Abstract:
OBJECTIVE:We investigated whether determination IL-6, IL-8, IL-1beta and TNF-alpha at baseline, total protein C (PC) levels at time of admission and 48 hours after initiation could complement the Acute Physiology and Chronic Health Evaluation (APACHE) II scoring system to identify patients with sepsis, severe sepsis or septic shock for clinical outcome. MATERIAL AND METHODS:The study was carried out prospectively. 60 consecutive patients with sepsis, severe sepsis or septic shock were included. Blood samples were obtained at baseline and 48 hours after initiation. Cytokines and PC levels in plasma were measured with an enzyme-linked immunoabsorbent assay (ELISA). APACHE II score was calculated on admission. RESULTS:Baseline IL-6 levels and PC levels 48 hours after initiation were predictive of increased mortality (p=0.016, p=0.044 respectively). Baseline IL-6, IL-8 and TNF-alpha baseline levels correlate with the severity of physiologic insult, as determined by the APACHE II score. However, our multiple logistic regression analysis of these did not reveal any predictive value in combination with the APACHE II score. CONCLUSION:Determination of baseline IL-6 and PC 48 hours after initiation were of predictive value for prognostic evaluation of septic patients, but did not significantly increase predictive power of the APACHE scoring system to identify patients with sepsis for fatal clinical outcome.
journal_name
Balkan Med Jjournal_title
Balkan medical journalauthors
Kartal ED,Karkaç E,Gülbaş Z,Alpat SN,Erben N,Colak Edoi
10.5152/balkanmedj.2011.016subject
Has Abstractpub_date
2012-06-01 00:00:00pages
174-8issue
2eissn
2146-3123issn
2146-3131pii
bmj-29-2-177journal_volume
29pub_type
杂志文章abstract:BACKGROUND:After resection, specimens are subjected to formalin fixation during histological processing. This procedure can result in tissue shrinkage, with the amount of shrinkage related to tissue composition and tissue type. AIMS:To evaluate the shrinkage of nasal mucosa and cartilage tissue and compare differences...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2015.1470
更新日期:2017-09-29 00:00:00
abstract:Background:Pericardial effusion in chronic hypoxemic lung diseases, such as Obstructive Sleep Apnea syndrome, usually occurs after the development of severe pulmonary arterial hypertension. However, data about the frequency of pericardial effusions in Obstructive Sleep Apnea syndrome without pulmonary arterial hyperten...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2017.0580
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulating adenos...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.15932
更新日期:2015-07-01 00:00:00
abstract::In this invited review article, I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway, with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination (i....
journal_title:Balkan medical journal
pub_type: 杂志文章,评审
doi:10.4274/balkanmedj.2017.1226
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS:To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2016.0012
更新日期:2017-04-05 00:00:00
abstract:OBJECTIVE:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. We aimed to investigate the matrix metalloproteinase-9 (MMP-9) level and MMP-9 gene polymorphism in sleep apnea patients with or without cardiovascular disease. STUDY DESIGN:Case-control study. MATER...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.068
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Suicide is frequently encountered in patients suffering from major depressive disorder (MDD). Since only a third of treated depressed patients are able to achieve remission, in the last few years, new theories have been proposed to better understand the mechanism of this illness. Our paper analyzes the inter...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.150842
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Electrophysiological studies show that critical illness polyneuromyopathy appears in the early stage of sepsis before the manifestation of clinical findings. The metabolic response observed during sepsis causes glutamine to become a relative essential amino acid. AIMS:We aimed to assess the changes in neuro...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.140483
更新日期:2016-05-01 00:00:00
abstract:Background:Oral immunotherapy for cow’s milk allergy is an effective treatment option because of its ability to increase the threshold for clinical reactions. Aims:To present our experience of oral immunotherapy for cow’s milk allergy in the pediatric allergy outpatient clinic, and to evaluate the long-term efficacy o...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2020.2020.1.140
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:Acrylamide is a widespread substance having many areas of utilization. Besides, it also forms a part of high-temperature processed starchy foods. To date, numerous in vivo and in vitro studies have documented that acrylamide has toxic effects on various organ systems. AIMS:To determine the potential protect...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2017.0830
更新日期:2018-04-04 00:00:00
abstract:INTRODUCTION:Pulmonary sarcomatoid carcinomas are very rare lung neoplasms, and no consensus exists regarding the optimal treatment. The prognosis of sarcomatoid carcinomas has been reported to be unfavorable compared to non-small-cell lung cancers; however, prognostic factors in patients undergoing surgery for sarcoma...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2020.2020.7.45
更新日期:2020-09-29 00:00:00
abstract:OBJECTIVE:To determine the prevalence of the most common allelic variants of CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, CYP2F1, CYP2J2 and CYP2S1 in a representative sample of the three ethnic groups (Russians, Tatars and Bashkirs) from Republic of Bashkortostan (Russia), and compare the results with existing data publish...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.039
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Many studies focusing on the effects of local anaesthetics on QT intervals have been performed, but the articles evaluating the relationship between thoracic epidural anaesthesia combined with general anaesthesia and QT parameters are very limited. AIMS:We aimed to compare the effects of bupivacaine and rop...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.9275
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Young maternal age is variously defined in studies of its effect on obstetrics and perinatal outcomes. Also, pregnancy has been reported as the leading cause of death in adolescent girls in low- and middle-income countries. AIMS:The aim of the study was to evaluate whether young maternal age was associated ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.150364
更新日期:2016-05-01 00:00:00
abstract:Background:Regardless of the notable reduction in infant deaths worldwide over the last 30 years, the proportion of neonatal mortality in total child mortality is increasing. Aims:To perform a trend analysis of neonatal mortality in Serbia. Study Design:Descriptive observational study. Methods:Joinpoint regression w...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2020.2019.5.145
更新日期:2020-04-10 00:00:00
abstract:BACKGROUND:Osborn wave, typically associated with hypothermia, is currently referred to as one of the J wave syndromes due to its clinical potential to develop lethal cardiac arrhythmia; it may rarely be observed in a non-hypothermic setting such as cannabis abuse. CASE REPORT:In this paper, we presented two young cas...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2015.1233
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Gap junctions (GJ) are important in pain signalling at the spinal cord level. AIMS:The aim of this investigation was to study the effects of GJ on nociception and the analgesic/hyperalgesic effects of morphine following administration of carbenoxolone as a GJ blocker. Male Wistar rats (200-250 g) were divid...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2014.13099
更新日期:2014-06-01 00:00:00
abstract:Background:Perception of acoustic details in the speech signal is important for speech sound development. The medial olivocochlear pathway, a part of the auditory efferent system, plays a role in stimulus-related control of the cochlea. One clinical tool to evaluate medial olivocohlear activity, which is thought to imp...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2020.2020.4.168
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:In order to determine the presence or absence of a certain disease, multiple diagnostic tests may be necessary. Performance of these tests can be sequentially evaluated. AIMS:The aim of the study is to determine the contribution of the test in each step, in reducing diagnostic uncertainty when multiple test...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.103
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Hemifacial spasm is a sudden, involuntary and synchronous spasm of the facial muscles. The most frequent cause of this condition is compression of the facial nerves due to vascular pathologies. The most commonly used method of treatment is Botulinum toxin injection. However, the gold standard treatment is su...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.150849
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Incarcerated inguinal hernia is a commonly encountered urgent surgical condition, and tension-free repair is a well-established method for the treatment of non-complicated cases. However, due to the risk of prosthetic material-related infections, the use of mesh in the repair of strangulated or incarcerated ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.150137
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Continuous ambulatory peritoneal dialysis is a successful treatment modality for patients with end-stage renal disease. Peritoneal fibrosis (PF) is the most critical complication of long-term peritoneal dialysis (PD). AIMS:In our study, we aimed to compare the effects of colchicine and sirolimus on PF induc...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.15183
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Bloodstream infections (BSI) are frequently seen after solid organ transplantation. The incidence of bloodstream infections differs among the types of transplantation. The microbiological features and antimicrobial resistance patterns change from centre to centre. AIMS:To evaluate the incidence and spectrum...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.9256
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Brugada syndrome is a disease characterized by a specific electrocardiographic pattern and an increased risk of sudden cardiac death. We present this case with the updated literature to emphasise the need to consider the diagnosis of Brugada syndrome in patients admitted to the emergency ward with sudden car...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2016.1301
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine the effect of massage to the sacral region after cesarean delivery instead of employing a urinary catheter for the prevention of urinary retention. STUDY DESIGN:Cross sectional study. MATERIAL AND METHODS:This interventional study population consisted of 60 women who we...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.083
更新日期:2013-03-01 00:00:00
abstract:Background:There is only limited information about the cost-effectiveness of drug-eluting stents compared with bare-metal stents in Turkey. Aims:To evaluate bare-metal and drug-eluting stents used in the treatment of coronary artery disease from the perspective of the reimbursement institution with cost-effectiveness ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2019.2018.12.28
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:Clinically, amyopathic dermatomyositis is a clinically distinct subgroup of dermatomyositis characterised by unique dermatological manifestations without muscle involvement. Clinically, amyopathic dermatomyositis is frequently associated with interstitial lung disease, which usually has a rapidly progressive...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2016.1061
更新日期:2017-08-04 00:00:00
abstract:BACKGROUND:The present study proposes to analyze the results obtained after transhiatal esophagectomies (THE), from the perspective of an Eastern European surgical center with low esophageal resection volume (LV). AIMS:Our analysis, which to the authors' knowledge is the first of its kind in Romania, has the purpose o...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.15514
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate possible mitochondrial DNA (mtDNA) mutations in patients with Leber's hereditary optic neuropathy (LHON) in order to provide a precise diagnosis and genetic counseling. MATERIAL AND METHODS:Between 1982 and 2007, ten patients were clinically diagnosed with LHON and six of these patients agreed...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.015
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Chronic kidney diseases are known to influence nitric oxide metabolites (NOx) and asymmetric dimethylarginine (ADMA), though the exact mechanism is still poorly understood. AIMS:The purpose of the present study was to examine eNOS Glu298Asp gene polymorphism, plasma NOx and ADMA concentration in subjects wi...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.16566
更新日期:2016-03-01 00:00:00