Abstract:
BACKGROUND:Cleft lip and palate (CLP) represents the most common malformation of the midfacial region worldwide. It can be suggested that the facial stigmatization, the speech impediment, and the long-standing pressure of treatment cause a range of life stressors. Neurocortical information is influenced by physiological and psychological factors and varies significantly in patients suffering from chronic stress, anxiety, depression, or other psychopathological conditions following maladaptation. The aims of the present study were to investigate the neurocortical information processing of patients with CLP using the contingent negative variation (CNV) paradigm and to evaluate secondary psychopathology, anxiety, and depression. MATERIALS AND METHODS:Twenty-five adults with CLP and 25 healthy volunteers, matched in age and gender, were investigated using recordings of the CNV. Initial CNV (iCNV), late CNV (lCNV), and total CNV (tCNV) as well as habituation slope of the iCNV were determined in each subject. Additionally, each participant had to complete the hospital anxiety and depression questionnaire (HADS) and the Symptom Checklist-90-R (SCL-90-R). RESULTS:Individuals with CLP did not differ significantly from healthy subjects according to any of the CNV parameters investigated. No correlations could be revealed between the measured items and the confounding factors age and gender. Additionally, there were no differences between the groups regarding depression and SCL-90-R; however, anxiety showed significant group differences on a subclinical level. CONCLUSIONS:These data suggest that subjects with CLP show normal neurocortical information processing. It seems likely that CLP and its treatment have no impact on psychosocial functioning and neurophysiological mechanisms of attention. CLINICAL RELEVANCE:The specific living conditions of patients with CLP do not result in disease-specific neurophysiological changes.
journal_name
Clin Oral Investigjournal_title
Clinical oral investigationsauthors
Gassling V,Receveur K,Niederberger U,Koos B,Overath CH,Birkenfeld F,Wiltfang J,Gerber WD,Siniatchkin Mdoi
10.1007/s00784-015-1465-9subject
Has Abstractpub_date
2016-01-01 00:00:00pages
23-30issue
1eissn
1432-6981issn
1436-3771pii
10.1007/s00784-015-1465-9journal_volume
20pub_type
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