Antibodies specific to the retinoic acid human nuclear receptors alpha and beta.

abstract：:Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Although the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. Because many questions rega...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linnemann AK,O'Geen H,Keles S,Farnham PJ,Bresnick EH

更新日期：2011-08-16 00:00:00

abstract：:Evolutionary thinking can be applied to both cultural microevolution and macroevolution. However, much of the current literature focuses on cultural microevolution. In this article, we argue that the growing availability of large cross-cultural datasets facilitates the use of computational methods derived from evoluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray RD,Watts J

更新日期：2017-07-25 00:00:00

abstract：:Debate over the influence of postwildfire management on future fire severity is occurring in the absence of empirical studies. We used satellite data, government agency records, and aerial photography to examine a forest landscape in southwest Oregon that burned in 1987 and then was subject, in part, to salvage-loggin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson JR,Spies TA,Ganio LM

更新日期：2007-06-19 00:00:00

abstract：:Successful adaptation to changes in an animal's emotional and motivational environment depends on behavioral flexibility accompanied by changes in bodily responses, e.g., autonomic and endocrine, which support the change in behavior. Here, we identify the orbitofrontal cortex (OFC) as pivotal in the flexible regulatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reekie YL,Braesicke K,Man MS,Roberts AC

更新日期：2008-07-15 00:00:00

abstract：:Protozoan parasites of the genus Leishmania undergo a complex life cycle involving transmission by biting sand flies and replication within mammalian macrophage phagolysosomes. A major component of the Leishmania surface coat is the glycosylphosphatidylinositol (GPI)-anchored polysaccharide called lipophosphoglycan (L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Späth GF,Epstein L,Leader B,Singer SM,Avila HA,Turco SJ,Beverley SM

更新日期：2000-08-01 00:00:00

abstract：:The intracellular signaling mechanisms regulating the generation and long-term persistence of memory T cells in vivo remain unclear. In this study, we used mouse models with conditional deletion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of 76 kDa (SLP-76), to analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bushar ND,Corbo E,Schmidt M,Maltzman JS,Farber DL

更新日期：2010-01-12 00:00:00

abstract：:Seismic magnitudes determined from surface and body waves for the Soviet underground nuclear explosion of September 14, 1988, are used to calculate the yield of that event from previously derived calibration curves. The yield obtained by combining the two seismic estimates is 113 kilotons, which is very close to those...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sykes LR,Ekström G

更新日期：1989-05-01 00:00:00

abstract：:Human breast cancers contain an RNA related to that of mouse mammary tumor virus. In 79% of the breast malignancies examined, this type of RNA is a 70S-component encapsulated with RNA-instructed DNA polymerase in a particle possessing the density characteristics of RNA tumor viruses. Further, the DNA synthesized by th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axel R,Gulati SC,Spiegelman S

更新日期：1972-11-01 00:00:00

abstract：:Actin filaments and integrin-based focal adhesions (FAs) form integrated systems that mediate dynamic cell interactions with their environment or other cells during migration, the immune response, and tissue morphogenesis. How adhesion-associated actin structures obtain their functional specificity is unclear. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skau CT,Plotnikov SV,Doyle AD,Waterman CM

更新日期：2015-05-12 00:00:00

abstract：:The levels of c-myc, c-fos, and JE mRNAs accumulate in a biphasic pattern following infection of quiescent BALB/c 3T3 mouse cells with polyomavirus. Maximal levels of c-myc and c-fos mRNAs were seen within 1 hr and were nearly undetectable at 6 hr after infection. At 12 hr after infection mRNA levels were again maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zullo J,Stiles CD,Garcea RL

更新日期：1987-03-01 00:00:00

abstract：:We have shown previously that hydroxyl radicals (HO*) can be produced by H2O2 and halogenated quinones, independent of transition metal ions; however, the underlying molecular mechanism is still unclear. In the present study, using the electron spin resonance secondary radical spin-trapping method, we found that tetra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu BZ,Kalyanaraman B,Jiang GB

更新日期：2007-11-06 00:00:00

abstract：:Heat shock factors (HSFs) are the master regulators of transcription under protein-damaging conditions, acting in an environment where the overall transcription is silenced. We determined the genomewide transcriptional program that is rapidly provoked by HSF1 and HSF2 under acute stress in human cells. Our results rev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vihervaara A,Sergelius C,Vasara J,Blom MA,Elsing AN,Roos-Mattjus P,Sistonen L

更新日期：2013-09-03 00:00:00

abstract：:Double-strand breaks (DSBs) in DNA are lethal unless repaired. Faithful repair requires processing of the DSB ends and interaction with intact homologous DNA, which can produce genetic recombinants. To determine the role of nucleases in DSB end-processing and joint molecule resolution, we studied recombination at the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farah JA,Cromie GA,Smith GR

更新日期：2009-06-09 00:00:00

abstract：:The feeling of being observed or merely participating in an experiment can affect individuals' behavior. Referred to as the Hawthorne effect, this inconsistently observed phenomenon can both provide insight into individuals' behavior and confound the interpretation of experimental manipulations. Here, we pursue both t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz D,Fischhoff B,Krishnamurti T,Sowell F

更新日期：2013-09-17 00:00:00

abstract：:The turnover rates of junctional acetylcholine receptors were measured in innervated and denervated mouse sternomastoid neuromuscular junctions by 125I-labeled alpha-bungarotoxin binding. First, we determined that the density of labeled toxin initially bound to the neuromuscular junction was essentially unchanged up t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loring RH,Salpeter MM

更新日期：1980-04-01 00:00:00

abstract：:HUMAN LIVER ALCOHOL DEHYDROGENASE (ALCOHOL: NAD(+) oxidoreductase, EC 1.1.1.1), homogeneous by physicochemical criteria, has been available in quantity only recently [Lange, L. G. & Vallee, B. L. (1976) Biochemistry 15, 4681-4686]. Until now, the biochemical basis of human alcohol metabolism had to be extrapolated fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li TK,Bosron WF,Dafeldecker WP,Lange LG,Vallee BL

更新日期：1977-10-01 00:00:00

abstract：:Creatine, a nitrogenous organic acid, replenishes cytoplasmic ATP at the expense of mitochondrial ATP via the phosphocreatine shuttle. Creatine levels are maintained by diet and endogenous synthesis from arginine and glycine. Glycine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turer E,McAlpine W,Wang KW,Lu T,Li X,Tang M,Zhan X,Wang T,Zhan X,Bu CH,Murray AR,Beutler B

更新日期：2017-02-14 00:00:00

abstract：:A procedure is described for selection of temperature-sensitive mutants affecting fatty-acid synthesis based upon radiation suicide of wild-type organisms by tritiated acetate selectively incorporated into fatty acids. At 37 degrees , two of the mutants extensively incorporate fatty-acid supplements provided in the me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harder ME,Beacham IR,Cronan JE Jr,Beacham K,Honegger JL,Silbert DF

更新日期：1972-11-01 00:00:00

abstract：:In this report we examine the effects of chronic anaerobic exposure and subsequent reoxygenation on protein synthesis patterns in Chinese hamster ovary cells. It is observed by two-dimensional gel electrophoresis (isoelectric focusing/NaDodSO4/PAGE) that the transition from an atmospheric environment to an anaerobic s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sciandra JJ,Subjeck JR,Hughes CS

更新日期：1984-08-01 00:00:00

abstract：:Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for proteome integrity and cellular health. Ribosome-associated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown during C-terminal Ala ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li S,Wu Z,Tantray I,Li Y,Chen S,Dong J,Glynn S,Vogel H,Snyder M,Lu B

更新日期：2020-10-06 00:00:00

abstract：:The fluorescence decay functions of individual, specifically labeled tRNAPhe molecules exhibit nonexponential character as a result of conformational dynamics occurring during the measurement on a single molecule. tRNAPhe conformational states that interchange much more slowly are evidenced by the distribution of life...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jia Y,Sytnik A,Li L,Vladimirov S,Cooperman BS,Hochstrasser RM

更新日期：1997-07-22 00:00:00

abstract：:Gaseous HCl generated from a variety of sources is ubiquitous in both outdoor and indoor air. Oxides of nitrogen (NO(y)) are also globally distributed, because NO formed in combustion processes is oxidized to NO(2), HNO(3), N(2)O(5) and a variety of other nitrogen oxides during transport. Deposition of HCl and NO(y) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raff JD,Njegic B,Chang WL,Gordon MS,Dabdub D,Gerber RB,Finlayson-Pitts BJ

更新日期：2009-08-18 00:00:00

abstract：:The three most common methods of sterilization in use today are ethylene oxide exposure, gamma-irradiation, and steam sterilization. Each of these methods has serious limitations for the sterilization of some materials used in medicine, especially thermally and hydrolytically sensitive polymers by themselves and in co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dillow AK,Dehghani F,Hrkach JS,Foster NR,Langer R

更新日期：1999-08-31 00:00:00

abstract：:Herpesviruses are dsDNA viruses, but their virions may additionally contain RNAs that can be transduced to recipient cells. The biological functions of herpes virion RNA species are unknown. Here we address this issue for EBV, a widespread human herpesvirus with oncogenic potential. We show that EBV-derived particles ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jochum S,Ruiss R,Moosmann A,Hammerschmidt W,Zeidler R

更新日期：2012-05-22 00:00:00

abstract：:Loss or reduction in function of tumor suppressor genes contributes to tumorigenesis. Here, by allelic DNA copy number analysis using single-nucleotide polymorphism genotyping array and mass spectrometry, we report homozygous deletion in glioblastoma multiformes at chromosome 13q21, where DACH1 gene is located. We fou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe A,Ogiwara H,Ehata S,Mukasa A,Ishikawa S,Maeda D,Ueki K,Ino Y,Todo T,Yamada Y,Fukayama M,Saito N,Miyazono K,Aburatani H

更新日期：2011-07-26 00:00:00

abstract：:Certain Escherichia coli mutants defective in phosphatidylglycerol biosynthesis accumulate two novel glycolipids, designated X and Y. Lipid X is a diacylglucosamine 1-phosphate bearing beta-hydroxymyristoyl groups at positions 2 and 3, and lipid Y has the same structure as X, except for the additional presence of a pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishijima M,Amano F,Akamatsu Y,Akagawa K,Tokunaga T,Raetz CR

更新日期：1985-01-01 00:00:00

abstract：:Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling? Interneuron gap junctions enhance synchrony of gamma oscillations (25-70 Hz) in isolated interneuron networks and also in network...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Traub RD,Pais I,Bibbig A,LeBeau FE,Buhl EH,Hormuzdi SG,Monyer H,Whittington MA

更新日期：2003-02-04 00:00:00

abstract：:The L-A double-stranded RNA virus of Saccharomyces cerevisiae makes a gag-pol fusion protein by a -1 ribosomal frameshift. The pol amino acid sequence includes consensus patterns typical of the RNA-dependent RNA polymerases (EC 2.7.7.48) of (+) strand and double-stranded RNA viruses of animals and plants. We have carr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribas JC,Wickner RB

更新日期：1992-03-15 00:00:00

abstract：:Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane excitability and myocardial dysfunction remain uncertain. Failing human cardiomyocytes exhibit increased CaMKII and voltage-gated Ca(2+) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koval OM,Guan X,Wu Y,Joiner ML,Gao Z,Chen B,Grumbach IM,Luczak ED,Colbran RJ,Song LS,Hund TJ,Mohler PJ,Anderson ME

更新日期：2010-03-16 00:00:00

abstract：:Trust is a critical social process that helps us to cooperate with others and is present to some degree in all human interaction. However, the underlying brain mechanisms of conditional and unconditional trust in social reciprocal exchange are still obscure. Here, we used hyperfunctional magnetic resonance imaging, in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krueger F,McCabe K,Moll J,Kriegeskorte N,Zahn R,Strenziok M,Heinecke A,Grafman J

更新日期：2007-12-11 00:00:00