Viscous carboxymethylcellulose in the prevention of epidural scar formation.

Abstract:

:Six chemical agents were evaluated for their efficacy in preventing epidural scar formation following laminectomy in rabbits. One agent was carboxymethylcellulose and the other five agents represented various compositions of modified carboxymethylcellulose. Four weeks after laminectomy, spines were harvested and decalcified, and transverse sections were prepared for histologic analysis. Subjective evaluation suggested that two agents appeared to inhibit epidural scar formation compared with the untreated controls. Objective evaluation was performed by quantitating scar tissue area at the laminectomy site with a digitizing tablet. In agreement with the subjective evaluation, two agents were found to have significantly reduced epidural scar tissue area compared with the control (control = 0.418 +/- 0.16 SE mm2vs. Agent 2 = 0.067 +/- 0.02 [P less than 0.05] and Agent 5 = 0.089 +/- 0.02 [P less than 0.05]). Of the remaining four agents, one of which was the unmodified carboxymethylcellulose, none showed significant reduction in scar tissue formation. These findings indicate that viscous preparations of modified carboxymethylcellulose can act as a barrier against epidural scar formation following laminectomy.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Kitano T,Zerwekh JE,Edwards ML,Usui Y,Allen MD

doi

10.1097/00007632-199107000-00023

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

820-3

issue

7

eissn

0362-2436

issn

1528-1159

journal_volume

16

pub_type

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