Gangliosides promote platelet adhesion and facilitate neuroblastoma cell adhesion under dynamic conditions simulating blood flow.


BACKGROUND:Aberrant gangliosides are produced and shed by some tumors into the extracellular milieu. Their concentration is related to disease progression in children with neuroblastoma and in experimental models. The mechanism for this tumor promoting effect is not known. PURPOSE:Here, we investigated the effect of gangliosides on platelet and tumor cell adhesion under shear forces simulating venous and arterial flow. RESULTS:High shear force increased platelet adhesion 2.5-fold compared to low force. Pre-incubation of platelets with gangliosides increased adhesion at low shear to a level comparable to high shear alone. The addition of gangliosides to platelets perfused at high shear did not further increase adhesion. LAN1 neuroblastoma cells are adherent to collagen in static assays. No effect of either shear or gangliosides was observed on cell adhesion under dynamic conditions. However, when perfused in the presence of platelets, an increase in binding of tumor cells was observed at both shear forces compared to cells alone. CONCLUSIONS:These results demonstrate that shear and gangliosides increase dynamic platelet adhesion to collagen. In addition, platelets facilitate tumor cell binding. Therefore, by acting as a mediator of platelet activation, gangliosides may promote blood borne metastasis by increasing platelet binding to the vessel wall and in turn facilitate tumor cell arrest in circulation.


Pediatr Blood Cancer


Pediatric blood & cancer


Jabbar AA,Kazarian T,Hakobyan N,Valentino LA





Has Abstract


2006-03-01 00:00:00












  • Tele-practice guidelines for the symptom management of children undergoing cancer treatment.

    abstract::The provision of tele-practice symptom management is often without the provision of evidence-based guidelines. Under the auspices of the Pediatric Oncology Group of Ontario, a nursing task force was established to appraise the evidence and develop guidelines. Promising new efforts to enhance symptom management through...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,实务指引,评审


    authors: Tsimicalis A,De Courcy MJ,Di Monte B,Armstrong C,Bambury P,Constantin J,Dagelman B,Eves M,Jansen P,Honeyford L,Stregger D,Pediatric Oncology Group of Ontario.

    更新日期:2011-10-01 00:00:00

  • The importance of enteral nutrition to prevent or treat undernutrition in children undergoing treatment for cancer.

    abstract::Nutrition therapy is a therapeutic approach to treating medical conditions and symptoms via diet, which can be done by oral, enteral or parenteral routes. It is desirable to include nutritional interventions as a standard of care in pediatric cancer units (PCUs) at all levels of care. The interventions are dependent o...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Trehan A,Viani K,da Cruz LB,Sagastizado SZ,Ladas EJ

    更新日期:2020-06-01 00:00:00

  • Metabolic syndrome in pediatric cancer survivors: a mechanistic review.

    abstract::Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that are involved in glucose homeostasis and lipid metabolism are adversely affected by chemotherapy. This review highlights the relevant tissu...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Rosen GP,Nguyen HT,Shaibi GQ

    更新日期:2013-12-01 00:00:00

  • Full-dose ifosfamide can be safely administered to outpatients.

    abstract::This report compares a traditional full-dose ifosfamide administration modality (24-hr hyperhydration and mesna infusion) with a simplified 9-hr hyperhydration and mesna infusion for use in outpatients. Acute ifosfamide toxicity was the same, suggesting that ifosfamide could be safely administered to outpatients, redu...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章


    authors: Meazza C,Bisogno G,Casanova M,Zanetti I,Carli M,Ferrari A

    更新日期:2008-02-01 00:00:00

  • High dose alkylator therapy for extracranial malignant rhabdoid tumors in children.

    abstract:BACKGROUND:Extracranial malignant rhabdoid tumor (MRT) is a rare pediatric cancer with a poor prognosis. The kidney is the most common site. Isolated reports have shown improvements in patient survival, but no specific treatment regimen has shown efficacy over others. PROCEDURE:Retrospective review of patients diagnos...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章


    authors: Venkatramani R,Shoureshi P,Malvar J,Zhou S,Mascarenhas L

    更新日期:2014-08-01 00:00:00

  • Self-concept in adult survivors of childhood acute lymphoblastic leukemia: a cooperative Children's Cancer Group and National Institutes of Health study.

    abstract:BACKGROUND:Self-concept was compared between adult survivors of childhood acute lymphoblastic leukemia (ALL) and sibling controls. Adult survivor subgroups at greatest risk for negative self-concept were identified. PROCEDURE:Survivors (n = 578) aged > or =18 years, treated before age 20 years on Children's Cancer Gro...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Seitzman RL,Glover DA,Meadows AT,Mills JL,Nicholson HS,Robison LL,Byrne J,Zeltzer LK

    更新日期:2004-03-01 00:00:00

  • Tumor cells are present in stem cell harvests of Ewings sarcoma patients and their persistence following transplantation is associated with relapse.

    abstract:BACKGROUND:Tumor cells frequently contaminate autologous stem cell products in a variety of malignancies, but their clinical significance remains controversial. We retrospectively monitored tumor contamination in stem cell harvests from patients with Ewing family of tumors (EFT) all harboring the specific translocation...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Yaniv I,Cohen IJ,Stein J,Zilberstein J,Liberzon E,Atlas O,Grunshpan A,Sverdlov Y,Ash S,Zaizov R,Avigad S

    更新日期:2004-05-01 00:00:00

  • Pediatric nonrhabdomyosarcoma soft tissue sarcomas arising at visceral sites.

    abstract:BACKGROUND:Pediatric nonrhabdomyosarcoma soft tissue sarcomas (NRSTS) may rarely occur in visceral tissues, and little is known about their clinical history. The present study retrospectively analyzed a group of patients prospectively registered in Italian pediatric protocols conducted between 1979 and 2004. METHODS:I...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Ferrari A,Magni C,Bergamaschi L,Cecchetto G,Alaggio R,Milano GM,Bertolini P,Basso E,Manzitti C,Di Martino M,Giurici N,Melchionda F,Cecinati V,Chiaravalli S,Affinita MC,Scagnellato A,Casanova M,Bisogno G

    更新日期:2017-09-01 00:00:00

  • Familial retinoblastoma in developing countries.

    abstract:BACKGROUND:Although screening for familial retinoblastoma has been shown to be beneficial we suspected that such screening programs may be less than optimal in developing countries (DC). METHODS:Retrospective cohort study comparing patients with familial retinoblastoma from five centers in DC (Argentina, Brazil, Turke...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Chantada GL,Dunkel IJ,Qaddoumi I,Antoneli CB,Totah A,Canturk S,Nawaiseh I,Fandiño A,Pífano I,Peksayar G,Ribeiro KB,Abramson DH

    更新日期:2009-09-01 00:00:00

  • The role of the initial bone marrow aspirate in the diagnosis of hemophagocytic lymphohistiocytosis.

    abstract:BACKGROUND:The identification of hemophagocytosis (HPC) in tissue or bone marrow (BM) represents only one of 5/8 criteria needed for the diagnosis of hemophagocytic lymphohistiocytosis (HLH). Yet, confirmation of HPC in bone marrow aspirates (BMA) is often relied upon to make therapeutic decisions. There is no standard...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Gupta A,Tyrrell P,Valani R,Benseler S,Weitzman S,Abdelhaleem M

    更新日期:2008-09-01 00:00:00

  • Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia.

    abstract:BACKGROUND:The efficacy of combination chemotherapy with methotrexate (MTX) and asparaginase is not well known in relapsed and refractory acute leukemia after contemporary therapy. PROCEDURE:A retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML) who received MTX and aspara...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Buaboonnam J,Cao X,Pauley JL,Pui CH,Ribeiro RC,Rubnitz JE,Inaba H

    更新日期:2013-07-01 00:00:00

  • Sustained remission with azacitidine monotherapy and an aberrant precursor B-lymphoblast population in juvenile myelomonocytic leukemia.

    abstract::Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. The hypomethylating agent, azacitidine, has been used as a bridging therapy to transplant. However, no patients have been treated with azacitidine without an ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Hashmi SK,Punia JN,Marcogliese AN,Gaikwad AS,Fisher KE,Roy A,Rao P,Lopez-Terrada DH,Ringrose J,Loh ML,Niemeyer CM,Rau RE

    更新日期:2019-10-01 00:00:00

  • Pheochromocytomas and paragangliomas in children: Data from the Italian Cooperative Study (TREP).

    abstract:BACKGROUND:Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of the adrenal gland, and paragangliomas (PGLs) are their extra-adrenal counterparts arising from ganglia along the sympathetic/parasympathetic chain. Surgery is the cornerstone of treatment. A sporatic or inherited germline ...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Virgone C,Andreetta M,Avanzini S,Chiaravalli S,De Pasquale D,Crocoli A,Inserra A,D'Angelo P,Alaggio R,Opocher G,Cecchetto G,Ferrari A,Bisogno G,Dall'Igna P

    更新日期:2020-08-01 00:00:00

  • Clinical characteristics and outcomes of HIV-infected children diagnosed with Kaposi sarcoma in Malawi and Botswana.

    abstract:BACKGROUND:Kaposi sarcoma (KS) is the most common HIV-associated malignancy in sub-Saharan Africa. The presentation and outcomes of pediatric KS are not well understood. PROCEDURE:We performed a retrospective cohort analysis of 81 HIV-infected children with KS at the Baylor Children's Clinical Centres of Excellence in...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Cox CM,El-Mallawany NK,Kabue M,Kovarik C,Schutze GE,Kazembe PN,Mehta PS

    更新日期:2013-08-01 00:00:00

  • Socioeconomic status and global variations in the incidence of neuroblastoma: call for support of population-based cancer registries in low-middle-income countries.

    abstract::Global variations in the incidence of pediatric cancers have been described; however, the causes of such differences are not known. We investigated the relationship between the incidence of embryonal tumors and human development index on a global scale. Increasing incidence of neuroblastoma correlates significantly wi...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Kamihara J,Ma C,Fuentes Alabi SL,Garrido C,Frazier AL,Rodriguez-Galindo C,Orjuela MA

    更新日期:2017-02-01 00:00:00

  • Loss of antibody titers and effectiveness of revaccination in post-chemotherapy pediatric sarcoma patients.

    abstract:BACKGROUND:Little is known about the effects of chemotherapy on patient antibody titers to vaccine-preventable infectious diseases; thus, there is no standard protocol for revaccinating post-chemotherapy patients. PROCEDURES:To assess losses of detectable antibody titers due to chemotherapy, we retrospectively examine...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Yu J,Chou AJ,Lennox A,Kleiman P,Wexler LH,Meyers PA,Gorlick R

    更新日期:2007-10-15 00:00:00

  • Osteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adults.

    abstract:BACKGROUND:Childhood cancer is relatively rare and tends to present specific age distribution, as a prognostic factor for some of these diseases. Information on how young age affects prognosis, response to chemotherapy, and local control options in children versus AYA with osteosarcoma (OST) is minimal. METHODS:In ord...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Eleutério SJ,Senerchia AA,Almeida MT,Da Costa CM,Lustosa D,Calheiros LM,Barreto JH,Brunetto AL,Macedo CR,Petrilli AS

    更新日期:2015-07-01 00:00:00

  • Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura.

    abstract::Acute immune thrombocytopenic purpura (ITP) occurs most commonly in young children who present with severe isolated thrombocytopenia and purpura. A marrow examination is not required unless glucocorticoids are used, lest treatment mask incipient acute lymphoblastic leukemia, but controversy exists here. The recommenda...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Segel GB,Feig SA

    更新日期:2009-09-01 00:00:00

  • Cytotoxic potential of IL-15-activated cytokine-induced killer cells against human neuroblastoma cells.

    abstract:BACKGROUND:Neuroblastoma (NB) is the most common solid extracranial tumor in childhood. Despite advances in therapy, the prognosis is poor and optimized therapies are urgently needed. Therefore, we investigated the antitumor potential of interleukin-15 (IL-15)-activated cytokine-induced killer (CIK) cells against diffe...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Cappel C,Huenecke S,Suemmerer A,Erben S,Rettinger E,Pfirrmann V,Heinze A,Zimmermann O,Klingebiel T,Ullrich E,Bader P,Bremm M

    更新日期:2016-12-01 00:00:00

  • Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review.

    abstract::Steroid-induced neuropsychological side effects impact quality of life in children with acute lymphoblastic leukemia. Dexamethasone induces more metabolic side effects than prednisone. To evaluate whether dexamethasone also leads to more neuropsychological side effects, we reviewed all available literature. Randomized...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Warris LT,van den Heuvel-Eibrink MM,den Hoed MA,Aarsen FK,Pieters R,van den Akker EL

    更新日期:2014-07-01 00:00:00

  • Beta-thalassemia major births after National Screening Program in Taiwan.

    abstract:OBJECTIVE:A National Thalassemia Screening Program was adopted in Taiwan in 1993. This report examined that program's results and impact. METHODS:Patients with beta-thalassemia major born between 1994 and 2003 were recruited through the help of all thalassemia clinics in Taiwan. A structured questionnaire was designed...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Chern JP,Lin KH,Lu MY,Lin DT,Jou ST,Yang YL,Chang HH,Su S,Lin KS

    更新日期:2008-01-01 00:00:00

  • Pencil beam scanned protons for the treatment of patients with Ewing sarcoma.

    abstract:BACKGROUND:Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS:Thirty-eight patients (median age, 9.9 yea...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Weber DC,Murray FR,Correia D,Bolsi A,Frei-Welte M,Pica A,Lomax AJ,Schneider R,Bachtiary B

    更新日期:2017-12-01 00:00:00

  • A novel mutation of ABCG5 gene in a Turkish boy with phytosterolemia presenting with macrotrombocytopenia and stomatocytosis.

    abstract::Phytosterolemia is a rare autosomal recessive sterol storage disease caused by mutations in ABCG5 and ABCG8 genes. A 9-year-old Turkish boy who was presented with exclusively hematologic abnormalities had elevated plant sterol levels. Sequencing of ABCG5 and ABCG8 genes revealed a novel homozygous IVS10-1 G>T mutation...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Kaya Z,Niu DM,Yorulmaz A,Tekin A,Gürsel T

    更新日期:2014-08-01 00:00:00

  • Children with HbSβ0 thalassemia have higher hemoglobin levels and lower incidence rate of acute chest syndrome compared to children with HbSS.

    abstract:BACKGROUND:Based on the presumed clinical similarity between the two most severe sickle cell disease (SCD) genotypes, hemoglobin (Hb) Sβ0 thalassemia and HbSS, randomized controlled trials (RCTs) have included both genotypes. Our group has demonstrated that healthcare providers inadequately distinguish the two diagnose...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Day ME,Rodeghier M,DeBaun MR

    更新日期:2018-11-01 00:00:00

  • Primary epithelial lung malignancies in the pediatric population.

    abstract:BACKGROUND:Primary epithelial lung malignancies are rare in childhood and adolescence. We reviewed the Memorial Sloan-Kettering Cancer Center experience with these tumors to better understand their histology, time to diagnosis, treatment, and outcome. PROCEDURE:A retrospective review was performed on all patients 21 y...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Lal DR,Clark I,Shalkow J,Downey RJ,Shorter NA,Klimstra DS,La Quaglia MP

    更新日期:2005-10-15 00:00:00

  • Sirolimus therapy in the treatment of pseudomyogenic hemangioendothelioma.

    abstract::Pseudomyogenic hemangioendothelioma (PMH) is a rare, mostly indolent vascular tumor. Extensive cases are treated with amputation as chemotherapy seems to be ineffective. Recently, promising results were published using mammalian target of rapamycin (mTOR) inhibitors in tumors of vascular origin. Here, we present a cas...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Gabor KM,Sapi Z,Tiszlavicz LG,Fige A,Bereczki C,Bartyik K

    更新日期:2018-02-01 00:00:00

  • The role of myeloablative chemotherapy with autologous hematopoietic cell rescue in central nervous system germ cell tumors.

    abstract::This review of the experience of high dose chemotherapy in patients with recurrent or refractory intracranial germ cell tumor confirms that sustained tumor control can be achieved with this modality both in germinoma and non-germinomatous germ cell tumors. Data from cooperative groups in Europe and North America sugge...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审


    authors: Bouffet E

    更新日期:2010-04-01 00:00:00

  • One-year results from a prospective randomized trial comparing phlebotomy with deferasirox for the treatment of iron overload in pediatric patients with thalassemia major following curative stem cell transplantation.

    abstract:BACKGROUND:Iron overload is well documented in patients with β-thalassemia major, and patients who have undergone hematopoietic stem cell transplantation (HSCT) remain at risk as a result of pre- and immediate post-HSCT transfusions. PROCEDURE:This is a prospective, randomized, 1-year clinical trial that compares the ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,随机对照试验


    authors: Inati A,Kahale M,Sbeiti N,Cappellini MD,Taher AT,Koussa S,Nasr TA,Musallam KM,Abbas HA,Porter JB

    更新日期:2017-01-01 00:00:00

  • Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy.

    abstract:BACKGROUND:Children with sickle cell disease (SCD) and moyamoya may benefit from indirect cerebral revascularization surgery in addition to chronic blood transfusion therapy for infarct prevention. We sought to compare overt and silent infarct recurrence rates in children with SCD undergoing revascularization. METHODS...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Hall EM,Leonard J,Smith JL,Guilliams KP,Binkley M,Fallon RJ,Hulbert ML

    更新日期:2016-08-01 00:00:00

  • Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia.

    abstract::Children with sickle cell anemia (SCA) have low bone mass though bone turnover has not been well described. In this study, growth and pubertal development were assessed twice, 1 year apart, in 80 young subjects with type-SS SCA, while whole body bone mineral content (BMC) and density where measured in a subset (n = 46...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章


    authors: Fung EB,Kawchak DA,Zemel BS,Rovner AJ,Ohene-Frempong K,Stallings VA

    更新日期:2008-03-01 00:00:00