A comparison of two immunoassay methods for the measurement of maternal serum placental growth factor in early pregnancy.

Abstract:

OBJECTIVES:To compare the DELFIA Xpress and Quantikine ELISA placental growth factor (PlGF) immunoassay platforms by analysing the same set of early first-trimester maternal serum samples from cases with trisomy 21 and euploid controls. METHODS:Thirty-seven trisomy 21 cases and 243 euploid control serum samples, drawn at 8(+0) to 10(+6) weeks of gestation, were reanalysed by Quantikine PlGF ELISA following original analysis on the DELFIA Xpress platform. RESULTS:PlGF levels increased with gestation in the euploid controls when measured on both platforms, although raw levels were in general lower on the DELFIA Xpress. After conversion to multiples of the median (MoMs), PlGF was increased in trisomy 21 cases when measured on the DELFIA Xpress platform (euploid: 1.00 MoM, trisomy 21: 1.32 MoM, p < 0.0001) but unchanged when measured on the Quantikine ELISA (euploid: 1.01 MoM, trisomy 21: 1.06 MoM, p = 0.84). CONCLUSIONS:Discrepancies exist in the measurement of PlGF when performed on these different platforms, which may to some extent contribute to the inconsistencies found in the literature with regard to PlGF in trisomy 21 pregnancies.

journal_name

Fetal Diagn Ther

authors

Cowans NJ,Kisanga M,Khan A,Spencer K

doi

10.1159/000336661

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

254-9

issue

4

eissn

1015-3837

issn

1421-9964

pii

000336661

journal_volume

31

pub_type

杂志文章
  • Obstetric evolution of pregnancies obtained from donated oocytes.

    abstract::Of 44 pregnancies obtained at the Tenon Maternity Hospital by in vitro fertilization (IVF) using donated oocytes, 25 have already been completed by spontaneous delivery or cesarean section: 22 (88%) single; 2 (8%) twins, and 1 (4%) triple. The most frequently seen complications of pregnancy were hypertension (16%) and...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263647

    authors: Cornet D,Antoine JM,Casanova S,Uzan S,Mandelbaum J,Plachot M,Salat-Baroux J

    更新日期:1992-01-01 00:00:00

  • Why cell culture is successful after early amniocentesis.

    abstract::The current interest in early amniocentesis as a possible alternative to chorion villus sampling has driven many centres to attempt cell culture from first trimester amniotic fluid. This study examines the cellular content of 125 amniotic fluid specimens collected between 8 and 18 weeks of gestation and shows that the...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263628

    authors: Byrne D,Azar G,Nicolaides K

    更新日期:1991-01-01 00:00:00

  • Screening for Sex Chromosome Aneuploidy by Cell-Free DNA Testing: Patient Choice and Performance.

    abstract:OBJECTIVE:To study patient choice regarding testing for sex chromosome aneuploidy (SCA) and the performance of cell-free DNA (cfDNA) screening for SCA. METHODS:Patient choice regarding screening for SCA and factors influencing this choice were evaluated in a single center. In a subsequent two-center study, cases that ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000479507

    authors: Bevilacqua E,Ordóñez E,Hurtado I,Rueda L,Mazzone E,Cirigliano V,Jani JC

    更新日期:2018-01-01 00:00:00

  • Sonographic screening for trisomy 21: fetal humerus:foot length ratio, a useful new marker.

    abstract::We have analyzed morphometric measurements from midgestational fetal necropsies and shown that arm and foot lengths are linear relationships versus gestational age (GA). Using foot length as the GA determinant, we found that the ratio of arm:foot length was also a linear relationship and was decreased in trisomy 21 fe...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000263920

    authors: Johnson MP,Michaelson JE,Barr M Jr,Treadwell MC,Isada NB,Dombrowski MP,Pryde PG,Addis J,Evans MI

    更新日期:1994-03-01 00:00:00

  • Prenatal diagnosis of a mixed type of total anomalous pulmonary venous return.

    abstract::Total anomalous pulmonary venous return (TAPVR) is a congenital heart malformation that can be diagnosed in the fetus by indirect indicators on an echocardiogram, such as inability to demonstrate the pulmonary veins returning to the left atrium by color Doppler, the presence of a chamber or the pulmonary venous conflu...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000279330

    authors: Cormier CM,Kramer LA,Gupta-Malhotra M

    更新日期:2010-01-01 00:00:00

  • Perinatal Outcome and Long-Term Neurodevelopment after Intracranial Haemorrhage due to Fetal and Neonatal Alloimmune Thrombocytopenia.

    abstract:OBJECTIVES:To evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. SUBJECTS AND METHODS:We performed an observational cohort study and ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000488280

    authors: Winkelhorst D,Kamphuis MM,Steggerda SJ,Rijken M,Oepkes D,Lopriore E,van Klink JMM

    更新日期:2019-01-01 00:00:00

  • Mathematical models for fetal growth: application for biparietal diameter measurement.

    abstract::Evaluation of the adequacy of fetal growth by measurements of fetal size required theoretical formulae for the assessment of present size from previous measurements. The various models presented in the literature assume the same mathematical formula for the whole pregnancy. In this study, a model of different polynomi...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263955

    authors: Nitzan M,Tadmor OP,Skomorowski Y,Rabinowitz R,Diamant Y

    更新日期:1994-09-01 00:00:00

  • Correlation of abnormal rapid FISH and chromosome results from amniocytes for prenatal diagnosis.

    abstract::Rapid fluorescence in situ hybridization (FISH) performed on 1,788 amniocenteses, using Aneuvision (Vysis) probes for chromosomes 13, 18, 21, X, and Y, over several years, yielded 115 cases with percentages of aneuploidy between 4 and 100%. All cases above 60% were confirmed to be positive by chromosome analysis. Fift...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000089310

    authors: Wyandt HE,Tonk VS,Huang XL,Evans AT,Milunsky JM,Milunsky A

    更新日期:2006-01-01 00:00:00

  • Variability of adjustments to indices in determining patient risk in biochemical screening.

    abstract::It has long been appreciated that the measurement of biochemical parameters for prenatal screening for neural tube defects, and later aneuploidy, is not as simple as measuring hemoglobin or hematocrit. Early in the game, it was recognized that there are gestational age curves, and that since alpha-fetoprotein (AFP), f...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000020887

    authors: Brooks K,Chik L,O'Brien JE,Ayoub M,Johnson MP,Evans MI

    更新日期:1999-01-01 00:00:00

  • Feasibility of retroviral vector-mediated in utero gene transfer to the fetal rabbit.

    abstract:OBJECTIVES:Successful treatment or prevention of severe hereditary diseases could conceivably be achieved by genetic intervention early in development. Viral vector-mediated fetal gene transfer is proving a valuable tool to test the above concept in relevant animal models. Although the pregnant rabbit is a well-recogni...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000088036

    authors: Moreno R,Rosal M,Cabero L,Gratacós E,Aran JM

    更新日期:2005-11-01 00:00:00

  • Brain damage to the survivor within 30 min of co-twin demise in monochorionic twins.

    abstract::Single fetal death in a twin pregnancy in the late second or early third trimester is associated with significant morbidity and mortality rate in the surviving co-twin, especially in monochorionic twin pregnancies. The common causes are twin-to-twin transfusion syndrome, chromosomal abnormalities, and congenital anoma...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000082429

    authors: Karageyim Karsidag AY,Kars B,Dansuk R,Api O,Unal O,Turan MC,Goynumer G

    更新日期:2005-03-01 00:00:00

  • Does Maternal Body Mass Index Affect the Quantity of Circulating Fetal Cells Available to Use for Cell-Based Noninvasive Prenatal Test in High-Risk Pregnancies?

    abstract::We present the first study that investigates the effect of maternal body mass index (BMI) on the quantity of circulating fetal cells available to use in cell-based noninvasive prenatal test (cbNIPT). cbNIPT has been proposed as a superior alternative to noninvasive prenatal test from cell-free fetal DNA. Kølvraa et al...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000492028

    authors: Kruckow S,Schelde P,Hatt L,Ravn K,Petersen OB,Uldbjerg N,Vogel I,Singh R

    更新日期:2019-01-01 00:00:00

  • Prenatal Growth in Fetuses with Isolated Cyanotic and Non-Cyanotic Congenital Heart Defects.

    abstract:BACKGROUND:Fetal growth may vary significantly in different congenital heart defects (CHDs). OBJECTIVES:To investigate prenatal growth of CHD fetuses and its correlation with classifications based upon expected oxygen delivery to the fetal brain or structural findings. METHODS:Seventy-nine euploid fetuses with isolat...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000493938

    authors: Inversetti A,Fesslova V,Deprest J,Candiani M,Giorgione V,Cavoretto P

    更新日期:2020-01-01 00:00:00

  • Prenatal diagnosis of fetal cardiac right ventricular diverticulum disappearing at three months of age. A case report and literature review.

    abstract::Congenital cardiac diverticula are transmural localized protrusions within the free wall of the ventricles. Right ventricular diverticula are rarely diagnosed during the fetal period, and due to their rarity, their natural history remains unclear. We present a case of prenatal diagnosis of right ventricular diverticul...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000196815

    authors: Perlitz Y,Mukary M,Lorber A,Ben-Ami M

    更新日期:2009-01-01 00:00:00

  • Prenatal diagnosis for Schmid metaphyseal chondrodysplasia in twins.

    abstract::We report prenatal diagnostic studies for metaphyseal chondrodysplasia of the Schmid type. Identification of a specific COL10A1 gene mutation in an affected father allowed prenatal diagnosis by chorionic villus sampling in a twin pregnancy. Neither of the nonidentical twins received the abnormal COL10A1 gene from thei...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020831

    authors: Milunsky J,Maher T,Lebo R,Milunsky A

    更新日期:1998-05-01 00:00:00

  • Amniotic fluid pressure in both cavities of twin-to-twin transfusion syndrome: a vote against septostomy.

    abstract:OBJECTIVE:To report our results of the measurement of the amniotic fluid pressure in twin-to-twin transfusion syndrome before and after amniodrainage and the separate measurement in the cavity of the stuck twin and the recipient, respectively, in 2 cases. METHOD:Six patients with severe TTS underwent therapeutic amnio...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020980

    authors: Hartung J,Chaoui R,Bollmann R

    更新日期:2000-03-01 00:00:00

  • Antenatal diagnosis and treatment of fetal bronchopulmonary sequestration.

    abstract::Bronchopulmonary sequestration with associated nonimmune hydrops has been previously reported with generally poor prognosis for the neonate. We report a case of bronchopulmonary sequestration and associated pleural effusion successfully managed with a transthoracic catheter placement. The embryology and clinical patho...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263532

    authors: Slotnick RN,McGahan J,Milio L,Schwartz M,Ablin D

    更新日期:1990-01-01 00:00:00

  • Human embryonic stem cells form embryoid bodies containing visceral endoderm-like derivatives.

    abstract:OBJECTIVE:The objective of this study was to determine the potential of human embryonic stem (hES) cells to provide an in vitro model of human extraembryonic endoderm development. METHODS:The hES cell line HES-2 was propagated in Dulbecco's modification of Eagle's medium (DMEM) in the presence of 20% fetal calf serum ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000076701

    authors: Conley BJ,Trounson AO,Mollard R

    更新日期:2004-05-01 00:00:00

  • Age of gestation (size) at embryonic demise: tailoring counseling for lethal versus potentially viable aneuploidy.

    abstract::The incidence of chromosomal abnormalities in spontaneous abortions is much higher than commonly appreciated. Using postmortem chorionic villus sampling (as we have previously described), our much increased yield of results allows us to divide embryos into two groups based upon potential viability. Embryonic size at t...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263821

    authors: Drugan A,Johnson MP,Isada NB,Evans MI

    更新日期:1993-05-01 00:00:00

  • Intracerebral periventricular pseudocysts in a fetus with mitochondrial depletion syndrome: an association or coincidence.

    abstract::We report the prenatal ultrasound and magnetic resonance imaging finding of periventricular, large subependymal pseudocysts (SEPCs) in a patient who was later diagnosed as having mitochondrial depletion syndrome (MDS). To our knowledge, this is the first report of fetal SEPCs in a patient with MDS. These findings may ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000209385

    authors: Rohrbach M,Chitayat D,Maegawa G,Shanske S,Davidzon G,Chong K,Clarke JT,Toi A,Tarnopolsky M,Robinson B,Blaser S

    更新日期:2009-01-01 00:00:00

  • Fetal pulse oximetry during labor of 62 patients.

    abstract::The objectives of the study were to assess the ability of a fetal pulse oximeter to measure the fetal oxygen saturation (SPO2) continuously during labor and to assess the correlation between readings of fetal pulse oximetry and cord blood gases at birth. The Nellcor N-400 Fetal Oximeter was used in 62 women prospectiv...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264277

    authors: Langer B,Boudier E,Haddad J,Pain L,Schlaeder G

    更新日期:1996-01-01 00:00:00

  • Optimal interval between middle cerebral artery velocity measurements when monitoring pregnancies complicated by red cell alloimmunization.

    abstract:OBJECTIVE:To evaluate the optimal interval between middle cerebral artery (MCA) Doppler measurements when monitoring pregnancies complicated by red cell alloimmunization. METHODS:Thirty-nine fetal blood samplings (FBS) performed on 24 pregnant women with red blood cell alloimmunization followed up using both MCA peak ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000089043

    authors: Bartha JL,Abdel-Fattah SA,Hunter A,Denbow M,Kyle P,Soothill PW

    更新日期:2006-01-01 00:00:00

  • Early Intrauterine Transfusion in Fetuses with Severe Anemia Caused by Parvovirus B19 Infection.

    abstract:OBJECTIVE:To describe procedure-related complications and perinatal survival after intrauterine transfusion (IUT) before 20 weeks of gestation in fetuses with severe anemia due to human parvovirus B19 infection. MATERIALS AND METHODS:A retrospective study was conducted of all fetuses requiring IUT before 20 weeks of g...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000477208

    authors: Hellmund A,Geipel A,Berg C,Bald R,Gembruch U

    更新日期:2018-01-01 00:00:00

  • Lung function following first-trimester amniocentesis or chorion villus sampling.

    abstract::Functional residual capacity (FRC) was measured at 2-8 (median 4) weeks of age in 100 infants whose mothers had entered a randomized trial of amniocentesis versus chorion villus sampling (CVS) at 10-13 weeks gestation. At measurement all of the infants were well and none had respiratory problems. No significant differ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263638

    authors: Thompson PJ,Greenough A,Nicolaides KH

    更新日期:1991-01-01 00:00:00

  • Refining the Prediction and Prevention of Emergency Operative Deliveries with the Fetal Reserve Index.

    abstract::Electronic fetal monitoring (EFM) is a poor predictor of outcomes attributable to delivery problems. Contextualizing EFM by adding maternal, obstetrical, and fetal risk-related information to create an index called the Fetal Reserve Index (FRI) improves the predictive capacity and facilitates the timing of interventio...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000494617

    authors: Britt DW,Evans MI,Schifrin BS,Eden RD

    更新日期:2019-01-01 00:00:00

  • Cord Occlusion in Monochorionic Twins with Early Selective Intrauterine Growth Restriction and Abnormal Umbilical Artery Doppler: A Consecutive Series of 90 Cases.

    abstract:OBJECTIVE:To describe perinatal outcomes achieved with cord occlusion (CO) in monochorionic twins with severe selective intrauterine growth restriction (sIUGR) and abnormal umbilical artery Doppler in the IUGR twin (types II and III). METHODS:We studied a consecutive series of 90 cases of sIUGR with abnormal Doppler t...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000439023

    authors: Parra-Cordero M,Bennasar M,Martínez JM,Eixarch E,Torres X,Gratacós E

    更新日期:2016-01-01 00:00:00

  • Maternal renal and interlobar arteries waveforms evaluation with color Doppler ultrasound in pregnancy-induced hypertension.

    abstract::The authors performed a color Doppler ultrasound examination of both renal and interlobar arteries of 15 pregnant women affected by pregnancy-induced hypertension. The pulsatility index (PI), the resistance index (RI) and the systolic/diastolic ratio (S/D) values were compared with those of 15 healthy pregnant women o...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264292

    authors: Boemi G,Bruno MT,La Ferrera G,Butera L,Pulvirenti G,Lanzone A,Mancuso S

    更新日期:1996-03-01 00:00:00

  • Fetal parvovirus B19 infection and meconium peritonitis.

    abstract::A 33-year-old primigravida at 26 weeks gestation presented with fetal hydrops and fetal anemia following prior parvovirus B19 infection. The fetus required two intrauterine transfusions of packed red cells. At 35 weeks gestation, a cesarean section was performed for obstetric reasons. As a consequence of a prenatal bo...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020794

    authors: Schild RL,Plath H,Thomas P,Schulte-Wissermann H,Eis-Hübinger AM,Hansmann M

    更新日期:1998-01-01 00:00:00

  • The changes in angiogenic gene expression in recurrent multiple chorioangiomas.

    abstract:OBJECTIVES:To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas. METHODS:Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal plac...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000098708

    authors: Gallot D,Marceau G,Laurichesse-Delmas H,Vanlieferinghen P,Dechelotte PJ,Lemery D,Sapin V

    更新日期:2007-01-01 00:00:00

  • Management of a case of twin-to-twin transfusion syndrome by a combined surgical approach.

    abstract:OBJECTIVE:The management of a case of severe twin-to-twin transfusion syndrome at 24 weeks of gestation is presented, using a combined surgical and medical approach. METHODS:Operative fetoscopy was used to coagulate placental vessels crossing the intertwin membranes. Repeated intrauterine transfusions were used to cor...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020809

    authors: Van Peborgh P,Pelletier G,Suarez B,Ville Y

    更新日期:1998-03-01 00:00:00