Abstract:
STUDY DESIGN:A histological, biological, and immunohisto-chemical study of human lumbar ligamentum flavum. OBJECTIVE:To analyze changes in the hypertrophied ligamentum flavum and clarify their etiology. SUMMARY OF BACKGROUND DATA:Hypertrophy of the ligamentum flavum has been considered a major contributor to the development of lumbar spinal canal stenosis (LSCS). Although previous studies have reported some factors related to ligamentum flavum hypertrophy, its etiology is still unclear. METHODS:Ligamentum flavum samples were collected from 20 patients with LSCS (LSCS group) and 10 patients with lumbar disc herniation (LDH group) as a control. The thickness of the ligamentum flavum was measured histologically. The amounts of elastic fibers and proteoglycans were assessed by Elastica-Masson staining and alcian blue staining, respectively. Gene and protein expressions related to fibrosis, inflammation, and chondrogenesis were analyzed by quantitative reverse transcription-polymerase chain reaction and immunohistochemistry. The total genes of the 2 groups were compared by DNA microarray analysis. RESULTS:The ligamentum flavum was significantly thicker in the LSCS group, which had a smaller amount of elastic fibers and a larger amount of proteoglycans. The gene expression related to fibrosis was significantly higher in the LSCS group; however, the immunoreactivities of collagen types I and III were weaker on the dorsal side of the ligamentum flavum in the LSCS group. The gene expression related to chondrogenesis and proteoglycan synthesis was significantly higher in the LSCS group. There was no significant difference in the gene expression related to inflammation between the 2 groups. CONCLUSION:Synthesis of the collagenous fibers and degradation of the elastic and collagenous fibers are both accelerated in the ligamentum flavum of patient with LSCS, which may be the reason for hypertrophy of the tissue. In addition, chondrogenesis and proteoglycan synthesis may have critical roles in the pathogenesis of the ligamentum flavum hypertrophy. LEVEL OF EVIDENCE:5.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Yabe Y,Hagiwara Y,Ando A,Tsuchiya M,Minowa T,Takemura T,Honda M,Hatori K,Sonofuchi K,Kanazawa K,Koide M,Sekiguchi T,Itoi Edoi
10.1097/BRS.0000000000000795subject
Has Abstractpub_date
2015-04-01 00:00:00pages
429-35issue
7eissn
0362-2436issn
1528-1159journal_volume
40pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:This is a case report. OBJECTIVE:The purpose was to report a patient whose migrated L4-S1 femur graft led to perforation of the cecum. SUMMARY OF BACKGROUND DATA:Autograft bone use during spinal surgery is quite commonplace nowadays. With time due to infection, technical mishaps, or disease recurrence, t...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181bb1bf2
更新日期:2010-02-01 00:00:00
abstract:STUDY DESIGN:Retrospective review of the Healthcare Cost and Utilization Project National Inpatient Sample, 2000 to 2013. OBJECTIVE:To determine the proportion of spinal epidural abscess (SEA) cases that were related to injection drug use (IDU) and to compare length of stay, leaving against medical advice, paralysis, ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003401
更新日期:2020-06-15 00:00:00
abstract:STUDY DESIGN:For in vitro studies, there is no basis for choosing a "load control study" over a "displacement control" study. This study qualitatively compared results from in vitro and in vivo tests, allowing the authors to address the experimental assumptions that in vitro testing contributes to the understanding of ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199408000-00015
更新日期:1994-08-01 00:00:00
abstract:STUDY DESIGN:A retrospective cohort study. OBJECTIVE:To assess the ability of local vancomycin powder to prevent wound infection after posterior cervical fusion. SUMMARY OF BACKGROUND DATA:Wound infections are a significant source of morbidity and cost associated with spine surgery. Intraoperative application of vanc...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318285b219
更新日期:2013-05-20 00:00:00
abstract::Facetectomy, either unilateral or bilateral, significantly altered the capacity of cervical spine functional units to withstand increasing compression-flexion loads applied in a constant mode to different specimen configurations. Unilateral facetectomy resulted in an average 31.6 +/- 9.7 percent decrease in strength w...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198807000-00017
更新日期:1988-07-01 00:00:00
abstract:STUDY DESIGN:An observational follow-up. OBJECTIVES:To analyze the role of physical exercise and inactivity on the long-term outcome after active outpatient low back rehabilitation. SUMMARY OF BACKGROUND DATA:There is considerable evidence documenting the efficacy of exercise in the conservative treatment of chronic ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200007150-00012
更新日期:2000-07-15 00:00:00
abstract:STUDY DESIGN:A retrospective review series. OBJECTIVE:To identify vascular anatomy and esophageal deviations that may interfere with a percutaneous anterior approach in cervical spine surgery. SUMMARY OF BACKGROUND DATA:The percutaneous anterior approach has been used for minimally invasive interventions of cervical ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000140
更新日期:2014-02-15 00:00:00
abstract:STUDY DESIGN:A case of primary Ewing sarcoma of the lumbar spine is presented. OBJECTIVE:To present and review a rare case of primary Ewing sarcoma of the lumbar spine that required differentiation from spinal infection. SUMMARY OF BACKGROUND DATA:Primary Ewing sarcoma originating from the spinal column is very rare....
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181995ec2
更新日期:2009-04-20 00:00:00
abstract::Six chemical agents were evaluated for their efficacy in preventing epidural scar formation following laminectomy in rabbits. One agent was carboxymethylcellulose and the other five agents represented various compositions of modified carboxymethylcellulose. Four weeks after laminectomy, spines were harvested and decal...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199107000-00023
更新日期:1991-07-01 00:00:00
abstract:STUDY DESIGN:Observational cohort study. OBJECTIVE:To evaluate by MRI whether a vertebral fracture during childhood is a risk factor for degeneration of adjacent discs. SUMMARY OF BACKGROUND DATA:Several studies infer that trauma is a major cause of disc degeneration. Only 1 study has by magnetic resonance imaging (M...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181573d6a
更新日期:2007-10-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of records and radiographs with postoperative questionnaire of patients with Marfan syndrome receiving surgical correction for spinal deformity. OBJECTIVE:To characterize and analyze the challenges of surgical correction for spinal deformity in Marfan syndrome and to present recommend...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200209150-00008
更新日期:2002-09-15 00:00:00
abstract:STUDY DESIGN:A retrospective study of patients undergoing palliative surgery for metastatic spinal tumors. OBJECTIVE:To investigate short-term functional recovery and duration of improvement after palliative surgery, to correlate these outcomes with the revised Tokuhashi score, and to examine the relationship between ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181878733
更新日期:2008-10-01 00:00:00
abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:The purpose of the study was to examine survival after surgery for a metastatic spinal tumor using prognostic factors in the new Katagiri score. SUMMARY OF BACKGROUND DATA:Surgery for spinal metastasis can improve quality of life and facilitate treatment of the primary canc...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003415
更新日期:2020-07-01 00:00:00
abstract::A retrospective review was carried out on 40 patients who met the criteria of 1) having a significant lumbar scoliosis associated with spinal stenosis, with symptoms of neurogenic claudication; and 2) having been treated with posterior decompression and pedicular screw fixation techniques. The average age of the patie...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199206001-00009
更新日期:1992-06-01 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:To report a case of false-negative intraoperative motor-evoked potentials (MEP) that developed paraplegia after surgery. SUMMARY OF BACKGROUND DATA:Although several false-negative results have been reported with somatosensory-evoked potentials, there is no report noted with MEP. Th...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e3181b40d4f
更新日期:2009-11-15 00:00:00
abstract:STUDY DESIGN:A case of primary osteogenic sarcoma at the second cervical vertebra is reported. OBJECTIVES:To document an osteogenic sarcoma of the second cervical vertebra and its treatment, and to review the literature. SUMMARY OF BACKGROUND DATA:Primary osteosarcoma of the cervical spine is encountered infrequently...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200109010-00025
更新日期:2001-09-01 00:00:00
abstract:STUDY DESIGN:A prospective minimum 5-year follow-up study of the cervical spine in patients with rheumatoid arthritis (RA) initially without cervical involvement. OBJECTIVE:To clarify the incidence and aggravation of cervical spine instabilities and their predictive risk factors in patients with RA. SUMMARY OF BACKGR...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31826def1c
更新日期:2012-12-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of 13 cases with craniovertebral tuberculosis treated conservatively. OBJECTIVE:To evaluate the results of conservative treatment of craniovertebral tuberculosis and compare with the literature. SUMMARY OF BACKGROUND DATA:Craniovertebral tuberculosis is a rare entity even in endemic ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318074d41e
更新日期:2007-07-01 00:00:00
abstract::Biopsy or subtotal resection followed by radiation for intramedullary astrocytomas of the spinal cord offer palliation but not cure. A treatment modality using an ultrasonic suction device has revolutionized the treatment of these tumors and has been extended to include the treatment of intramedullary tumors involving...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198710000-00006
更新日期:1987-10-01 00:00:00
abstract:STUDY DESIGN:A randomized, prospective and controlled animal study. OBJECTIVE:To evaluate lumbar spinal fusion using recombinant human bone morphogenetic protein 2 in a canine model. SUMMARY OF BACKGROUND DATA:Spinal fusion using autogenous bone grafting is associated with donor site morbidity and a nonunion rate of ...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-199910010-00002
更新日期:1999-10-01 00:00:00
abstract:STUDY DESIGN:Systematic review of cross-cultural adaptation. OBJECTIVE:To perform a systematic review of cross-cultural adaptations of the Neck Disability Index (NDI) and to give a critical assessment to improve its translation. SUMMARY OF BACKGROUND DATA:The NDI is used to assess functional capacity and physical act...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0000000000000788
更新日期:2015-04-01 00:00:00
abstract:STUDY DESIGN:The lumbar vertebral canal was measured in two cohorts of 10-year-old children (n = 161) using magnetic resonance imaging (MRI) and compared with obstetric records. OBJECTIVE:To investigate whether there are identifiable obstetric factors that determine the size of the lumbar vertebral canal. SUMMARY OF ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000067086.39849.B3
更新日期:2003-07-01 00:00:00
abstract:STUDY DESIGN:An in vitro biomechanical investigation to quantify the endplates resistance to compressive loads, in the thoracic and lumbar spine. Comparisons were made to determine the regional strength of the endplate, the optimal size and geometry of interbody support, and the effects of endplate removal on structura...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000143623.18098.e5
更新日期:2004-11-01 00:00:00
abstract:SUMMARY OF BACKGROUND DATA:Although high geographic variation in back surgery rates within the United States have been documented, international comparisons have not been published. METHODS:The authors compared rates of back surgery in eleven developed countries to determine if back surgery rates are higher: 1) in the...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199405310-00001
更新日期:1994-06-01 00:00:00
abstract::A posterolateral technique to decompress retropulsed bone from the spinal canal has been employed in nine patients, confirmed with intraoperative canal inspection and pre- and postoperative computed axial tomographic (CAT) evaluation. This technique has allowed reduction of retropulsed bony elements from the spinal ca...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198504000-00005
更新日期:1985-04-01 00:00:00
abstract:STUDY DESIGN:A comparative study of aggrecanases and aggrecan fragmentation profile in the human intervertebral disc at early and advanced stages of disc degeneration. OBJECTIVE:To determine differences in the content of the aggrecanases and the profile of aggrecan fragmentation in early and advanced stages of disc de...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318158cb85
更新日期:2007-11-01 00:00:00
abstract:STUDY DESIGN:Loads acting in vivo on a vertebral body replacement (VBR) and the shape of the back were measured. OBJECTIVE:To find an explanation for the contradictory results in literature regarding spinal loads for sitting and standing. SUMMARY OF BACKGROUND DATA:In several in vivo studies, the intradiscal pressure...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181d55d52
更新日期:2010-10-15 00:00:00
abstract:STUDY DESIGN:A retrospective analysis. OBJECTIVE:This study aimed to compare the safety and efficacy between the fusion-nonfusion hybrid construct (HC: anterior cervical corpectomy and fusion plus artificial disc replacement, ACCF plus cADR) and anterior cervical hybrid decompression and fusion (ACHDF: anterior cervic...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000588
更新日期:2014-11-01 00:00:00
abstract:STUDY DESIGN:A prospective cohort study. OBJECTIVE:This study aimed to compare the outcome of cervical laminoplasty between diabetic patients and nondiabetic patients with cervical spondylotic myelopathy. SUMMARY OF BACKGROUND DATA:A few retrospective studies have investigated the outcomes of cervical myelopathy in d...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000102
更新日期:2014-02-01 00:00:00
abstract:STUDY DESIGN:Retrospective review of prospectively collected data. OBJECTIVE:Assess outcomes of adult spinal deformity (ASD) surgery performed by one versus two attending surgeons. SUMMARY OF BACKGROUND DATA:ASD centers have developed two attending teams to improve efficiency; their effects on complications and outco...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000002071
更新日期:2017-07-01 00:00:00