Abstract：
BACKGROUND:Reactive oxygen species contribute to periodontal tissue homeostasis under control of anti-oxidative responses. Disruption in this balance induces severe inflammation and extended tissue degradation. PURPOSE:Aim of this study was to identify the expression levels of nuclear factor, erythroid 2 like 2 (NFE2L2/NRF2), Parkinsonism associated deglycase (PARK7/DJ-1), kelch-like ECH associated protein 1 (KEAP1), and 8-hydroxy-deoxyguanosine (8-OHdG) in peri-implant mucosal tissues affected by peri-implantitis, and to compare the levels to those of periodontally diseased and healthy tissue samples. METHODS:Tissue biopsies were collected from systemically healthy, non-smoking 12 peri-implantitis patients, 13 periodontitis patients, and 13 periodontally healthy controls. Expression levels of NFE2L2/NRF2, PARK7/DJ-1, KEAP1, and 8-OHdG in tissue samples were analyzed immunohistochemically. Statistical analysis was performed by one-way ANOVA with Tukey's HSD test. RESULTS:Inflammatory cell infiltration in the connective tissue and loss of architecture in the spinous layer of the epithelium were prominent in peri-implantitis. Proportions of 8-OHdG and PARK7/DJ-1 expressing cells were elevated in both peri-implantitis (P = .025 for 8-OHdG and P = .014 for PARK7/DJ-1) and periodontitis (P = .038 for 8-OHdG and P = .012 for PARK7/DJ-1) groups in comparison with controls. Staining intensities of 8-OHdG and PARK7/DJ-1 were higher in the periodontitis and peri-implantitis groups than in the control (P < .01) groups. There was no difference in the expression levels of NFE2L2/NRF2 between the groups. KEAP1 was not observed in any tissue sample. CONCLUSIONS:Peri-implantitis is characterized by severe inflammation and architectural changes in the epithelium and connective tissue. The expressions of 8-OHdG and PARK7/DJ-1 are elevated in both peri-implantitis and periodontitis.
journal_name
Clin Implant Dent Relat Resjournal_title
Clinical implant dentistry and related researchauthors
Kasnak G,Firatli E,Könönen E,Olgac V,Zeidán-Chuliá F,Gursoy UKdoi
10.1111/cid.12619subject
Has Abstractpub_date
2018-08-01 00:00:00pages
574-582issue
4eissn
1523-0899issn
1708-8208journal_volume
20pub_type
杂志文章abstract：BACKGROUND:There is a need for more studies investigating the outcome of implant-supported rehabilitations in patients with systemic disorders. MATERIALS AND METHODS:This retrospective clinical study included 721 patients with systemic disorders or smoking habits (422 females; 299 males), with an average age of 51 yea...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12346
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Long-term data (>10 years) concerning the survival and success rates of implants and implant-supported prostheses are scarce. PURPOSE:The present investigation represents one of the first studies on dental implants covering an observational period of 25 years. MATERIALS AND METHODS:This study presents the ...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12944
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Implant restorations became the first choice for single-tooth replacement today. PURPOSE:The prospective clinical trial aims to investigate computer-aided-design (CAD)/computer-aided-manufacturing (CAM)-processed implant crowns after 5 years of loading. MATERIALS AND METHODS:Twenty patients were included f...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章,随机对照试验
doi：10.1111/cid.12681
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:To compare five different implant treatment protocols in the anterior maxilla, including immediate, early, and delayed implant placement, as well as implant placement in conjunction with simultaneous guided bone regeneration and implant placement 3 months following horizontal autologous bone block grafting. MA...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12212
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Intrasocket reactive soft tissue can be used for primary closure during augmentation of infected extraction sites exhibiting severe bone loss prior to implant placement. The present study evaluated the histological characteristics of the initially used intrasocket reactive soft tissue, the overlying soft tis...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/j.1708-8208.2010.00281.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Long-term success and patient satisfaction of dental implant systems can only be achieved by fulfilling clinical as well as biological needs related to maintenance, aesthetics, soft tissue sealing, and osseointegration, among others. Surface properties largely contribute to the biological and clinical perfor...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12736
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:The purpose of this study was to document the long-term outcome of Brånemark implants installed in augmented maxillary bone and to identify parameters that are associated with peri-implant bone level. MATERIAL AND METHODS:Patients of a periodontal practice who had been referred to a maxillofacial surgeon for i...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/j.1708-8208.2011.00359.x
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:This study evaluated the autogenous graft resorption rate in a calvarial block graft in the anterior region of an atrophic maxilla and compared it with the thickness of the remaining ridge. MATERIALS AND METHODS:Twelve patients were included in the study. They were submitted to cranial calotte graft surgery, a...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12869
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To evaluate the histological and microtomographic response of peri-implant bone tissue around titanium implants with different surface treatments, placed in bone defects filled or not filled with bone substitute materials. MATERIALS AND METHODS:Thirty rabbits were divided into two groups according to the imp...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12880
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Autogenous bone grafts are the most favorable and predictable types of bone graft due to their osteogenic, osteoinductive, and osteoconductive properties. The advantages of harvesting from mandibular bone are that it requires only local anesthesia, is less invasive, has less morbidity, and avoids harvesting ...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12789
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Customized sealing socket abutment (SSA) has been claimed to optimize the peri-implant hard and soft tissues in type 1 implant placement. However, the evidence to claim the benefits of this technique over the use a conventional healing abutment remains weak. PURPOSE:The aim of this retrospective study was t...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12974
更新日期：2021-01-13 00:00:00
abstract：BACKGROUND:There is a need for prospective, long-term follow-up studies of implants placed after maxillary sinus floor augmentation (MSFA). PURPOSE:The aim of the present study was to determine whether deprotenized bovine bone (DPBB) used for MSFA may result in long-term stability of placed dental implants. MATERIAL ...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12008
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Application of adipose-derived stem cells originated from buccal fat pad (BFP) can simplify surgical procedures and diminish clinical risks compared to large autograft harvesting. PURPOSE:This study sought to evaluate and compare the efficacy of buccal fat pad-derived stem cells (BFPSCs) in combination with...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12729
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:The surface chemical and physical properties of materials used for implants have a major influence on blood clot organization. This study aims to evaluate the blood clot extension (bce) on zirconia and titanium. bce was measured in association to surface roughness (Ra) and static contact angle (θ). MATERIALS A...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12038
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:It is hypothesized that peri-implant conditions are worse with increasing severity of obesity, because systemic low-grade inflammatory marker (C-reactive protein [CRP]) is higher in severe form of obese individuals. PURPOSE:The aim of the cross-sectional retrospective study was to compare clinical and radio...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12556
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:In previous studies, immediate implant placement in molar sites has been widely applied. PURPOSE:To study the clinical effect and feasibility of immediate implant placement combined with maxillary sinus floor elevation utilizing the transalveolar approach and nonsubmerged healing for failing teeth in the ma...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章,随机对照试验
doi：10.1111/cid.12783
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Bone allografts have shown satisfactory clinical results in alveolar ridge reconstructions. However, the process of incorporation and the resorption rates of these grafts are not yet fully understood. PURPOSE:The aim of this study was to use computed tomography (CT), histology, and histomorphometry to asses...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章,随机对照试验
doi：10.1111/cid.12108
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:By mixing hydroxyapatite (HA) and tricalcium phosphate (TCP), biphasic calcium phosphate ceramics can be obtained, and by varying their ratio it is possible to tailor the characteristics of the biomaterial. PURPOSE:The aim of the present human study was to evaluate the histological and radiographical aspect...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12145
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:To investigate the effectiveness of adding leukocyte and platelet-rich fibrin (L-PRF) to deproteinized bovine bone mineral (DBBM) for early implant placement after maxillary sinus augmentation. MATERIALS AND METHODS:Twelve patients requiring two-stage bilateral maxillary sinus augmentation were enrolled to the...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章,随机对照试验
doi：10.1111/cid.12713
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:The purpose of this study is to evaluate the retention of two-piece computer-aided design (CAD)/computer aided manufacturing (CAM) zirconia abutments after artificial aging under simulated oral conditions using three different types of resin-based luting agents. MATERIAL AND METHODS:Twenty-one CAD/CAM-generate...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12060
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:In vivo bone response was assessed by removal torque, hystological and histometrical analysis on a recently developed biomedical Ti-15Mo alloy, after surface modification by laser beam irradiation, installed in the tibia of rabbits. MATERIALS AND METHODS:A total of 32 wide cylindrical Ti-15Mo dental implants w...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/j.1708-8208.2011.00354.x
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To describe the early bone tissue response to implants with and without micro threads designed to the full length of an oxidized titanium implant. MATERIALS AND METHODS:A pair of two-dimensional finite element models was designed using a computer aided three-dimensional interactive application files of an impl...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12143
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Immediate/early loading protocols are becoming frequently used in implant dentistry, but the prerequisites for achieving good results and the limitations of such protocols are not fully known. Moreover, the terminology used in immediate/early loading is still confusing. PURPOSE:The purpose of this article i...
journal_title：Clinical implant dentistry and related research
pub_type： 共识发展会议,杂志文章,评审
doi：10.1111/j.1708-8208.2003.tb00183.x
更新日期：2003-01-01 00:00:00
abstract：UNLABELLED:Osteonecrosis of the jaw (ONJ) is a severe complication of bisphosphonate treatment. PURPOSE:A detailed characterization of sampled peri-necrotic jawbone from bisphosphonate-treated patients was performed at tissue and cellular level (histological analyses and gene expression). MATERIALS AND METHODS:Alveol...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12307
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to prospectively evaluate the clinical and radiographic outcomes of immediate full-arch fixed maxillary prosthesis supported by two axial and four tilted implants after 3 years of loading. MATERIALS AND METHODS:Thirty-two patients with atrophic maxilla were consecutively enrolled and ...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/j.1708-8208.2012.00482.x
更新日期：2014-04-01 00:00:00
abstract：PURPOSE:The purpose of this prospective follow-up study was to evaluate survival and success of early-loaded implants placed in the edentulous mandible and the survival of the fixed dental prostheses (FDPs) after in mean 7.2 years. MATERIALS AND METHODS:Thirty-seven patients (mean age 64.5 years, 18.9% male) received ...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12062
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:The aim of the present 1-year clinical and radiographic study was to evaluate a hydrophilic dental implant when used in everyday cases in one clinic. The purpose was also to compare augmented with nonaugmented sites. MATERIALS AND METHODS:The study group consisted of 50 consecutive patients treated with 159 de...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12329
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Implant-supported overdentures represent a successful treatment for edentulous patients. As early diagnosis, detection and supportive care are considered key factors for the prevention of peri-implant diseases, consistent maintenance of these implants is becoming increasingly relevant. PURPOSE:This retrospe...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12963
更新日期：2021-01-18 00:00:00
abstract：BACKGROUND:In the maxillary incisor area infraposition of implant restorations can be an esthetic problem. PURPOSE:The aim was to analyze the prevalence of infraposition of single-tooth implant restorations in the anterior maxilla in adolescent and adult patients. MATERIAL AND METHODS:The study comprised of 31 patien...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/cid.12818
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:The use of computer numeric controlled (CNC)-milled titanium frameworks is a new technique for framework fabrication, and few clinical reports have been made on this treatment modality. PURPOSE:The goal of this study was to report the clinical performance of implant-supported prostheses with CNC-milled tita...
journal_title：Clinical implant dentistry and related research
pub_type： 杂志文章
doi：10.1111/j.1708-8208.2002.tb00159.x
更新日期：2002-01-01 00:00:00
