当前位置： SCI文献检索 > CLINICAL NEUROLOGY AND NEUROSURGERY期刊下所有文献 > Clinical and pharmacokinetic evaluation of controlled-release levodopa/carbidopa (CR-4) in parkinsonian patients with severe motor fluctuations: a six month follow-up study.

Clinical and pharmacokinetic evaluation of controlled-release levodopa/carbidopa (CR-4) in parkinsonian patients with severe motor fluctuations: a six month follow-up study.

Abstract：

:The results of a six month open-label study comparing the efficacy of controlled-release levodopa-carbidopa (Sinemet CR-4 200 mg/50 mg) with standard levodopa/carbidopa (250 mg/25 mg) in 17 patients with idiopathic Parkinson's disease and severe response fluctuations, are reported. Major clinical benefits included; improvement of disability, reduction of the number of 'off' periods (predominantly end-of-dose hypokinesia) and a slight increase in 'on' time. No improvement was observed in two of our patients. Mean levodopa plasma levels were comparable between the two types of formulations during optimal treatment, however systemic bioavailability was significantly higher with CR-4. Delayed onset of antiparkinsonian effect of CR-4, resulting from an increase of Tmax for levodopa, was one of the major complaints and required additional small amounts of standard levodopa in three patients.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Deleu D,Jacques M,Michotte Y,Ebinger G

doi

10.1016/0303-8467(89)90005-x

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

303-9

issue

4

eissn

0303-8467

issn

1872-6968

pii

0303-8467(89)90005-X

journal_volume

91

pub_type

杂志文章

相关文献

CLINICAL NEUROLOGY AND NEUROSURGERY文献大全
  • Some clinical aspects of late onset parkinsonism.

    abstract：:Thirty-six parkinsonian patients were selected by age of onset of over 70 and a minimum of five years duration of illness. The mean age of onset was 73.5 years and 30 patients were still alive after a mean of 7.2 years. We found that late onset Parkinson's disease has a relatively benign course with more "axial sympto...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/0303-8467(92)90049-9

    authors： Petit H,Vermersch P,Pasquier F

    更新日期：1992-01-01 00:00:00

  • The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults.

    abstract：:We studied an adenosine deaminase (ADA) activity in the cerebrospinal fluid (CSF) of 182 patients with meningitis. The patients were subdivided into four groups, (1) 36 cases of tuberculous meningitis; (2) 130 cases of viral or aseptic meningitis; (3) nine cases of bacterial meningitis; (4) seven cases of cryptococcal...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/s0303-8467(01)00159-7

    authors： Choi SH,Kim YS,Bae IG,Chung JW,Lee MS,Kang JM,Ryu J,Woo JH

    更新日期：2002-01-01 00:00:00

  • Ulcerative colitis and interstitial myositis.

    abstract：:Amongst the protean extra-intestinal manifestations of inflammatory bowel disease, scant mention is made of muscle involvement. This report outlines the clinical features, electrodiagnostic and muscle biopsy findings in a patient with ulcerative colitis who developed progressive proximal muscle weakness. The demonstra...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/s0303-8467(87)80026-4

    authors： Bhigjee AI,Bill PL,Cosnett JE

    更新日期：1987-01-01 00:00:00

  • Checklist for cognitive and emotional consequences following stroke (CLCE-24): development, usability and quality of the self-report version.

    abstract：OBJECTIVE:In this paper a new checklist (CLCE-24) for identification of cognitive and emotional problems after stroke is presented. The CLCE-24 is intended to support a clinical interview by health care professionals other than the trained (neuro)psychologist. METHODS:Patients were interviewed with the CLCE-24, 6 mont...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2006.10.002

    authors： van Heugten C,Rasquin S,Winkens I,Beusmans G,Verhey F

    更新日期：2007-04-01 00:00:00

  • Syndrome of continuous muscle fibre activity confined to the legs.

    abstract：:We report a 35-year-old woman with painful muscle cramps in both legs, this being the only symptom of the syndrome of continuous muscle fibre activity. Diagnosis was confirmed by electromyography during sleep. ...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/0303-8467(90)90035-4

    authors： de Waal M,Bertelsmann FW,Strijers RL

    更新日期：1990-01-01 00:00:00

  • Evaluation of clinical parameters during and after treatment of attack in patients with clinically isolated syndrome: comparison of the results with that of multiple sclerosis patients.

    abstract：OBJECTIVES:The aim of the present study was to examine the changes in the measurement of functions during and after pulse methylprednisolone (MP) treatment during a clinically isolated syndrome (CIS) attack, using the multiple sclerosis functional composite (MSFC) and Expanded Disability Status Scale (EDSS), and to com...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2013.09.003

    authors： Piri Cinar B,Ozakbas S,Idiman E

    更新日期：2013-12-01 00:00:00

  • Serum AGR2 as a useful biomarker for pituitary adenomas.

    abstract：OBJECTIVE:This study aims to evaluate whether the serum Anterior Gradient-2 (AGR2) can be used as a potential biomarker screening in the diagnosis of Pituitary adenomas(PAs). PATIENTS AND METHODS:The serum AGR2 protein levels were preoperatively measured in 163 PA patients, 43 patients with other sellar lesions exclud...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2017.01.004

    authors： Tohti M,Li J,Tang C,Wen G,Abdujilil A,Yizim P,Ma C

    更新日期：2017-03-01 00:00:00

  • Association of statin induced reduction in serum coenzyme Q10 level and conduction deficits in motor and sensory nerves: An observational cross-sectional study.

    abstract：OBJECTIVE:The reduction of Coenzyme Q10 (CoQ10) levels following statin use has been linked to cause peripheral neuropathy. Hence, this study was planned to explore the effect of statin on the serum HMGCR (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase), serum CoQ10 levels and nerve conduction and their correlation. ...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2020.106046

    authors： Gurha N,Rehan HS,Yadav M,Gupta LK

    更新日期：2020-09-01 00:00:00

  • Mesencephalic haematoma, successful surgical evacuation. Case report.

    abstract：:A case of mesencephalic haematoma is reported. Emergency surgical evacuation of haematoma was done. The patient improved and has done well for five years. Subtemporal and infratentorial supracerebellar approaches have been used earlier to remove mesencephalic haematoma. It is possible to remove caudal midbrain haemato...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/0303-8467(90)90094-l

    authors： Jain VK,Multani JK,Reddy AK,Das BS

    更新日期：1990-01-01 00:00:00

  • Secondary gliosarcoma with extra-cranial metastases: a report and review of the literature.

    abstract：OBJECTIVE:To describe a unique case of secondary gliosarcoma (SGS) with widespread extra-cranial metastases that developed more than 5 years after the initial diagnosis of glioblastoma multiforme (GBM). This interval is the longest among the cases reported to date. METHODS:A PUBMED search using the key words "secondar...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2012.06.017

    authors： Dawar R,Fabiano AJ,Qiu J,Khushalani NI

    更新日期：2013-04-01 00:00:00

  • The combination of neuronavigation with transcranial magnetic stimulation for treatment of opercular gliomas of the dominant brain hemisphere.

    abstract：OBJECTIVE:The objective of this study is to investigate the application of transcranial magnetic stimulation combined with neuronavigation for preoperative mapping of the language area in neurosurgical interventions on the opercular area of the dominant hemisphere. METHODS:Five patients were operated upon gliomas in t...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2010.05.005

    authors： Shamov T,Spiriev T,Tzvetanov P,Petkov A

    更新日期：2010-10-01 00:00:00

  • The quality of life of patients after a lumbar microdiscectomy: a four-year monitoring study.

    abstract：INTRODUCTION/AIM:Health-conditioned quality of patients' life is equally a result of their subjective perception of the disease and their objective condition. The aim of this paper is to evaluate the quality of life of surgically treated lumbar radiculopathy patients by using a generic and a lumbar disease-specific que...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2010.03.014

    authors： Bosković K,Cigić T,Grajić M,Todorović-Tomasević S,Knezević A

    更新日期：2010-09-01 00:00:00

  • An investigation on the effect of improved X-rays-guided radiofrequency thermocoagulation denervation on lumbar facet joint syndrome.

    abstract：OBJECTIVES:This study aims to observe the clinical efficacy and feasibility of improved X-rays-guided radiofrequency thermocoagulation denervation for treating low back pain secondary to lumbar facet joint syndrome (LFJS). PATIENTS AND METHODS:Eighty LFJS patients were randomly assigned into two groups: the denervatio...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2016.07.018

    authors： Zhou Q,Zhou F,Wang L,Liu K

    更新日期：2016-09-01 00:00:00

  • Endoscopic resection of cavernoma of foramen of Monro in a patient with familial multiple cavernomatosis.

    abstract：:Intraventricular cavernomas are extremely infrequent and only 11 cases of cavernous hemangioma to occur at the foramen of Monro have been reported in the literature. This 56 years old patient was admitted with progressive and intractable headache of 10 days of evolution. He was known to suffer familial multiple cavern...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2008.05.011

    authors： Prat R,Galeano I

    更新日期：2008-09-01 00:00:00

  • Montreal Cognitive Assessment score correlates with regional cerebral blood flow in post-stroke patients.

    abstract：OBJECTIVE:Valid and reliable measures are needed to assess post-stroke cognitive impairment. The Montreal Cognitive Assessment (MoCA) has been considered a superior screening test to the Mini-Mental State Examination (MMSE) for patients with post-stroke cognitive impairment, particularly in executive function, which ma...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2018.09.004

    authors： Nakaoku Y,Oishi N,Hase Y,Hase M,Saito S,Mitsueda T,Matsui M,Toyoda K,Nagatsuka K,Kalaria RN,Fukuyama H,Ihara M,Takahashi R

    更新日期：2018-11-01 00:00:00

  • Dialysis disequilibrium: another reversible posterior leukoencephalopathy syndrome?

    abstract：:Dialysis disequilibrium syndrome is a disorder of the central nervous system in patients on dialysis. The underlying etiology is thought to be primarily due to cerebral edema; however, neuroradiologic findings have not been described previously. We describe a patient who presented with new onset headaches and status e...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/s0303-8467(03)00039-8

    authors： Sheth KN,Wu GF,Messé SR,Wolf RL,Kasner SE

    更新日期：2003-09-01 00:00:00

  • Theory of mind and empathy in patients at an early stage of relapsing remitting multiple sclerosis.

    abstract：INTRODUCTION:Early after having been diagnosed with relapsing remitting multiple sclerosis (RRMS), young patients coping with the new situation require good social support and interactions. Successful social interaction is critically dependent upon the ability to understand the minds of others and their feelings. Socia...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2012.10.027

    authors： Kraemer M,Herold M,Uekermann J,Kis B,Wiltfang J,Daum I,Dziobek I,Berlit P,Diehl RR,Abdel-Hamid M

    更新日期：2013-07-01 00:00:00

  • Factors influencing the symmetry of Parkinson's disease symptoms.

    abstract：INTRODUCTION:The presence of asymmetry in symptoms and clinical signs favours the diagnosis of Parkinson's disease (PD). The aim of this study is to analyse this symptom asymmetry as a function of different variables and compare it with other parkinsonisms. MATERIALS AND METHODS:201 Patients with PD were studied. The ...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2009.12.017

    authors： Gómez-Esteban JC,Tijero B,Ciordia R,Berganzo K,Somme J,Lezcano E,Zarranz JJ

    更新日期：2010-05-01 00:00:00

  • Glossopharyngeal schwannoma, an uncommon posterior fossa tumor: diagnostical and therapeutical aspects: a case report.

    abstract：:Among posterior fossa tumors, schwannomas arising from glossopharyngeal nerve are rare; only about 30 cases of glossopharyngeal neuroma have been described. Though a typical 'jugular foramen syndrome' has been described for tumors of this region, the clinical onset may often closely resemble that of acoustic neuromas ...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/s0303-8467(97)00016-4

    authors： Rapanà A,Lamaida E,Bracale C,Lepore P,Pizza V,Graziussi G

    更新日期：1997-08-01 00:00:00

  • A detailed analysis of intracerebral hemorrhages in DBS surgeries.

    abstract：OBJECTIVES:Deep brain stimulation is nowadays a frequently performed surgery in patients with movement disorders, intractable epilepsy, and severe psychiatric disorders. The most feared complication of this surgery is an intracerebral hemorrhage due to the electrode placement, either for intraoperative electrophysiolog...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2015.10.017

    authors： Tonge M,Ackermans L,Kocabicak E,van Kranen-Mastenbroek V,Kuijf M,Oosterloo M,Kubben P,Temel Y

    更新日期：2015-12-01 00:00:00

  • Development of intimal thickening in superficial temporal arteries in patients with moyamoya disease.

    abstract：:To investigate the possible mechanism of neointimal formation in Moyamoya disease, we histologically examined the superficial temporal arteries and also investigated cultured smooth muscle cells (SMCs) from the arteries. Intimal thickening of the scalp arteries developed significantly at an early age in Moyamoya patie...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/s0303-8467(97)00046-2

    authors： Aoyagi M,Fukai N,Yamamoto M,Matsushima Y,Yamamoto K

    更新日期：1997-10-01 00:00:00

  • Frequency of reported European ancestry among multiple sclerosis patients from four cities in the southern and southeastern regions of Brazil.

    abstract：UNLABELLED:Recent reports on the prevalence of multiple sclerosis (MS) have described discrepancies between the rates in cities in the northeastern and southeastern regions of Brazil, representing a north-south gradient. European immigrants settled in southeastern and southern Brazil at the beginning of the twentieth c...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2013.02.024

    authors： Comini-Frota ER,Brum DG,Kaimen-Maciel DR,Fragoso YD,Barreira AA,Donadi EA

    更新日期：2013-09-01 00:00:00

  • Stimulation of the motor cortex for disabling essential tremor.

    abstract：OBJECTIVE:To examine the safety and efficacy of targeted stimulation of the motor cortex as a treatment for essential tremor (ET). PATIENTS AND METHODS:At the University of Kansas Medical Center, two patients with essential tremor received stimulation of the (contralateral) motor cortex using an investigational implan...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clineuro.2006.01.001

    authors： Lyons KE,Wilkinson SB,Pahwa R

    更新日期：2006-09-01 00:00:00

  • Molecular and clinical prognostic factors for favorable outcome following surgical resection of adult intramedullary spinal cord astrocytomas.

    abstract：OBJECTIVE:Intramedullary spinal cord astrocytomas are uncommon but important entities. Aggressive surgical resection is believed to be critical to prevent subsequent neurological deterioration; however, the prognostic significance of numerous patient and molecular variables remains unclear. We sought to investigate the...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2016.03.009

    authors： Xiao R,Abdullah KG,Miller JA,Lubelski D,Steinmetz MP,Shin JH,Krishnaney AA,Mroz TE,Benzel EC

    更新日期：2016-05-01 00:00:00

  • Concepts in undergraduate neurological teaching.

    abstract：:Common neurological problems in family practice were determined to assess what knowledge of neurology is essential to the graduating medical student. The family practitioner's difficulties in managing these problems and needs for referral, were studied. Types of problems seen in a teaching hospital neurology service w...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/s0303-8467(76)80022-4

    authors： Murray TJ

    更新日期：1977-01-01 00:00:00

  • An extremely unusual presentation of varicella zoster viral infection of cranial nerves mimicking Garcin syndrome.

    abstract：:We report a patient with the varicella zoster viral (VZV) infection of multiple cranial nerves mimicking Garcin syndrome, who initially presented with Ramsay Hunt syndrome (herpes zoster oticus). A 78-year-old man showed left facial palsy with zosteric eruptions in his left auricle and dysphagia, followed by left tota...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2005.09.002

    authors： Nishioka K,Fujishima K,Kobayashi H,Mizuno Y,Okuma Y

    更新日期：2006-12-01 00:00:00

  • Risk factors for glioblastoma therapy associated complications.

    abstract：OBJECTIVE:Thromboembolic events, seizures, neurologic symptoms and adverse effects from corticosteroids and chemotherapies are frequent clinical complications seen in Glioblastoma (GB) patients. The exact impact these have on dismal patient outcome has not been fully elucidated. We aimed at assessing treatment associat...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2015.01.006

    authors： Ening G,Osterheld F,Capper D,Schmieder K,Brenke C

    更新日期：2015-07-01 00:00:00

  • Symptomatic and asymptomatic abnormalities in patients with lumbosacral radicular syndrome: Clinical examination compared with MRI.

    abstract：OBJECTIVE:To determine the frequency of symptomatic and asymptomatic herniated discs and root compression in patients with lumbosacral radicular syndrome (LRS) and to correlate clinical localization with MRI findings. METHODS:Fifty-seven patients with unilateral LRS were included in the study. Using the visual analogu...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/j.clineuro.2005.10.003

    authors： van Rijn JC,Klemetso N,Reitsma JB,Majoie CB,Hulsmans FJ,Peul WC,Bossuyt PM,Heeten GJ,Stam J

    更新日期：2006-09-01 00:00:00

  • Hereditary spastic paraparesis. Clinical and genetic data from a large Dutch family.

    abstract：:A large Dutch family is presented with pure hereditary spastic paraparesis. Pedigree analysis indicates autosomal dominant inheritance with complete penetrance and possibly anticipation in successive generations. These observations may have implications for genetic studies. Linkage studies in this family have excluded...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/0303-8467(93)90006-3

    authors： Bruyn RP,van Deutekom J,Frants RR,Padberg GW

    更新日期：1993-06-01 00:00:00

  • Muscle activation features of the osteoarthritic knee with patellar lateral subluxation.

    abstract：OBJECTIVE:The aim of the study was to compare the muscle activation feature of vastus medialis obliquus (VMO) and vastus lateralis (VL) between the osteoarthritic knee patients with patellar lateral subluxation (Group 1B) and without patellar lateral subluxation (Group 1A). METHODS:Isokinetic muscle strength of the kn...

    journal_title：Clinical neurology and neurosurgery

    pub_type： 杂志文章

    doi：10.1016/S0303-8467(15)30009-3

    authors： Tang SF,Wu CK,Chen CH,Chen JT,Tang AC,Wu SH

    更新日期：2015-02-01 00:00:00