Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes.

Abstract:

BACKGROUND:To improve neonatal outcomes in pregnancies at heightened risk for early-onset neonatal sepsis (EONS), there is a need to identify fetuses that benefit from expectant management as opposed to early delivery. Detectable haptoglobin and haptoglobin-related protein (Hp&HpRP switch-on status) in cord blood has been proposed as a biomarker of antenatal exposure to intra-amniotic infection and/or inflammation (IAI), an important determinant of EONS. SUBJECTS AND METHODS:We analyzed 185 singleton newborns delivered secondary to preterm premature rupture of membranes (PPROM). In 123 cases, amniocentesis was performed to exclude amniotic fluid (AF) infection. Delivery was indicated for 61 cases with confirmed infection. Women without AF infection (n = 62) and those without amniocentesis (n = 62) were managed expectantly. Interleukin 6 and Hp&HpRP switch-on status were evaluated by ELISA and Western blot. Newborns were followed prospectively for short-term outcomes until hospital discharge or death. RESULTS:Newborns exposed antenatally to IAI had an increased risk of adverse neonatal outcome [OR: 3.0 (95% CI: 1.15-7.59)]. Increasing gestational age [OR: 0.61 (95% CI: 0.52-0.70)] and management with amniocentesis [OR: 0.37 (95% CI: 0.14-0.95)] lowered the newborn's risk of developing adverse outcomes. DISCUSSION:In the setting of PPROM and IAI, early delivery benefits a select subgroup of fetuses that have not yet progressed to Hp&HpRP switch-on status.

journal_name

Fetal Diagn Ther

authors

Archabald KL,Buhimschi IA,Bahtiyar MO,Dulay AT,Abdel-Razeq SS,Pettker CM,Lipkind HS,Hardy JT,McCarthy ME,Zhao G,Bhandari V,Buhimschi CS

doi

10.1159/000450997

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

99-110

issue

2

eissn

1015-3837

issn

1421-9964

pii

000450997

journal_volume

42

pub_type

杂志文章
  • Maturity of the myenteric plexus is decreased in the gastroschisis rat model.

    abstract:BACKGROUND:Amniotic fluid (AF) and its components, such as fetal urine and meconium, may lead to intestinal alterations in gastroschisis, which cause immaturity of the myenteric plexus and consequent intestinal hypomotility and malabsorption. In this study we identified morphological and histological alterations of the...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000109228

    authors: França WM,Langone F,de la Hoz CL,Gonçalves A,Bittencourt D,Pereira LV,Sbragia L

    更新日期:2008-01-01 00:00:00

  • Cerebral injury and neurodevelopmental impairment after amnioreduction versus laser surgery in twin-twin transfusion syndrome: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To estimate the odds of severe cerebral injury and long-term neurodevelopmental impairment in monochorionic twins treated with amnioreduction versus laser surgery for twin-twin transfusion syndrome. METHODS:A systematic review and meta-analysis of studies on cerebral injury and long-term impairment after amn...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000341814

    authors: van Klink JM,Koopman HM,van Zwet EW,Oepkes D,Walther FJ,Lopriore E

    更新日期:2013-01-01 00:00:00

  • New first-trimester crown-rump length equations from a French general population.

    abstract:INTRODUCTION:The purpose of this study was to obtain precise knowledge of fetal biometric measurements, in particular crown-rump length (CRL). Our results have been carefully compared to equations found in the literature. MATERIALS AND METHODS:Single-operator measurements of 2,123 spontaneous pregnancies from a genera...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000339272

    authors: Constant M,Tran VC,Benoit B,Vasseur F

    更新日期:2012-01-01 00:00:00

  • Pre- and perinatal relations of hemophilia A and B.

    abstract:OBJECTIVE:The authors conducted a retrospective study of obstetric and genetic data, obstetric problems, and pregnancy outcome by investigating 149 pregnancies of patients who received genetic counselling because of hemophilia A or B over a 20-year period. METHODS:In cases with a heterozygous mother, fetal sex was det...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000066378

    authors: Beke A,Bán Z,Nagy B,Tóth-Pál E,Papp C,Csaba A,Papp Z

    更新日期:2003-01-01 00:00:00

  • Percutaneous Intratumor Laser Ablation for Fetal Sacrococcygeal Teratoma.

    abstract:OBJECTIVE:To evaluate the efficiency of percutaneous intratumor laser ablation for fetal solid sacrococcygeal teratoma (SCT). SUBJECTS AND METHODS:We carried out percutaneous ultrasound-guided intratumor laser ablation through a 17-gauge needle using an output of 40 W in 7 fetuses with large solid SCT and reviewed the...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000500775

    authors: Litwińska M,Litwińska E,Janiak K,Piaseczna-Piotrowska A,Szaflik K

    更新日期:2020-01-01 00:00:00

  • Prenatal diagnosis of oral cyst caused by foregut duplication.

    abstract::Prenatal diagnosis of oral cystic lesions is rare but is reported more frequently. The diagnosis of sublingual cyst is important because of the potential for airway obstruction. A rare case of a foregut duplication cyst associated with unilateral sclerocorneal microphthalmia is reported. The differential diagnosis and...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000235883

    authors: Aviram R,Yaffe D,Kidron D,Tepper R,Regev R

    更新日期:2009-01-01 00:00:00

  • Amniopatch treatment for spontaneous previable, preterm premature rupture of membranes associated or not with incompetent cervix.

    abstract:OBJECTIVE:We reviewed women with previable spontaneous premature rupture of membranes (sPPROM) in whom an amniopatch was performed and compared their pregnancy outcomes with a conservative management group. METHODS:Amniopatch, an amnioinfusion of autologous platelet concentrate followed by cryoprecipitate, was perform...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000342418

    authors: Kwak HM,Choi HJ,Cha HH,Yu HJ,Lee JH,Choi SJ,Oh SY,Roh CR,Kim JH

    更新日期:2013-01-01 00:00:00

  • Successful treatment of supraventricular tachycardia with flecainide acetate: a case report.

    abstract:BACKGROUND:Efficacy of flecainide acetate for the treatment of fetal supraventricular tachycardia with cardiac failure was reported. CASE:For a case in which maternal digoxin therapy failed, flecainide acetate (400 mg/day) is used from 27 weeks. Cardioversion with improved cardiac function occurred 6 days after treatm...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264498

    authors: Amano K,Harada Y,Shoda T,Nishijima M,Hiraishi S

    更新日期:1997-11-01 00:00:00

  • Beckwith-Wiedemann syndrome presenting with an elevated triple screen in the second trimester of pregnancy.

    abstract:BACKGROUND:Beckwith-Wiedemann syndrome (BWS) is a distinct clinical syndrome with unique features, generally diagnosed postnatally. CASE:A 26-year-old patient, gravida 4, para 3-0-0-3, was noted to have an abnormal maternal serum screen. Amniocentesis with imaging studies were remarkable only for a two-vessel umbilica...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000095837

    authors: Aagaard-Tillery KM,Buchbinder A,Boente MP,Ramin KD

    更新日期:2007-01-01 00:00:00

  • A study to determine if human umbilical cord hematopoietic stem cells can survive in baboon extra-embryonic celomic fluid: a prerequisite for determining the feasibility of in-utero stem cell xeno-transplantation via celocentesis.

    abstract:OBJECTIVES:To determine if: (1) human umbilical cord stem cells could survive for 20 h in extra-embryonic celomic fluid obtained at 40 days of development from baboon pregnancies by ultrasound-guided celocentesis and, (2) human hematopoietic stem cell survival could be enhanced by adding increasing concentrations of he...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000097112

    authors: Santolaya-Forgas J,Galan I,Deleon-Luis J,Wolf R

    更新日期:2007-01-01 00:00:00

  • Rapid prenatal diagnosis of trisomy 21 by polymerase chain reaction- associated analysis of small tandem repeats and S100B in chromosome 21.

    abstract:OBJECTIVES:The incidence of Down syndrome increases with maternal age and a rapid and accurate method for prenatal diagnosis is a necessity. This study was devised to evaluate and compare the methods for detecting trisomy 21 by polymerase chain reaction (PCR)-associated analysis of small tandem repeats (STR) of D21S11 ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020870

    authors: Yang YH,Kim IK,Oh SH,Kim CK,Kim JY

    更新日期:1998-11-01 00:00:00

  • Transabdominal amnioinfusion in preterm pregnancies complicated by fetal growth restriction, oligohydramnios and umbilical cord compression.

    abstract::Fetal growth restriction with oligohydramnios occurring in the preterm gestation is associated with significant fetal morbidity and mortality. We investigated the possibility that transabdominal amnioinfusion might relieve acute cord compression and allow prolongation of gestation long enough to administer corticoster...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264266

    authors: Sarno AP,Polzin WJ,Feinstein SJ,Maslow A

    更新日期:1995-11-01 00:00:00

  • Monozygotic twinning as a congenital defect and congenital defects in monozygotic twins.

    abstract::The process of monozygotic twinning in animals and humans is presented. In addition, congenital defects in monozygotic twins versus dizygotic twins and singletons is discussed. Overall, the rates of congenital anomalies are higher among whites as compared to blacks, males as compared to females, and multiples as compa...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000263545

    authors: Luke B,Keith LG

    更新日期:1990-01-01 00:00:00

  • Maternal mortality following diagnostic 2nd-trimester amniocentesis.

    abstract::We present 2 cases of maternal mortality after transabdominal amniocentesis performed during the 2nd trimester of pregnancy. In both these cases, blood cultures revealed Escherichia coli. Broad-spectrum intravenous antibiotic treatment started immediately after admission to the hospital did not change the rapid progre...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000075150

    authors: Elchalal U,Shachar IB,Peleg D,Schenker JG

    更新日期:2004-03-01 00:00:00

  • Management of a case of twin-to-twin transfusion syndrome by a combined surgical approach.

    abstract:OBJECTIVE:The management of a case of severe twin-to-twin transfusion syndrome at 24 weeks of gestation is presented, using a combined surgical and medical approach. METHODS:Operative fetoscopy was used to coagulate placental vessels crossing the intertwin membranes. Repeated intrauterine transfusions were used to cor...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020809

    authors: Van Peborgh P,Pelletier G,Suarez B,Ville Y

    更新日期:1998-03-01 00:00:00

  • Clinical and Economic Impact of Adopting Noninvasive Prenatal Testing as a Primary Screening Method for Fetal Aneuploidies in the General Pregnancy Population.

    abstract:OBJECTIVE:To evaluate the clinical and economic impact of adopting noninvasive prenatal testing (NIPT) using circulating cell-free DNA as a first-line screening method for trisomy 21, 18, and 13 in the general pregnancy population. METHODS:A decision-analytical model was developed to assess the impact of adopting NIPT...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000491750

    authors: Kostenko E,Chantraine F,Vandeweyer K,Schmid M,Lefevre A,Hertz D,Zelle L,Bartha JL,Di Renzo GC

    更新日期:2019-01-01 00:00:00

  • Noninvasive Sampling of the Intrauterine Environment in Women with Preterm Labor and Intact Membranes.

    abstract::Spontaneous preterm birth has enormous consequences for newborns, children, and families. Intra-amniotic inflammation (IAI) is the leading cause of spontaneous preterm delivery, mainly at earlier gestational ages. Amniocentesis is the only method used to identify IAI in clinical practice. Although it is an invasive pr...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000480232

    authors: Cobo T,Kacerovsky M,Jacobsson B

    更新日期:2018-01-01 00:00:00

  • Mid-trimester thoracoamniotic shunting for the treatment of fetal primary pleural effusions in a twin pregnancy. a case report.

    abstract::Thoracoamniotic shunting has been described as having a beneficial role in the antenatal management of primary pleural effusions in singleton pregnancies. We report a case of a twin pregnancy in which progressive pleural effusions and hydrops were diagnosed in one of the fetuses at 16 weeks of gestation. An initial ev...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000021007

    authors: Grisaru-Granovsky S,Seaward PG,Windrim R,Wyatt P,Kelly EN,Ryan G

    更新日期:2000-07-01 00:00:00

  • Perinatal Outcome and Long-Term Neurodevelopment after Intracranial Haemorrhage due to Fetal and Neonatal Alloimmune Thrombocytopenia.

    abstract:OBJECTIVES:To evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. SUBJECTS AND METHODS:We performed an observational cohort study and ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000488280

    authors: Winkelhorst D,Kamphuis MM,Steggerda SJ,Rijken M,Oepkes D,Lopriore E,van Klink JMM

    更新日期:2019-01-01 00:00:00

  • Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A case report.

    abstract::We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 x 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. Hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 microIU/ml) and a low free...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000073143

    authors: Matsumoto T,Miyakoshi K,Kasai K,Ishimoto H,Tanaka M,Ikeda K,Yoshimura Y

    更新日期:2003-11-01 00:00:00

  • Supernumerary ring chromosome: an etiology for Pallister-Killian syndrome?

    abstract::Characterization of marker chromosomes before the introduction of array CGH (aCGH) assays was only based on their banding patterns (G, C, and NOR staining) and fluorescent in situ hybridization techniques. The use of aCGH greatly improves the identification of marker chromosomes in some cases. We describe an atypical ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000347049

    authors: Lloveras E,Canellas A,Cirigliano V,Català V,Cerdan C,Plaja A

    更新日期:2013-01-01 00:00:00

  • Human placental growth hormone is increased in maternal serum in pregnancies affected by Down syndrome.

    abstract:OBJECTIVE:To evaluate the relationship between maternal serum levels of human placental growth hormone (hPGH) and fetal Down syndrome at gestational midtrimester. METHODS:We retrospectively analyzed samples of serum from 21 women with Down syndrome pregnancies detected at gestational midtrimester. The samples were obt...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000116743

    authors: Papadopoulou E,Sifakis S,Giahnakis E,Fragouli Y,Karkavitsas N,Koumantakis E,Kalmanti M

    更新日期:2008-01-01 00:00:00

  • Fetal Stomach Position Predicts Neonatal Outcomes in Isolated Left-Sided Congenital Diaphragmatic Hernia.

    abstract:INTRODUCTION:We sought to determine the relationship between the degree of stomach herniation by antenatal sonography and neonatal outcomes in fetuses with isolated left-sided congenital diaphragmatic hernia (CDH). MATERIALS AND METHODS:We retrospectively reviewed neonatal medical records and antenatal sonography of f...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000440649

    authors: Basta AM,Lusk LA,Keller RL,Filly RA

    更新日期:2016-01-01 00:00:00

  • Uterine artery pulsatility index assessment at 11-13 weeks' gestation.

    abstract:INTRODUCTION:First-trimester uterine artery pulsatility index (PI) measurements form part of an algorithm used to assess the risk of developing pre-eclampsia. The objective of this study was to construct a population-specific reference range for both the lower and mean maternal uterine artery PI at 11-13(+6) weeks' ges...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000361021

    authors: Ridding G,Schluter PJ,Hyett JA,McLennan AC

    更新日期:2014-01-01 00:00:00

  • Sonographic screening for trisomy 21: fetal humerus:foot length ratio, a useful new marker.

    abstract::We have analyzed morphometric measurements from midgestational fetal necropsies and shown that arm and foot lengths are linear relationships versus gestational age (GA). Using foot length as the GA determinant, we found that the ratio of arm:foot length was also a linear relationship and was decreased in trisomy 21 fe...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000263920

    authors: Johnson MP,Michaelson JE,Barr M Jr,Treadwell MC,Isada NB,Dombrowski MP,Pryde PG,Addis J,Evans MI

    更新日期:1994-03-01 00:00:00

  • The (Pulsed-Wave) Doppler Fetal Myocardial Performance Index: Technical Challenges, Clinical Applications and Future Research.

    abstract::Functional cardiovascular assessment is becoming an increasingly important tool in the study of fetal pathology. The myocardial performance index (MPI) is a parameter measuring global myocardial function. Since its introduction, several studies have proposed methods to improve its reproducibility and have constructed ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000363181

    authors: Mahajan A,Henry A,Meriki N,Hernandez-Andrade E,Crispi F,Wu L,Welsh AW

    更新日期:2015-01-01 00:00:00

  • Solutes in maternal circulation and gestational sac compartments during early human development.

    abstract:OBJECTIVES:The aim of this study was to review previous work reporting the concentration of solutes measured in maternal circulation, extra-embryonic celomic fluid, and amniotic fluid, to gain insights into the mechanism that could lead to compartmentalization of fluid and solutes within the gestational sac prior to th...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000091358

    authors: Santolaya-Forgas J,De Leon-Luis J,Espinoza J,Gonçalves LF,Romero R

    更新日期:2006-01-01 00:00:00

  • Direct fetal intravenous immunoglobulin infusion as an adjunct to intrauterine fetal blood transfusion in rhesus-allommunized pregnancies: a pilot study.

    abstract:OBJECTIVES:To study the usefulness of direct fetal intravenous immunoglobulin (IVIG) infusion along with intrauterine transfusion (IUT) in the management of severe fetal anemia in rhesus (Rh) alloimmunized pregnancies. METHODS:Thirty-four consecutive Rh-isoimmunized pregnant women who required serial IUTs received eit...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章

    doi:10.1159/000353236

    authors: Deka D,Sharma KA,Dadhwal V,Singh A,Kumar G,Vanamail P

    更新日期:2013-01-01 00:00:00

  • Neurodevelopmental Effects of Undernutrition and Placental Underperfusion in Fetal Growth Restriction Rabbit Models.

    abstract:INTRODUCTION:Chronic reduction of oxygen and nutrient delivery to the fetus has been related to neurodevelopmental problems. Placental underperfusion induces a significant reduction in oxygen and nutrient delivery, whereas maternal undernutrition causes mainly nutrient deficiency. A comparison of the neurodevelopmental...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000454859

    authors: Illa M,Eixarch E,Muñoz-Moreno E,Batalle D,Leal-Campanario R,Gruart A,Delgado-García JM,Figueras F,Gratacós E

    更新日期:2017-01-01 00:00:00

  • Prenatal Diagnosis of Dextrocardia with Complex Congenital Heart Disease Using Fetal Intelligent Navigation Echocardiography (FINE) and a Literature Review.

    abstract::Fetal dextrocardia is a type of cardiac malposition where the major axis from base to apex points to the right side. This condition is usually associated with a wide spectrum of complex cardiac defects. As a result, dextrocardia is conceptually difficult to understand and diagnose on prenatal ultrasound. The advantage...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000468929

    authors: Yeo L,Luewan S,Markush D,Gill N,Romero R

    更新日期:2018-01-01 00:00:00