives of postoperative radiographic examinations of implants is to evaluate the marginal bone height and its changes over time. PURPOSE:The purpose of this study was to assess the influence of digital image processing on measurements of the marginal bone level around implants. MATERIAL AND ...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2000.tb00102.x

    authors: Borg E,Gröndahl K,Persson LG,Gröndahl HG

    更新日期:2000-01-01 00:00:00

  • The radiological evaluation of posterior superior alveolar artery topography by using computed tomography.

    abstract:BACKGROUND:Posterior superior alveolar artery (PSAA) is the most important limiting anatomic structure while lateral approach sinus surgeries. PSAA should be taken into consideration to avoid bleeding during preparation of bony window. PURPOSE:The aim of this article was to inform topography of PSAA and to evaluate me...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12794

    authors: Duruel O,Ataman-Duruel ET,Tözüm MD,Karabulut E,Tözüm TF

    更新日期:2019-08-01 00:00:00

  • Sinus Floor Augmentation Using Straumann® BoneCeramic™ and Bio-Oss® in a Split Mouth Design and Later Placement of Implants: A 5-Year Report from a Longitudinal Study.

    abstract:BACKGROUND:Straumann® BoneCeramic™ is a synthetic biphasic calcium phosphate (BCP) aimed for sinus floor augmentation. Long-term follow-up of implants placed in BCP after sinus augmentation is still missing. PURPOSE:The primary aim of the study was to compare survival rates and marginal bone loss of Straumann SLActive...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12374

    authors: Mordenfeld A,Lindgren C,Hallman M

    更新日期:2016-10-01 00:00:00

  • Biologic outcome of single-implant restorations as tooth replacements: a long-term follow-up study.

    abstract:BACKGROUND:The replacement of a single tooth or several teeth by means of single-implant restorations is an increasingly used method that needs long-term validation. PURPOSE:The goal of this study was to evaluate the outcome of single-implant restorations by means of fixed restorations and to define the prognosis thro...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/j.1708-8208.2000.tb00119.x

    authors: Naert I,Koutsikakis G,Duyck J,Quirynen M,Jacobs R,van Steenberghe D

    更新日期:2000-01-01 00:00:00

  • Biomarkers for Bisphosphonate-Related Osteonecrosis of the Jaw.

    abstract:PURPOSE:The aim of this study was to investigate a possible biomarker for bisphosphonate-related osteonecrosis of the jaw (BRONJ) in an animal model. MATERIALS AND METHODS:Forty-eight Sprague-Dawley rats were randomly divided into the bisphosphonate group (n = 36), who were injected once a week with zoledronic acid, a...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12297

    authors: Kim JW,Cha IH,Kim SJ,Kim MR

    更新日期:2016-04-01 00:00:00

  • Does Timing of Implant Placement Affect Implant Therapy Outcome in the Aesthetic Zone? A Clinical, Radiological, Aesthetic, and Patient-Based Evaluation.

    abstract:PURPOSE:To compare five different implant treatment protocols in the anterior maxilla, including immediate, early, and delayed implant placement, as well as implant placement in conjunction with simultaneous guided bone regeneration and implant placement 3 months following horizontal autologous bone block grafting. MA...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12212

    authors: Hof M,Pommer B,Ambros H,Jesch P,Vogl S,Zechner W

    更新日期:2015-12-01 00:00:00

  • Mandibular implant-supported overdentures in (frail) elderly: A prospective study with 20-year follow-up.

    abstract:PURPOSE:To prospectively assess long-term (20 year) clinical, radiographic, and patient-reported outcomes of an elderly population provided with mandibular implant-supported overdentures. MATERIALS AND METHODS:A total of 53 elderly (aged ≥60 years at the time of treatment) were provided with two endosseous implants su...

    journal_title:Clinical implant dentistry and related research

    pub_type: 杂志文章

    doi:10.1111/cid.12772

    authors: Bakker MH,Vissink A,Meijer HJA,Raghoebar GM,Visser A

    更新日期:2019-08-01 00:00:00