Hereditary spastic paraparesis. Clinical and genetic data from a large Dutch family.

Abstract:

:A large Dutch family is presented with pure hereditary spastic paraparesis. Pedigree analysis indicates autosomal dominant inheritance with complete penetrance and possibly anticipation in successive generations. These observations may have implications for genetic studies. Linkage studies in this family have excluded more than 40% of the autosomal genome.

journal_name

Clin Neurol Neurosurg

authors

Bruyn RP,van Deutekom J,Frants RR,Padberg GW

doi

10.1016/0303-8467(93)90006-3

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

125-9

issue

2

eissn

0303-8467

issn

1872-6968

pii

0303-8467(93)90006-3

journal_volume

95

pub_type

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