Brachial Artery Flow Mediated Dilation in the First Trimester to Predict the Occurrence of Hypertensive Disorders during Pregnancy.

Abstract:

OBJECTIVES:To determine whether brachial artery flow-mediated dilation (FMD) assessed by ultrasonography during the late first trimester is able to predict the occurrence of hypertensive disorders during pregnancy. METHODS:Maternal endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery in 487 pregnant women at 11-13(+6) weeks' gestation. Subjects were prospectively followed and grouped according to the outcomes related to hypertensive disorders. We determined the areas under receiver operating characteristic (ROC) curve with their respective 95% confidence intervals (CI) for using low FMD results to predict the occurrence of hypertensive disorders during pregnancy. RESULTS:Among 487 women, 9 (1.8%) were diagnosed with early-onset preeclampsia, 22 (4.5%) were diagnosed with late-onset preeclampsia, 47 (9.7%) developed gestational hypertension, and the remaining 409 (84%) pregnancies were unaffected by hypertensive disorders. Area under ROC curve analyses demonstrated that FMD was not able to predict pregnancies that developed hypertensive disorders. CONCLUSIONS:We conclude that FMD should not be considered a potential first-trimester marker of hypertensive disorders during pregnancy.

journal_name

Fetal Diagn Ther

authors

Alves JA,Miyague AH,de Sousa PC,Maia SB,Costa Fda S,Martins WP

doi

10.1159/000366059

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

316-20

issue

4

eissn

1015-3837

issn

1421-9964

pii

000366059

journal_volume

37

pub_type

杂志文章
  • Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes.

    abstract:BACKGROUND:To improve neonatal outcomes in pregnancies at heightened risk for early-onset neonatal sepsis (EONS), there is a need to identify fetuses that benefit from expectant management as opposed to early delivery. Detectable haptoglobin and haptoglobin-related protein (Hp&HpRP switch-on status) in cord blood has b...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000450997

    authors: Archabald KL,Buhimschi IA,Bahtiyar MO,Dulay AT,Abdel-Razeq SS,Pettker CM,Lipkind HS,Hardy JT,McCarthy ME,Zhao G,Bhandari V,Buhimschi CS

    更新日期:2017-01-01 00:00:00

  • Does intervention in utero preserve the obstructed kidneys of fetal lambs? A radiological and pathological study.

    abstract:OBJECTIVE:Ureteropelvic junction obstruction is a common cause of end-stage pediatric nephropathy. Our aim was to investigate whether in utero decompression can influence its development. METHODS:A silastic tube was tied around the superior segment of the left ureter to cause partial unilateral obstruction in 22 fetal...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000320966

    authors: Sun J,Wang F,Deng G,Mo J

    更新日期:2010-01-01 00:00:00

  • Levels of maternal serum angiogenic factors in third-trimester normal pregnancies: reference ranges, influence of maternal and pregnancy factors and fetoplacental Doppler indices.

    abstract:AIM:To establish normal ranges of maternal placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PlGF ratio at 32-41 weeks' gestation and to evaluate the influence of maternal characteristics, and of fetoplacental Doppler. MATERIAL AND METHODS:Serum levels of PlGF, sFlt-1 and sFlt-1/Pl...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000360078

    authors: Lobmaier SM,Figueras F,Mercade I,Crovetto F,Peguero A,Parra-Saavedra M,Ortiz JU,Crispi F,Gratacós E

    更新日期:2014-01-01 00:00:00

  • Rate and Outcomes of Pulmonary Stenosis and Functional Pulmonary Atresia in Recipient Twins with Twin-Twin Transfusion Syndrome.

    abstract:OBJECTIVE:To evaluate the rate of pulmonary stenosis and functional pulmonary atresia (PS/PA) in recipient twins prior to fetal surgery for twin-twin transfusion syndrome (TTTS) and their pre- and postnatal outcomes. METHODS:We carried out a prospective study including 260 cases of TTTS. Echocardiography was performed...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000448075

    authors: Ortiz JU,Masoller N,Gómez O,Bennasar M,Eixarch E,Lobmaier SM,Crispi F,Gratacos E,Martinez JM

    更新日期:2017-01-01 00:00:00

  • Decompression of fetal axillary lymphangioma to prevent dystocia.

    abstract:BACKGROUND:Lymphangiomas are commonly diagnosed by prenatal ultrasound. These anomalies are most often cervical, but occasionally present in the axilla, thorax and abdomen. We present a case in which intrauterine drainage was followed by an uneventful vaginal delivery. CASE:A 30-year-old G4P3 female was referred to ou...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264305

    authors: Kaufman GE,D'Alton ME,Crombleholme TM

    更新日期:1996-05-01 00:00:00

  • Amiodarone in treatment of fetal supraventricular tachycardia. A case report and review of literature.

    abstract::We report a case of nonimmune hydrops fetalis detected at 32 weeks of gestation. Fetal heart rate was 300 beats per minute. Ultrasound and fetal Doppler echocardiography showed it to be due to supraventricular tachycardia (SVT). Following failed maternal therapy with digoxin alone, amiodarone with digoxin was used. Co...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000089052

    authors: Pradhan M,Manisha M,Singh R,Kapoor A

    更新日期:2006-01-01 00:00:00

  • Prenatal diagnosis, phenotypic and obstetric characteristics of holoprosencephaly.

    abstract::The diagnosis of fetal malformations, especially those of the central nervous system, is strikingly important in the practice of genetic counseling. Early diagnosis is very significant, not only because of the prognosis, but also because of the emotional effects caused by the accompanying craniofacial malformations. T...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000083897

    authors: Joó GJ,Beke A,Papp C,Tóth-Pál E,Szigeti Z,Bán Z,Papp Z

    更新日期:2005-05-01 00:00:00

  • Monozygotic twinning as a congenital defect and congenital defects in monozygotic twins.

    abstract::The process of monozygotic twinning in animals and humans is presented. In addition, congenital defects in monozygotic twins versus dizygotic twins and singletons is discussed. Overall, the rates of congenital anomalies are higher among whites as compared to blacks, males as compared to females, and multiples as compa...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000263545

    authors: Luke B,Keith LG

    更新日期:1990-01-01 00:00:00

  • Neonatal leukemoid reaction and early development of bronchopulmonary dysplasia in a very low-birth-weight infant.

    abstract::The factors controlling the recruitment of inflammatory cells and the activation of the cytokine cascade in low-birth-weight premature infants have been implicated in the sequence of multiorgan inflammatory diseases, including the chronic lung disease of prematurity, bronchopulmonary dysplasia. This article describes ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000053900

    authors: Zanardo V,Magarotto M,Rosolen A

    更新日期:2001-05-01 00:00:00

  • Are amniotic fluid alpha-fetoprotein levels influenced by the gender in twin pairs?

    abstract:OBJECTIVES:To examine the assumption that amniotic fluid alpha-fetoprotein (AFAFP) levels are different in female and male twin fetuses. DESIGN:Amniotic fluid levels of AFP in pregnancies with female and male fetuses in gender-concordant and gender-discordant twins were compared. A t test of p < 0.05 was considered si...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000071015

    authors: Sharony R,Drugan A,Amiel A,Grinshpun-Cohen J,Markov S,Fejgin MD

    更新日期:2003-07-01 00:00:00

  • The role of homeobox genes in the development of placental insufficiency.

    abstract::Intrauterine growth restriction (IUGR) is an adverse pregnancy outcome associated with significant perinatal and pediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. While a number of maternal, fetal and environmental factors are known causes of IUGR, the majority of IUGR ca...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000339657

    authors: Murthi P,Kalionis B,Rajaraman G,Keogh RJ,Da Silva Costa F

    更新日期:2012-01-01 00:00:00

  • Think of the Conus Medullaris at the Time of Diagnosis of Fetal Sacral Agenesis.

    abstract:BACKGROUND:There is no precise prenatal indicator to refine an accurate prognosis in case of sacral agenesis and to define the diagnostic approach and outcome criteria in case of fetal sacral agenesis using 3 characteristics of the conus medullaris (CM): its position, its appearance, and associated spinal abnormalities...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000451080

    authors: Mottet N,Martinovic J,Baeza C,Guimiot F,Bault JP,Aubry MC,Riethmuller D,Zerah M,Cretolle C,Benachi A

    更新日期:2017-01-01 00:00:00

  • Early Intrauterine Transfusion in Fetuses with Severe Anemia Caused by Parvovirus B19 Infection.

    abstract:OBJECTIVE:To describe procedure-related complications and perinatal survival after intrauterine transfusion (IUT) before 20 weeks of gestation in fetuses with severe anemia due to human parvovirus B19 infection. MATERIALS AND METHODS:A retrospective study was conducted of all fetuses requiring IUT before 20 weeks of g...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000477208

    authors: Hellmund A,Geipel A,Berg C,Bald R,Gembruch U

    更新日期:2018-01-01 00:00:00

  • First-trimester diagnosis of sirenomelia. A case report.

    abstract::We report a case of sirenomelia diagnosed at 13 gestational weeks. This rare malformation sequence is characterized by fusion and rotation of the lower limbs to various degrees and anorectal atresia, usually associated with absence of bladder and agenesis or dysgenesis of the kidneys. Diagnosis is commonly made later ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000053929

    authors: Carbillon L,Seince N,Largillière C,Bucourt M,Uzan M

    更新日期:2001-09-01 00:00:00

  • Prenatal diagnosis of X-linked ichthyosis using molecular cytogenetics.

    abstract::A case is presented in which X-linked ichthyosis was diagnosed prenatally using fluorescence in situ hybridization. Fetal sex was known by second trimester ultrasound in a woman with very low second trimester MSUE3. All of the 15 maternal peripheral blood metaphase spreads examined displayed two hybridization signals ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264422

    authors: Santolaya-Forgas J,Cohen L,Vengalil S,Field F,Rodriguez A,McCorquadale M,McCorquadale DJ

    更新日期:1997-01-01 00:00:00

  • Calprotectin in Serially Collected Meconium Portions as a Biomarker for Intrauterine Fetal Environment.

    abstract:OBJECTIVE:Understanding the pathomechanisms underlying high meconium calprotectin concentrations is the key to the potential uses of this parameter for the assessment of the intrauterine environment in which the fetus develops. The aim of this study was to measure calprotectin concentrations in serial meconium portions...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000472150

    authors: Lisowska-Myjak B,Skarżyńska E,Żytyńska-Daniluk J

    更新日期:2018-01-01 00:00:00

  • Multifetal pregnancies: evolution of methods of initiation and impact of REI certification for patients seeking reduction.

    abstract:OBJECTIVE:Multifetal pregnancy as a result of ovulation induction (OI) and assisted reproductive technologies (ART) correlate with Board certification in reproductive endocrinology and infertility (REI). DESIGN:Retrospective chart analysis of 304 patients referred to Wayne State University (WSU) and Thomas Jefferson U...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000068550

    authors: Calhoun B,Evans MI,Krivchenia EL,Waters T,Urban AJ,Morgan P,Hume RF,Wapner RJ

    更新日期:2003-03-01 00:00:00

  • Perinatal outcome of monochorionic twins with selective intrauterine growth restriction and different types of umbilical artery Doppler under expectant management.

    abstract:OBJECTIVES:To evaluate the prognosis of monochorionic twins with selective intrauterine growth restriction (sIUGR), classified according to the type of umbilical artery Doppler, under expectant management. METHODS:The outcome of 81 cases with isolated sIUGR was evaluated according to a classification based on umbilica...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000253880

    authors: Ishii K,Murakoshi T,Takahashi Y,Shinno T,Matsushita M,Naruse H,Torii Y,Sumie M,Nakata M

    更新日期:2009-01-01 00:00:00

  • History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experience.

    abstract::Since its inception in 1995, the mission of the Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia (CHOP) has been to provide comprehensive, multidisciplinary expertise in all facets of prenatal diagnosis, reproductive genetics, and prenatal, perinatal, and postnatal treatment for abno...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000068075

    authors: Hedrick HL,Flake AW,Crombleholme TM,Howell LJ,Johnson MP,Wilson RD,Adzick NS

    更新日期:2003-03-01 00:00:00

  • Fetal pulse oximetry during labor of 62 patients.

    abstract::The objectives of the study were to assess the ability of a fetal pulse oximeter to measure the fetal oxygen saturation (SPO2) continuously during labor and to assess the correlation between readings of fetal pulse oximetry and cord blood gases at birth. The Nellcor N-400 Fetal Oximeter was used in 62 women prospectiv...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264277

    authors: Langer B,Boudier E,Haddad J,Pain L,Schlaeder G

    更新日期:1996-01-01 00:00:00

  • Screening of fetal stem cells for infection and cytogenetic abnormalities.

    abstract::Fetal stem cell transplantation may rely on material from therapeutic abortions. It is essential that the stem cell transplant does not transmit any microorganisms that may affect the fetus and that genetically abnormal cells are avoided. To evaluate such contamination, human fetal stem cells collected February 1992 -...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264065

    authors: Ek S,Westgren M,Pschera H,Seiger A,Sundström E,Bui TH,Ringdén O

    更新日期:1994-11-01 00:00:00

  • Maternal mortality following diagnostic 2nd-trimester amniocentesis.

    abstract::We present 2 cases of maternal mortality after transabdominal amniocentesis performed during the 2nd trimester of pregnancy. In both these cases, blood cultures revealed Escherichia coli. Broad-spectrum intravenous antibiotic treatment started immediately after admission to the hospital did not change the rapid progre...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000075150

    authors: Elchalal U,Shachar IB,Peleg D,Schenker JG

    更新日期:2004-03-01 00:00:00

  • Antibodies to trophoblast antigens HLA-G, placenta growth factor, and neuroD2 do not improve detection of circulating trophoblast cells in maternal blood.

    abstract:OBJECTIVES:Non-invasive prenatal diagnosis using circulating fetal trophoblast cells has been challenging due to lack of a reproducible trophoblast-specific antibody. We investigated the use of three trophoblast cell-specific antibodies, HLA-G, placenta growth factor, and neuroD2, for the isolation of trophoblast cells...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000097102

    authors: Tjoa ML,Delli-Bovi L,Johnson KL,Bianchi DW

    更新日期:2007-01-01 00:00:00

  • Plasma cysteine concentrations in uncomplicated pregnancies.

    abstract:OBJECTIVE:To measure levels of total plasma cysteine, homocysteine, cysteinylglycine and glutathione of normotensive primiparous pregnant women in the second and the third trimester. METHODS:Two consecutive blood samples were taken from 65 healthy primiparous women in the 19th to 21st weeks of pregnancy and then in th...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000100785

    authors: Viskova H,Vesela K,Janosikova B,Krijt J,Visek JA,Calda P

    更新日期:2007-01-01 00:00:00

  • A comparison of two immunoassay methods for the measurement of maternal serum placental growth factor in early pregnancy.

    abstract:OBJECTIVES:To compare the DELFIA Xpress and Quantikine ELISA placental growth factor (PlGF) immunoassay platforms by analysing the same set of early first-trimester maternal serum samples from cases with trisomy 21 and euploid controls. METHODS:Thirty-seven trisomy 21 cases and 243 euploid control serum samples, drawn...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000336661

    authors: Cowans NJ,Kisanga M,Khan A,Spencer K

    更新日期:2012-01-01 00:00:00

  • Evaluation of First-Trimester Physiological Midgut Herniation Using Three-Dimensional Ultrasound.

    abstract:INTRODUCTION:The aim of this study was to investigate the development of midgut herniation in vivo using three-dimensional (3D) ultrasonographic volume and distance measurements and to create reference data for physiological midgut herniation in ongoing pregnancies in a tertiary hospital population. MATERIALS AND METH...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000489260

    authors: Bogers H,Baken L,Cohen-Overbeek TE,Koning AHJ,Willemsen SP,van der Spek PJ,Exalto N,Steegers EAP

    更新日期:2019-01-01 00:00:00

  • Screening for placental insufficiency by transvaginal uterine artery Doppler at 22-24 weeks of gestation.

    abstract:OBJECTIVE:To determine the value of routine transvaginal color Doppler assessment of the uterine arteries at 22-24 weeks of gestation in the prediction of placental insufficiency. METHODS:Women with singleton pregnancies scheduled for routine ultrasound scans at 22-24 weeks were offered Doppler assessment of the uteri...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000178141

    authors: Palma-Dias RS,Fonseca MM,Brietzke E,Fritsch A,Schlatter D,Maurmann CB,Stein NR,Magalhães JA

    更新日期:2008-01-01 00:00:00

  • Incidence and Causes of Intentional Fetal or Neonatal Demise in Twin-Twin Transfusion Syndrome.

    abstract:INTRODUCTION:The aim of this study is to evaluate the incidence and causes of intentional fetal and neonatal demise in twin-twin transfusion syndrome (TTTS). MATERIAL AND METHODS:All TTTS pregnancies managed at our centre between 2000 and 2014 were included. We evaluated incidence and causes of intentional fetal/neona...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000461580

    authors: Spruijt MS,Tameeris E,Zhao DP,Middeldorp JM,Haak MC,Oepkes D,Lopriore E

    更新日期:2018-01-01 00:00:00

  • Uterine artery pulsatility index assessment at 11-13 weeks' gestation.

    abstract:INTRODUCTION:First-trimester uterine artery pulsatility index (PI) measurements form part of an algorithm used to assess the risk of developing pre-eclampsia. The objective of this study was to construct a population-specific reference range for both the lower and mean maternal uterine artery PI at 11-13(+6) weeks' ges...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000361021

    authors: Ridding G,Schluter PJ,Hyett JA,McLennan AC

    更新日期:2014-01-01 00:00:00

  • Alcohol injection for the intrauterine treatment of chorioangioma in a pregnancy with transfusion resistant fetal anemia: a case report.

    abstract::Chorioangiomas are usually small, clinically inevident, benign vascular lesions of the placenta, but larger ones may cause serious perinatal and neonatal complications. There is need for in utero intervention in these fetuses. Several interventions are described to relieve pathophysiologic insult on fetus. Alcohol inj...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000098718

    authors: Deren O,Ozyuncu O,Onderoglu LS,Durukan T

    更新日期:2007-01-01 00:00:00