Abstract:
AIM:The study was carried out on elderly nursing home residents in Taiwan. We assessed whether the serial QuantiFERON-TB Gold (QFT-G) assay and serial tuberculin skin test (TST) were reliable tools to predict or exclude the development of active tuberculosis (TB). METHODS:This prospective observational cohort study involved non-bacillus Calmette-Guérin-vaccinated 259 elderly nursing home residents free of active TB at baseline. Of these, 147 were eligible for follow up. Participants underwent serial QFT-G and TST at baseline and 2-year follow up, and were monitored for active TB over 5 years. Agreement between QFT-G and TST, incidence rate ratio, positive predictive value, and negative predictive value for progression to active TB were measured. RESULTS:During 5-year follow up, three participants developed active TB. The agreement between these two tests was 54.13% (ĸ = 0.167, P = 0.001). The incidence rate ratio was 15.8 (P = 0.016) for the QFT-G-conversion group compared with the TST-positive group at baseline. Positive predictive value for QFT-G conversion groups was 25%. Negative predictive value was 100% for the TST-negative group at baseline. CONCLUSION:In the elderly nursing home residents, QFT-G conversion is a more reliable tool to predict the development of active TB. Meanwhile, TST is a valuable tool for predicting the chance of not developing active TB.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Tsou PH,Huang WC,Huang CC,Lin CF,Wu KM,Hsu JY,Shen GHdoi
10.1111/ggi.12416subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1179-84issue
10eissn
1444-1586issn
1447-0594journal_volume
15pub_type
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
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journal_title:Geriatrics & gerontology international
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journal_title:Geriatrics & gerontology international
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1447-0594.2008.00509.x
更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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更新日期:2017-05-01 00:00:00