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Secondary gliosarcoma with extra-cranial metastases: a report and review of the literature.

Abstract：

OBJECTIVE:To describe a unique case of secondary gliosarcoma (SGS) with widespread extra-cranial metastases that developed more than 5 years after the initial diagnosis of glioblastoma multiforme (GBM). This interval is the longest among the cases reported to date. METHODS:A PUBMED search using the key words "secondary gliosarcoma" and "extra-cranial metastases" was performed followed by a review of cited literature. RESULTS:Including our report, we found 44 cases of SGS, of which only 5 developed extra-cranial metastases. CONCLUSION:SGS with extra-cranial metastases is extremely rare. Of previously reported cases, the longest survival was 2 months after the diagnosis of SGS. The present case had a survival of 6.5 months. Our case highlights the importance of screening for extra-cranial metastases in SGS. The optimal treatment of SGS is not known and strategies based on GBM and sarcoma treatments have been employed with limited success. A combination of treatment modalities may extend survival as in the present report; however the prognosis remains poor.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Dawar R,Fabiano AJ,Qiu J,Khushalani NI

doi

10.1016/j.clineuro.2012.06.017

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

375-80

issue

4

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(12)00336-8

journal_volume

115

pub_type

杂志文章

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