99Tcm-diastereomeric dimercaptosuccinic acid complexes: comparison of their biodistribution.

Abstract:

:The biodistribution of two stereoisomeric 99Tcm complexes derived from diastereomeric dimercaptosuccinic acids (DMSA), 99Tcm-dl-DMSA and 99Tcm-meso-DMSA, was examined in sarcoma 180 tumour-bearing mice. The biodistribution pattern of meso-complex was not significantly different from 99Tc(V)m-DMSA, a new tumour imaging agent, while the dl-complex did not show the osteotropic property observed in meso- and 99Tc(V)m-DMSA complexes. The ratio of tumour to blood was superior for the 99Tcm-dl-DMSA (2.68) over the 99Tcm-meso-DMSA (1.25) at 3 h, and the ratio was reversed at 6 h, 3.13 to 4.28. The results indicate that dl-complex is of importance for the possible use in tumour imaging.

journal_name

Nucl Med Commun

authors

Awh OD,Kim JR,Shim SC

doi

10.1097/00006231-198906000-00011

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

449-54

issue

6

eissn

0143-3636

issn

1473-5628

journal_volume

10

pub_type

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