Abstract:
:Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is considered the most common form of chronic liver disease in children. Several factors contribute to NAFLD development, including race/ethnicity, genetic factors, environmental exposures, and alterations in the gut microbiome. The histologic spectrum of NAFLD ranges from simple steatosis to the more aggressive nonalcoholic steatohepatitis (NASH). Fibrosis and eventually cirrhosis can develop from NAFLD during childhood. Diagnosing advanced disease is challenging and may require a liver biopsy, highlighting the urgent need for reliable, noninvasive markers of disease severity. The mainstay of treatment for NAFLD remains lifestyle modifications and weight loss. Probiotics and ω-3 fatty acids may ameliorate disease progression. Recent data have suggested that vitamin E may be considered as a NASH-specific therapy in children, and there are several ongoing human studies evaluating different therapeutic targets for NAFLD. We provide an up-to-date review of the risk factors, diagnosis, and treatment to manage this common disease in children.
journal_name
JAMA Pediatrjournal_title
JAMA pediatricsauthors
Nobili V,Alkhouri N,Alisi A,Della Corte C,Fitzpatrick E,Raponi M,Dhawan Adoi
10.1001/jamapediatrics.2014.2702subject
Has Abstractpub_date
2015-02-01 00:00:00pages
170-6issue
2eissn
2168-6203issn
2168-6211pii
2022277journal_volume
169pub_type
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