Multicenter outbreak of infections by Saprochaete clavata, an unrecognized opportunistic fungal pathogen.

abstract：UNLABELLED:Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully used to study human-tropic pathogens in the past, we challenged BALB/c mice defici...

journal_title：mBio

authors： Taube S,Kolawole AO,Höhne M,Wilkinson JE,Handley SA,Perry JW,Thackray LB,Akkina R,Wobus CE

更新日期：2013-07-16 00:00:00

abstract：:The apparent mislocalization or excretion of cytoplasmic proteins is a commonly observed phenomenon in both bacteria and eukaryotes. However, reports on the mechanistic basis and the cellular function of this so-called "nonclassical protein secretion" are limited. Here we report that protein overexpression in recombin...

journal_title：mBio

authors： Morra R,Del Carratore F,Muhamadali H,Horga LG,Halliwell S,Goodacre R,Breitling R,Dixon N

更新日期：2018-01-30 00:00:00

abstract：:As the GroES/GroEL chaperonin system is the only bacterial chaperone that is essential under all conditions, we have been interested in the development of GroES/GroEL inhibitors as potential antibiotics. Using Escherichia coli GroES/GroEL as a surrogate, we have discovered several classes of GroES/GroEL inhibitors tha...

journal_title：mBio

authors： Sivinski J,Ambrose AJ,Panfilenko I,Zerio CJ,Machulis JM,Mollasalehi N,Kaneko LK,Stevens M,Ray AM,Park Y,Wu C,Hoang QQ,Johnson SM,Chapman E

更新日期：2021-01-12 00:00:00

abstract：UNLABELLED:Male circumcision reduces female-to-male HIV transmission. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. We compared the coronal sulcus microbiota of men from a group of uncircumcised controls (n = 77) a...

journal_title：mBio

authors： Liu CM,Hungate BA,Tobian AA,Serwadda D,Ravel J,Lester R,Kigozi G,Aziz M,Galiwango RM,Nalugoda F,Contente-Cuomo TL,Wawer MJ,Keim P,Gray RH,Price LB

更新日期：2013-04-16 00:00:00

abstract：:Flavor production in yeast fermentation is of paramount importance for industrial production of alcoholic beverages. Although major enzymes of flavor compound biosynthesis have been identified, few specific mutations responsible for strain diversity in flavor production are known. The ATF1-encoded alcohol acetyl coenz...

journal_title：mBio

authors： Holt S,Trindade de Carvalho B,Foulquié-Moreno MR,Thevelein JM

更新日期：2018-08-28 00:00:00

abstract：UNLABELLED:Mycoplasma pneumoniae, a pathogenic bacterium, glides on host surfaces using a unique mechanism. It forms an attachment organelle at a cell pole as a protrusion comprised of knoblike surface structures and an internal core. Here, we analyzed the three-dimensional structure of the organelle in detail by elect...

journal_title：mBio

authors： Kawamoto A,Matsuo L,Kato T,Yamamoto H,Namba K,Miyata M

更新日期：2016-04-12 00:00:00

abstract：:Pneumocystis species are opportunistic mammalian pathogens that cause severe pneumonia in immunocompromised individuals. These fungi are highly host specific and uncultivable in vitro Human Pneumocystis infections present major challenges because of a limited therapeutic arsenal and the rise of drug resistance. To inv...

journal_title：mBio

authors： Cissé OH,Ma L,Wei Huang D,Khil PP,Dekker JP,Kutty G,Bishop L,Liu Y,Deng X,Hauser PM,Pagni M,Hirsch V,Lempicki RA,Stajich JE,Cuomo CA,Kovacs JA

更新日期：2018-05-08 00:00:00

abstract：:Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughput purposes. Here, we made a...

journal_title：mBio

authors： Moudjou M,Sibille P,Fichet G,Reine F,Chapuis J,Herzog L,Jaumain E,Laferrière F,Richard CA,Laude H,Andréoletti O,Rezaei H,Béringue V

更新日期：2013-12-31 00:00:00

abstract：:The pharmacopeia used by physicians and laypeople in medieval Europe has largely been dismissed as placebo or superstition. While we now recognize that some of the materia medica used by medieval physicians could have had useful biological properties, research in this area is limited by the labor-intensive process of ...

journal_title：mBio

authors： Connelly E,Del Genio CI,Harrison F

更新日期：2020-02-11 00:00:00

abstract：:Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of ...

journal_title：mBio

authors： Cobián Güemes AG,Lim YW,Quinn RA,Conrad DJ,Benler S,Maughan H,Edwards R,Brettin T,Cantú VA,Cuevas D,Hamidi R,Dorrestein P,Rohwer F

更新日期：2019-04-16 00:00:00

abstract：:Protein lysine acetylation, a prevalent posttranslational modification, regulates numerous crucial biological processes in cells. Nevertheless, how lysine acetylation interacts with other types of regulation to coordinate metabolism remains largely unknown owing to the complexity of the process. Here, using a represen...

journal_title：mBio

authors： Zhang L,Liu Y,Zhao R,Zhang C,Jiang W,Gu Y

更新日期：2020-08-18 00:00:00

abstract：:Bordetella pertussis controls the expression of its virulence regulon through the two-component system BvgAS. BvgS is a prototype for a family of multidomain sensor kinases. In BvgS, helical linkers connect periplasmic Venus flytrap (VFT) perception domains to a cytoplasmic Per-Arnt-Sim (PAS) domain and the PAS domain...

journal_title：mBio

authors： Lesne E,Dupré E,Lensink MF,Locht C,Antoine R,Jacob-Dubuisson F

更新日期：2018-02-27 00:00:00

abstract：UNLABELLED:Human immunodeficiency virus type 1 (HIV-1) Nef enhances virus replication and contributes to immune evasion in vivo, but the underlying molecular mechanisms remain incompletely defined. Nef interferes with host cell actin dynamics to restrict T lymphocyte responses to chemokine stimulation and T cell recept...

journal_title：mBio

authors： Imle A,Abraham L,Tsopoulidis N,Hoflack B,Saksela K,Fackler OT

更新日期：2015-09-08 00:00:00

abstract：UNLABELLED:Carbonate chimneys at the Lost City hydrothermal field are coated in biofilms dominated by a single phylotype of archaea known as Lost City Methanosarcinales. In this study, we have detected surprising physiological complexity in single-species biofilms, which is typically indicative of multispecies biofilm ...

journal_title：mBio

authors： Brazelton WJ,Mehta MP,Kelley DS,Baross JA

更新日期：2011-09-01 00:00:00

abstract：:While Shiga toxins (Stx) are key determinants of enterohemorrhagic Escherichia coli (EHEC) pathophysiology in humans, their dissemination to target organs following gastrointestinal EHEC infection is still poorly understood. Most types of Stx target cells with globotriaosylceramide (Gb3) receptors, which are expressed...

journal_title：mBio

authors： Lengeling A,Mahajan A,Gally DL

更新日期：2013-11-12 00:00:00

abstract：:Motility is an important virulence trait for many bacterial pathogens, allowing them to position themselves in appropriate locations at appropriate times. The motility structures type IV pili and flagella are also involved in sensing surface contact, which modulates pathogenicity. In Pseudomonas aeruginosa, the PilS-P...

journal_title：mBio

authors： Kilmury SLN,Burrows LL

更新日期：2018-07-24 00:00:00

abstract：:The yeast Yarrowia lipolytica is a potent accumulator of lipids, and lipogenesis in this organism can be influenced by a variety of factors, such as genetics and environmental conditions. Using a multifactorial study, we elucidated the effects of both genetic and environmental factors on regulation of lipogenesis in Y...

journal_title：mBio

authors： Kerkhoven EJ,Kim YM,Wei S,Nicora CD,Fillmore TL,Purvine SO,Webb-Robertson BJ,Smith RD,Baker SE,Metz TO,Nielsen J

更新日期：2017-06-20 00:00:00

abstract：:Plant-infecting viruses utilize various strategies involving multiple viral and host factors to achieve successful systemic infections of their compatible hosts. Lettuce infectious yellows virus (LIYV), genus Crinivirus, family Closteroviridae, has long, filamentous flexuous virions and causes phloem-limited infection...

journal_title：mBio

authors： Qiao W,Medina V,Kuo YW,Falk BW

更新日期：2018-11-20 00:00:00

abstract：:Staphylococcus aureus is an important human pathogen whose success is largely attributed to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the human host. The expression of these virulence factors is controlled by the quorum sensing accessory gene regulator (Agr) system. ...

journal_title：mBio

authors： Gor V,Takemura AJ,Nishitani M,Higashide M,Medrano Romero V,Ohniwa RL,Morikawa K

更新日期：2019-08-06 00:00:00

abstract：:Bacterial viruses, or bacteriophages, are highly abundant in the biosphere and have a major impact on microbial populations. Many examples of phage interactions with their hosts, including establishment of dormant lysogenic and active lytic states, have been characterized at the level of the individual cell. However, ...

journal_title：mBio

authors： Laganenka L,Sander T,Lagonenko A,Chen Y,Link H,Sourjik V

更新日期：2019-09-10 00:00:00

abstract：UNLABELLED:Marine methane seeps are globally distributed geologic features in which reduced fluids, including methane, are advected upward from the subsurface. As a result of alkalinity generation during sulfate-coupled methane oxidation, authigenic carbonates form slabs, nodules, and extensive pavements. These carbona...

journal_title：mBio

authors： Case DH,Pasulka AL,Marlow JJ,Grupe BM,Levin LA,Orphan VJ

更新日期：2015-12-22 00:00:00

abstract：:Acute flaccid myelitis (AFM) is a rare but serious illness of the nervous system, specifically affecting the gray matter of the spinal cord, motor-controlling regions of the brain, and cranial nerves. Most cases of AFM are pathogen associated, typically with poliovirus and enterovirus infections, and occur in children...

journal_title：mBio

authors： Rosenfeld AB,Warren AL,Racaniello VR

更新日期：2019-10-22 00:00:00

abstract：UNLABELLED:In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P. jirovecii) were compared among themselves and with the free-living, phylogenetically related fission yeast (Schizosaccharomyces pombe)...

journal_title：mBio

authors： Porollo A,Sesterhenn TM,Collins MS,Welge JA,Cushion MT

更新日期：2014-11-04 00:00:00

abstract：:In bacteria, elongation factor Tu is a translational cofactor that forms ternary complexes with aminoacyl-tRNA (aa-tRNA) and GTP. Binding of a ternary complex to one of four flexible L7/L12 units on the ribosome tethers a charged tRNA in close proximity to the ribosomal A site. Two sequential tests for a match between...

journal_title：mBio

authors： Mustafi M,Weisshaar JC

更新日期：2018-01-16 00:00:00

abstract：:Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobact...

journal_title：mBio

authors： Hagan AK,Tripathi A,Berger D,Sherman DH,Hanna PC

更新日期：2017-09-12 00:00:00

abstract：UNLABELLED:β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients. Systematically tracking β-lactam resistance could benefit disease surveillance. Here we developed a classification syst...

journal_title：mBio

authors： Li Y,Metcalf BJ,Chochua S,Li Z,Gertz RE Jr,Walker H,Hawkins PA,Tran T,Whitney CG,McGee L,Beall BW

更新日期：2016-06-14 00:00:00

abstract：:The members of the OM43 clade of Betaproteobacteria are abundant coastal methylotrophs with a range of carbon-utilizing capabilities. However, their underlying transcriptional and metabolic responses to shifting conditions or different carbon substrates remain poorly understood. We examined the transcriptional dynamic...

journal_title：mBio

authors： Gifford SM,Becker JW,Sosa OA,Repeta DJ,DeLong EF

更新日期：2016-11-22 00:00:00

abstract：UNLABELLED:The prominent host muramidase lysozyme cleaves bacterial peptidoglycan (PG), and the enzyme is abundant in mucosal secretions. The lytic enzyme susceptibility of Gram-negative bacteria and mechanisms they use to thwart lytic enzyme activity are poorly studied. We previously characterized a Helicobacter pylor...

journal_title：mBio

authors： Wang G,Lo LF,Forsberg LS,Maier RJ

更新日期：2012-12-04 00:00:00

abstract：:Long noncoding RNA (lncRNA) plays important roles in sexual development in eukaryotes. In filamentous fungi, however, little is known about the expression and roles of lncRNAs during fruiting body formation. By profiling developmental transcriptomes during the life cycle of the plant-pathogenic fungus Fusarium gramine...

journal_title：mBio

authors： Kim W,Miguel-Rojas C,Wang J,Townsend JP,Trail F

更新日期：2018-08-14 00:00:00

abstract：UNLABELLED:The ability to cultivate food is an innovation that has produced some of the most successful ecological strategies on the planet. Although most well recognized in humans, where agriculture represents a defining feature of civilization, species of ants, beetles, and termites have also independently evolved sy...

journal_title：mBio

authors： Aylward FO,Suen G,Biedermann PH,Adams AS,Scott JJ,Malfatti SA,Glavina del Rio T,Tringe SG,Poulsen M,Raffa KF,Klepzig KD,Currie CR

更新日期：2014-11-18 00:00:00