Abstract:
INTRODUCTION:Pulmonary sarcomatoid carcinomas are very rare lung neoplasms, and no consensus exists regarding the optimal treatment. The prognosis of sarcomatoid carcinomas has been reported to be unfavorable compared to non-small-cell lung cancers; however, prognostic factors in patients undergoing surgery for sarcomatoid carcinomas remain unclear. MATERIAL AND METHODS:We designed a retrospective cross-sectional study in patients who underwent surgery for pulmonary sarcomatoid carcinomas and statistically analyzed the prognostic factors regarding clinicopathological features with respect to survival outcomes. RESULTS:We had a total of 44 patients with sarcomatoid carcinoma who had pulmonary resection. Sex distribution was 34 (77 %) males and 10 (22.7 %) females determined by declaration. The mean age of patients was 57.3 ± 16 with a median of 60 years The 5 year progression-free survival and overall survival rates were 59 % and 58 %, respectively. The 5 year survival rates were significantly different for tumors greater than 5 cm (p = 0.044), T status (p = 0.016), N status (p = 0.005) and pathologic TNM stage (p = 0.0001). However, histologic subtype (p = 0.628) and adjuvant treatment (p = 0.804) did not have any significant effect on survival. Similarly, the significant prognostic factors in univariate analysis were tumor size (p = 0.085), T status (p = 0.005), N status (p = 0.028) and pathologic TNM stage (p = 0.0001). Multivariate analysis showed only T status (p = 0.058), N status (p = 0.018), and pathologic TNM stage (p = 0.019) as independent prognostic factors with statistical power of %87, %43.1 and %21.2. CONCLUSION:Surgery appears as an optimal treatment with favorable outcomes for patients with pulmonary sarcomatoid carcinoma. Patients with small tumors at earlier stages are very likely to benefit from surgery, regardless of histologic subtype.
journal_name
Balkan Med Jjournal_title
Balkan medical journalauthors
Özkan B,Erdoğdu E,Duman S,Amirov F,Çimenoğlu B,Özlük Y,Kara M,Yılmazbayhan D,Toker Adoi
10.4274/balkanmedj.galenos.2020.2020.7.45subject
Has Abstractpub_date
2020-09-29 00:00:00eissn
2146-3123issn
2146-3131pub_type
杂志文章abstract:BACKGROUND:Electrophysiological studies show that critical illness polyneuromyopathy appears in the early stage of sepsis before the manifestation of clinical findings. The metabolic response observed during sepsis causes glutamine to become a relative essential amino acid. AIMS:We aimed to assess the changes in neuro...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.140483
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To investigate possible mitochondrial DNA (mtDNA) mutations in patients with Leber's hereditary optic neuropathy (LHON) in order to provide a precise diagnosis and genetic counseling. MATERIAL AND METHODS:Between 1982 and 2007, ten patients were clinically diagnosed with LHON and six of these patients agreed...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.015
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Recently, accumulated research has found that the expression of telomerase activity (TA) was associated with colorectal cancer (CRC) advancement, whereas the TA prognostic effect in CRC patients is still controversial. AIMS:To investigate relationships between TA and CRC clinicopathological parameters. STU...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.151182
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Family history of premature atherosclerosis imposes a high risk to people. The relationship between atherosclerosis and gene polymorphisms of various biomarkers such as Endothelial Nitric Oxide Synthase (eNOS), C-Reactive Protein (CRP), and Interleukin-6 (IL-6) has shown in previous studies. AIMS:The major ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.151190
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Respiratory distress syndrome (RDS) is a common critical disease in term neonates, but reasons for the occurrence of RDS remains unclear. AIMS:This study aimed to investigate the cause of RDS in full-term neonates by a retrospective case-control study. STUDY DESIGN:Case-control study. METHODS:Among the pa...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2014.8733
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning. Our previous experimental study showed that citalopram may be lead to QT prolongation by stimulating adenos...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.15932
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Gap junctions (GJ) are important in pain signalling at the spinal cord level. AIMS:The aim of this investigation was to study the effects of GJ on nociception and the analgesic/hyperalgesic effects of morphine following administration of carbenoxolone as a GJ blocker. Male Wistar rats (200-250 g) were divid...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2014.13099
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:We investigated whether determination IL-6, IL-8, IL-1beta and TNF-alpha at baseline, total protein C (PC) levels at time of admission and 48 hours after initiation could complement the Acute Physiology and Chronic Health Evaluation (APACHE) II scoring system to identify patients with sepsis, severe sepsis or...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2011.016
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Hemifacial spasm is a sudden, involuntary and synchronous spasm of the facial muscles. The most frequent cause of this condition is compression of the facial nerves due to vascular pathologies. The most commonly used method of treatment is Botulinum toxin injection. However, the gold standard treatment is su...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.150849
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Double-J stents are widely used in urology practice, and removal of these stents can sometimes be forgotten. AIMS:To investigate whether indwelling time of double-J stent can predict which treatment modality is required for removal of the stent from the body. STUDY DESIGN:A multicentre, retrospective obser...
journal_title:Balkan medical journal
pub_type: 杂志文章,多中心研究
doi:10.4274/balkanmedj.2015.1562
更新日期:2017-08-04 00:00:00
abstract:BACKGROUND:Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS:To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and A...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2015.0865
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of the most common allelic variants of CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, CYP2F1, CYP2J2 and CYP2S1 in a representative sample of the three ethnic groups (Russians, Tatars and Bashkirs) from Republic of Bashkortostan (Russia), and compare the results with existing data publish...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.039
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have recently raised the interest as a possible thrombophilic factors. AIMS:We aimed to assess the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic venous thromboembolism (VTE) in a Romanian po...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.7159
更新日期:2013-06-01 00:00:00
abstract::In this invited review article, I present a translational perspective and overview of our research on auditory hallucinations in schizophrenia at the University of Bergen, Norway, with a focus on the neuronal mechanisms underlying the phenomenology of experiencing "hearing voices". An auditory verbal hallucination (i....
journal_title:Balkan medical journal
pub_type: 杂志文章,评审
doi:10.4274/balkanmedj.2017.1226
更新日期:2017-12-01 00:00:00
abstract:Background:Scoring systems are useful to inform the patients about the success and complication rates of the operation prior the surgery. Aims:To determine the applicability of the popular scoring systems (Guy’s, stone size, tract length, obstruction, number of involved calices, and essence/stone density and Clinical ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2017.1631
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Presacral teratomas are usually observed in the first two decades of life and have a 50-67% incidence of malignant transformation. Surgery is the treatment of choice. CASE REPORT:Here, we report the case of 24-year-old female with chronic urinary retention after surgery for a presacral teratoma. CONCLUSION...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2014.9449
更新日期:2014-03-01 00:00:00
abstract:Background:The ideal prophylaxis duration for transrectal ultrasonography-guided prostate biopsy is incompletely defined. Aims:To compare the infectious complications of transrectal ultrasonography-guided prostate biopsy with and without extended antibiotic prophylaxis. The secondary aim was to evaluate the risk facto...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2018.0477
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:Bloodstream infections (BSI) are frequently seen after solid organ transplantation. The incidence of bloodstream infections differs among the types of transplantation. The microbiological features and antimicrobial resistance patterns change from centre to centre. AIMS:To evaluate the incidence and spectrum...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.9256
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:In women with endometrial hyperplasia, there is a risk for co-existent endometrial cancer when patients are subjected to immediate surgical treatment. AIMS:The aim of this study was to investigate the frequency of endometrial cancer and the accuracy of frozen section analysis at the time of hysterectomy amo...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2016.151232
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. We aimed to investigate the matrix metalloproteinase-9 (MMP-9) level and MMP-9 gene polymorphism in sleep apnea patients with or without cardiovascular disease. STUDY DESIGN:Case-control study. MATER...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.068
更新日期:2013-03-01 00:00:00
abstract:Background:Regardless of the notable reduction in infant deaths worldwide over the last 30 years, the proportion of neonatal mortality in total child mortality is increasing. Aims:To perform a trend analysis of neonatal mortality in Serbia. Study Design:Descriptive observational study. Methods:Joinpoint regression w...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2020.2019.5.145
更新日期:2020-04-10 00:00:00
abstract:BACKGROUND:Inflammatory myofibroblastic tumors are rare benign tumors that can mimic malignancy. Their precise aetiology is unknown. They are seen more frequently in childhood and the most common involvement is seen in the lungs. Primary inflammatory myofibroblastic tumors of the gallbladder are rather infrequent. The ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.8263
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Many studies focusing on the effects of local anaesthetics on QT intervals have been performed, but the articles evaluating the relationship between thoracic epidural anaesthesia combined with general anaesthesia and QT parameters are very limited. AIMS:We aimed to compare the effects of bupivacaine and rop...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2013.9275
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:In order to determine the presence or absence of a certain disease, multiple diagnostic tests may be necessary. Performance of these tests can be sequentially evaluated. AIMS:The aim of the study is to determine the contribution of the test in each step, in reducing diagnostic uncertainty when multiple test...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2012.103
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Apigenin is a plant-derived compound belonging to the flavone class, which possess antioxidant, free-radical-scavenging and anti-inflammatory properties. AIMS:To address the effects of apigenin on serum anti-mullerian hormone levels, tissue oxidative stress parameters and histopathological changes in ovaria...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2016.1386
更新日期:2017-09-29 00:00:00
abstract::Morphologically congenital sensorineural hearing loss can be investigated under two categories. The majority of congenital hearing loss causes (80%) are membranous malformations. Here, the pathology involves inner ear hair cells. There is no gross bony abnormality and, therefore, in these cases high-resolution compute...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2017.0367
更新日期:2017-09-29 00:00:00
abstract:BACKGROUND:After resection, specimens are subjected to formalin fixation during histological processing. This procedure can result in tissue shrinkage, with the amount of shrinkage related to tissue composition and tissue type. AIMS:To evaluate the shrinkage of nasal mucosa and cartilage tissue and compare differences...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.2015.1470
更新日期:2017-09-29 00:00:00
abstract:BACKGROUND:Calvarial lesions are often detected incidentally in routine radiology. Most lytic lesions of the skull are benign. Enlarged parietal foramina are benign lesions caused by deficient intramembranous ossification. CASE REPORT:An 11 month-old female patient was admitted with a mass on the right of the back of ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2014.14528
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the ex-utero intrapartum therapy (EXIT) applied to 3 of the 7 cases with oropharyngeal or neck masses and review the indicators of the need for an EXIT procedure. CASE REPORT:Prenatal presentation, size and localization of the masses, existence of fetal hydrops and associ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.5152/balkanmedj.2015.150096
更新日期:2015-04-01 00:00:00
abstract:Background:There is only limited information about the cost-effectiveness of drug-eluting stents compared with bare-metal stents in Turkey. Aims:To evaluate bare-metal and drug-eluting stents used in the treatment of coronary artery disease from the perspective of the reimbursement institution with cost-effectiveness ...
journal_title:Balkan medical journal
pub_type: 杂志文章
doi:10.4274/balkanmedj.galenos.2019.2018.12.28
更新日期:2019-08-22 00:00:00