Systematic review of statins for the prevention of vascular dementia or dementia.

Abstract:

AIM:Non-hypolipidemic effects of statins, known as pleiotropic effects, are likely to explain the effect of statins on dementia. Results of the relationship between statins and dementia in previous studies are conflicting. There is no systematic review investigating the effect of statins on vascular dementia (VaD). This systematic review evaluates the role of statins in the prevention of VaD or dementia. The possible causes of conflicting results in the existing published work will be explored. METHODS:Relevant studies were systematically identified and reviewed. The Cochrane Controlled Trials and three electronic databases (MEDLINE, EMBASE and PsycInfo) were searched. The selection criteria were defined a priori. Included studies were rated by quality assessment checklists and two independent reviewers. RESULTS:Six studies in dementia, two studies in VaD (one study reported both dementia and VaD) and two meta-analyses met the selection criteria. The studies covered 1372 cases of dementia from 14 430 participants and 116 cases of VaD from 4924 participants from the USA and UK. There was no association between statin use and risk of VaD. The protective effect of statins on dementia was demonstrated only in a nested case-control study of lower quality and one recently published cohort study. In most other cohort and high quality studies, statin use did not show a beneficial effect. CONCLUSION:Study design differences among the studies and methodological shortcomings may have resulted in different outcomes. On the basis of these conflicting results, statins could not be recommended as a preventative treatment for dementia.

journal_name

Geriatr Gerontol Int

authors

Muangpaisan W,Brayne C,Alzheimer's Society Vascular Dementia Systematic Review Group.

doi

10.1111/j.1447-0594.2009.00579.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

199-208

issue

2

eissn

1444-1586

issn

1447-0594

pii

GGI579

journal_volume

10

pub_type

杂志文章,评审
  • Association between dysphagia risk and unplanned hospitalization in older patients receiving home medical care.

    abstract:AIM:Home medical care for older adults with chronic conditions is becoming an increasing important issue in Japan. We need to support long-term medical care at home and avoid unplanned hospitalizations, which can adversely affect activities of daily living and quality of life. In this study, we investigated whether swa...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.13753

    authors: Watanabe K,Umegaki H,Huang CH,Arakawa Martins B,Asai A,Kanda S,Nomura H,Kuzuya M

    更新日期:2019-10-01 00:00:00

  • Reduction in the numbers of drugs administered to elderly in-patients with polypharmacy by a multidisciplinary review of medication using electronic medical records.

    abstract:AIM:Polypharmacy is a major problem for elderly patients in developed countries. We investigated whether a multidisciplinary medication review using electronic medical records could reduce the number of drugs administered to elderly patients receiving polypharmacy. METHODS:The present study included 432 elderly patien...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12764

    authors: Hayashi Y,Godai A,Yamada M,Yoshikura N,Harada N,Koumura A,Kimura A,Okayasu S,Matsuno Y,Kinosada Y,Itoh Y,Inuzuka T

    更新日期:2017-04-01 00:00:00

  • Sevoflurane anesthesia impairs metabotropic glutamate receptor-dependent long-term depression and cognitive functions in senile mice.

    abstract:AIM:Postoperative cognitive dysfunction is often observed in older patients. Previous reports described the link between postoperative cognitive dysfunction and general anesthetics, such as sevoflurane, but the exact mechanism remains unclear. We therefore sought to characterize the effects of sevoflurane on hippocampa...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.13619

    authors: Yu X,Zhang F,Shi J

    更新日期:2019-04-01 00:00:00

  • Relationship of thresholds of physical performance to nutritional status in older hospitalized male cardiac patients.

    abstract:AIM:Nutrition is the focus of a new treatment target in older hospitalized cardiac patients. However, little is known about the differences in nutritional status in relation to physical performance in these inpatients. We determined the differences in physical performance based on the Geriatric Nutritional Risk Index (...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12257

    authors: Izawa KP,Watanabe S,Oka K

    更新日期:2015-02-01 00:00:00

  • Genetic association of BIN1 and GAB2 in Alzheimer's disease: A meta-analysis and systematic review.

    abstract:AIM:Heredity plays an important role in the pathogenesis of Alzheimer's disease (AD) especially for single-nucleotide polymorphism (SNPs) of susceptible genes, which is one of the significant factors in the pathogenesis of AD. The SNPs of BIN1 rs744373, BIN1 rs7561528 and GAB2 rs2373115 are associated with AD in Asian ...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.14109

    authors: Hao X,Wang A,Li C,Shao L,Li Y,Yang P

    更新日期:2020-12-16 00:00:00

  • Prevalence of potentially reversible conditions in dementia and mild cognitive impairment in a geriatric clinic.

    abstract:AIM:To examine the prevalence of potentially reversible conditions in dementia and mild cognitive impairment (MCI) patients in a geriatric clinic. METHODS:We retrospectively reviewed the medical records of patients who attended the outpatient geriatric clinic at Siriraj Hospital, Bangkok between January 2005 and Decem...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/j.1447-0594.2011.00728.x

    authors: Muangpaisan W,Petcharat C,Srinonprasert V

    更新日期:2012-01-01 00:00:00

  • Stress-induced blood pressure elevation in subjects with mild cognitive impairment: effects of the dual-type calcium channel blocker, cilnidipine.

    abstract:AIM:We investigated whether mental stress-induced blood pressure elevation was related to cognitive function in the elderly, and further examined the effects of the dual-type calcium channel blocker, cilnidipine, on stress induced hypertension in subjects with mild cognitive impairment. METHODS:In study I, 39 consecut...

    journal_title:Geriatrics & gerontology international

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1447-0594.2008.00482.x

    authors: Kawashima Y,Akishita M,Hasegawa H,Kozaki K,Toba K

    更新日期:2008-12-01 00:00:00

  • Epileptic activities are common in older people with delirium.

    abstract:AIM:Delirium is responsible for up to 56% of hospital admissions in the elderly. Epilepsy and delirium share most risk factors and are both associated with confusion. The aim of this work was to study whether a link between epileptic activity (EA) and delirium existed, and if this link was relevant. METHODS:Charts of ...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12128

    authors: Naeije G,Bachir I,Gaspard N,Legros B,Pepersack T

    更新日期:2014-04-01 00:00:00

  • Effects of a multifactorial intervention comprising resistance exercise, nutritional and psychosocial programs on frailty and functional health in community-dwelling older adults: A randomized, controlled, cross-over trial.

    abstract:AIM:To examine the effects of a multifactorial intervention on frailty and functional health among community-dwelling older adults, a 6-month randomized, controlled, cross-over trial was carried out within the Hatoyama Cohort Study. METHODS:A total of 77 pre-frail or frail older adults (mean age 74.6 years) were rando...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ggi.13016

    authors: Seino S,Nishi M,Murayama H,Narita M,Yokoyama Y,Nofuji Y,Taniguchi Y,Amano H,Kitamura A,Shinkai S

    更新日期:2017-11-01 00:00:00

  • Screening of patients with cognitive impairment when entering a rehabilitation unit.

    abstract:AIM:The objective of this study is to evaluate the feasibility of an early screening of cognitive impairment in rehabilitation units, and the proportion of cognitive impairments (in particular, Alzheimer's disease) among this population. METHODS:This is a multicentric, non-interventional, epidemiological, transverse, ...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1447-0594.2011.00715.x

    authors: Porte P,Lahmi K,Auque JM,Carnet Y,Galliou A,Preux PM,Labourdette M,Zawieja P,Métais P

    更新日期:2012-01-01 00:00:00

  • Does ongoing general practitioner care in elderly patients help reduce the risk of unplanned hospitalization related to Beers potentially inappropriate medications?

    abstract:AIM:To compare estimates of unplanned hospitalizations associated with exposure to Beers potentially inappropriate medications (PIM) in elderly people receiving different levels of ongoing general practitioner (GP) care. METHODS:Using the pharmaceutical claims and other linked health data of 245,436 Western Australian...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12400

    authors: Price SD,Holman CD,Sanfilippo FM,Emery JD

    更新日期:2015-08-01 00:00:00

  • Validation of the Insomnia in the Elderly Scale for the detection of insomnia in older adults.

    abstract:AIM:The main objective of this study was the validation of a brief support instrument for the diagnosis of insomnia in older adults. METHODS:An observational study was carried out for the evaluation of the Insomnia in the Elderly Scale using the psychiatric interview as the gold standard. Data was collected in a prima...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/j.1447-0594.2012.00958.x

    authors: Navarro B,López-Torres J,Andrés F,Latorre JM,Montes MJ,Párraga I

    更新日期:2013-07-01 00:00:00

  • Factors influencing weaning from mechanical ventilation in elderly patients with severe pneumonia.

    abstract:AIMS:The purpose of this study was to determine the factors that adversely affect the weaning of elderly patients with community-acquired pneumonia from mechanical ventilation. METHODS:This study retrospectively investigated the medical records of 71 elderly patients (65 years or older) who were admitted to the hospit...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/j.1447-0594.2011.00765.x

    authors: Fujii M,Iwakami S,Takagi H,Itoigawa Y,Ichikawa M,Iwakami N,Ishiwata T,Seyama K,Takahashi K

    更新日期:2012-04-01 00:00:00

  • Clinical characteristics and therapeutic outcomes of elderly patients with chronic myeloid leukemia: A retrospective multicenter study.

    abstract:AIMS:We aimed to investigate whether older age leads to limitations in the starting dose of imatinib in daily treatment of chronic myeloid leukemia, and to determine the compliance of elderly patients with tyrosine kinase inhibitors (TKI) therapy. METHODS:Data including the clinical characteristics, therapeutic outcom...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ggi.12341

    authors: Korkmaz S,Dal MS,Berber I,Sahin DG,Dogu MH,Ayyildiz O,Nizam I,Albayrak M,Esen R,Namdaroglu S,Sencan M,Akay OM,Hacioglu S,Yildirim R,Eser A,Tombak A,Pala C,Ilhan O

    更新日期:2015-06-01 00:00:00

  • Comparison of the psychosocial quality of life in hemodialysis patients between the elderly and non-elderly using a visual analogue scale: the importance of appetite and depressive mood.

    abstract:AIM:The number of hemodialysis (HD) patients is increasing along with their mean age in Japan. The assessment of their psychosocial status and quality of life (QOL) is therefore becoming more and more important along with laboratory data or comorbidities. METHODS:We examined the psychosocial status of 211 HD patients ...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/j.1447-0594.2011.00731.x

    authors: Kanamori H,Nagai K,Matsubara T,Mima A,Yanagita M,Iehara N,Takechi H,Fujimaki K,Usami K,Fukatsu A,Kita T,Matsubayashi K,Arai H

    更新日期:2012-01-01 00:00:00

  • Low alanine aminotransferase levels predict low muscle strength in older patients with diabetes: A nationwide cross-sectional study in Korea.

    abstract:AIM:Low alanine aminotransferase (ALT) level is associated with frailty in the older adult population. We investigated the usefulness of ALT in predicting low muscle strength among older patients with diabetes. METHODS:We included 550 men aged ≥50 years and 525 postmenopausal women. All participants had diabetes, and ...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.13868

    authors: Chung SM,Moon JS,Yoon JS,Won KC,Lee HW

    更新日期:2020-04-01 00:00:00

  • Geriatric oral health predicaments in New Delhi, India.

    abstract:OBJECTIVES:The aim of the present study was to analyze geriatric oral health predicaments in India. Specifically, to assess the oral health status and treatment needs among the geriatric population attending health camps in New Delhi, Northern India. METHODS:The sample size for the cross-sectional study comprised of 2...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12434

    authors: Singh A,Purohit BM,Masih N

    更新日期:2016-01-01 00:00:00

  • Positive affect as a predictor of lower risk of functional decline in community-dwelling elderly in Japan.

    abstract:AIM:To investigate whether positive affect independently predicts a lower risk of functional decline among community-dwelling older Japanese. METHODS:A 2-year prospective study was carried out among 505 residents of Tosa Town aged 65 years and older without disability in carrying out basic activities of daily living (...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12008

    authors: Hirosaki M,Ishimoto Y,Kasahara Y,Konno A,Kimura Y,Fukutomi E,Chen W,Nakatsuka M,Fujisawa M,Sakamoto R,Ishine M,Okumiya K,Otsuka K,Wada T,Matsubayashi K

    更新日期:2013-10-01 00:00:00

  • Longitudinal study of regional cerebral blood flow in elderly patients with idiopathic rapid eye movement sleep behavior disorder.

    abstract:AIM:Single photon emission computed tomography (SPECT) studies showed that regional cerebral blood flow (rCBF) abnormalities in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) are similar to those seen in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The aim of the present study was t...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12068

    authors: Sakurai H,Hanyu H,Inoue Y,Kanetaka H,Nakamura M,Miyamoto T,Sasai T,Iwamoto T

    更新日期:2014-01-01 00:00:00

  • Factors contributing to food insecurity among older persons in Malaysia: Findings from the National Health and Morbidity Survey (NHMS) 2018.

    abstract:AIM:Older persons are vulnerable to food insecurity. Therefore, this study aimed to determine the prevalence of food insecurity and associated factors among older persons in Malaysia. METHODS:This is a cross-sectional study with two-stage stratified random sampling. In total, 3977 older persons participated in this st...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.14006

    authors: Salleh R,Man CS,Ahmad MH,Palaniveloo L,Zulkafly N,Ab Halim SA,Baharudin Shaharuddin A,Sulaiman N,Che Abdul Rahim N,Abdul Aziz NS,Mohd Sallehuddin S,Pardi M,Zainuddin AA,Abdul Ghaffar S,Shahar S,Selamat R,Ibrahim Wong N

    更新日期:2020-12-01 00:00:00

  • Early case-fatality rates in elderly stroke patients do not increase when age increases.

    abstract:AIM:We studied the association between age and survival after stroke. We particularly focused on deaths that could be attributed to the stroke lesion itself; that is, early death in severe stroke. METHODS:A registry of all hospitalized stroke patients in Denmark included 93897 patients with information on stroke sever...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ggi.12165

    authors: Dehlendorff C,Andersen KK,Olsen TS

    更新日期:2014-10-01 00:00:00

  • Delirium among elderly patients admitted to a post-acute care facility and 3-months outcome.

    abstract:AIM:To investigate the prevalence and risk factors of delirium in an extended care unit, the persistence of delirium and 3-month outcome. METHOD:Patients aged >65 years were recruited. Basic demographic data, medical comorbidity using the Charlson Comorbidity Index, pre-existing cognitive impairment using the informan...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12521

    authors: Miu DK,Chan CW,Kok C

    更新日期:2016-05-01 00:00:00

  • Depressive symptoms and all-cause mortality in Korean older adults: A 3-year population-based prospective study.

    abstract:AIM:To examine the association between depressive symptoms and all-cause mortality in a population-based prospective study. METHODS:Data from the 2008 baseline and 2011 follow-up assessments of the Living Profiles of Older People Survey involving 14 976 Korean adults aged ≥60 years (59% women) were used. Depressive sy...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.13270

    authors: Park SH,Kim D,Cho J,Jin Y,Lee I,Lee K,Kang H

    更新日期:2018-06-01 00:00:00

  • Possible mechanism underlying the association between higher hemoglobin level and hypertension in older Japanese men.

    abstract:AIM:Hemoglobin is reported to be positively associated with hypertension. However, the underlying mechanism of this association is unknown. Recently, bone marrow-derived CD34-positive cells have been reported to play an important role in endothelial repair in conjunction with platelets. As the association between hyper...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.13068

    authors: Shimizu Y,Sato S,Koyamatsu J,Yamanashi H,Nagayoshi M,Kadota K,Kawashiri SY,Maeda T

    更新日期:2017-12-01 00:00:00

  • Performance of severity scores for home care-based patients suffering from pneumonia.

    abstract:AIM:The Pneumonia Severity Index (PSI) is used to determine the prognosis of community-acquired pneumonia (CAP). The concept of nursing- and healthcare-associated pneumonia (NHCAP) has recently been established in Japan. The present study aims to examine whether the PSI can predict the prognosis of home care-based pati...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12274

    authors: Ishibashi F,Sunohara M,Kawagoe S

    更新日期:2015-03-01 00:00:00

  • Validating the Life Events Scale for the Elderly with proxy-based data: A case-control psychological autopsy study in rural China.

    abstract:AIM:The present study aimed to evaluate the validity of proxy informants' reports on Life Event Scale for the Elderly (LESE) by using psychological autopsy method among rural older adults in China. METHODS:A multistage stratified cluster sampling method was used to select research sites. Using a case-control psycholog...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.13658

    authors: Mo Q,Zhou L,He Q,Jia C,Ma Z

    更新日期:2019-06-01 00:00:00

  • Differential impact of some risk factors on trochanteric and cervical hip fractures.

    abstract:AIM:To investigate the potential distinct risk factors associated with trochanteric and cervical hip fractures. METHODS:Elderly patients aged 65 years and older (n = 1161) were admitted to the orthopedic department with hip fractures during the years 2006-2011. Demographic and clinical data, as well as routine blood t...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12294

    authors: Tal S,Gurevich A,Sagiv S,Guller V

    更新日期:2015-04-01 00:00:00

  • Prevalence and risk factors of constipation and pollakisuria among older home-care patients.

    abstract:AIM:The prevalence of constipation and prevalence of pollakisuria among older patients receiving home medical care have not been reported, and risk factors for these symptoms are not clear in this setting. The present study sought to determine the prevalence and risk factors of constipation and pollakisuria among older...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.13610

    authors: Komiya H,Umegaki H,Asai A,Kanda S,Maeda K,Nomura H,Kuzuya M

    更新日期:2019-04-01 00:00:00

  • Combined association of leisure-time physical activity and fruit and vegetable consumption with depressive symptoms in older Taiwanese: Results of a national cohort study.

    abstract:AIMS:To determine the independent and combined associations of leisure-time physical activity (LTPA) and fruit and vegetable consumption with subsequent new depressive symptoms in Taiwanese aged ≥53 years. METHODS:We analyzed the 1999 and 2003 datasets of the Taiwan Longitudinal Survey on Aging and used the Center for...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/ggi.12459

    authors: Chi SH,Wang JY,Tsai AC

    更新日期:2016-02-01 00:00:00

  • Lipids' peroxidation markers in Alzheimer's disease and vascular dementia.

    abstract:AIM:Although a large body of evidence supports a role of oxidative stress in the etiopathogenesis of dementia, there is still a substantial lack of data regarding the biomarkers of oxidative stress characteristic of Alzheimer's disease (AD) as opposed to different types of dementia. In this study, the level of various ...

    journal_title:Geriatrics & gerontology international

    pub_type: 杂志文章

    doi:10.1111/j.1447-0594.2009.00571.x

    authors: Gustaw-Rothenberg K,Kowalczuk K,Stryjecka-Zimmer M

    更新日期:2010-04-01 00:00:00