Abstract:
AIMS:We aimed to investigate whether older age leads to limitations in the starting dose of imatinib in daily treatment of chronic myeloid leukemia, and to determine the compliance of elderly patients with tyrosine kinase inhibitors (TKI) therapy. METHODS:Data including the clinical characteristics, therapeutic outcomes and compliance with TKI therapy of elderly patients with chronic myeloid leukemia aged >65 years were collected from 13 institutions in Turkey, retrospectively. RESULTS:A total of 69 patients (27 [39%] men, 42 [61%] women) were evaluated retrospectively. The median age of the patients was 71 years (range 66-85 years). Of the patients, 66 (96%) were in the chronic phase and three (4.3%) were in the accelerated phase when diagnosed. A total of 63 (91.3%) patients were receiving imatinib as the first-line therapy. The initial dose of imatinib was 400 mg/day in 59 patients (93.6%). Imatinib treatment induced 57 (90.5%) complete hematological responses at 3 months, 29 (46%) complete cytogenetic responses at 6 months and 49 (77.7%) major molecular responses at 12 months. As a result, nilotinib and dasatinib were used in 14 patients as second-line therapy. Second-line TKI induced nine complete hematological responses (64.3%) at 3 months, four complete cytogenetic responses (28.6%) at 12 months and seven major molecular responses (50%) at 18 months. A total of 56 of the patients (81.2%) are still alive. The median overall survival and progression-free survival rates were 35 months (range 1-95 months) and 17 months (range 0.8-95 months), respectively. CONCLUSION:Elderly patients should receive TKI according to the same guidelines that apply to younger patients.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Korkmaz S,Dal MS,Berber I,Sahin DG,Dogu MH,Ayyildiz O,Nizam I,Albayrak M,Esen R,Namdaroglu S,Sencan M,Akay OM,Hacioglu S,Yildirim R,Eser A,Tombak A,Pala C,Ilhan Odoi
10.1111/ggi.12341subject
Has Abstractpub_date
2015-06-01 00:00:00pages
729-35issue
6eissn
1444-1586issn
1447-0594journal_volume
15pub_type
杂志文章,多中心研究abstract:AIM:Lactoferrin and lactoperoxidase have antimicrobial effects against oral pathogens. This randomized, double-blinded, placebo-controlled parallel group study tested the efficacy of a lactoferrin and lactoperoxidase-containing tablet (LF + LPO tablet) in improving the oral hygiene status of older individuals. METHODS...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
doi:10.1111/ggi.12776
更新日期:2017-05-01 00:00:00
abstract:AIM:Home medical care for older adults with chronic conditions is becoming an increasing important issue in Japan. We need to support long-term medical care at home and avoid unplanned hospitalizations, which can adversely affect activities of daily living and quality of life. In this study, we investigated whether swa...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13753
更新日期:2019-10-01 00:00:00
abstract:AIM:To evaluate the association between the amount and frequency of alcohol consumption and incident dementia in older Japanese adults using large sample size data over a long follow-up period. METHODS:This was a retrospective cohort study carried out in Japan. A total of 53 311 older adults were followed from 2008 to...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13694
更新日期:2019-08-01 00:00:00
abstract:AIM:The behavioral and psychological symptoms of dementia place a heavy burden on caregivers. Antipsychotic drugs, though used to reduce the symptoms, frequently decrease patients' activities of daily living and reduce their quality of life. Recently, it was suggested that ferulic acid is an effective treatment for beh...
journal_title:Geriatrics & gerontology international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1447-0594.2010.00687.x
更新日期:2011-07-01 00:00:00
abstract:AIM:The present study aimed to evaluate the relationship between the change of carotid intima-media thickness (CIMT) and clinical characteristics in Japanese patients without a history of cardiovascular disease. METHODS:The study participants were 149 Japanese patients without a history of cardiovascular disease treat...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12402
更新日期:2015-08-01 00:00:00
abstract:AIM:To re-evaluate the suitability of calf circumference as a surrogate marker of low muscle mass measured by both bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA). We also examined the effects of obesity and age on low muscle mass screening using calf circumference. METHODS:In total, ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14025
更新日期:2020-10-01 00:00:00
abstract:AIM:We studied the association between age and survival after stroke. We particularly focused on deaths that could be attributed to the stroke lesion itself; that is, early death in severe stroke. METHODS:A registry of all hospitalized stroke patients in Denmark included 93897 patients with information on stroke sever...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/ggi.12165
更新日期:2014-10-01 00:00:00
abstract:AIM:Nutrition is the focus of a new treatment target in older hospitalized cardiac patients. However, little is known about the differences in nutritional status in relation to physical performance in these inpatients. We determined the differences in physical performance based on the Geriatric Nutritional Risk Index (...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12257
更新日期:2015-02-01 00:00:00
abstract:AIM:Functional status at one moment in time is a determinant of future functional status and survival. Physical deterioration tends to occur early in the disabling process; however, etiological questions remain. This study investigated the association between physical performance characteristics and functioning indepen...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00890.x
更新日期:2013-04-01 00:00:00
abstract:AIM:To identify and evaluate the causes and characteristics of road traffic accidents (RTA) and to analyze injury patterns in elderly road traffic victims in order to apply appropriate measures for the prevention of RTA in the elderly. METHODS:Two hundred and fifty-eight elderly road traffic victims admitted to the Em...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2009.00535.x
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to analyze geriatric oral health predicaments in India. Specifically, to assess the oral health status and treatment needs among the geriatric population attending health camps in New Delhi, Northern India. METHODS:The sample size for the cross-sectional study comprised of 2...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12434
更新日期:2016-01-01 00:00:00
abstract:AIM:To determine whether elderly subjects with distinct histories of falls presented differences concerning the influence of sensory interaction on balance. METHODS:Cross-sectional research. Ninety-six community-dwelling elderly subjects were divided into three groups, according to the history of falls within the past...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2009.00516.x
更新日期:2009-06-01 00:00:00
abstract:AIM:Sensitive, specific neuropsychological screening tests, such as the Addenbrooke's Cognitive Examination Revised (ACE-R), are essential for dementia diagnosis. We aimed to validate the use of the Korean version of ACE-R (K-ACER) to differentiate Alzheimer's disease (AD) from subcortical ischemic vascular dementia (S...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2010.00624.x
更新日期:2010-10-01 00:00:00
abstract:AIM:Calf circumference, which is a known simple indicator of muscle mass, increases during edema. However, the extent to which edema increases calf circumference in older adults is unclear. METHODS:This retrospective cross-sectional study included patients aged ≥65 years whose nutritional status was assessed by nutrit...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13756
更新日期:2019-10-01 00:00:00
abstract:AIM:Aging shifts body composition to comprising more fat and less muscle. Sarcopenia, particularly in the knee extensors, and obesity, particularly visceral obesity, either alone or in combination, may exacerbate age-related physical disability. We investigated the association between age-related quadriceps (Qc) sarcop...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2010.00610.x
更新日期:2010-07-01 00:00:00
abstract:AIM:To examine the association between depressive symptoms and all-cause mortality in a population-based prospective study. METHODS:Data from the 2008 baseline and 2011 follow-up assessments of the Living Profiles of Older People Survey involving 14 976 Korean adults aged ≥60 years (59% women) were used. Depressive sy...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13270
更新日期:2018-06-01 00:00:00
abstract:AIMS:The purpose of this study was to determine the factors that adversely affect the weaning of elderly patients with community-acquired pneumonia from mechanical ventilation. METHODS:This study retrospectively investigated the medical records of 71 elderly patients (65 years or older) who were admitted to the hospit...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00765.x
更新日期:2012-04-01 00:00:00
abstract:AIM:Delirium is responsible for up to 56% of hospital admissions in the elderly. Epilepsy and delirium share most risk factors and are both associated with confusion. The aim of this work was to study whether a link between epileptic activity (EA) and delirium existed, and if this link was relevant. METHODS:Charts of ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12128
更新日期:2014-04-01 00:00:00
abstract:AIM:To examine the efficacy of rehabilitation for elderly individuals with dementia at intermediate facilities between hospitals and home, based on the policies for elderly individuals to promote community-based care at home and dehospitalization. METHODS:Participants were older adults with dementia newly admitted to ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/ggi.12080
更新日期:2014-01-01 00:00:00
abstract:AIM:There is little data regarding the prevalence and associated comorbidities of anemia in Chinese nursing home older adults. The objective of this study was to investigate the prevalence and associated comorbidities of anemia in Chinese nursing home older adults. METHODS:We carried out a retrospective cross-sectiona...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1447-0594.2012.00942.x
更新日期:2013-07-01 00:00:00
abstract:AIM:As the Japanese population ages, the number of older patients with chronic obstructive pulmonary disease (COPD) is expected to increase, but the prevalence of COPD in patients aged ≥80 years remains unclear. The purpose of the present study was to determine the prevalence of COPD in independent community-dwelling o...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13091
更新日期:2017-12-01 00:00:00
abstract::A community is the totality of human relationships, in which individuals live with and for others. This article discusses promoting dementia-friendly community from the perspective of human relationships within a community. Improving the social well-being of aging people is important; it is especially important for pe...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.13896
更新日期:2020-06-01 00:00:00
abstract:AIM:The aim of this study was to examine how geriatricians decide the indication of tube feeding in the elderly with eating difficulty as a result of several disorders, and to determine the factors associated with their decision making and interventions for dysphagia. METHODS:The design was a cross-sectional study. Al...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00831.x
更新日期:2012-10-01 00:00:00
abstract:AIM:To evaluate the safety, tolerability and pharmacokinetic profile of bapineuzumab after a single intravenous injection in Japanese patients with mild to moderate Alzheimer's disease. METHODS:Participants received either a placebo (n = 8), or bapineuzumab 0.15 (n = 6), 0.5 (n = 6), 1.0 (n = 6) or 2.0 (n = 6) mg/kg. ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/ggi.12516
更新日期:2016-05-01 00:00:00
abstract::Now that the number of elderly people has increased and the number of dementia patients is rapidly increasing, dementia might be regarded as a common disease. Under these circumstances, the establishment of systems to support the elderly with dementia from the early stages, and to provide primary care doctors and care...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.12248
更新日期:2014-04-01 00:00:00
abstract:AIM:This study analyzed the trend of gender gaps in life expectancy (GGLE) in Japan between 1947 and 2010, and explored the correlations of GGLE with gender mortality ratio and social development indices. METHODS:Using GGLE and social indices data collected from the official websites, we carried out trends analysis of...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12001
更新日期:2013-07-01 00:00:00
abstract:AIM:The aim of the present study was to assess the relationship between neighborhood perception and poor self-rated health among older Mexican Americans, adjusting for important background characteristics, such as neighborhood ethnic composition and other health conditions. METHODS:Drawing on the 2004-2005 Hispanic Es...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13089
更新日期:2017-12-01 00:00:00
abstract:AIM:To investigate the prevalence and risk factors of delirium in an extended care unit, the persistence of delirium and 3-month outcome. METHOD:Patients aged >65 years were recruited. Basic demographic data, medical comorbidity using the Charlson Comorbidity Index, pre-existing cognitive impairment using the informan...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12521
更新日期:2016-05-01 00:00:00
abstract::More than 50 years ago, Hayflick et al. found that no long-lived, proliferative cells remained in long-term cell culture experiments; this phenomenon is called "cellular senescence." This finding has allowed us to understand basic individual tissue aging and cancer inhibition from the view of cellular aging. Senescent...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.13851
更新日期:2020-02-01 00:00:00
abstract:AIM:To measure illuminance in the home lives of elderly people to clarify the current state of affairs and concurrently investigate quantification methods for this purpose. METHODS:Illuminance and the physical and mental health of 24 elderly people living, with some assistance, in their homes in a prefecture in the Ho...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12021
更新日期:2013-07-01 00:00:00