Calprotectin in Serially Collected Meconium Portions as a Biomarker for Intrauterine Fetal Environment.


OBJECTIVE:Understanding the pathomechanisms underlying high meconium calprotectin concentrations is the key to the potential uses of this parameter for the assessment of the intrauterine environment in which the fetus develops. The aim of this study was to measure calprotectin concentrations in serial meconium portions passed after birth and to calculate the individual variations in the total meconium calprotectin content accumulated during gestation. METHODS:Calprotectin concentrations were measured using Calprotectin ELISA kit (Immundiagnostik AG) in all meconium portions (n = 81) from 20 healthy neonates. For each neonate, total meconium calprotectin was calculated, reflecting the sum of calprotectin content in all meconium portions from this neonate. RESULTS:The calprotectin concentration in meconium was (mean ± SD) 286.5 ± 214.6 μg/g (range 34.7-1,067.1). Calprotectin concentrations in the last portions passed were nearly 3-fold higher than in the first portions (p = 0.0004). The total individual calprotectin content of (mean ± SD) 3,668.7 ± 1,819.0 μg (range 1,158.9-8,155.5) was related to the birth weight (r = 0.46, p = 0.042). CONCLUSIONS:Wide intra- and interindividual differences in calprotectin concentrations in the meconium may reflect intestinal inflammation associated with the fetal adaptation to life outside the uterus. Calprotectin may serve as a biomarker useful for the identification of endogenous and exogenous factors with impact on the intrauterine environment.


Fetal Diagn Ther


Lisowska-Myjak B,Skarżyńska E,Żytyńska-Daniluk J




Has Abstract


2018-01-01 00:00:00














  • Non-invasive fetal RHD exon 7 and exon 10 genotyping using real-time PCR testing of fetal DNA in maternal plasma.

    abstract:OBJECTIVE:In this prospective study, we assessed the feasibility of foetal RHD genotyping by analysis of DNA extracted from plasma samples of Rhesus (Rh) D-negative pregnant women using real-time PCR and primers and probes targeted toward exon 7 and 10 of RHD gene. METHODS:We analysed 24 RhD-negative pregnant woman an...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Hromadnikova I,Vechetova L,Vesela K,Benesova B,Doucha J,Kulovany E,Vlk R

    更新日期:2005-07-01 00:00:00

  • Prenatally diagnosed ectrodactyly at 16 weeks' gestation by 2- and 3-dimensional ultrasonography: a case report.

    abstract:OBJECTIVE:Ectrodactyly is a rare malformation with various presentations. The current report describes a case of ectrodactyly detected using 2-dimensional (2D) and 3-dimensional (3D) ultrasonography at 16 weeks' gestation. METHODS AND RESULTS:The 2D ultrasonographic findings were ectrodactyly in the right hand and mon...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Koo BS,Baek SJ,Kim MR,Joo WD,Yoo HJ

    更新日期:2008-01-01 00:00:00

  • Understanding the Parent Perspective on Prenatal Consultation for Fetuses with Congenital Anomalies.

    abstract:INTRODUCTION:An increasing number of congenital anomalies are diagnosed prenatally. Understanding the implications of these diagnoses on the life of their child is critical for parents, and the surgical consultation is often the primary venue for this education. Little is known about the parent perspective on prenatal ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Berman L,Costanzo C,Smola S,Taggi-Pinto A,Luks FL

    更新日期:2018-01-01 00:00:00

  • Screening for placental insufficiency by transvaginal uterine artery Doppler at 22-24 weeks of gestation.

    abstract:OBJECTIVE:To determine the value of routine transvaginal color Doppler assessment of the uterine arteries at 22-24 weeks of gestation in the prediction of placental insufficiency. METHODS:Women with singleton pregnancies scheduled for routine ultrasound scans at 22-24 weeks were offered Doppler assessment of the uteri...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章


    authors: Palma-Dias RS,Fonseca MM,Brietzke E,Fritsch A,Schlatter D,Maurmann CB,Stein NR,Magalhães JA

    更新日期:2008-01-01 00:00:00

  • Three-dimensional magnetic resonance imaging of the postmortem fetal heart.

    abstract::Five postmortem fetuses were scanned by magnetic resonance (MR) imaging. Of eight three-dimensional (3D) data sets reconstructed on an MGI workstation, five sets demonstrated detailed 3D fetal cardiac structures, and one depicted clear information regarding the disposition and compression of the heart and lungs in dia...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Deng J,Brookes JA,Gardener JE,Rodeck CH,Lees WR

    更新日期:1996-11-01 00:00:00

  • Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review.

    abstract::Fetal dextrocardia is a type of cardiac malposition where the major axis from base to apex points to the right side. This condition is usually associated with a wide spectrum of complex cardiac defects. As a result, dextrocardia is conceptually difficult to understand and diagnose on prenatal ultrasound. The advantage...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审


    authors: Yeo L,Luewan S,Markush D,Gill N,Romero R

    更新日期:2018-01-01 00:00:00

  • Increased nuchal translucency in a case of long-chain 3-hydroxyacyl- coenzyme A dehydrogenase deficiency.

    abstract::We present a case where the embryo showed an increased nuchal edema and a metabolic disorder. At 31 weeks of gestation the fetus developed a cardiomegaly and a hydrops. In this case, a long-chain 3-hydroxacyl-coenzyme A dehydrogenase deficiency (LCHAD deficiency) was confirmed by biochemical investigations in cultured...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Tercanli S,Uyanik G,Hösli I,Cagdas A,Holzgreve W

    更新日期:2000-11-01 00:00:00

  • Demonstration of the Pericallosal Artery at 11-13 Weeks of Gestation Using 3D Ultrasound.

    abstract:OBJECTIVE:To assess the sonographic visualization of the pericallosal arteries in normal fetuses at 11-13 weeks of gestation using 3D ultrasound. METHODS:We prospectively enrolled women with a singleton pregnancy undergoing ultrasound at 11-13 weeks of gestation. A 3D volume with high-definition power Doppler was acqu...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Conturso R,Contro E,Bellussi F,Youssef A,Pacella G,Martelli F,Rizzo N,Pilu G,Ghi T

    更新日期:2015-01-01 00:00:00

  • Hemimegalencephaly: 2D, 3D Ultrasound and MRI Correlation.

    abstract:BACKGROUND:Hemimegalencephaly (HMC) is a disorder associated with enlarged and dysplastic hamartomatous overgrowth of all or part of the one cerebral hemisphere that can be isolated or associated with other syndromes. In the normal development of the brain it is important to bear in mind that there are two main process...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Romero XC,Molina FS,Pastor E,Amaya F

    更新日期:2011-01-01 00:00:00

  • Fetal heart disease: severity, associated anomalies and parental decision.

    abstract:OBJECTIVE:This study describes the association between the complexity of congenital cardiac and extracardiac malformations, and the parental decision of pregnancy continuation or termination. METHODS:Congenital heart defects (CHD) was diagnosed by ultrasound in 251 fetuses before the 24th week (23 + 6 weeks) of gestat...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Nell S,Wijngaarde CA,Pistorius LR,Slieker M,ter Heide H,Manten GT,Freund MW

    更新日期:2013-01-01 00:00:00

  • Fetal pulse oximetry during labor of 62 patients.

    abstract::The objectives of the study were to assess the ability of a fetal pulse oximeter to measure the fetal oxygen saturation (SPO2) continuously during labor and to assess the correlation between readings of fetal pulse oximetry and cord blood gases at birth. The Nellcor N-400 Fetal Oximeter was used in 62 women prospectiv...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Langer B,Boudier E,Haddad J,Pain L,Schlaeder G

    更新日期:1996-01-01 00:00:00

  • Maternal plasma and amniotic fluid cytokines in monochorionic, diamniotic twin pregnancies complicated by twin-to-twin transfusion syndrome.

    abstract:INTRODUCTION:Cytokine imbalance has been implicated in placental-related pathologies, i.e. recurrent miscarriage and pre-eclampsia. Such conditions are more prevalent in multiple pregnancies. Twin-to-twin transfusion syndrome (TTTS) is associated with asymmetric placental blood flow and intra-cardiac pressures. We hypo...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Fox CE,Lash GE,Pretlove SJ,Chan BC,Holder R,Kilby MD

    更新日期:2014-01-01 00:00:00

  • Prenatal diagnosis of vein of Galen aneurysmal malformations.

    abstract::Vein of Galen aneurysmal malformations are rarely seen intracranial malformations. They represent less than 1% of the cerebral arteriovenous malformations. Prenatal diagnosis of an arteriovenous fistula malformation may be achieved by real-time and Doppler sonography with color flow imaging, by identifying dilated vei...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Paternoster DM,Manganelli F,Moroder W,Nicolini U

    更新日期:2003-11-01 00:00:00

  • A study to determine if human umbilical cord hematopoietic stem cells can survive in baboon extra-embryonic celomic fluid: a prerequisite for determining the feasibility of in-utero stem cell xeno-transplantation via celocentesis.

    abstract:OBJECTIVES:To determine if: (1) human umbilical cord stem cells could survive for 20 h in extra-embryonic celomic fluid obtained at 40 days of development from baboon pregnancies by ultrasound-guided celocentesis and, (2) human hematopoietic stem cell survival could be enhanced by adding increasing concentrations of he...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Santolaya-Forgas J,Galan I,Deleon-Luis J,Wolf R

    更新日期:2007-01-01 00:00:00

  • Detection of DeltaF508del using quantitative real-time PCR, comparison of the results obtained by fluorescent PCR.

    abstract:OBJECTIVE:Cystic fibrosis (CF) is the most common autosomal recessive genetic disorder in the Caucasian population. The molecular diagnosis is difficult since there are about 1,000 mutations in the CF transmembrane regulator gene. The DeltaF508del is the cause of the CF in 64% of the cases in Hungary. Our aim was to co...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Nagy B,Nagy GR,Lázár L,Bán Z,Papp Z

    更新日期:2007-01-01 00:00:00

  • Severity of Fetal Brain Abnormalities in Congenital Heart Disease in Relation to the Main Expected Pattern of in utero Brain Blood Supply.

    abstract:OBJECTIVES:We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between the expected pattern of in utero brain blood supply and the severity of neurodevelopmental impairment. METHODS:A total of 58 fetuses with CHD and 58 controls underwent a Doppler ultrasound and feta...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Masoller N,Sanz-Cortés M,Crispi F,Gómez O,Bennasar M,Egaña-Ugrinovic G,Bargalló N,Martínez JM,Gratacós E

    更新日期:2016-01-01 00:00:00

  • Lentiviral-mediated fetal gene therapy for monogenic disorders: development of an in vitro rabbit model.

    abstract:OBJECTIVE:Fetal gene replacement is a novel, potential therapy for monogenic disorders which are diagnosed prenatally. The purpose of this study was to develop in vitro, respiratory-epithelium targeted, lentiviral (LV)-mediated gene transfer in fetal rabbit tracheas. METHODS:Via triple plasmid transfection, vesicular ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Huang L,Reebye SC,Yeung AY,Jia WW,Skarsgard ED

    更新日期:2006-01-01 00:00:00

  • Supernumerary ring chromosome: an etiology for Pallister-Killian syndrome?

    abstract::Characterization of marker chromosomes before the introduction of array CGH (aCGH) assays was only based on their banding patterns (G, C, and NOR staining) and fluorescent in situ hybridization techniques. The use of aCGH greatly improves the identification of marker chromosomes in some cases. We describe an atypical ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Lloveras E,Canellas A,Cirigliano V,Català V,Cerdan C,Plaja A

    更新日期:2013-01-01 00:00:00

  • Fetal parvovirus B19 infection and meconium peritonitis.

    abstract::A 33-year-old primigravida at 26 weeks gestation presented with fetal hydrops and fetal anemia following prior parvovirus B19 infection. The fetus required two intrauterine transfusions of packed red cells. At 35 weeks gestation, a cesarean section was performed for obstetric reasons. As a consequence of a prenatal bo...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Schild RL,Plath H,Thomas P,Schulte-Wissermann H,Eis-Hübinger AM,Hansmann M

    更新日期:1998-01-01 00:00:00

  • Perinatal outcome of monochorionic twins with selective intrauterine growth restriction and different types of umbilical artery Doppler under expectant management.

    abstract:OBJECTIVES:To evaluate the prognosis of monochorionic twins with selective intrauterine growth restriction (sIUGR), classified according to the type of umbilical artery Doppler, under expectant management. METHODS:The outcome of 81 cases with isolated sIUGR was evaluated according to a classification based on umbilica...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Ishii K,Murakoshi T,Takahashi Y,Shinno T,Matsushita M,Naruse H,Torii Y,Sumie M,Nakata M

    更新日期:2009-01-01 00:00:00

  • Amnioinfusion with Hartmann's solution: a safe distention medium for endoscopic fetal surgery in the ovine model.

    abstract::In this study, we have investigated the maternal effects of distending the uterine cavity with Hartmann's solution in 2nd trimester equivalent pregnant sheep. In 7 pregnant ewes, double endoscopic cannulation of the amniotic cavity was performed under general anesthesia, and 1 liter of Hartmann's solution at 38 degree...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Evrard VA,Verbeke K,Peers KH,Luks FI,Lerut AE,Vandenberghe K,Deprest JA

    更新日期:1997-05-01 00:00:00

  • Preterm premature rupture of membranes in a patient with the hypermobility type of the Ehlers-Danlos syndrome. A case report.

    abstract:OBJECTIVES:This report wants to focus on the risk of severe prematurity in patients with the hypermobility type of the Ehlers-Danlos syndrome (EDS), a heritable disorder of connective tissue. Although various obstetrical complications have been reported in patients with EDS, most reports specifically comment on the sev...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: De Vos M,Nuytinck L,Verellen C,De Paepe A

    更新日期:1999-07-01 00:00:00

  • Leiden mutation, bed rest and infection: simultaneous triggers for maternal deep-vein thrombosis and neonatal intracranial hemorrhage?

    abstract::The possible etiologic roles of infection and bed rest are discussed in connection with a case of maternal homozygous Leiden mutation leading to prematurity, maternal deep-vein thrombosis and neonatal intracranial hemorrhage in a heterozygous premature baby. Maternal bacterial infection and bed rest may trigger deep-v...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Sikovanyecz J,Orvos H,Pál A,Katona M,Endreffy E,Horváth E,Szabó J

    更新日期:2004-05-01 00:00:00

  • Mathematical models for fetal growth: application for biparietal diameter measurement.

    abstract::Evaluation of the adequacy of fetal growth by measurements of fetal size required theoretical formulae for the assessment of present size from previous measurements. The various models presented in the literature assume the same mathematical formula for the whole pregnancy. In this study, a model of different polynomi...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Nitzan M,Tadmor OP,Skomorowski Y,Rabinowitz R,Diamant Y

    更新日期:1994-09-01 00:00:00

  • Prenatal diagnosis for Schmid metaphyseal chondrodysplasia in twins.

    abstract::We report prenatal diagnostic studies for metaphyseal chondrodysplasia of the Schmid type. Identification of a specific COL10A1 gene mutation in an affected father allowed prenatal diagnosis by chorionic villus sampling in a twin pregnancy. Neither of the nonidentical twins received the abnormal COL10A1 gene from thei...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Milunsky J,Maher T,Lebo R,Milunsky A

    更新日期:1998-05-01 00:00:00

  • First-trimester diagnosis of sirenomelia. A case report.

    abstract::We report a case of sirenomelia diagnosed at 13 gestational weeks. This rare malformation sequence is characterized by fusion and rotation of the lower limbs to various degrees and anorectal atresia, usually associated with absence of bladder and agenesis or dysgenesis of the kidneys. Diagnosis is commonly made later ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审


    authors: Carbillon L,Seince N,Largillière C,Bucourt M,Uzan M

    更新日期:2001-09-01 00:00:00

  • The influence of smoking and parity on serum markers for Down's syndrome screening.

    abstract:OBJECTIVE:To evaluate the impact of smoking and number of previous births on maternal serum levels of alpha-fetoprotein and free beta-subunit of human chorionic gonadotropin (free beta-hCG). METHODS:The study included 3,252 completed unaffected singleton pregnancies that proceeded beyond 37 weeks' gestation and result...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Tislarić D,Brajenović-Milić B,Ristić S,Latin V,Zuvić-Butorac M,Bacić J,Petek M,Kapović M

    更新日期:2002-01-01 00:00:00

  • Rate and Outcomes of Pulmonary Stenosis and Functional Pulmonary Atresia in Recipient Twins with Twin-Twin Transfusion Syndrome.

    abstract:OBJECTIVE:To evaluate the rate of pulmonary stenosis and functional pulmonary atresia (PS/PA) in recipient twins prior to fetal surgery for twin-twin transfusion syndrome (TTTS) and their pre- and postnatal outcomes. METHODS:We carried out a prospective study including 260 cases of TTTS. Echocardiography was performed...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Ortiz JU,Masoller N,Gómez O,Bennasar M,Eixarch E,Lobmaier SM,Crispi F,Gratacos E,Martinez JM

    更新日期:2017-01-01 00:00:00

  • Early Intrauterine Transfusion in Fetuses with Severe Anemia Caused by Parvovirus B19 Infection.

    abstract:OBJECTIVE:To describe procedure-related complications and perinatal survival after intrauterine transfusion (IUT) before 20 weeks of gestation in fetuses with severe anemia due to human parvovirus B19 infection. MATERIALS AND METHODS:A retrospective study was conducted of all fetuses requiring IUT before 20 weeks of g...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,多中心研究


    authors: Hellmund A,Geipel A,Berg C,Bald R,Gembruch U

    更新日期:2018-01-01 00:00:00

  • Angiogenic Gene Expression in Down Syndrome Fetal Hearts.

    abstract:INTRODUCTION:Forty percent of Down syndrome (DS) fetuses have congenital heart defects (CHD). An abnormal angiogenic environment has been described in euploid fetuses with CHD. However, the underlying pathophysiologic pathway that contributes to CHD in DS remains unknown. The objective was to compare the expression of ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章


    authors: Sánchez O,Domínguez C,Ruiz A,Ribera I,Alijotas J,Cabero L,Carreras E,Llurba E

    更新日期:2016-01-01 00:00:00