Risk for CMV reactivation in children undergoing allogeneic hematopoietic stem cell transplantation.

abstract：:We describe five cases of children who completed chemotherapy for infantile acute lymphoblastic leukemia (ALL) and soon after were diagnosed with severe T-cell, non-HIV immunodeficiency, with varying B-cell and NK-cell depletion. There was near absence of CD3(+) , CD4(+) , and CD8(+) cells. All patients developed mult...

journal_title：Pediatric blood & cancer

authors： Geerlinks AV,Issekutz T,Wahlstrom JT,Sullivan KE,Cowan MJ,Dvorak CC,Fernandez CV

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Infection in neutropenic children is a major cause of morbidity and mortality in children treated for cancer. In developing countries, children with cancer are often malnourished at diagnosis. In Blantyre, Malawi, children with Burkitt lymphoma are treated with a local protocol with limited toxicity. The aim...

journal_title：Pediatric blood & cancer

authors： Israëls T,van de Wetering MD,Hesseling P,van Geloven N,Caron HN,Molyneux EM

更新日期：2009-07-01 00:00:00

abstract：:Osteosarcoma is the most common bone tumor in children and young adults, with few advances in survival and treatment, especially for metastatic disease, in the last 30 years. Recently, immunotherapy has begun to show promise in various adult cancers, but the utility of this approach for osteosarcoma remains relatively...

journal_title：Pediatric blood & cancer

authors： Wedekind MF,Wagner LM,Cripe TP

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Follicular variant of papillary thyroid carcinoma (FVPTC) has been shown to be an intermediate entity between papillary (PTC) and follicular/Hurtle cell (FTC) thyroid carcinoma in adults. However, the tumor characteristics and prognosis of FVPTCs has not been studied in the pediatric population and is the fo...

journal_title：Pediatric blood & cancer

authors： Lerner J,Goldfarb M

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Males have a higher incidence of medulloblastoma (MB) than females, but the effect of gender on survival is unclear. Studies have yielded conflicting results, possibly due to small sample sizes or differences in how researchers defined MB. We aimed to determine the effect of gender on survival in MB using a ...

journal_title：Pediatric blood & cancer

authors： Curran EK,Sainani KL,Le GM,Propp JM,Fisher PG

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Severe congenital neutropenia is a rare disease, and autosomal dominantly inherited ELANE mutation is the most frequently observed genetic defect in the registries from North America and Western Europe. However, in eastern countries where consanguineous marriages are common, autosomal recessive forms might b...

journal_title：Pediatric blood & cancer

authors： Yılmaz Karapınar D,Patıroğlu T,Metin A,Çalışkan Ü,Celkan T,Yılmaz B,Karakaş Z,Karapınar TH,Akıncı B,Özkınay F,Onay H,Yeşilipek MA,Akar HH,Tüysüz G,Tokgöz H,Özdemir GN,Aslan Kıykım A,Karaman S,Kılınç Y,Oymak Y,Küpe

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (ES) is a malignant tumor of bone and soft tissue of children and young adults. Patients with ES are treated with intensive chemotherapy regimens. We describe predictors of acute chemotherapy-associated toxicity in this population. PROCEDURE:In this retrospective cohort study, records of ES pa...

journal_title：Pediatric blood & cancer

authors： Sharib JM,Cyrus J,Horvai A,Gray Hazard FK,Neuhaus J,Matthay KK,Goldsby R,Marina N,DuBois SG

更新日期：2012-10-01 00:00:00

abstract：:We aimed to provide recommendations on the infusion duration of anthracycline chemotherapy agents in children with cancer. This study also serves as a practice example of the essential steps that need to be taken when using a previously published systematic review to develop a high-quality clinical practice guideline....

journal_title：Pediatric blood & cancer

authors： Loeffen EAH,van Dalen EC,Mulder RL,van de Wetering MD,Kremer LCM,Tissing WJE,Anthracycline Cardiotoxicity Working Group.

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Previous studies have found that parents of children with cancer desire more prognostic information than is often given even when prognosis is poor. We explored in audio-recorded consultations the kinds of information they seek. METHODS:Ethnographic study including observation and audio recording of consult...

journal_title：Pediatric blood & cancer

authors： Bluebond-Langner M,Hall N,Vincent K,Henderson EM,Russell J,Beecham E,Bryan G,Gains JE,Gaze MN,Slater O,Langner RW,Hargrave D

更新日期：2021-03-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal stem cell disorder. Eculizumab and bone marrow transplantation are disease-modifying treatments for PNH but may not be readily available in resource-constrained settings. Of 52 pediatric patients with PNH, 20 had classical PNH and 32 had PNH/aplastic ...

journal_title：Pediatric blood & cancer

authors： Halder R,Mishra P,Aggarwal M,Mannivanan P,Dhawan R,Seth T,Tyagi S,Mahapatra M,Pati HP,Saxena R

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Aberrant gangliosides are produced and shed by some tumors into the extracellular milieu. Their concentration is related to disease progression in children with neuroblastoma and in experimental models. The mechanism for this tumor promoting effect is not known. PURPOSE:Here, we investigated the effect of g...

journal_title：Pediatric blood & cancer

authors： Jabbar AA,Kazarian T,Hakobyan N,Valentino LA

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication of autologous stem cell transplant (ASCT) in children with historically high mortality rates. Defibrotide has shown proven benefit in its treatment and may have a modest role in prevention. We report our experience with SOS in children u...

journal_title：Pediatric blood & cancer

authors： Roy Moulik N,Johnson I,Van Bruggen L,Petterson T,Mycroft J,Vaidya SJ

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Many pediatric oncology patients undergoing hematopoietic stem cell transplantation (HSCT) require nutritional support (NS) because of their inability to consume adequate caloric intake enough calories orally. Although NS can be provided either enteraly (EN) or parenteraly (PN), EN is the preferred method of...

journal_title：Pediatric blood & cancer

authors： Williams-Hooker R,Adams M,Havrilla DA,Leung W,Roach RR,Mosby TT

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Long-term neuropsychological deficits associated with pediatric cancers and the related treatments have been consistently reported. Whole brain cranial radiation therapy (CRT) is associated with neurocognitive impairment. As a result, physicians are reticent to use CRT in favor of systemic or intrathecal che...

journal_title：Pediatric blood & cancer

authors： Pierson C,Waite E,Pyykkonen B

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Research using banked tissue is key to advancing risk-stratification and treatment of children with cancer. Knowledge of parental attitudes to ethical issues arising in tissue banking is very limited but essential in obtaining respectful consent. METHODS:One hundred parents of consecutively diagnosed children ...

journal_title：Pediatric blood & cancer

authors： McMurter B,Parker L,Fraser RB,Magee JF,Kozancyzn C,Fernandez CV

更新日期：2011-12-15 00:00:00

abstract：:To assess safety and tolerability, we administered valacyclovir, an oral anti-viral medication that inhibits erythrocyte sickling in vitro, to 14 subjects with sickle-cell anemia for 1 week at a standard dose of 1,000 mg every 8 hr. No clinically significant adverse effects occurred. In 11 subjects in steady state, th...

journal_title：Pediatric blood & cancer

authors： Ender KL,DeBellis RH,Erlanger BF,Billote GB,Brittenham GM

更新日期：2011-05-01 00:00:00

abstract：:Rhabdomyosarcoma arising within a congenital cystic adenomatoid malformation (CCAM) is an unusual entity. The patient underwent a lobectomy of his right lower lobe of lung due to a CCAM at the age of two. One year later, he developed a solid embryonal rhabdomyosarcoma at the same location. He received 1-year period ch...

journal_title：Pediatric blood & cancer

authors： Pai S,Eng HL,Lee SY,Hsiao CC,Huang WT,Huang SC

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Only a few studies have assessed cardiovascular risk factors (CRFs) in childhood cancer survivors. We determined the prevalence of CRFs in long-term survivors of acute lymphoblastic leukemia (ALL) and Wilms tumor. PROCEDURE:Adult survivors of ALL and Wilms tumor treated with radiotherapy and chemotherapy (R...

journal_title：Pediatric blood & cancer

authors： Geenen MM,Bakker PJ,Kremer LC,Kastelein JJ,van Leeuwen FE

更新日期：2010-10-01 00:00:00

abstract：:Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all-trans-retinoic acid. One patient developed FG. These lesions are predominantly seen i...

journal_title：Pediatric blood & cancer

authors： Naithani R,Kumar R,Mahapatra M

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:Chemotherapy during radiation and/or bone-seeking radioisotope therapy (153-samarium; 1 mCi/kg) during radiation may improve osteosarcoma cancer control. PATIENTS AND METHODS:We analyzed our preliminary radiation experience in high-risk, metastatic, and/or recurrent patients during a consecutive period of 20 m...

journal_title：Pediatric blood & cancer

authors： Mahajan A,Woo SY,Kornguth DG,Hughes D,Huh W,Chang EL,Herzog CE,Pelloski CE,Anderson P

更新日期：2008-05-01 00:00:00

abstract：:Hemoglobin O-Arab [Beta 121 Glu → Lys] (Hb O-Arab) is a rare abnormal hemoglobin (Hb) whose clinical and hematological features have been described in adults but not in children. We report three children, 9, 12, and 36 months of age, with homozygous Hb O-Arab and assess the value of supplementary folic acid as treatme...

journal_title：Pediatric blood & cancer

authors： Dror S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Transcranial Doppler ultrasound (TCD) has been demonstrated to be a powerful predictor of stroke risk due to sickle cell disease (SCD) in pediatric populations. Little is known about how this healthcare innovation has disseminated into preventive care for SCD. The objective of this study was to determine TCD...

journal_title：Pediatric blood & cancer

authors： Raphael JL,Shetty PB,Liu H,Mahoney DH,Mueller BU

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Regret about loss is one of the most intense types of regret experienced in life. Little is known about the bereavement regret of parents whose child has died of cancer. Although knowledge about parents' experiences after their child's death is vital for supporting these families, parents' regret is mostly...

journal_title：Pediatric blood & cancer

authors： Sim CW,Heuse S,Weigel D,Kendel F

更新日期：2020-06-01 00:00:00

abstract：:A 17-year-old girl with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with persistent minimal residual disease (MRD) who underwent standard chemotherapy was found to have a BCR-ABL1-like gene expression pattern. Genome sequencing revealed a JAK2 mutation not previously described in BCP-ALL and a potential th...

journal_title：Pediatric blood & cancer

authors： Mayfield JR,Czuchlewski DR,Gale JM,Matlawska-Wasowska K,Vasef MA,Nickl C,Pickett G,Ness SA,Winter SS

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Primary hemophagocytic lymphohistiocytosis (HLH) represents a group of inherited hyperinflammatory immunodeficiencies, including familial HLH (FHL), Griscelli syndrome type 2 (GS2), and X-linked lymphoproliferative syndrome (XLP). We previously reported an annual incidence of suspected primary HLH in Sweden ...

journal_title：Pediatric blood & cancer

authors： Meeths M,Horne A,Sabel M,Bryceson YT,Henter JI

更新日期：2015-02-01 00:00:00

abstract：:Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant odontogenic tumor. Complete surgical excision is the treatment of choice. Deaths due to disease recurrence and/or progression are documented. Here, we report the case of a 15-year-old female with multiple recurrent AFOS. She responded to chemothera...

journal_title：Pediatric blood & cancer

authors： Gatz SA,Thway K,Mandeville H,Kerawala C,MacVicar D,Chisholm J

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The introduction of the United Kingdom Medical Research Council's 10th AML trial (MRC AML 10) protocol incorporating high-dose anthracycline therapy has improved outcome of children with acute myeloid leukemia (AML). In this study, we review the results of childhood AML therapy in a Singapore university hosp...

journal_title：Pediatric blood & cancer

authors： Tan RM,Quah TC,Aung L,Liang S,Kirk RC,Yeoh AE

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Fever in neutropenic (FN) patients requires immediate broad-spectrum antibiotics, however, such patients do not represent a homogeneous population and the majority of them are at low risk of developing complication. Gatifloxacin (GA) is an alternative, though it has not been thoroughly studied in Pediatrics ...

journal_title：Pediatric blood & cancer

authors： Petrilli A,Altruda Carlesse F,Alberto Pires Pereira C

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:Platelet counts below normal values define thrombocytopenia. However, platelet counts alone do not reveal the underlying pathomechanism. New blood cell counters provide additional information on platelet size and volume, and enable the distinction of sub-populations. In this preliminary study, we evaluate wh...

journal_title：Pediatric blood & cancer

authors： Strauss G,Vollert C,von Stackelberg A,Weimann A,Gaedicke G,Schulze H

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Despite the increasing cure rates for children with acute lymphoblastic leukemia (ALL), patients who relapse continue to have poor prognosis. The Children's Oncology Group (COG) conducted a limited institution Phase II trial of Campath-1H, a monoclonal antibody that targets CD52 on leukemic cells, in childre...

journal_title：Pediatric blood & cancer

authors： Angiolillo AL,Yu AL,Reaman G,Ingle AM,Secola R,Adamson PC

更新日期：2009-12-01 00:00:00