MicroRNA-214 regulates osteosarcoma survival and growth by directly targeting phosphatase and tensin homolog.

abstract：:The effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport were examined in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP. Sensitivity to mitoxantrone, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly reversed by ...

journal_title：Molecular medicine reports

authors： Takara K,Matsubara M,Yamamoto K,Minegaki T,Takegami S,Takahashi M,Yokoyama T,Okumura K

更新日期：2012-03-01 00:00:00

abstract：:Intrauterine adhesions (IUA) may be caused by endometrial stromal cell proliferation, increases in myofibroblasts or increases in extracellular matrix secretion. However, the specific mechanisms underlying the development of IUA have yet to be elucidated. The present study identified that angiotensin (Ang) II is capab...

journal_title：Molecular medicine reports

authors： Shan T,Zhang L,Zhao C,Chen W,Zhang Y,Li G

更新日期：2014-06-01 00:00:00

abstract：:Retinitis pigmentosa (RP) is a group of inherited diseases that primarily affect light‑sensitive rods and cones in the retina. Rhodopsin mutations, including the T17M mutation, are associated with the autosomal dominant form of retinitis pigmentosa (ADRP) and have been linked to abnormal protein folding. However, the ...

journal_title：Molecular medicine reports

authors： Jiang H,Xiong S,Xia X

更新日期：2014-05-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in the development and progression of cancer. Recently HNF1A antisense RNA 1 (HNF1A‑AS1), a lncRNA, has been reported as exhibiting a potential oncogenic role in the development of many types of cancer. However, the expression and the role ...

journal_title：Molecular medicine reports

authors： Zhu W,Zhuang P,Song W,Duan S,Xu Q,Peng M,Zhou J

更新日期：2017-10-01 00:00:00

abstract：:Dietary n‑3 polyunsaturated fatty acid (PUFA) exerts anti‑inflammatory and immunoregulatory effects via downregulation of the innate and adaptive immune responses. However, the effect of dietary n‑3 PUFA on experimental Crohn's Disease (CD) in rats and the underlying mechanisms are unclear. The present study aimed to ...

journal_title：Molecular medicine reports

authors： Yao J,Lu Y,Zhi M,Hu P,Wu W,Gao X

更新日期：2017-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of an immune response in vivo can injure and reject MSC‑based tissues. Toll‑like ...

journal_title：Molecular medicine reports

authors： Yang Y,Wang Y,Li L,Bao J,Chen F,Zhang L

更新日期：2015-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a type of movement disorder caused by loss of dopamine‑producing neurons in the midbrain. In order to identify the synergistic microRNA (miRNA) pattern in PD, miRNA and mRNA double expression profiles of PD were downloaded. Differentially expressed miRNA and mRNA were identified [P<0.01, fo...

journal_title：Molecular medicine reports

authors： Hao B,Chen X,Dai D,Zou C,Wu X,Chen J

更新日期：2015-02-01 00:00:00

abstract：:Sepsis is a leading killer of children worldwide with numerous differentially expressed genes reported to be associated with sepsis. Identifying core pathways in an individual is important for understanding septic mechanisms and for the future application of custom therapeutic decisions. Samples used in the study were...

journal_title：Molecular medicine reports

authors： Li B,Zeng Q

更新日期：2017-10-01 00:00:00

abstract：:Aldose reductase (AR) is involved in the pathogenesis of nonalcoholic steatohepatitis. This study aimed to determine the mechanism by which AR affects the development of murine diet-induced nonalcoholic steatohepatitis. Steatohepatitis was induced in C57BL/6 mice by administration of a methionine-choline-deficient (MC...

journal_title：Molecular medicine reports

authors： Chen T,Shi D,Chen J,Yang Y,Qiu M,Wang W,Qiu L

更新日期：2015-01-01 00:00:00

abstract：:Dbl-family guanine nucleotide exchange factors (GEFs) are important activators of Rho GTPases, which are significantly associated with tumorigenesis and metastasis. The catalytic ability of the Dbl-family GEFs to activate Rho GTPases depends on their Dbl-homology domain followed by a pleckstrin-homology domain. In the...

journal_title：Molecular medicine reports

authors： Wang H,Li Y,Wang Y,Han ZG,Cai B

更新日期：2012-05-01 00:00:00

abstract：:Heat shock proteins (HSPs) are molecular chaperones that were initially identified as proteins expressed following exposure of cells to environmental stress. However, the function of HSPs in epithelial‑to‑mesenchymal transition (EMT) of peritoneal mesothelial cells remains unknown. In the present study, the regulation...

journal_title：Molecular medicine reports

authors： Liu J,Bao J,Hao J,Peng Y,Hong F

更新日期：2014-08-01 00:00:00

abstract：:Endothelial microparticles (EMPs) and endothelial cells (ECs) are involved in the pathophysiological mechanisms of sepsis and septic shock. EMPs are small vesicles released by ECs and are considered biomarkers for endothelial cell function and mediators for intercellular information exchange. However, the effect of EM...

journal_title：Molecular medicine reports

authors： Liu Y,Zhang R,Qu H,Wu J,Li L,Tang Y

更新日期：2017-03-01 00:00:00

abstract：:Twenty‑three clinical Streptococcus pneumoniae (SP) strains were isolated from blood and sputum specimens from the Second Affiliated Hospital of Wenzhou Medical College in 2009. These strains and the ATCC 49619 standard strain were cultured and suspended in normal saline (at a turbidity of 1.0 McFarland). The producti...

journal_title：Molecular medicine reports

authors： Zhang J,Hu DK,Wang DG,Liu Y,Liu CB,Yu LH,Qu Y,Luo XH,Yang JH,Yu J,Liu SC,Li XY

更新日期：2013-11-01 00:00:00

abstract：:Acute kidney injury (AKI) is a clinical syndrome associated with high rates of morbidity and mortality. It has previously been reported that stem cells may be considered a potential therapeutic strategy for the treatment of AKI. The present study aimed to determine whether administration of urine‑derived stem cells (U...

journal_title：Molecular medicine reports

authors： Tian SF,Jiang ZZ,Liu YM,Niu X,Hu B,Guo SC,Wang NS,Wang Y

更新日期：2017-10-01 00:00:00

abstract：:Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease, which has been divided into two types according to whether it involves premature ovarian failure (POF). Mutations in forkhead box L2 (FOXL2) have been identified in the majority of patients with BPES. The present study ai...

journal_title：Molecular medicine reports

authors： Yang L,Li T,Xing Y

更新日期：2017-10-01 00:00:00

abstract：:Gonadotrophin‑releasing hormone (GnRH) agonists (GnRHa) have been widely used to induce a state of downregulation for in vitro fertilization, and its direct effects on the pituitary are well known. However, the effects of GnRHa on the expression of anti‑mullerian hormone (AMH) by follicles in varying stages in vivo re...

journal_title：Molecular medicine reports

authors： Huang J,Wang X,Li Z,Ma R,Xiao W

更新日期：2015-09-01 00:00:00

abstract：:Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for 4 h twice a day, from days 7‑21 of pregnancy. Hypoxia was confirmed by a decrease in the partial pressure of oxygen...

journal_title：Molecular medicine reports

authors： Ding H,Luo Y,Hu K,Huang H,Liu P,Xiong M,Zhu L,Yi J,Xu Y

更新日期：2020-11-01 00:00:00

abstract：:Accumulating evidence indicates that long non‑coding RNAs (lncRNAs) may serve essential roles during tumorigenesis of colorectal cancer (CRC). The lncRNA ZFPM2‑AS1 was observed to be involved in the progression of numerous types of cancer, such as lung adenocarcinoma and cervical cancer. The aim of the present study w...

journal_title：Molecular medicine reports

authors： Xiao M,Liang Z,Yin Z

更新日期：2021-02-01 00:00:00

abstract：:The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway. Male albino Wistar rats were injected subcutaneously with isoproterenol (100 ...

journal_title：Molecular medicine reports

authors： Jia G,Zao M,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a hematological malignancy with a low survival rate. Curcumin, which is a multi-targeted anticancer agent, has been shown to exert anti‑oxidant, anti‑inflammatory, anti‑mutagenic and anti‑carcinogenic activities. Naringenin is extracted from citrus fruits and exerts anti‑mutagenic and a...

journal_title：Molecular medicine reports

authors： Shi D,Xu Y,Du X,Chen X,Zhang X,Lou J,Li M,Zhuo J

更新日期：2015-12-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized by fibrosis of the skin and visceral organs, and peripheral circulatory disturbance. α2‑antiplasmin (α2AP) is the major circulating inhibitor of plasmin and is a key regulator of fibrinolysis. It has been demonstrated that the e...

journal_title：Molecular medicine reports

authors： Niwa H,Kanno Y,Shu E,Seishima M

更新日期：2020-10-01 00:00:00

abstract：:The clinical significance of microRNA (miR)‑136‑5p in hepatocellular carcinoma (HCC) has not been verified. Therefore, in the current study, the authors aimed to explore miR‑136‑5p expression and its clinical significance in HCC, as well as to investigate its potential target genes function. The authors detected the l...

journal_title：Molecular medicine reports

authors： Ding H,Ye ZH,Wen DY,Huang XL,Zeng CM,Mo J,Jiang YQ,Li JJ,Cai XY,Yang H,Chen G

更新日期：2017-10-01 00:00:00

abstract：:Uveal melanoma (UM) represents the most frequent primary tumor of the eye. Despite the development of new drugs and screening programs, the prognosis of patients with UM remains poor and no effective prognostic biomarkers are yet able to identify high‑risk patients. Therefore, in the present study, microRNA (miRNA or ...

journal_title：Molecular medicine reports

authors： Falzone L,Romano GL,Salemi R,Bucolo C,Tomasello B,Lupo G,Anfuso CD,Spandidos DA,Libra M,Candido S

更新日期：2019-04-01 00:00:00

abstract：:S100 calcium binding protein A16 (S100A16) is the most recent member of the S100 calcium-binding protein family. The function of S100A16 has been associated with various types of cancer; however, its role in colorectal cancer (CRC) remains unknown. Therefore, the aim of the present study was to investigate the role of...

journal_title：Molecular medicine reports

authors： Ou S,Liao Y,Shi J,Tang J,Ye Y,Wu F,Wang W,Fei J,Xie F,Bai L

更新日期：2021-02-01 00:00:00

abstract：:The present study investigated the effect of microRNA (miR)‑15a‑3p on the proliferation, migration and apoptosis of lens epithelial cells and its potential mechanism, in order to further elucidate the pathogenesis of age‑related cataracts (ARCs). The HLE‑B3 human lens epithelial cell line was transfected with miR‑15a‑...

journal_title：Molecular medicine reports

authors： Liu SJ,Wang WT,Zhang FL,Yu YH,Yu HJ,Liang Y,Li N,Li YB

更新日期：2019-02-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:LL‑37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL‑37 may modulate various inflammatory reactions. The authors previously revealed that LL‑37 improves the survival of a murine cecal ligation and puncture (CLP)...

journal_title：Molecular medicine reports

authors： Hosoda H,Nakamura K,Hu Z,Tamura H,Reich J,Kuwahara-Arai K,Iba T,Tabe Y,Nagaoaka I

更新日期：2017-10-01 00:00:00

abstract：:Lung cancer is a leading cause of cancer mortality worldwide and patients occasionally develop local recurrence or distant metastasis soon after curative resection. Reports of new therapeutic strategies for lung squamous cell carcinoma (SqCC) are extremely rare, while selective anti...

journal_title：Molecular medicine reports

authors： Masuda R,Kijima H,Imamura N,Aruga N,Nakamura Y,Masuda D,Takeichi H,Kato N,Nakagawa T,Tanaka M,Inokuchi S,Iwazaki M

更新日期：2012-11-01 00:00:00

abstract：:Recent studies have reported structural and functional abnormalities in multiple brain regions of classical trigeminal neuralgia (CTN) patients. Differences in spontaneous neuronal activity between CTN patients and healthy subjects, however, remain unknown. The aim of the present study was to investigate alterations i...

journal_title：Molecular medicine reports

authors： Chen Y,Xiang CQ,Liu WF,Jiang N,Zhu PW,Ye L,Li B,Lin Q,Min YL,Su T,He LC,Shao Y

更新日期：2019-08-01 00:00:00

abstract：:HS-1-associated protein X-1 (Hax-1) has been suggested to be expressed in various rodent and human tissues. Accumulating evidence has demonstrated that Hax‑1 exerts an anti‑apoptotic effect in neurological diseases. Furthermore, it has also been reported that Hax‑1 interacts with various apoptosis‑associated proteins,...

journal_title：Molecular medicine reports

authors： Cui L,He WJ,Xu F,Jiang L,Lv ML,Huang H,Xu JP,Wu Y,Zhong HB,Zhang SY,Chen LF,Shen CL,Yao G,Li L,Li M,Zeng SM

更新日期：2016-11-01 00:00:00